{"654592":{"#nid":"654592","#data":{"type":"event","title":"PhD Proposal by Lauren Liebman","body":[{"value":"\u003Cp\u003ELauren Liebman\u003Cbr \/\u003E\r\nBME PhD Proposal Presentation\u003Cbr \/\u003E\r\n\u003Cbr \/\u003E\r\n\u003Cstrong\u003EDate\u003C\/strong\u003E:2022-02-03\u003Cbr \/\u003E\r\n\u003Cstrong\u003ETime\u003C\/strong\u003E: 8:30 AM\u003Cbr \/\u003E\r\n\u003Cstrong\u003ELocation \/ Meeting Link\u003C\/strong\u003E: IBB Suddath Room, \u003Ca href=\u0022https:\/\/bluejeans.com\/965751828\/9658\u0022\u003Ehttps:\/\/bluejeans.com\/965751828\/9658\u003C\/a\u003E\u003Cbr \/\u003E\r\n\u003Cbr \/\u003E\r\n\u003Cstrong\u003ECommittee Members:\u003C\/strong\u003E\u003Cbr \/\u003E\r\nJ. Brandon Dixon, PhD (Advisor); Edward Botchwey, PhD; Zachary Buchwald, MD, PhD; Andres Garcia, PhD; Johnna Temenoff, PhD\u003Cbr \/\u003E\r\n\u003Cbr \/\u003E\r\n\u003Cbr \/\u003E\r\n\u003Cstrong\u003ETitle\u003C\/strong\u003E: Investigation of and therapeutic intervention in the crosstalk between inflammation and lymphatic function\u003Cbr \/\u003E\r\n\u003Cbr \/\u003E\r\n\u003Cstrong\u003EAbstract\u003C\/strong\u003E: The lymphatic system is a complex network of lymphatic vessels, lymph nodes, and lymphoid organs responsible for transporting interstitial fluid, lipids, macromolecules, and immune cells. Crosstalk between inflammation and lymphatic function is a hallmark of numerous pathologies, including lymphedema\u0026mdash;a disease that often arises following lymphatic damage by cancer treatment. Application of specialized pro-resolving mediators (SPMs) is a potential approach to rescue lymphatic function and attenuate inflammation to treat inflammatory diseases. The proposed work will investigate crosstalk between inflammation and lymphatic function in two murine models: a radiotherapy model for the treatment of melanoma and a surgical model of lymphedema. We will evaluate lymphatic function and remodeling after radiotherapy with and without surgical disruptions of lymphatic vessels in a mouse model of metastatic melanoma (Aim 1). We will also investigate effects of SPM treatment on lymphatic endothelial cells (LECs) and lymphatic muscle cells in multiple in vitro studies: transwell assays to evaluate LEC permeability following treatment and application of our laboratory\u0026rsquo;s custom three-dimensional spheroid platform to evaluate lymphangiogenic response to treatment (Aim 2). In Aim 3, we will evaluate sustained delivery of SPMs as a therapeutic strategy to resolve lymphatic injury in a surgical mouse tail model of lymphedema. Mice will be injected with SPM-loaded polymeric particles that have been optimized to prolong SPM release. In total, these studies will further our understanding of interactions between inflammation and lymphatic function and will establish a new therapeutic strategy for lymphatic injury.\u003C\/p\u003E\r\n","summary":null,"format":"limited_html"}],"field_subtitle":"","field_summary":"","field_summary_sentence":[{"value":"Investigation of and therapeutic intervention in the crosstalk between inflammation and lymphatic function"}],"uid":"27707","created_gmt":"2022-01-19 19:13:07","changed_gmt":"2022-01-19 19:13:07","author":"Tatianna Richardson","boilerplate_text":"","field_publication":"","field_article_url":"","field_event_time":{"event_time_start":"2022-02-03T08:30:00-05:00","event_time_end":"2022-02-03T22:31:00-05:00","event_time_end_last":"2022-02-03T22:31:00-05:00","gmt_time_start":"2022-02-03 13:30:00","gmt_time_end":"2022-02-04 03:31:00","gmt_time_end_last":"2022-02-04 03:31:00","rrule":null,"timezone":"America\/New_York"},"extras":[],"groups":[{"id":"221981","name":"Graduate Studies"}],"categories":[],"keywords":[{"id":"102851","name":"Phd proposal"}],"core_research_areas":[],"news_room_topics":[],"event_categories":[{"id":"1788","name":"Other\/Miscellaneous"}],"invited_audience":[{"id":"78761","name":"Faculty\/Staff"},{"id":"78771","name":"Public"},{"id":"78751","name":"Undergraduate students"}],"affiliations":[],"classification":[],"areas_of_expertise":[],"news_and_recent_appearances":[],"phone":[],"contact":[],"email":[],"slides":[],"orientation":[],"userdata":""}}}