{"65543":{"#nid":"65543","#data":{"type":"event","title":"Small RNA Regulation of the Quorum Sensing Response in the Bacterial Pathogen Vibrio Cholerae","body":[{"value":"\u003Cp\u003E\u003Cem\u003EIBB Breakfast Club Seminar Series\u003C\/em\u003E\u003C\/p\u003E\u003Cp\u003E\u003Cstrong\u003EBrian Hammer, PhD\u003C\/strong\u003E - Assistant Professor, School of Biology\u003C\/p\u003E\u003Cp\u003E\u003Cem\u003EAbstract:\u003C\/em\u003E\u003C\/p\u003E\u003Cp\u003E\u003Cem\u003EVibrio cholerae\u003C\/em\u003E, the waterborne bacterium\nresponsible for the deadly disease cholera, is both a transient human pathogen\nand a ubiquitous inhabitant of marine environments. The pathogenesis and\necology of this deadly microbe are the focus of research in the Hammer lab. \u003Cem\u003EV.\ncholerae\u003C\/em\u003E has become a model organism to understand a process of microbial\ncell-cell communication called quorum sensing, which allows bacterial groups to\nact in unison by synchronizing gene expression in response to population\ndensity. \u003Cem\u003EV. cholerae\u003C\/em\u003E, and many other \u003Cem\u003EVibrio\u003C\/em\u003E species, achieves\nquorum sensing by producing and then responding to chemical signal molecules,\ncalled autoinducers, which control the production of multiple regulatory small\nRNAs. In \u003Cem\u003EV. cholerae\u003C\/em\u003E, these non-coding sRNAs are predicted to base-pair\nwith, and alter the translation of, several mRNAs encoding protein regulators\nthat alter the expression of \u0026gt;100 genes. Many of the quorum-sensing\nregulated genes (such as the cholera toxin and attachment factors) are critical\nfor host colonization, while others (such as genes involved in horizontal gene\ntransfer) are important in marine ecosystems. We are currently using genetic,\nbiochemical, and computational methods to define the mechanism of sRNA control and\nthe role of \u003Cem\u003EV. cholerae\u003C\/em\u003E quorum sensing in clinical and environmental\nsettings.\u003C\/p\u003E\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\u003Cp\u003EThe IBB Breakfast Club seminar series was started with the spirit of the Institute\u0027s interdisciplinary mission in mind. The goal of the seminar series is to highlight research taking place throughout the institute to enable the IBB community to further collaborative opportunities and interdisciplinary research. Faculty are often asked to speak at other universities and conferences, but rarely present at their home institution, this seminar series is an attempt to close that gap. The IBB Breakfast Club is open to anyone in the bio-community.\u003C\/p\u003E\u003Cp\u003EContinental breakfast and coffee will be served.\u003C\/p\u003E\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\u003Cp\u003E\u003Cem\u003E\u003Cbr \/\u003E\u003C\/em\u003E\u003C\/p\u003E","summary":null,"format":"limited_html"}],"field_subtitle":"","field_summary":[{"value":"\u003Cp\u003EIBB Breakfast Club Seminar Series\u003C\/p\u003E\u003Cp\u003EBrian Hammer, PhD - Assistant Professor, School of Biology\u003C\/p\u003E","format":"limited_html"}],"field_summary_sentence":[{"value":"Brian Hammer, PhD - Assistant Professor, School of Biology"}],"uid":"27195","created_gmt":"2011-04-13 09:56:41","changed_gmt":"2016-10-08 01:54:46","author":"Colly Mitchell","boilerplate_text":"","field_publication":"","field_article_url":"","field_event_time":{"event_time_start":"2011-06-14T09:30:00-04:00","event_time_end":"2011-06-14T10:30:00-04:00","event_time_end_last":"2011-06-14T10:30:00-04:00","gmt_time_start":"2011-06-14 13:30:00","gmt_time_end":"2011-06-14 14:30:00","gmt_time_end_last":"2011-06-14 14:30:00","rrule":null,"timezone":"America\/New_York"},"extras":[],"hg_media":{"65800":{"id":"65800","type":"image","title":"IBB Breakfast Club Seminar Series","body":null,"created":"1449176884","gmt_created":"2015-12-03 21:08:04","changed":"1475894582","gmt_changed":"2016-10-08 02:43:02","alt":"IBB Breakfast Club Seminar Series","file":{"fid":"192404","name":"IBB_Breakfast_Club_Logo_2010.jpg","image_path":"\/sites\/default\/files\/images\/IBB_Breakfast_Club_Logo_2010_0.jpg","image_full_path":"http:\/\/www.tlwarc.hg.gatech.edu\/\/sites\/default\/files\/images\/IBB_Breakfast_Club_Logo_2010_0.jpg","mime":"image\/jpeg","size":55737,"path_740":"http:\/\/www.tlwarc.hg.gatech.edu\/sites\/default\/files\/styles\/740xx_scale\/public\/images\/IBB_Breakfast_Club_Logo_2010_0.jpg?itok=uPdPtcAW"}},"65805":{"id":"65805","type":"image","title":"Brian Hammer, PhD - Assistant Professor, School of Biology","body":null,"created":"1449176884","gmt_created":"2015-12-03 21:08:04","changed":"1475894582","gmt_changed":"2016-10-08 02:43:02","alt":"Brian Hammer, PhD - Assistant Professor, School of Biology","file":{"fid":"192408","name":"Hammer.jpg","image_path":"\/sites\/default\/files\/images\/Hammer_1.jpg","image_full_path":"http:\/\/www.tlwarc.hg.gatech.edu\/\/sites\/default\/files\/images\/Hammer_1.jpg","mime":"image\/jpeg","size":8705,"path_740":"http:\/\/www.tlwarc.hg.gatech.edu\/sites\/default\/files\/styles\/740xx_scale\/public\/images\/Hammer_1.jpg?itok=PtE7wxj1"}}},"media_ids":["65800","65805"],"related_links":[{"url":"http:\/\/www.ibb.gatech.edu\/brian-hammer","title":"Brian Hammer profile"},{"url":"http:\/\/www.ibb.gatech.edu\/breakfast-club","title":"IBB Breakfast Club"}],"groups":[{"id":"1292","name":"Parker H. 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