{"652571":{"#nid":"652571","#data":{"type":"event","title":"Biomedical Engineering Seminars \u2013 CD\u0026I Distinguished Lectures","body":[{"value":"\u003Cp\u003E\u003Cstrong\u003EThis event is offered virtually. \u003Ca href=\u0022https:\/\/zoom.us\/j\/97421219805?pwd=b2ZUZElTQ044anlVbFRib2VIQk1IQT09\u0022\u003EPlease click here to join via Zoom.\u003C\/a\u003E\u003C\/strong\u003E\u003Cbr \/\u003E\r\n\u0026nbsp;\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u003Cstrong\u003E\u0026quot;Understanding cell-cell particle-cell interaction in blood: Implication in the design and clinical translational of vascular-targeted drug carriers\u0026quot;\u003C\/strong\u003E\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u003Cstrong\u003E\u003Ca href=\u0022https:\/\/che.engin.umich.edu\/people\/eniola-adefeso-lola\/\u0022\u003ELola Eniola-Adefeso, Ph.D.\u003C\/a\u003E\u003C\/strong\u003E\u003Cbr \/\u003E\r\nAssociate Dean for Graduate \u0026amp; Professional Education, University Diversity and Social Transformation Professor of Chemical Engineering\u003Cbr \/\u003E\r\nUniversity of Michigan\u003Cbr \/\u003E\r\n\u0026nbsp;\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u003Cstrong\u003EABSTRACT\u003C\/strong\u003E\u003Cbr \/\u003E\r\nVascular-targeted particle therapeutics offer the possibility of increased drug effectiveness while minimizing side effects often associated with systemic drug administration. Factors that influence the likelihood of targeted particle therapeutics to reach the vascular wall are the ability to identify: 1) a disease-specific target, 2) the appropriate drug carrier type and geometry for efficient interaction with the vascular wall, and 3) a drug-carrier combination that allows for the desired release of the targeted therapeutics. Our work focuses on probing the role of particle geometry, material chemistry, and blood rheology\/dynamics on the ability of vascular-targeted drug carriers to interact with the blood vessel wall - an important consideration that will control the effectiveness of drug targeting regardless of the targeted disease or delivered therapeutically. This presentation will highlight the carrier-blood cell interactions that affect drug carrier binding to the vascular wall and alter critical neutrophil functions in disease. The talk will present the material design parameters for optimal drug carriers\u0026#39; design for active and passive use in treating many inflammatory diseases.\u003Cbr \/\u003E\r\n\u0026nbsp;\u003C\/p\u003E\r\n\r\n\u003Cp\u003EFaculty Host: Dr. Maysam Nezafati\u003Cbr \/\u003E\r\n\u0026nbsp;\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u003Cem\u003EAs part of the Coulter BME Seminar Series, these talks recognize excellence in science, community, diversity, and inclusion.\u003C\/em\u003E\u003C\/p\u003E\r\n","summary":null,"format":"limited_html"}],"field_subtitle":"","field_summary":[{"value":"\u003Cp\u003E\u0026quot;Understanding cell-cell particle-cell interaction in blood: Implication in the design and clinical translational of vascular-targeted drug carriers\u0026quot; - Lola Eniola-Adefeso, Ph.D., University of Michigan\u003C\/p\u003E\r\n","format":"limited_html"}],"field_summary_sentence":[{"value":"\u0022Understanding cell-cell particle-cell interaction in blood: Implication in the design and clinical translational of vascular-targeted drug carriers\u0022 - Lola Eniola-Adefeso, Ph.D., University of Michigan"}],"uid":"27446","created_gmt":"2021-11-08 20:18:59","changed_gmt":"2021-11-08 20:18:59","author":"Joshua Stewart","boilerplate_text":"","field_publication":"","field_article_url":"","field_event_time":{"event_time_start":"2021-11-15T14:00:00-05:00","event_time_end":"2021-11-15T15:00:00-05:00","event_time_end_last":"2021-11-15T15:00:00-05:00","gmt_time_start":"2021-11-15 19:00:00","gmt_time_end":"2021-11-15 20:00:00","gmt_time_end_last":"2021-11-15 20:00:00","rrule":null,"timezone":"America\/New_York"},"extras":[],"hg_media":{"652568":{"id":"652568","type":"image","title":"11-15-2021 BME Seminar - Adefeso","body":null,"created":"1636402231","gmt_created":"2021-11-08 20:10:31","changed":"1636402231","gmt_changed":"2021-11-08 20:10:31","alt":"Seminar Speaker: Lola Eniola-Adefeso, Ph.D., University of Michigan. \u201cUnderstanding cell-cell particle-cell interaction in blood: Implication in the design and clinical translational of vascular-targeted drug carriers\u201d","file":{"fid":"247578","name":"2021-11-15 BME Seminar Eniola-Adefeso.jpeg","image_path":"\/sites\/default\/files\/images\/2021-11-15%20BME%20Seminar%20Eniola-Adefeso.jpeg","image_full_path":"http:\/\/www.tlwarc.hg.gatech.edu\/\/sites\/default\/files\/images\/2021-11-15%20BME%20Seminar%20Eniola-Adefeso.jpeg","mime":"image\/jpeg","size":169788,"path_740":"http:\/\/www.tlwarc.hg.gatech.edu\/sites\/default\/files\/styles\/740xx_scale\/public\/images\/2021-11-15%20BME%20Seminar%20Eniola-Adefeso.jpeg?itok=zTj4Wc8N"}}},"media_ids":["652568"],"related_links":[{"url":"https:\/\/zoom.us\/j\/97421219805?pwd=b2ZUZElTQ044anlVbFRib2VIQk1IQT09","title":"Join via Zoom"}],"groups":[{"id":"1292","name":"Parker H. Petit Institute for Bioengineering and Bioscience (IBB)"},{"id":"1254","name":"Wallace H. Coulter Dept. of Biomedical Engineering"}],"categories":[],"keywords":[],"core_research_areas":[],"news_room_topics":[],"event_categories":[],"invited_audience":[{"id":"78761","name":"Faculty\/Staff"},{"id":"177814","name":"Postdoc"},{"id":"174045","name":"Graduate students"},{"id":"78751","name":"Undergraduate students"}],"affiliations":[],"classification":[],"areas_of_expertise":[],"news_and_recent_appearances":[],"phone":[],"contact":[],"email":[],"slides":[],"orientation":[],"userdata":""}}}