{"64200":{"#nid":"64200","#data":{"type":"event","title":"A Woman is Not a Small Man","body":[{"value":"\u003Cp\u003EAbstract:\u0026nbsp; More women die of cardiovascular disease than the next seven\ncauses of death combined. While the rate of cardiovascular disease has\nbeen steadily declining in men, it has remained relatively constant in\nwomen. However, most drugs and devices used to treat heart disease have\nbeen studied in men and then applied to women, assuming that doses and\ndevices should be scaled down, purely by size. Medical treatment should\ntake biologic sex\/gender into consideration. For example, women having\na heart attack may have different symptoms than men.Those symptoms in\nwomen might include fatigue, body aches and jaw pain. In support of\nthese sex differences, low doses of aspirin are beneficial for both\nsexes but in women, low-dose aspirin helps prevent stroke but not heart\nattacks. In men, low-dose aspirin helps prevent heart attacks but not\nstroke. These facts emphasize the inadequacy of studying drugs and\ndevices only in men. Researchers are now beginning to conduct studies\nthat include female animals and women.This is a welcome change given\nthat sex differences extend to many arenas, including responses to\nexercise and to the effect of cancer on the heart. For instance, male\nmice voluntarily run 25 to 31 miles per week. But female mice run twice\nthe distance of males each week, and they have stronger cardiac\nresponses to a given amount of exercise than males. Similarly, hearts\nof male animals response much more pathologically than hearts of\nfemales to cancer. These differences have been studied in mice and\nobserved in humans. Males with cancer lose more body weight and cardiac\nmass than do females; and both of these are detrimental. This\ndifference is due to higher levels of estrogen in females. When\nestrogen receptors are blocked in female mice, they experience weight\nloss and heart-mass loss similar to males. At the same time, if male\nmice are given estrogen, they get worse, indicating that estrogen might\nbe protective in females, but harmful in males. This could be relevant\nto humans who ingest large quantities of soy (Americans spent $8\nbillion on soy products in 2008), which contain large quantities of\nplant estrogens.\u0026nbsp;Normal laboratory mouse food is soy-based, and male\nmice fed this diet have much worse heart disease than do female mice.\nTaken together these facts suggest that soy consumption in laboratory\nanimals may influence functional outcomes and that sex-based medicine\nshould be an important consideration.\u003C\/p\u003E","summary":null,"format":"limited_html"}],"field_subtitle":"","field_summary":[{"value":"\u003Cp\u003EIBB Seminar Series\u003C\/p\u003E\u003Cp\u003ELeslie Anne Leinwand, PhD - University of Colorado at Boulder\u003C\/p\u003E\u003Cp\u003EA Woman is Not a Small Man\u003C\/p\u003E","format":"limited_html"}],"field_summary_sentence":[{"value":"Leslie Anne Leinwand, PhD - University of Colorado at Boulder"}],"uid":"27195","created_gmt":"2011-02-11 12:06:34","changed_gmt":"2016-10-08 01:54:05","author":"Colly Mitchell","boilerplate_text":"","field_publication":"","field_article_url":"","field_event_time":{"event_time_start":"2011-02-17T10:00:00-05:00","event_time_end":"2011-02-17T11:00:00-05:00","event_time_end_last":"2011-02-17T11:00:00-05:00","gmt_time_start":"2011-02-17 15:00:00","gmt_time_end":"2011-02-17 16:00:00","gmt_time_end_last":"2011-02-17 16:00:00","rrule":null,"timezone":"America\/New_York"},"extras":[],"related_links":[{"url":"http:\/\/cimb.colorado.edu\/directory\/leinwand","title":"Leinwand profile"}],"groups":[{"id":"1292","name":"Parker H. Petit Institute for Bioengineering and Bioscience (IBB)"}],"categories":[],"keywords":[{"id":"248","name":"IBB"},{"id":"5168","name":"IBB Seminar"},{"id":"11880","name":"Leinwand"}],"core_research_areas":[],"news_room_topics":[],"event_categories":[{"id":"1795","name":"Seminar\/Lecture\/Colloquium"}],"invited_audience":[],"affiliations":[],"classification":[],"areas_of_expertise":[],"news_and_recent_appearances":[],"phone":[],"contact":[{"value":"\u003Cp\u003EFaculty host:\u0026nbsp; Bob Guldberg (404) 894-6589\u003C\/p\u003E","format":"limited_html"}],"email":[],"slides":[],"orientation":[],"userdata":""}}}