{"643845":{"#nid":"643845","#data":{"type":"event","title":"QBioS Student Seminar Series - Guanlin Li","body":[{"value":"\u003Cp\u003E\u003Cem\u003E\u003Cstrong\u003EOptimizing use of multiphage \u0026lsquo;cocktails\u0026rsquo; for treatment of immunodeficient hosts: a model-based control approach\u003C\/strong\u003E\u003C\/em\u003E\u003C\/p\u003E\r\n\r\n\u003Cp\u003EThe addition of therapeutic phage to treat Multi-Drug Resistant (MDR) pathogens imposes a strong selective pressure for the emergence of phage-resistant bacteria. Modeling and \u003Cem\u003Ein vivo\u003C\/em\u003E experiments\u0026nbsp;have established that phage-resistant bacteria proliferate in Myd88-\/- (immunodeficient) mice, corresponding to a\u0026nbsp;failure of phage therapy. This work\u0026nbsp;aims to\u0026nbsp;develop evolutionarily robust phage therapy in immunodeficient hosts.\u0026nbsp;First,\u0026nbsp;we consider a model where bacteria evolve in an abstract discrete phenotypic space\u0026nbsp;against different types of phages present in a\u0026nbsp;therapeutic phage library.\u0026nbsp;Second, we formulate a single-dose optimization problem subject to the proposed eco-evolutionary dynamics.\u0026nbsp;The goal is to minimize the total bacterial population while\u0026nbsp;penalizing the treatment costs by optimizing the phage therapy administrations. Finally, we extend single-dose treatment to multi-dose treatment and find the optimal policy via control theory.\u0026nbsp;\u003C\/p\u003E\r\n\r\n\u003Cp\u003EThis seminar will be hosted at \u003Ca href=\u0022https:\/\/bluejeans.com\/558060212\u0022\u003Ethis bluejeans link\u003C\/a\u003E.\u003C\/p\u003E\r\n","summary":null,"format":"limited_html"}],"field_subtitle":"","field_summary":[{"value":"\u003Cp\u003EQBioS 4th year student Guanlin Li (homeschool of physics), advised by Joshua Weitz, will present \u0026quot;Optimizing use of multiphage \u0026lsquo;cocktails\u0026rsquo; for treatment of immunodeficient hosts: a model-based control approach\u0026quot;\u003C\/p\u003E\r\n","format":"limited_html"}],"field_summary_sentence":[{"value":"QBioS Seminar Series - Guanlin Li"}],"uid":"35673","created_gmt":"2021-02-03 20:13:08","changed_gmt":"2021-02-04 02:07:51","author":"dmuratore3","boilerplate_text":"","field_publication":"","field_article_url":"","field_event_time":{"event_time_start":"2021-02-11T16:00:00-05:00","event_time_end":"2021-02-11T17:00:00-05:00","event_time_end_last":"2021-02-11T17:00:00-05:00","gmt_time_start":"2021-02-11 21:00:00","gmt_time_end":"2021-02-11 22:00:00","gmt_time_end_last":"2021-02-11 22:00:00","rrule":null,"timezone":"America\/New_York"},"extras":[],"hg_media":{"643828":{"id":"643828","type":"image","title":"qbios_seminar_02_11_2021_flyer","body":null,"created":"1612377519","gmt_created":"2021-02-03 18:38:39","changed":"1612377519","gmt_changed":"2021-02-03 18:38:39","alt":"","file":{"fid":"244441","name":"guanlin_poster.png","image_path":"\/sites\/default\/files\/images\/guanlin_poster.png","image_full_path":"http:\/\/www.tlwarc.hg.gatech.edu\/\/sites\/default\/files\/images\/guanlin_poster.png","mime":"image\/png","size":565543,"path_740":"http:\/\/www.tlwarc.hg.gatech.edu\/sites\/default\/files\/styles\/740xx_scale\/public\/images\/guanlin_poster.png?itok=XeGMwGoZ"}}},"media_ids":["643828"],"groups":[{"id":"562111","name":"QBioS"}],"categories":[],"keywords":[{"id":"138191","name":"go-qbios"},{"id":"147941","name":"go_qbios"},{"id":"168667","name":"QBioS"},{"id":"182721","name":"Qbios seminar"}],"core_research_areas":[],"news_room_topics":[],"event_categories":[{"id":"1795","name":"Seminar\/Lecture\/Colloquium"}],"invited_audience":[{"id":"78761","name":"Faculty\/Staff"},{"id":"177814","name":"Postdoc"},{"id":"78771","name":"Public"},{"id":"174045","name":"Graduate students"},{"id":"78751","name":"Undergraduate students"}],"affiliations":[],"classification":[],"areas_of_expertise":[],"news_and_recent_appearances":[],"phone":[],"contact":[{"value":"\u003Cp\u003EBluejeans link for the seminar is available \u003Ca href=\u0022https:\/\/bluejeans.com\/558060212\u0022\u003Ehere\u003C\/a\u003E.\u003C\/p\u003E\r\n\r\n\u003Cp\u003EContact Daniel Muratore (\u003Ca href=\u0022https:\/\/qbios.gatech.edu\/people\/Daniel%20Muratore\u0022\u003Ehere\u003C\/a\u003E) for questions.\u0026nbsp;\u003C\/p\u003E\r\n","format":"limited_html"}],"email":[],"slides":[],"orientation":[],"userdata":""}}}