{"63942":{"#nid":"63942","#data":{"type":"news","title":"Georgia Tech and TERMIS Partner for 2013 Annual Meeting","body":[{"value":"\u003Cp\u003EThe Tissue Engineering and Regenerative Medicine International Society (TERMIS) will partner with the Parker H. Petit Institute for Bioengineering and Bioscience at Georgia Tech in 2013 by hosting its annual North American Conference in Atlanta. \u003Cbr \/\u003E \u003Cbr \/\u003ETwo members of the Petit Institute\u2019s faculty have been designated to head the 2013 TERMIS conference. The conference chair will be Robert E. Guldberg, Ph.D., the director of the Petit Institute and professor in mechanical engineering and the program chair will be Todd McDevitt, PhD, associate professor in biomedical engineering and the director of the Stem Cell Engineering Center at Georgia Tech. \u003Cbr \/\u003E \u003Cbr \/\u003E\u201cWe are honored to be selected and look forward to putting on a great meeting,\u201d Guldberg said. TERMIS brings together an international community to promote discussion of the scientific challenges and therapeutic benefits for the development and application of the tissue engineering and regenerative medicine fields. TERMIS\u2019 mission is to promote worldwide science and technology advancement and education in these fields. It does so through regular worldwide conferences, publishing the Tissue Engineering journal that it endorses and providing quarterly newsletters and other communications for its members. \u003Cbr \/\u003E \u003Cbr \/\u003E\u201cBob and I are dedicated to creating a dynamic program that will honor the meetings of the past as well as introduce some new elements,\u201d McDevitt remarked. TERMIS has been evolving over the last decade. Its roots began in 2001 as an annual workshop called \u201cTissue Growth Engineering\u201d that was organized by the Pittsburgh Tissue Engineering Initiative. In 2004, this small workshop evolved into the larger, national meeting called Regenerate. In 2006, the Regenerate World Congress was held in Pittsburgh where the meeting had grown significantly and had a large international following. By the following year, the society was rebranded into TERMIS to encompass its international presence. The society has continued to grow and now has chapters in Europe and Asia. TERMIS is open to anyone engaged in research in the tissue engineering or regenerative medicine arenas. \u003Cbr \/\u003E \u003Cbr \/\u003EThe 2011 TERMIS North American conference was held in Houston, Texas and in 2012 the entire society will come together for the TERMIS World Congress in Vienna, Austria.\u003C\/p\u003E","summary":null,"format":"limited_html"}],"field_subtitle":"","field_summary":[{"value":"\u003Cp\u003EThe Tissue Engineering and Regenerative Medicine International Society (TERMIS) will partner with the Institute for Bioengineering and Bioscience (IBB) at Georgia Tech in 2013 by hosting its annual North American Conference in Atlanta.\u003C\/p\u003E","format":"limited_html"}],"field_summary_sentence":[{"value":"Georgia Tech and TERMIS Partner for 2013 Annual Meeting"}],"uid":"27224","created_gmt":"2011-01-14 01:00:00","changed_gmt":"2016-10-08 03:08:06","author":"Megan McDevitt","boilerplate_text":"","field_publication":"","field_article_url":"","dateline":{"date":"2011-01-18T00:00:00-05:00","iso_date":"2011-01-18T00:00:00-05:00","tz":"America\/New_York"},"extras":[],"hg_media":{"64111":{"id":"64111","type":"image","title":"TERMIS","body":null,"created":"1449176720","gmt_created":"2015-12-03 21:05:20","changed":"1475894559","gmt_changed":"2016-10-08 02:42:39","alt":"TERMIS","file":{"fid":"191940","name":"termis_logo_1.jpg","image_path":"\/sites\/default\/files\/images\/termis_logo_1_0.jpg","image_full_path":"http:\/\/www.tlwarc.hg.gatech.edu\/\/sites\/default\/files\/images\/termis_logo_1_0.jpg","mime":"image\/jpeg","size":127070,"path_740":"http:\/\/www.tlwarc.hg.gatech.edu\/sites\/default\/files\/styles\/740xx_scale\/public\/images\/termis_logo_1_0.jpg?itok=ha69ZdMV"}}},"media_ids":["64111"],"related_links":[{"url":"http:\/\/ibb.gatech.edu\/","title":"Parker H. Petit Institute for Bioengineering and Bioscience"},{"url":"http:\/\/www.termis.org\/","title":"TERMIS"},{"url":"http:\/\/scec.gatech.edu\/","title":"Stem Cell Engineering Center"}],"groups":[{"id":"1292","name":"Parker H. Petit Institute for Bioengineering and Bioscience (IBB)"}],"categories":[{"id":"129","name":"Institute and Campus"},{"id":"131","name":"Economic Development and Policy"},{"id":"132","name":"Institute Leadership"},{"id":"141","name":"Chemistry and Chemical Engineering"},{"id":"133","name":"Special Events and Guest Speakers"},{"id":"134","name":"Student and Faculty"},{"id":"145","name":"Engineering"},{"id":"146","name":"Life Sciences and Biology"},{"id":"149","name":"Nanotechnology and Nanoscience"},{"id":"135","name":"Research"}],"keywords":[{"id":"1489","name":"Regenerative Medicine"},{"id":"11629","name":"Robert Guldberg"},{"id":"4891","name":"Tissue Engineering"},{"id":"760","name":"Todd McDevitt"}],"core_research_areas":[],"news_room_topics":[],"event_categories":[],"invited_audience":[],"affiliations":[],"classification":[],"areas_of_expertise":[],"news_and_recent_appearances":[],"phone":[],"contact":[{"value":"\u003Cp\u003E\u003Cstrong\u003EMegan McDevitt\u003C\/strong\u003E\u003Cbr \/\u003EIBB\u003Cbr \/\u003E\u003Ca href=\u0022http:\/\/www.gatech.edu\/contact\/index.html?id=mm504\u0022\u003EContact Megan McDevitt\u003C\/a\u003E\u003Cbr \/\u003E\u003Cstrong\u003E404-385-7001\u003C\/strong\u003E\u003C\/p\u003E","format":"limited_html"}],"email":["megan.mcdevitt@ibb.gatech.edu"],"slides":[],"orientation":[],"userdata":""}},"61395":{"#nid":"61395","#data":{"type":"news","title":"Manu Platt Wins $1.5M NIH Director\u0027s New Innovator Award","body":[{"value":"\u003Cp\u003EA researcher from the biomedical engineering department operated by Georgia Tech and Emory University has received a $1.5 million NIH Director\u0027s New Innovator Award to support a project aimed at reducing the incidence of stroke in children with sickle cell disease. Manu Platt, an assistant professor in the Wallace H. Coulter Department of Biomedical Engineering, will use the National Institutes of Health (NIH) funding to develop models for identifying which children with the disease are at risk for stroke.\n\u003C\/p\u003E\n\u003Cp\u003EThe first case of sickle cell disease was identified in 1910 and today it affects more than 70,000 Americans. It is seen mostly in persons of African descent, but also in individuals of Middle Eastern, Mediterranean, Central and South American, and Asian Indian heritage. Approximately 10 percent of children with sickle cell disease suffer a stroke. Having experienced one stroke, they are at high risk of having another. \n\u003C\/p\u003E\n\u003Cp\u003E\u0022Current therapies to prevent strokes in children with sickle cell disease have substantial side effects, so we need to create better ways to predict which patients need intervention,\u0022 said Platt, who is also a Georgia Cancer Coalition Distinguished Cancer Scholar. \u0022My goal is to use experimental and clinical data to develop a mathematical model for predicting stroke risk in pediatric patients with sickle cell disease to allow for earlier intervention.\u0022 \n\u003C\/p\u003E\n\u003Cp\u003ENow in its fourth year, the 2010 NIH Director\u0027s New Innovator Awards will support 52 exceptionally creative new investigators who propose highly innovative projects that have the potential for unusually high impact. \n\u003C\/p\u003E\n\u003Cp\u003E\u0022NIH is pleased to be supporting early-stage investigators from across the country who are taking considered risks in a wide range of areas in order to accelerate research,\u0022 said Francis S. Collins, M.D., Ph.D., director of the National Institutes of Health. \u0022We look forward to the results of their work.\u0022 \n\u003C\/p\u003E\n\u003Cp\u003EPlatt\u0027s research project will integrate cell biology, clinical pediatric hematology, enzyme kinetic modeling and dynamics, predictive statistical regression modeling, biomechanics, tissue remodeling and personalized medicine. \n\u003C\/p\u003E\n\u003Cp\u003E\u0022Successful integration of all these areas would significantly advance the diagnosis and therapeutic intervention of strokes in children with sickle cell disease in a way that has not been seen in the one hundred years since this disease was first identified,\u0022 said Platt. \n\u003C\/p\u003E\n\u003Cp\u003EThe disease hits close to home for Platt, whose brother was recently diagnosed with sickle cell trait -- meaning he inherited a sickle cell gene from one of his parents and a normal gene from the other. In Georgia, one in every 1,300 children is born with sickle cell disease. \n\u003C\/p\u003E\n\u003Cp\u003ESickle cell disease is a genetic condition present at birth. It involves an altered gene that produces abnormal hemoglobin -- the protein that carries oxygen in the blood. In sickle cell disease, red blood cells become hard, sticky and \u0022C\u0022 shaped. Sickle cells die early, which causes a constant shortage of red blood cells. \n\u003C\/p\u003E\n\u003Cp\u003EThe abnormal cells also clog the flow in small blood vessels, causing chronic pain and other serious problems such as infections and acute chest syndrome. Strokes, however, occur in large arteries with high blood flow rates and other biomechanical parameters known to cause plaque formation in atherosclerosis. The damage caused by sickled red blood cells in the arteries and links to remodeling of the arteries have not been extensively studied. \n\u003C\/p\u003E\n\u003Cp\u003ETo understand the coordination of the mechanisms that produce structural changes in the arterial wall leading to stroke, Platt plans to model sickle cell disease from the molecular level to the human level based on clinical data, novel biomarkers and patient outcomes. First, he plans to develop a quantitative model that will detail the activation and inactivation of proteases -- enzymes that break down proteins -- in the artery walls of individuals with sickle cell disease. \n\u003C\/p\u003E\n\u003Cp\u003E\u0022I will focus on incorporating different cathepsins, elastin and collagens into the model,\u0022 said Platt. \u0022I plan to use an assay recently developed in my laboratory that reliably detects and quantifies mature cathepsins using a technique called gelatin zymography.\u0022\n\u003C\/p\u003E\n\u003Cp\u003EAfter determining which proteases play a role in sickle cell disease, Platt will then determine how biomechanical conditions of sickle cell disease, such as altered blood flow and red blood cell stiffness, affect cell-mediated remodeling of arteries by these proteases. This will be done in collaboration with Coulter Department professor Gilda Barabino. With this information, Platt can link quantitative measures of blood flow and inflammatory markers found in sickle cell disease to the narrowing of artery openings and associated protease remodeling. \n\u003C\/p\u003E\n\u003Cp\u003EThese markers will first be validated with animal models of sickle cell disease, in collaboration with Solomon Ofori-Acquah, an assistant professor of pediatrics at Emory University and the Children\u0027s Healthcare of Atlanta Aflac Cancer Center and Blood Disorders Service. Further validation will come from blood samples collected from individuals with sickle cell disease, which will be provided by Beatrice Gee, medical director of the Hematology and Sickle Cell Program at Children\u0027s Healthcare of Atlanta at Hughes Spalding and an associate professor of clinical pediatrics at the Morehouse School of Medicine. \n\u003C\/p\u003E\n\u003Cp\u003EOverall, Platt will integrate biochemical and biomechanical mechanisms of cardiovascular disease with predictive mathematical models that robustly interpret clinical biomarkers to develop a personalized medicine protocol that will predict strokes in individuals with sickle cell disease and reveal new mechanisms for therapeutic targets. If these methods are successful, they could be expanded to broader categories of cardiovascular disease, such as atherosclerosis, myocardial infarctions and heart valve stenosis. \n\u003C\/p\u003E","summary":null,"format":"limited_html"}],"field_subtitle":"","field_summary":[{"value":"A researcher from the biomedical engineering department operated by Georgia Tech and Emory University has received a $1.5 million NIH Director\u0027s New Innovator Award to support a project aimed at reducing the incidence of stroke in children with sickle cell disease. Manu Platt, an assistant professor in the Wallace H. Coulter Department of Biomedical Engineering, will use the National Institutes of Health (NIH) funding to develop models for identifying which children with the disease are at risk for stroke.","format":"limited_html"}],"field_summary_sentence":[{"value":"Manu Platt Wins $1.5M NIH Director\u0027s New Innovator Award"}],"uid":"27349","created_gmt":"2010-10-01 00:00:00","changed_gmt":"2016-10-08 03:07:31","author":"Floyd Wood","boilerplate_text":"","field_publication":"","field_article_url":"","dateline":{"date":"2010-09-30T00:00:00-04:00","iso_date":"2010-09-30T00:00:00-04:00","tz":"America\/New_York"},"extras":[],"groups":[{"id":"1292","name":"Parker H. Petit Institute for Bioengineering and Bioscience (IBB)"}],"categories":[{"id":"129","name":"Institute and Campus"},{"id":"141","name":"Chemistry and Chemical Engineering"},{"id":"134","name":"Student and Faculty"},{"id":"145","name":"Engineering"},{"id":"135","name":"Research"}],"keywords":[{"id":"1612","name":"BME"},{"id":"109","name":"Georgia Tech"},{"id":"248","name":"IBB"},{"id":"10832","name":"Manu Platt"},{"id":"10833","name":"NIH Director\u0027s New Innovator Award"}],"core_research_areas":[],"news_room_topics":[],"event_categories":[],"invited_audience":[],"affiliations":[],"classification":[],"areas_of_expertise":[],"news_and_recent_appearances":[],"phone":[],"contact":[{"value":"\u003Cstrong\u003EAbby Vogel Robinson\u003C\/strong\u003E\u003Cbr \/\u003EResearch News and Publications\u003Cbr \/\u003E\u003Ca href=\u0022http:\/\/www.gatech.edu\/contact\/index.html?id=avogel6\u0022\u003EContact Abby Vogel Robinson\u003C\/a\u003E\u003Cbr \/\u003E\u003Cstrong\u003E404-385-3364\u003C\/strong\u003E","format":"limited_html"}],"email":["abby@innovate.gatech.edu"],"slides":[],"orientation":[],"userdata":""}},"60675":{"#nid":"60675","#data":{"type":"news","title":"NSF Awards Stem Cell Bio-Manufacturing Research and Edu. Program to GT","body":[{"value":"\u003Cp\u003EThe National Science Foundation (NSF) has awarded $3 million to the Georgia Institute of Technology to fund a unique research program on stem cell bio-manufacturing. The program is specifically focused on developing engineering methods for stem cell production, in order to meet the anticipated demand for stem cells. The award comes through the NSF\u0027s Integrative Graduate Education and Research Traineeship (IGERT) Program, which supports innovation in graduate education in fields that cross academic disciplines and have broad societal impact.\n\u003C\/p\u003E\n\u003Cp\u003EWhile stem cell research is on the verge of broadly impacting many elements of the medical field - regenerative medicine, drug discovery and development, cell-based diagnostics and cancer - the bio-process engineering that will be required to manufacture sufficient quantities of functional stem cells for these diagnostic and therapeutic purposes has not been rigorously explored.\n\u003C\/p\u003E\n\u003Cp\u003E\u0022Successfully integrating knowledge of stem cell biology with bioprocess engineering and process development into single individuals is the challenging goal of this program,\u0022 said Todd McDevitt, an associate professor in the Wallace H. Coulter Department of Biomedical Engineering at Georgia Tech and Emory University and a Petit Faculty Fellow in the Parker H. Petit Institute for Bioengineering and Biosciences at Georgia Tech.\n\u003C\/p\u003E\n\u003Cp\u003EMcDevitt is leading the IGERT with Robert M. Nerem, professor emeritus of the George W. Woodruff School of Mechanical Engineering at Georgia Tech. Nerem is also director of the Georgia Tech\/Emory Center (GTEC) for Regenerative Medicine, which will administer this award.\n\u003C\/p\u003E\n\u003Cp\u003EPh.D. students funded by Georgia Tech\u0027s stem cell bio-manufacturing IGERT will receive interdisciplinary educational training in the biology, engineering, enabling technologies, commercialization and public policy related to stem cells. Their research efforts will focus on developing innovative engineering approaches to bridge the gap between basic discoveries made in stem cell biology and therapeutic stem cell-based technologies.\n\u003C\/p\u003E\n\u003Cp\u003E\u0022This program provides a unique opportunity for engineers to generate standardized and quantitative methods for stem cell isolation, characterization, propagation and differentiation,\u0022 said Nerem. \u0022These techniques must be developed in a scalable manner to efficiently produce sufficient numbers of stem cells and derivatives in accessible formats in order to yield a spectrum of novel therapeutic and diagnostic applications of stem cells.\u0022\n\u003C\/p\u003E\n\u003Cp\u003EThe Georgia Tech program is centered around three main research thrusts, which focus on several critical technologies that must be developed to enable the application and use of stem cell-based products:\n\u003C\/p\u003E\n\u003Cp\u003E* Creating reproducible, controlled and scalable methods to expand and differentiate stem cells with defined phenotypes and epigenetic states.\u003Cbr \/\u003E\n* Developing reliable, rapid and quantifiable methods to characterize the composition and function of stem cells to be generated.\u003Cbr \/\u003E\n* Designing low-cost systems capable of producing large populations of defined stem cells and derivatives.\n\u003C\/p\u003E\n\u003Cp\u003EStudents in the program will be able to take advantage of the core facilities provided by the new Stem Cell Engineering Center at Georgia Tech, which is directed by McDevitt. Technologies developed by the students supported through this IGERT will be rapidly integrated into academic and industrial stem cell practices and cell-based products.\n\u003C\/p\u003E\n\u003Cp\u003EThe award will support 30 new Ph.D. students over the next five years and brings together more than two dozen faculty members from Georgia Tech, Emory University, the University of Georgia and the Morehouse School of Medicine. In addition, plans are being made for students to participate in international research collaborations with the National University of Ireland at Galway, Imperial College London, the University of Cambridge and the University of Toronto.\n\u003C\/p\u003E\n\u003Cp\u003E\u0022We anticipate this program will produce the future leaders and innovators in the field of stem cell bio-manufacturing who will contribute significantly at the interface of stem cell engineering, biology and therapy,\u0022 added McDevitt.\n\u003C\/p\u003E","summary":null,"format":"limited_html"}],"field_subtitle":"","field_summary":[{"value":"Biomedical engineering associate professor Todd McDevitt is co-leading Georgia Tech\u0027s new research program on stem cell bio-manufacturing, which is specifically focused on developing engineering methods for stem cell production in order to meet the anticipated demand for stem cells.","format":"limited_html"}],"field_summary_sentence":[{"value":"NSF Awards Stem Cell Bio-Manufacturing Research and Edu. Program"}],"uid":"27349","created_gmt":"2010-08-16 00:00:00","changed_gmt":"2016-10-08 03:07:19","author":"Floyd Wood","boilerplate_text":"","field_publication":"","field_article_url":"","dateline":{"date":"2010-08-16T00:00:00-04:00","iso_date":"2010-08-16T00:00:00-04:00","tz":"America\/New_York"},"extras":[],"hg_media":{"60676":{"id":"60676","type":"image","title":"Todd McDevitt","body":null,"created":"1449176281","gmt_created":"2015-12-03 20:58:01","changed":"1475894528","gmt_changed":"2016-10-08 02:42:08","alt":"Todd McDevitt","file":{"fid":"191188","name":"tjb64868.jpg","image_path":"\/sites\/default\/files\/images\/tjb64868_0.jpg","image_full_path":"http:\/\/www.tlwarc.hg.gatech.edu\/\/sites\/default\/files\/images\/tjb64868_0.jpg","mime":"image\/jpeg","size":36421,"path_740":"http:\/\/www.tlwarc.hg.gatech.edu\/sites\/default\/files\/styles\/740xx_scale\/public\/images\/tjb64868_0.jpg?itok=aJ1zxIjr"}}},"media_ids":["60676"],"groups":[{"id":"1292","name":"Parker H. Petit Institute for Bioengineering and Bioscience (IBB)"}],"categories":[{"id":"129","name":"Institute and Campus"},{"id":"140","name":"Cancer Research"},{"id":"132","name":"Institute Leadership"},{"id":"141","name":"Chemistry and Chemical Engineering"},{"id":"134","name":"Student and Faculty"},{"id":"145","name":"Engineering"},{"id":"146","name":"Life Sciences and Biology"},{"id":"149","name":"Nanotechnology and Nanoscience"},{"id":"135","name":"Research"}],"keywords":[{"id":"1612","name":"BME"},{"id":"248","name":"IBB"},{"id":"10506","name":"IGERT"},{"id":"6217","name":"McDevitt"},{"id":"363","name":"NSF"},{"id":"171009","name":"stem cell bio-manufacturing"}],"core_research_areas":[],"news_room_topics":[],"event_categories":[],"invited_audience":[],"affiliations":[],"classification":[],"areas_of_expertise":[],"news_and_recent_appearances":[],"phone":[],"contact":[{"value":"\u003Cstrong\u003EAbby Vogel Robinson\u003C\/strong\u003E\u003Cbr \/\u003EResearch News and Publications\u003Cbr \/\u003E\u003Ca href=\u0022http:\/\/www.gatech.edu\/contact\/index.html?id=avogel6\u0022\u003EContact Abby Vogel Robinson\u003C\/a\u003E\u003Cbr \/\u003E\u003Cstrong\u003E404-385-3364\u003C\/strong\u003E","format":"limited_html"}],"email":["abby@innovate.gatech.edu"],"slides":[],"orientation":[],"userdata":""}},"48923":{"#nid":"48923","#data":{"type":"news","title":"Delivering Stem Cells Improves Repair of Major Bone Injuries in Rats","body":[{"value":"\u003Cp\u003EA study published this week reinforces the potential value of stem cells in repairing major injuries involving the loss of bone structure.  \u003C\/p\u003E\n\u003Cp\u003EThe study shows that delivering stem cells on a polymer scaffold to treat large areas of missing bone leads to improved bone formation and better mechanical properties compared to treatment with the scaffold alone. This type of therapeutic treatment could be a potential alternative to bone grafting operations.\n\u003C\/p\u003E\n\u003Cp\u003E\u0022Massive bone injuries are among the most challenging problems that orthopedic surgeons face, and they are commonly seen as a result of accidents as well as in soldiers returning from war,\u0022 said the study\u0027s lead author Robert Guldberg, a professor in Georgia Tech\u0027s Woodruff School of Mechanical Engineering. \u0022This study shows that there is promise in treating these injuries by delivering stem cells to the injury site. These are injuries that would not heal without significant medical intervention.\u0022\n\u003C\/p\u003E\n\u003Cp\u003EDetails of the research were published in the early edition of the journal \u003Cem\u003EProceedings of the National Academy of Sciences\u003C\/em\u003E on January 11, 2010. This work was funded by the National Institutes of Health and the National Science Foundation.\n\u003C\/p\u003E\n\u003Cp\u003EThe study was conducted in rats in which two bone gaps eight millimeters in length were created to simulate massive injuries. One gap was treated with a polymer scaffold seeded with stem cells and the other with scaffold only. The results showed that injuries treated with the stem cell scaffolds showed significantly more bone growth than injuries treated with scaffolds only. \n\u003C\/p\u003E\n\u003Cp\u003EGuldberg and mechanical engineering graduate student Kenneth Dupont experimented with scaffolds containing two different types of human stem cells -- bone marrow-derived mesenchymal adult stem cells and amniotic fluid fetal stem cells. \n\u003C\/p\u003E\n\u003Cp\u003E\u0022We were able to directly evaluate the therapeutic potential of human stem cells to repair large bone defects by implanting them into rats with a reduced immune system,\u0022 explained Guldberg, who is also the director of the Petit Institute for Bioengineering and Bioscience at Georgia Tech.\u003C\/p\u003E\n\u003Cp\u003EMicro-CT measurements showed no significant differences in bone regeneration between the two stem cell groups. However, combining the two types of stem cells produced significantly higher bone volume and strength compared to scaffolds without cellular augmentation.\n\u003C\/p\u003E\n\u003Cp\u003EAlthough stem cell delivery significantly enhanced bone growth and biomechanical properties, it was not able to consistently repair the injury. Eight weeks after the treatment, new bone bridged the gaps in four of nine defects treated with scaffolds seeded with adult stem cells, one of nine defects treated with scaffolds seeded with fetal stem cells, and none of the defects treated with the scaffold alone.\n\u003C\/p\u003E\n\u003Cp\u003E\u0022We thought that the functional regeneration of the bone defects may have been limited by stem cells migrating away from the injury site, so we decided to investigate the fate and distribution of the delivered cells,\u0022 said Guldberg.\n\u003C\/p\u003E\n\u003Cp\u003ETo do this, Guldberg labeled stem cells with fluorescent quantum dots -- nanometer-scale particles that emit light when excited by near-infrared radiation -- to track the distribution of stem cells after delivery on the scaffolds and completed the same experiments as previously described. \n\u003C\/p\u003E\n\u003Cp\u003EThroughout the entire study, the researchers observed significant fluorescence at the stem cell scaffold sites. However, beginning seven to 10 days after treatment, signals appeared at the scaffold-only sites. Additional analysis with immunostaining revealed that the quantum dots present at the scaffold-only sites were contained in inflammatory cells called macrophages that had taken up quantum dots released from dead stem cells.\n\u003C\/p\u003E\n\u003Cp\u003E\u0022While our overall study shows that stem cell therapy has a lot of promise for treating massive bone defects, this experiment shows that we still need to develop an improved way of delivering the stem cells so that they stay alive longer and thus remain at the injury site longer,\u0022 explained Guldberg.\u003C\/p\u003E\n\u003Cp\u003EThe researchers also found that the quantum dots diminished the function of the transplanted stem cells and thus their therapeutic effect. When the stem cells were labeled with quantum dots, the results showed a failure to enhance bone formation or bridge defects. However, the same low concentration of quantum dots did not affect cell viability or the ability of the stem cells to become bone cells in laboratory studies. \n\u003C\/p\u003E\n\u003Cp\u003E\u0022Although in vitro laboratory studies remain important, this work provides further evidence that well-characterized in vivo models are necessary to test the ability of regenerative tissue strategies to effectively integrate and restore function in complex living organisms,\u0022 added Guldberg. \u0022Improved methods of non-invasive cell tracking that do not alter cell function in vivo are needed to optimize stem cell delivery strategies and compare the effectiveness of different stem cell sources for tissue regeneration.\u0022\n\u003C\/p\u003E\n\u003Cp\u003EGuldberg is currently exploring alternative cell tracking methods, such as genetically modifying the stem cells to express green fluorescent protein and\/or other luminescent enzymes such as luciferase. He is also investigating the addition of programming cues to the scaffold that will direct the stem cells to differentiate into bone cells. These signals may be particularly effective for fetal stem cells, which are believed to be more primitive than adult stem cells, according to Guldberg. \n\u003C\/p\u003E\n\u003Cp\u003ELessons learned from the current work are also being applied to develop effective stem cell therapies for severe composite injuries to multiple tissues including bone, nerve, vasculature and muscle. This follow-on work is being conducted in the Georgia Tech Center for Advanced Bioengineering for Soldier Survivability in collaboration with Ravi Bellamkonda and Barbara Boyan, professors in the Wallace H. Coulter Department of Biomedical Engineering at Georgia Tech and Emory University.\n\u003C\/p\u003E\n\u003Cp\u003EOther authors on the paper include Andres Garcia, professor and Woodruff Faculty Fellow in Georgia Tech\u0027s Woodruff School of Mechanical Engineering and the Petit Institute for Bioengineering and Bioscience; Georgia Tech research scientist Hazel Stevens, Georgia Tech graduate student Joel Boerckel; and National University of Ireland medical student Kapil Sharma.\n\u003C\/p\u003E\n\u003Cp\u003E\u003Cem\u003EThis work was funded by grant number R01-AR051336 from the National Institutes of Health (NIH) and by grant number EEC-9731643 from the National Science Foundation (NSF). The content is solely the responsibility of the principal investigator and does not necessarily represent the official views of the NIH or NSF.\u003C\/em\u003E\n\u003C\/p\u003E\n\u003Cp\u003E\u003Cstrong\u003EResearch News \u0026amp; Publications Office\u003Cbr \/\u003E\nGeorgia Institute of Technology\u003Cbr \/\u003E\n75 Fifth Street, N.W., Suite 314\u003Cbr \/\u003E\nAtlanta, Georgia  30308  USA\n\u003C\/strong\u003E\u003C\/p\u003E\n\u003Cp\u003E\u003Cstrong\u003EMedia Relations Contacts:\u003C\/strong\u003E Abby Vogel (avogel@gatech.edu; 404-385-3364) or John Toon (jtoon@gatech.edu; 404-894-6986).\n\u003C\/p\u003E\n\u003Cp\u003E\u003Cstrong\u003EWriter:\u003C\/strong\u003E Abby Vogel\u003C\/p\u003E","summary":null,"format":"limited_html"}],"field_subtitle":"","field_summary":[{"value":"A new study published this week shows that delivering stem cells on a polymer scaffold to treat large areas of missing bone leads to improved bone formation and better mechanical properties compared to treatment with scaffold alone.","format":"limited_html"}],"field_summary_sentence":[{"value":"Study reinforces potential value of stem cells to repair bone in"}],"uid":"27206","created_gmt":"2010-01-11 01:00:00","changed_gmt":"2016-10-08 03:04:04","author":"Abby Vogel Robinson","boilerplate_text":"","field_publication":"","field_article_url":"","dateline":{"date":"2010-01-11T00:00:00-05:00","iso_date":"2010-01-11T00:00:00-05:00","tz":"America\/New_York"},"extras":[],"hg_media":{"48924":{"id":"48924","type":"image","title":"Robert Guldberg bone regeneration","body":null,"created":"1449175408","gmt_created":"2015-12-03 20:43:28","changed":"1475894463","gmt_changed":"2016-10-08 02:41:03","alt":"Robert Guldberg bone regeneration","file":{"fid":"101291","name":"try39853.jpg","image_path":"\/sites\/default\/files\/images\/try39853_0.jpg","image_full_path":"http:\/\/www.tlwarc.hg.gatech.edu\/\/sites\/default\/files\/images\/try39853_0.jpg","mime":"image\/jpeg","size":1255705,"path_740":"http:\/\/www.tlwarc.hg.gatech.edu\/sites\/default\/files\/styles\/740xx_scale\/public\/images\/try39853_0.jpg?itok=V0huypJw"}},"48925":{"id":"48925","type":"image","title":"Bone regeneration with stem cell scaffold","body":null,"created":"1449175408","gmt_created":"2015-12-03 20:43:28","changed":"1475894463","gmt_changed":"2016-10-08 02:41:03","alt":"Bone regeneration with stem cell scaffold","file":{"fid":"101292","name":"tyd39853.jpg","image_path":"\/sites\/default\/files\/images\/tyd39853_0.jpg","image_full_path":"http:\/\/www.tlwarc.hg.gatech.edu\/\/sites\/default\/files\/images\/tyd39853_0.jpg","mime":"image\/jpeg","size":405535,"path_740":"http:\/\/www.tlwarc.hg.gatech.edu\/sites\/default\/files\/styles\/740xx_scale\/public\/images\/tyd39853_0.jpg?itok=SU7f1o5P"}},"48926":{"id":"48926","type":"image","title":"Robert Guldberg bone regeneration","body":null,"created":"1449175408","gmt_created":"2015-12-03 20:43:28","changed":"1475894463","gmt_changed":"2016-10-08 02:41:03","alt":"Robert Guldberg bone regeneration","file":{"fid":"101293","name":"the39853.jpg","image_path":"\/sites\/default\/files\/images\/the39853_0.jpg","image_full_path":"http:\/\/www.tlwarc.hg.gatech.edu\/\/sites\/default\/files\/images\/the39853_0.jpg","mime":"image\/jpeg","size":1050118,"path_740":"http:\/\/www.tlwarc.hg.gatech.edu\/sites\/default\/files\/styles\/740xx_scale\/public\/images\/the39853_0.jpg?itok=crlQN6aN"}}},"media_ids":["48924","48925","48926"],"related_links":[{"url":"http:\/\/www.me.gatech.edu\/faculty\/guldberg.shtml","title":"Robert Guldberg"},{"url":"http:\/\/www.me.gatech.edu\/","title":"George W. Woodruff School of Mechanical Engineering"},{"url":"http:\/\/www.ibb.gatech.edu\/","title":"Petit Institute for Bioengineering and Bioscience"}],"groups":[{"id":"1188","name":"Research Horizons"}],"categories":[{"id":"145","name":"Engineering"},{"id":"135","name":"Research"}],"keywords":[{"id":"8233","name":"amniotic fluid fetal stem cells"},{"id":"530","name":"bone"},{"id":"8227","name":"bone defect"},{"id":"8231","name":"Bone Marrow Derived Stem Cells"},{"id":"8226","name":"Bone Regeneration"},{"id":"8225","name":"Bone Repair"},{"id":"8232","name":"fetal stem cells"},{"id":"6891","name":"fluorescence"},{"id":"8230","name":"Mesenchymal Stem Cells"},{"id":"8228","name":"Orthopedics"},{"id":"8229","name":"polymer scaffold"},{"id":"2363","name":"quantum dots"},{"id":"1489","name":"Regenerative Medicine"},{"id":"167413","name":"Stem Cell"},{"id":"167139","name":"Stem Cell Research"},{"id":"167130","name":"Stem Cells"}],"core_research_areas":[],"news_room_topics":[],"event_categories":[],"invited_audience":[],"affiliations":[],"classification":[],"areas_of_expertise":[],"news_and_recent_appearances":[],"phone":[],"contact":[{"value":"\u003Cp\u003E\u003Cstrong\u003EAbby Vogel\u003C\/strong\u003E\u003Cbr \/\u003EResearch News and Publications\u003Cbr \/\u003E\u003Ca href=\u0022http:\/\/www.gatech.edu\/contact\/index.html?id=avogel6\u0022\u003EContact Abby Vogel\u003C\/a\u003E\u003Cbr \/\u003E\u003Cstrong\u003E404-385-3364\u003C\/strong\u003E\u003C\/p\u003E","format":"limited_html"}],"email":["avogel@gatech.edu"],"slides":[],"orientation":[],"userdata":""}},"56406":{"#nid":"56406","#data":{"type":"news","title":"Labs report progress in regrowing bones","body":[{"value":"\u003Cp\u003EATLANTA \u2014 As military doctors in Iraq and Afghanistan have seen more horrific injuries involving skin, nerve, vascular and bone losses from explosions, they have tried to think of what more could be done for the victims besides bandaging things up and hoping for the best.\n\u003C\/p\u003E\n\u003Cp\u003EMaybe they could regrow the tissue: Grow the cartilage, grow the blood vessels, grow the nerves and even grow the bone. \n\u003C\/p\u003E\n\u003Cp\u003E\u003Ca href=\u0027http:\/\/www.armytimes.com\/news\/2009\/10\/marine_bone_101109w\/\u0027\u003EView full article\u003C\/a\u003E\u003C\/p\u003E","summary":null,"format":"limited_html"}],"field_subtitle":"","field_summary":[{"value":"ATLANTA \u2014 As military doctors in Iraq and Afghanistan have seen more horrific injuries involving skin, nerve, vascular and bone losses from explosions, they have tried to think of what more could be done for the victims besides bandaging things up and hoping for the best.","format":"limited_html"}],"field_summary_sentence":[{"value":"Labs report progress in regrowing bones"}],"uid":"27224","created_gmt":"2009-10-12 00:00:00","changed_gmt":"2016-10-08 03:06:06","author":"Megan McDevitt","boilerplate_text":"","field_publication":"","field_article_url":"","dateline":{"date":"2009-10-12T00:00:00-04:00","iso_date":"2009-10-12T00:00:00-04:00","tz":"America\/New_York"},"extras":[],"groups":[{"id":"1292","name":"Parker H. Petit Institute for Bioengineering and Bioscience (IBB)"}],"categories":[{"id":"129","name":"Institute and Campus"},{"id":"134","name":"Student and Faculty"}],"keywords":[{"id":"535","name":"boyan"},{"id":"6973","name":"Guldberg"},{"id":"9524","name":"orthopedic"},{"id":"167413","name":"Stem Cell"}],"core_research_areas":[],"news_room_topics":[],"event_categories":[],"invited_audience":[],"affiliations":[],"classification":[],"areas_of_expertise":[],"news_and_recent_appearances":[],"phone":[],"contact":[{"value":"\u003Cstrong\u003EMegan McDevitt\u003C\/strong\u003E\u003Cbr \/\u003EIBB\u003Cbr \/\u003E\u003Ca href=\u0022http:\/\/www.gatech.edu\/contact\/index.html?id=mm504\u0022\u003EContact Megan McDevitt\u003C\/a\u003E\u003Cbr \/\u003E\u003Cstrong\u003E404-385-7001\u003C\/strong\u003E","format":"limited_html"}],"email":["megan.mcdevitt@ibb.gatech.edu"],"slides":[],"orientation":[],"userdata":""}},"56455":{"#nid":"56455","#data":{"type":"news","title":"Delivery of Adult Versus Fetal Stem Cells for Bone Regeneration","body":[{"value":"\u003Cp\u003E\u003Cstrong\u003EEngineered Delivery of Adult Versus Fetal Stem Cells for Bone Regeneration\u003C\/strong\u003E\n\u003C\/p\u003E\n\u003Cp\u003EAlexandra Peister and her collaborators received an NIH program project grant which will support research at Morehouse, Georgia Institute of Technology, University of Rochester, Emory University, and the University of Queensland in Australia. The grant will be funded for the next two years and will support research at Morehouse at a level of $36,000 per year. Co-Investigator, NIH Challenge Grant (American Recovery and Reinvestment Act funded): Engineered Delivery of Adult Versus Fetal Stem Cells for Bone Regeneration in collaboration with Georgia Tech. The grant will be funded September 2009.\n\u003C\/p\u003E","summary":null,"format":"limited_html"}],"field_subtitle":"","field_summary":[{"value":"Alexandra Peister and her collaborators received an NIH program project grant which will support research at Morehouse, Georgia Institute of Technology, University of Rochester, Emory University, and the University of Queensland in Australia.","format":"limited_html"}],"field_summary_sentence":[{"value":"Delivery of Adult Versus Fetal Stem Cells for Bone Regeneration"}],"uid":"27349","created_gmt":"2009-10-14 00:00:00","changed_gmt":"2016-10-08 03:06:11","author":"Floyd Wood","boilerplate_text":"","field_publication":"","field_article_url":"","dateline":{"date":"2009-10-14T00:00:00-04:00","iso_date":"2009-10-14T00:00:00-04:00","tz":"America\/New_York"},"extras":[],"hg_media":{"56456":{"id":"56456","type":"image","title":"Dr. Alexandra Peister","body":null,"created":"1449175653","gmt_created":"2015-12-03 20:47:33","changed":"1475894501","gmt_changed":"2016-10-08 02:41:41","alt":"Dr. Alexandra Peister","file":{"fid":"190475","name":"tor48197.jpg","image_path":"\/sites\/default\/files\/images\/tor48197_0.jpg","image_full_path":"http:\/\/www.tlwarc.hg.gatech.edu\/\/sites\/default\/files\/images\/tor48197_0.jpg","mime":"image\/jpeg","size":31305,"path_740":"http:\/\/www.tlwarc.hg.gatech.edu\/sites\/default\/files\/styles\/740xx_scale\/public\/images\/tor48197_0.jpg?itok=o-sEj3UK"}}},"media_ids":["56456"],"groups":[{"id":"1292","name":"Parker H. Petit Institute for Bioengineering and Bioscience (IBB)"}],"categories":[{"id":"129","name":"Institute and Campus"},{"id":"141","name":"Chemistry and Chemical Engineering"},{"id":"134","name":"Student and Faculty"},{"id":"145","name":"Engineering"},{"id":"135","name":"Research"}],"keywords":[{"id":"8226","name":"Bone Regeneration"},{"id":"247","name":"Emory"},{"id":"109","name":"Georgia Tech"},{"id":"9556","name":"Morehouse College"},{"id":"167413","name":"Stem Cell"}],"core_research_areas":[],"news_room_topics":[],"event_categories":[],"invited_audience":[],"affiliations":[],"classification":[],"areas_of_expertise":[],"news_and_recent_appearances":[],"phone":[],"contact":[{"value":"\u003Cstrong\u003EFloyd Wood\u003C\/strong\u003E\u003Cbr \/\u003EIBB\u003Cbr \/\u003E\u003Ca href=\u0022http:\/\/www.gatech.edu\/contact\/index.html?id=fwood3\u0022\u003EContact Floyd Wood\u003C\/a\u003E","format":"limited_html"}],"email":["floyd.wood@ibb.gatech.edu"],"slides":[],"orientation":[],"userdata":""}},"56421":{"#nid":"56421","#data":{"type":"news","title":"McDevitt and Nerem Discuss Georgia Stem Cell Research Debate","body":[{"value":"\u003Cp\u003E\u0022Cell Division\u0022\u003Cbr \/\u003E\nGeorgia Trend -  September 2009\n\u003C\/p\u003E\n\u003Cp\u003E.. . It\u2019s a debate fraught with irony. Georgia has some of the nation\u2019s leading researchers in the area of embryonic stem cells, scientists recruited and paid for by the state as eminent scholars; and state leadership has identified the life sciences as a strategic industry of interest. And yet, many of Georgia\u2019s elected officialshave made it clear that they do not want new research in embryonic stem cells happening in Georgia,... \u201cInduced pluripotent cells are a great success story, but it\u2019s owed wholly to the fact that we had a starting basis in embryonic stem cells,\u201d says Todd McDevitt, a Georgia Tech scientist who directs stem cell technology research in his lab and focuses most of his attention on ES cells... For Georgia Tech professor Bob Nerem, research needs to move forward in all areas.  \u201cAt some point we will know about what makes the most sense from a patient point of view,\u201d says Nerem, director of both the Parker H. Petit Institute for Bioengineering and Bioscience at Tech, and the Georgia Tech-Emory Collabora-tion for Regenerative Medicine (GTEC)...  But for a young scientist like Todd McDevitt, whose lab at Georgia Tech has attracted some $2 million in federal funds and employs 10 other researchers, a differing opinion that has the potential to criminalize his work forces him to consider other options.\n\u003C\/p\u003E\n\u003Cp\u003E\u003Ca href=\u0027http:\/\/georgiatrend.com\/cover-story\/09_09_stemcell.shtml\u0027\u003EFull article\u003C\/a\u003E \n\u003C\/p\u003E\n\u003Cp\u003E\u003Ca href=\u0027http:\/\/mcdevitt.bme.gatech.edu\u0027\u003EMcDevitt lab\u003C\/a\u003E\n\u003C\/p\u003E\n\u003Cp\u003E\u003Ca href=\u0027http:\/\/www.ibb.gatech.edu\/about\/nerem.php\u0027\u003ENerem lab\u003C\/a\u003E\n\u003C\/p\u003E","summary":null,"format":"limited_html"}],"field_subtitle":"","field_summary":[{"value":"Todd McDevitt, PhD, and Bob Nerem, PhD, discuss Georgia debate regarding stem cell research in Georgia Trends article.","format":"limited_html"}],"field_summary_sentence":[{"value":"McDevitt and Nerem Discuss Georgia Stem Cell Research Debate"}],"uid":"27195","created_gmt":"2009-09-03 00:00:00","changed_gmt":"2016-10-08 03:06:06","author":"Colly Mitchell","boilerplate_text":"","field_publication":"","field_article_url":"","dateline":{"date":"2009-09-01T00:00:00-04:00","iso_date":"2009-09-01T00:00:00-04:00","tz":"America\/New_York"},"extras":[],"hg_media":{"56422":{"id":"56422","type":"image","title":"Georgia debates stem cell research","body":null,"created":"1449175629","gmt_created":"2015-12-03 20:47:09","changed":"1475894501","gmt_changed":"2016-10-08 02:41:41","alt":"Georgia debates stem cell research","file":{"fid":"190467","name":"tlh49182.jpg","image_path":"\/sites\/default\/files\/images\/tlh49182_0.jpg","image_full_path":"http:\/\/www.tlwarc.hg.gatech.edu\/\/sites\/default\/files\/images\/tlh49182_0.jpg","mime":"image\/jpeg","size":50180,"path_740":"http:\/\/www.tlwarc.hg.gatech.edu\/sites\/default\/files\/styles\/740xx_scale\/public\/images\/tlh49182_0.jpg?itok=S0LlQdr5"}}},"media_ids":["56422"],"groups":[{"id":"1292","name":"Parker H. Petit Institute for Bioengineering and Bioscience (IBB)"}],"categories":[{"id":"129","name":"Institute and Campus"},{"id":"140","name":"Cancer Research"},{"id":"141","name":"Chemistry and Chemical Engineering"},{"id":"134","name":"Student and Faculty"},{"id":"146","name":"Life Sciences and Biology"},{"id":"135","name":"Research"}],"keywords":[{"id":"900","name":"Bob Nerem"},{"id":"342","name":"Georgia"},{"id":"109","name":"Georgia Tech"},{"id":"248","name":"IBB"},{"id":"167413","name":"Stem Cell"},{"id":"760","name":"Todd McDevitt"}],"core_research_areas":[],"news_room_topics":[],"event_categories":[],"invited_audience":[],"affiliations":[],"classification":[],"areas_of_expertise":[],"news_and_recent_appearances":[],"phone":[],"contact":[{"value":"\u003Cstrong\u003EColly Mitchell\u003C\/strong\u003E\u003Cbr \/\u003EParker H. Petit Institute for Bioengineering and Bioscience\u003Cbr \/\u003E\u003Ca href=\u0022http:\/\/www.gatech.edu\/contact\/index.html?id=cmitchell6\u0022\u003EContact Colly Mitchell\u003C\/a\u003E\u003Cbr \/\u003E\u003Cstrong\u003E404-894-5982\u003C\/strong\u003E","format":"limited_html"}],"email":["colly.mitchell@ibb.gatech.edu"],"slides":[],"orientation":[],"userdata":""}},"46312":{"#nid":"46312","#data":{"type":"news","title":"New Center Aims to Improve Recovery of Soldiers with Severe Injuries","body":[{"value":"\u003Cp\u003EWhen a soldier is wounded during combat, surgeons must focus on reducing infection and reconstructing damaged bone and tissues. Technologies that could improve the repair and regeneration processes are being developed in research laboratories across the country, but they are not being moved quickly enough into military trauma centers.\u003C\/p\u003E\n\u003Cp\u003EOrganizers of the recently established Georgia Tech Center for Advanced Bioengineering for Soldier Survivability want to change that.\n\u003C\/p\u003E\n\u003Cp\u003E\u0022The goal of the center is to rapidly move new technologies from the laboratory to patients so that we can improve the quality of life for our veterans as they return from the wars the United States is fighting,\u0022 said center director Barbara Boyan, the Price Gilbert, Jr. Chair in Tissue Engineering at the Wallace H. Coulter Department of Biomedical Engineering at Georgia Tech and Emory University.\n\u003C\/p\u003E\n\u003Cp\u003EThe center will leverage the expertise of Georgia Tech researchers in musculoskeletal biology and regenerative medicine to quickly move tools that are clinically valuable, safe and effective from laboratories to use in trauma centers. To reduce the amount of time from invention to clinical use, engineers and scientists in the center work in teams that include a clinician with experience in combat medical care and a medical device industry partner. \n\u003C\/p\u003E\n\u003Cp\u003ESupport for the center is provided by the Armed Forces Institute of Regenerative Medicine, the U.S. Army Institute of Surgical Research\u0027s Orthopedic Trauma Research Program, the U.S. Department of Defense and industry.\u003C\/p\u003E\n\u003Cp\u003EResearchers in the center will initially focus on ways to improve the healing of wounds, segmental bone defects and massive soft tissue defects. Traumatic injuries that affect the arms, legs, head and neck require technologies for treatment at the time of injury and in the ensuing days and months.  \n\u003C\/p\u003E\n\u003Cp\u003E\u0022These combat injuries are complicated to treat because they are large and typically infected, so even determining when a soldier should be treated for optimal recovery is a challenge,\u0022 said Boyan, who is also the associate dean for research in Georgia Tech\u0027s College of Engineering and a Georgia Research Alliance Eminent Scholar. \u0022It is not known whether a regenerative therapy will be most effective if used immediately following injury or at some later time after scar tissue has been established at the wound site.\u0022\n\u003C\/p\u003E\n\u003Cp\u003EBy developing models that accurately reflect the complex aspects of injuries sustained by soldiers in combat, the researchers will be able to test assumptions about when to employ specific strategies and how to ensure their effectiveness. The models must also allow them to examine the use of technologies on both male and female patients, and on complex tissues that consist of nerves, a blood supply and multiple cell types.  \n\u003C\/p\u003E\n\u003Cp\u003E\u0022Since the processes of bone, vascular and neural formation are naturally linked during normal tissue development, growth and repair, our approach is to harness this knowledge by developing delivery strategies that present the right biologic cues in the right place at the right time to promote functional regeneration of multiple integrated tissues,\u0022 said associate director of the center Robert Guldberg, a professor in Georgia Tech\u0027s Woodruff School of Mechanical Engineering.\n\u003C\/p\u003E\n\u003Cp\u003ETo enhance tissue repair and regeneration following a traumatic injury, the researchers are focusing their efforts on stem cells. Even though stem cells have tremendous potential for repairing such defects, effective methods do not yet exist for delivering them to an injury site and of ensuring that they survive and remain at that site long enough to impact the regeneration process.\n\u003C\/p\u003E\n\u003Cp\u003E\u0022Clinicians currently inject stem cells into a vein and hope that the cells will migrate to sites of injury and remain at those sites long enough to participate in the repair process. While some cells certainly do migrate to injury sites, the actual percentage is very small and those that arrive at the site do not remain to engraft with the host tissue,\u0022 explained Boyan.\u003C\/p\u003E\n\u003Cp\u003EThis limited effect may be the result of the injection process, according to Boyan, so researchers in the center are developing ways to protect the cells from damaging forces they might encounter when inserted into the body.\n\u003C\/p\u003E\n\u003Cp\u003E\u0022Studies in our laboratory have shown that when stem cells are encapsulated in microbeads, they can be injected by needle without loss of cell viability and they remain at the injury site for at least two months,\u0022 said Boyan.\n\u003C\/p\u003E\n\u003Cp\u003EProtecting the cells during insertion is just the first step toward improved tissue repair. The researchers must also examine whether the stem cells will turn into cells typical of the implanted tissue and if they produce or should be paired with molecules that can enhance the healing of the implanted tissues.\n\u003C\/p\u003E\n\u003Cp\u003ECenter researchers are also investigating whether bone marrow-derived stem cells can be used in the body to heal large defects in bone and cartilage if they are inserted in fiber mesh scaffolds and silk sponges during a surgical procedure.\n\u003C\/p\u003E\n\u003Cp\u003EAdditional projects in the center include assessing tissue viability, preventing the growth of bone in the soft tissues of the body and improving pre-hospital care of orthopedic injuries. Since effective treatment of traumatic injuries is an important goal for the general public as well as the military population, the researchers also hope to adapt their technologies for use in hospitals.\n\u003C\/p\u003E\n\u003Cp\u003EOther researchers in the center include Ravi Bellamkonda, a professor in the Coulter Department; Andres Garcia, the Woodruff Faculty Fellow in the Woodruff School of Mechanical Engineering; Robert Taylor, a professor in the Coulter Department and Emory\u0027s Division of Cardiology; Zvi Schwartz, a visiting professor in the Coulter Department; and U.S. Army surgical medicine consultants Michael Yaszemski and David Cohen.\n\u003C\/p\u003E\n\u003Cp\u003E\u003Cstrong\u003EResearch News \u0026amp; Publications Office\u003Cbr \/\u003E\nGeorgia Institute of Technology\u003Cbr \/\u003E\n75 Fifth Street, N.W., Suite 100\u003Cbr \/\u003E\nAtlanta, Georgia  30308  USA\n\u003C\/strong\u003E\u003C\/p\u003E\n\u003Cp\u003EMedia Relations Contacts: Abby Vogel (404-385-3364); E-mail: (\u003Ca href=\u0022mailto:avogel@gatech.edu\u0022\u003Eavogel@gatech.edu\u003C\/a\u003E) or John Toon (404-894-6986); E-mail: (\u003Ca href=\u0022mailto:jtoon@gatech.edu\u0022\u003Ejtoon@gatech.edu\u003C\/a\u003E).\n\u003C\/p\u003E\n\u003Cp\u003E\u003Cstrong\u003EWriter:\u003C\/strong\u003E Abby Vogel\u003C\/p\u003E","summary":null,"format":"limited_html"}],"field_subtitle":[{"value":"Musculoskeletal Biology and Regenerative Medicine Expertise are Keys"}],"field_summary":[{"value":"The new Georgia Tech Center for Advanced Bioengineering for Soldier Survivability is working to quickly move tools that are clinically valuable, safe and effective from laboratories to use in military trauma centers.","format":"limited_html"}],"field_summary_sentence":[{"value":"New center aims to improve recovery of severely-injured soldiers"}],"uid":"27206","created_gmt":"2009-05-26 00:00:00","changed_gmt":"2016-10-08 03:03:14","author":"Abby Vogel Robinson","boilerplate_text":"","field_publication":"","field_article_url":"","dateline":{"date":"2009-05-26T00:00:00-04:00","iso_date":"2009-05-26T00:00:00-04:00","tz":"America\/New_York"},"extras":[],"hg_media":{"46313":{"id":"46313","type":"image","title":"Barbara Boyan","body":null,"created":"1449174375","gmt_created":"2015-12-03 20:26:15","changed":"1475894416","gmt_changed":"2016-10-08 02:40:16","alt":"Barbara Boyan","file":{"fid":"101089","name":"toy61295.jpg","image_path":"\/sites\/default\/files\/images\/toy61295_0.jpg","image_full_path":"http:\/\/www.tlwarc.hg.gatech.edu\/\/sites\/default\/files\/images\/toy61295_0.jpg","mime":"image\/jpeg","size":1083074,"path_740":"http:\/\/www.tlwarc.hg.gatech.edu\/sites\/default\/files\/styles\/740xx_scale\/public\/images\/toy61295_0.jpg?itok=XMwONj2V"}},"46314":{"id":"46314","type":"image","title":"bone defect","body":null,"created":"1449174401","gmt_created":"2015-12-03 20:26:41","changed":"1475894416","gmt_changed":"2016-10-08 02:40:16","alt":"bone defect","file":{"fid":"101090","name":"tcq61295.jpg","image_path":"\/sites\/default\/files\/images\/tcq61295_0.jpg","image_full_path":"http:\/\/www.tlwarc.hg.gatech.edu\/\/sites\/default\/files\/images\/tcq61295_0.jpg","mime":"image\/jpeg","size":35753,"path_740":"http:\/\/www.tlwarc.hg.gatech.edu\/sites\/default\/files\/styles\/740xx_scale\/public\/images\/tcq61295_0.jpg?itok=fbnt2zCT"}},"46315":{"id":"46315","type":"image","title":"Robert Guldberg","body":null,"created":"1449174401","gmt_created":"2015-12-03 20:26:41","changed":"1475894416","gmt_changed":"2016-10-08 02:40:16","alt":"Robert Guldberg","file":{"fid":"101091","name":"tgx61295.jpg","image_path":"\/sites\/default\/files\/images\/tgx61295_0.jpg","image_full_path":"http:\/\/www.tlwarc.hg.gatech.edu\/\/sites\/default\/files\/images\/tgx61295_0.jpg","mime":"image\/jpeg","size":1098693,"path_740":"http:\/\/www.tlwarc.hg.gatech.edu\/sites\/default\/files\/styles\/740xx_scale\/public\/images\/tgx61295_0.jpg?itok=RfWhTAre"}}},"media_ids":["46313","46314","46315"],"related_links":[{"url":"http:\/\/www.bme.gatech.edu\/facultystaff\/faculty_record.php?id=48","title":"Barbara Boyan"},{"url":"http:\/\/www.me.gatech.edu\/faculty\/guldberg.shtml","title":"Robert Guldberg"},{"url":"http:\/\/www.bme.gatech.edu\/","title":"Wallace H. Coulter Department of Biomedical Engineering"},{"url":"http:\/\/www.me.gatech.edu\/","title":"George W. Woodruff School of Mechanical Engineering"}],"groups":[{"id":"1188","name":"Research Horizons"}],"categories":[{"id":"145","name":"Engineering"},{"id":"146","name":"Life Sciences and Biology"},{"id":"147","name":"Military Technology"},{"id":"149","name":"Nanotechnology and Nanoscience"},{"id":"135","name":"Research"}],"keywords":[{"id":"534","name":"barbara"},{"id":"277","name":"Biology"},{"id":"530","name":"bone"},{"id":"535","name":"boyan"},{"id":"532","name":"cell"},{"id":"531","name":"defect"},{"id":"528","name":"device"},{"id":"537","name":"goldberg"},{"id":"521","name":"injury"},{"id":"527","name":"medical"},{"id":"524","name":"medicine"},{"id":"525","name":"military"},{"id":"522","name":"muskuloskeletal"},{"id":"523","name":"regenerative"},{"id":"536","name":"robert"},{"id":"170849","name":"soldier"},{"id":"167258","name":"STEM"},{"id":"533","name":"tissue"},{"id":"526","name":"trauma"},{"id":"529","name":"wound"}],"core_research_areas":[],"news_room_topics":[],"event_categories":[],"invited_audience":[],"affiliations":[],"classification":[],"areas_of_expertise":[],"news_and_recent_appearances":[],"phone":[],"contact":[{"value":"\u003Cstrong\u003EAbby Vogel\u003C\/strong\u003E\u003Cbr \/\u003EResearch News and Publications\u003Cbr \/\u003E\u003Ca href=\u0022http:\/\/www.gatech.edu\/contact\/index.html?id=avogel6\u0022\u003EContact Abby Vogel\u003C\/a\u003E\u003Cbr \/\u003E\u003Cstrong\u003E404-385-3364\u003C\/strong\u003E","format":"limited_html"}],"email":["avogel@gatech.edu"],"slides":[],"orientation":[],"userdata":""}},"56436":{"#nid":"56436","#data":{"type":"news","title":"GTEC Celebrates Success - Renews Commitment to Regenerative Medicine","body":[{"value":"\u003Cp\u003EGeorgia Tech and Emory Celebrate Success and Renew Their Commitment to Regenerative Medicine \n\u003C\/p\u003E\n\u003Cp\u003EJanuary 13, 2009.  The Georgia Tech Emory Center for the Engineering of Living Tissues (GTEC), a National Science Foundation Engineering Research Center, celebrated its tenth year of innovative research. When founded in 1998, GTEC\u0027s focus was on replacing tissues or growing cell-based substitutes outside the body for implantation into the body. As GTEC has evolved over the last decade, its approach has broadened from a focus on tissue engineering to one that includes tissue regeneration.  \u003C\/p\u003E\n\u003Cp\u003ENow, a decade after the $25 million National Science Foundation award, GTEC is internationally recognized for its strengths and novel applications in the emerging field of Regenerative Medicine.  The center\u003C\/p\u003E","summary":null,"format":"limited_html"}],"field_subtitle":"","field_summary":[{"value":"January 13, 2009.  The Georgia Tech Emory Center for the Engineering of Living Tissues (GTEC), a National Science Foundation Engineering Research Center, celebrated its tenth year of innovative research. When founded in 1998, GTEC\u0027s focus was on replacing tissues or growing cell-based substitutes outside the body for implantation into the body. As GTEC has evolved over the last decade, its approach has broadened from a focus on tissue engineering to one that includes tissue regeneration.","format":"limited_html"}],"field_summary_sentence":[{"value":"GTEC Celebrates Success - Renews Commitment to Regenerative Med"}],"uid":"27224","created_gmt":"2009-01-26 01:00:00","changed_gmt":"2016-10-08 03:06:06","author":"Megan McDevitt","boilerplate_text":"","field_publication":"","field_article_url":"","dateline":{"date":"2009-01-26T00:00:00-05:00","iso_date":"2009-01-26T00:00:00-05:00","tz":"America\/New_York"},"extras":[],"hg_media":{"56437":{"id":"56437","type":"image","title":"GTEC\\\u0027s Impact on State","body":null,"created":"1449175629","gmt_created":"2015-12-03 20:47:09","changed":"1475894501","gmt_changed":"2016-10-08 02:41:41","alt":"GTEC\\\u0027s Impact on State","file":{"fid":"190471","name":"tkn90302.jpg","image_path":"\/sites\/default\/files\/images\/tkn90302_0.jpg","image_full_path":"http:\/\/www.tlwarc.hg.gatech.edu\/\/sites\/default\/files\/images\/tkn90302_0.jpg","mime":"image\/jpeg","size":44700,"path_740":"http:\/\/www.tlwarc.hg.gatech.edu\/sites\/default\/files\/styles\/740xx_scale\/public\/images\/tkn90302_0.jpg?itok=qSlCTNMo"}},"56438":{"id":"56438","type":"image","title":"GTEC Celebration Dinner","body":null,"created":"1449175653","gmt_created":"2015-12-03 20:47:33","changed":"1475894501","gmt_changed":"2016-10-08 02:41:41","alt":"GTEC Celebration Dinner","file":{"fid":"190472","name":"tbm90302.jpg","image_path":"\/sites\/default\/files\/images\/tbm90302_0.jpg","image_full_path":"http:\/\/www.tlwarc.hg.gatech.edu\/\/sites\/default\/files\/images\/tbm90302_0.jpg","mime":"image\/jpeg","size":71285,"path_740":"http:\/\/www.tlwarc.hg.gatech.edu\/sites\/default\/files\/styles\/740xx_scale\/public\/images\/tbm90302_0.jpg?itok=iVv8YOXI"}}},"media_ids":["56437","56438"],"groups":[{"id":"1292","name":"Parker H. Petit Institute for Bioengineering and Bioscience (IBB)"}],"categories":[{"id":"130","name":"Alumni"},{"id":"129","name":"Institute and Campus"},{"id":"140","name":"Cancer Research"},{"id":"132","name":"Institute Leadership"},{"id":"141","name":"Chemistry and Chemical Engineering"},{"id":"134","name":"Student and Faculty"},{"id":"145","name":"Engineering"},{"id":"146","name":"Life Sciences and Biology"},{"id":"149","name":"Nanotechnology and Nanoscience"},{"id":"135","name":"Research"},{"id":"150","name":"Physics and Physical Sciences"}],"keywords":[{"id":"247","name":"Emory"},{"id":"109","name":"Georgia Tech"},{"id":"1487","name":"GTEC"},{"id":"1489","name":"Regenerative Medicine"},{"id":"167130","name":"Stem Cells"}],"core_research_areas":[],"news_room_topics":[],"event_categories":[],"invited_audience":[],"affiliations":[],"classification":[],"areas_of_expertise":[],"news_and_recent_appearances":[],"phone":[],"contact":[{"value":"\u003Cstrong\u003EMegan McDevitt\u003C\/strong\u003E\u003Cbr \/\u003EIBB\u003Cbr \/\u003E\u003Ca href=\u0022http:\/\/www.gatech.edu\/contact\/index.html?id=mm504\u0022\u003EContact Megan McDevitt\u003C\/a\u003E\u003Cbr \/\u003E\u003Cstrong\u003E404-385-7001\u003C\/strong\u003E","format":"limited_html"}],"email":["megan.mcdevitt@ibb.gatech.edu"],"slides":[],"orientation":[],"userdata":""}},"56433":{"#nid":"56433","#data":{"type":"news","title":"Stem Cells Could Be Big Business for Georgia","body":[{"value":"\u003Cp\u003EColumn by Steve L. Stice, Director of the UGA Regenerative Bioscience Center and Robert M. Nerem, Parker H. Petit Distinguished Chair for Engineering in Medicine, Institute Professor,and Director of the Parker H. Petit Institute for Bioengineering and Bioscience at Georgia Tech.\n\u003C\/p\u003E\n\u003Cp\u003EPresident-elect Obama\u003C\/p\u003E","summary":null,"format":"limited_html"}],"field_subtitle":"","field_summary":[{"value":"Column by Steve L. Stice of the UGA Regenerative Bioscience Center and Robert M. Nerem, Parker H. Petit Distinguished Chair for Engineering in Medicine, Institute Professor,and Director of the Parker H. Petit Institute for Bioengineering and Bioscience.","format":"limited_html"}],"field_summary_sentence":[{"value":"Stem Cells Could Be Big Business for Georgia"}],"uid":"27195","created_gmt":"2009-01-21 01:00:00","changed_gmt":"2016-10-08 03:06:06","author":"Colly Mitchell","boilerplate_text":"","field_publication":"","field_article_url":"","dateline":{"date":"2009-01-18T00:00:00-05:00","iso_date":"2009-01-18T00:00:00-05:00","tz":"America\/New_York"},"extras":[],"groups":[{"id":"1292","name":"Parker H. Petit Institute for Bioengineering and Bioscience (IBB)"}],"categories":[{"id":"129","name":"Institute and Campus"},{"id":"155","name":"Congressional Testimony"},{"id":"140","name":"Cancer Research"},{"id":"141","name":"Chemistry and Chemical Engineering"},{"id":"134","name":"Student and Faculty"},{"id":"145","name":"Engineering"},{"id":"146","name":"Life Sciences and Biology"},{"id":"135","name":"Research"}],"keywords":[{"id":"109","name":"Georgia Tech"},{"id":"1516","name":"Nerem"},{"id":"167413","name":"Stem Cell"},{"id":"170975","name":"Stice"}],"core_research_areas":[],"news_room_topics":[],"event_categories":[],"invited_audience":[],"affiliations":[],"classification":[],"areas_of_expertise":[],"news_and_recent_appearances":[],"phone":[],"contact":[{"value":"\u003Cstrong\u003EColly Mitchell\u003C\/strong\u003E\u003Cbr \/\u003EParker H. Petit Institute for Bioengineering and Bioscience\u003Cbr \/\u003E\u003Ca href=\u0022http:\/\/www.gatech.edu\/contact\/index.html?id=cmitchell6\u0022\u003EContact Colly Mitchell\u003C\/a\u003E\u003Cbr \/\u003E\u003Cstrong\u003E404-894-5982\u003C\/strong\u003E","format":"limited_html"}],"email":["colly.mitchell@ibb.gatech.edu"],"slides":[],"orientation":[],"userdata":""}},"56401":{"#nid":"56401","#data":{"type":"news","title":"Andres Garcias Research Published in PNAS","body":[{"value":"\u003Cp\u003EAndres Garcia, PhD, Professor in the School of Mechanical Engineering, has article published in the Proceedings of the National Academy of Sciences of the United States of America (PNAS).\n\u003C\/p\u003E\n\u003Cp\u003E\u003Cem\u003E\u003Cstrong\u003E\u0022Engineering Graded Tissue Interfaces\u0022\u003C\/strong\u003E\u003C\/em\u003E\n\u003C\/p\u003E\n\u003Cp\u003E\u003Cstrong\u003EJennifer E. Phillips, Kellie L. Burns, Joseph M. Le Doux, Robert E. Guldberg and Andr\u003C\/strong\u003E\u003C\/p\u003E","summary":null,"format":"limited_html"}],"field_subtitle":"","field_summary":[{"value":"Engineering Graded Tissue Interfaces\n\nJennifer E. Phillips, Kellie L. Burns, Joseph M. Le Doux, Robert E. Guldberg and Andr","format":"limited_html"}],"field_summary_sentence":[{"value":"Andres Garcia"}],"uid":"27195","created_gmt":"2008-08-27 00:00:00","changed_gmt":"2016-10-08 03:06:06","author":"Colly Mitchell","boilerplate_text":"","field_publication":"","field_article_url":"","dateline":{"date":"2008-08-21T00:00:00-04:00","iso_date":"2008-08-21T00:00:00-04:00","tz":"America\/New_York"},"extras":[],"groups":[{"id":"1292","name":"Parker H. Petit Institute for Bioengineering and Bioscience (IBB)"}],"categories":[{"id":"129","name":"Institute and Campus"},{"id":"141","name":"Chemistry and Chemical Engineering"},{"id":"134","name":"Student and Faculty"},{"id":"135","name":"Research"}],"keywords":[{"id":"9517","name":"Engineering graded tissue interfaces"},{"id":"2025","name":"garcia"},{"id":"541","name":"Mechanical Engineering"}],"core_research_areas":[],"news_room_topics":[],"event_categories":[],"invited_audience":[],"affiliations":[],"classification":[],"areas_of_expertise":[],"news_and_recent_appearances":[],"phone":[],"contact":[{"value":"\u003Cstrong\u003EColly Mitchell\u003C\/strong\u003E\u003Cbr \/\u003EParker H. Petit Institute for Bioengineering and Bioscience\u003Cbr \/\u003E\u003Ca href=\u0022http:\/\/www.gatech.edu\/contact\/index.html?id=cmitchell6\u0022\u003EContact Colly Mitchell\u003C\/a\u003E\u003Cbr \/\u003E\u003Cstrong\u003E404-894-5982\u003C\/strong\u003E","format":"limited_html"}],"email":["colly.mitchell@ibb.gatech.edu"],"slides":[],"orientation":[],"userdata":""}},"56402":{"#nid":"56402","#data":{"type":"news","title":"McDevitt Research Highlighted in Nature Materials","body":[{"value":"\u003Cp\u003E\u003Cstrong\u003E\u0022Materials in a Cellular World\u0022\n\u003C\/strong\u003E\u003C\/p\u003E\n\u003Cp\u003E\u003Cstrong\u003EBiological factors are not the only influence on stem-cell behaviour\u003C\/strong\u003E\u003C\/p\u003E","summary":null,"format":"limited_html"}],"field_subtitle":"","field_summary":[{"value":"Following his presentation at the World Biomaterials Congress in Amsterdam in May 2008, Todd McDevitt, PhD, research is highlighted in Nature Materials Journal.  \u0022Materials in a Cellular World\u0022","format":"limited_html"}],"field_summary_sentence":[{"value":"McDevitt Research Highlighted in Nature Materials"}],"uid":"27195","created_gmt":"2008-08-28 00:00:00","changed_gmt":"2016-10-08 03:06:06","author":"Colly Mitchell","boilerplate_text":"","field_publication":"","field_article_url":"","dateline":{"date":"2008-08-01T00:00:00-04:00","iso_date":"2008-08-01T00:00:00-04:00","tz":"America\/New_York"},"extras":[],"groups":[{"id":"1292","name":"Parker H. Petit Institute for Bioengineering and Bioscience (IBB)"}],"categories":[{"id":"140","name":"Cancer Research"},{"id":"145","name":"Engineering"},{"id":"146","name":"Life Sciences and Biology"},{"id":"135","name":"Research"}],"keywords":[{"id":"3024","name":"biomaterials"},{"id":"6217","name":"McDevitt"},{"id":"9518","name":"Nature Materials"},{"id":"1489","name":"Regenerative Medicine"},{"id":"167413","name":"Stem Cell"},{"id":"4891","name":"Tissue Engineering"}],"core_research_areas":[],"news_room_topics":[],"event_categories":[],"invited_audience":[],"affiliations":[],"classification":[],"areas_of_expertise":[],"news_and_recent_appearances":[],"phone":[],"contact":[{"value":"\u003Cstrong\u003EColly Mitchell\u003C\/strong\u003E\u003Cbr \/\u003EParker H. Petit Institute for Bioengineering and Bioscience\u003Cbr \/\u003E\u003Ca href=\u0022http:\/\/www.gatech.edu\/contact\/index.html?id=cmitchell6\u0022\u003EContact Colly Mitchell\u003C\/a\u003E\u003Cbr \/\u003E\u003Cstrong\u003E404-894-5982\u003C\/strong\u003E","format":"limited_html"}],"email":["colly.mitchell@ibb.gatech.edu"],"slides":[],"orientation":[],"userdata":""}},"56396":{"#nid":"56396","#data":{"type":"news","title":"Biomaterials Team  Awarded NIH Training Grant","body":[{"value":"\u003Cp\u003E\u003Cstrong\u003EGraduate Training for Rationally Designed,\u003Cbr \/\u003E\nIntegrative Biomaterials: GTBioMAT\u003C\/strong\u003E\n\u003C\/p\u003E\n\u003Cp\u003EA training grant, entitled \u0022Graduate Training for Rationally Designed, Integrative Biomaterials\u0022 or \u0022GTBioMAT\u0022 was awarded by the National Institutes of Health to the Georgia Tech\/Emory Biomaterials Research Team.  \u003Cstrong\u003ERavi Bellamkonda\u003C\/strong\u003E, PhD, Principal Investigator and Director and \u003Cstrong\u003EJulie Babensee\u003C\/strong\u003E, PhD, Co-Director, will be responsible for the overall management and implementation of the program\u003C\/p\u003E","summary":null,"format":"limited_html"}],"field_subtitle":"","field_summary":[{"value":"A training grant, entitled \u0022Graduate Training for Rationally Designed, Integrative Biomaterials\u0022 or \u0022GTBioMAT\u0022 was awarded by the National Institutes of Health to the Georgia Tech\/Emory Biomaterials Research Team.  Ravi Bellamkonda, PhD, Principal Investigator and Director and Julie Babensee, PhD, Co-Director, will be responsible for the overall management and implementation of the program","format":"limited_html"}],"field_summary_sentence":[{"value":"Biomaterials Team  Awarded NIH Training Grant"}],"uid":"27224","created_gmt":"2008-07-09 00:00:00","changed_gmt":"2016-10-08 03:06:06","author":"Megan McDevitt","boilerplate_text":"","field_publication":"","field_article_url":"","dateline":{"date":"2008-07-09T00:00:00-04:00","iso_date":"2008-07-09T00:00:00-04:00","tz":"America\/New_York"},"extras":[],"groups":[{"id":"1292","name":"Parker H. Petit Institute for Bioengineering and Bioscience (IBB)"}],"categories":[{"id":"140","name":"Cancer Research"},{"id":"141","name":"Chemistry and Chemical Engineering"},{"id":"149","name":"Nanotechnology and Nanoscience"},{"id":"135","name":"Research"}],"keywords":[{"id":"9508","name":"Babensee"},{"id":"9492","name":"bellamkonda"},{"id":"3024","name":"biomaterials"}],"core_research_areas":[],"news_room_topics":[],"event_categories":[],"invited_audience":[],"affiliations":[],"classification":[],"areas_of_expertise":[],"news_and_recent_appearances":[],"phone":[],"contact":[{"value":"\u003Cstrong\u003EMegan McDevitt\u003C\/strong\u003E\u003Cbr \/\u003EIBB\u003Cbr \/\u003E\u003Ca href=\u0022http:\/\/www.gatech.edu\/contact\/index.html?id=mm504\u0022\u003EContact Megan McDevitt\u003C\/a\u003E\u003Cbr \/\u003E\u003Cstrong\u003E404-385-7001\u003C\/strong\u003E","format":"limited_html"}],"email":["megan.mcdevitt@ibb.gatech.edu"],"slides":[],"orientation":[],"userdata":""}},"56393":{"#nid":"56393","#data":{"type":"news","title":"Non-invasive tracking of nanocarrier distribution in tumors","body":[{"value":"\u003Cp\u003ENanocarrier-mediated chemotherapy has great promise in the treatment of cancer due to its ability to prolong the blood plasma half-life of the encapsulated chemotherapeutic and to selectively accumulate in tumors. However, in spite of important advances in the development of nano-chemotherapeutics, systemic chemotherapy is not the treatment of choice for malignant brain tumors, primarily due to the toxicity caused to non-tumor tissue. Therefore, novel techniques are required to understand and improve the drug availability at the tumor site while reducing harmful side effects. Nano-chemotherapeutics are able to accumulate at the tumor lesion due to the prolonged circulation of the nanocarrier and presence of abnormal leaky vasculature at the tumor site via the enhanced permeation and retention effect (EPR). \u003C\/p\u003E","summary":null,"format":"limited_html"}],"field_subtitle":"","field_summary":[{"value":"Nanocarrier-mediated chemotherapy has great promise in the treatment of cancer due to its ability to prolong the blood plasma half-life of the encapsulated chemotherapeutic and to selectively accumulate in tumors. However, in spite of important advances in the development of nano-chemotherapeutics, systemic chemotherapy is not the treatment of choice for malignant brain tumors, primarily due to the toxicity caused to non-tumor tissue. Therefore, novel techniques are required to understand and improve the drug availability at the tumor site while reducing harmful side effects. Nano-chemotherapeutics are able to accumulate at the tumor lesion due to the prolonged circulation of the nanocarrier and presence of abnormal leaky vasculature at the tumor site via the enhanced permeation and retention effect (EPR).","format":"limited_html"}],"field_summary_sentence":[{"value":"Non-invasive tracking of nanocarrier distribution in tumors"}],"uid":"27224","created_gmt":"2008-07-03 00:00:00","changed_gmt":"2016-10-08 03:06:06","author":"Megan McDevitt","boilerplate_text":"","field_publication":"","field_article_url":"","dateline":{"date":"2008-07-03T00:00:00-04:00","iso_date":"2008-07-03T00:00:00-04:00","tz":"America\/New_York"},"extras":[],"related_links":[{"url":"http:\/\/nanotechweb.org\/cws\/article\/lab\/34875","title":"Read Full Story"}],"groups":[{"id":"1292","name":"Parker H. Petit Institute for Bioengineering and Bioscience (IBB)"}],"categories":[{"id":"129","name":"Institute and Campus"},{"id":"140","name":"Cancer Research"},{"id":"134","name":"Student and Faculty"},{"id":"145","name":"Engineering"},{"id":"146","name":"Life Sciences and Biology"},{"id":"149","name":"Nanotechnology and Nanoscience"},{"id":"135","name":"Research"}],"keywords":[{"id":"9492","name":"bellamkonda"},{"id":"2286","name":"nano"}],"core_research_areas":[],"news_room_topics":[],"event_categories":[],"invited_audience":[],"affiliations":[],"classification":[],"areas_of_expertise":[],"news_and_recent_appearances":[],"phone":[],"contact":[{"value":"\u003Cstrong\u003EMegan McDevitt\u003C\/strong\u003E\u003Cbr \/\u003EIBB\u003Cbr \/\u003E\u003Ca href=\u0022http:\/\/www.gatech.edu\/contact\/index.html?id=mm504\u0022\u003EContact Megan McDevitt\u003C\/a\u003E\u003Cbr \/\u003E\u003Cstrong\u003E404-385-7001\u003C\/strong\u003E","format":"limited_html"}],"email":["megan.mcdevitt@ibb.gatech.edu"],"slides":[],"orientation":[],"userdata":""}}}