{"65795":{"#nid":"65795","#data":{"type":"event","title":"Molecular simulations of protein binding and switching","body":[{"value":"\u003Cp\u003E\u003Cem\u003EPhysical Chemistry Seminar Series \u003C\/em\u003E\u003C\/p\u003E\u003Cp\u003ELillian Chong, PhD - University of Pittsburgh\u003Cbr \/\u003E\u003Cstrong\u003EAbstract:\u003C\/strong\u003E\u003C\/p\u003E\u003Cp\u003EA major challenge in the field of biomolecular simulations is to access the long-timescale dynamics of biologically relevant protein motions such as the relative motions of protein domains and allosteric transitions. My group uses a variety of approaches for providing detailed views of such motions that might aid the design of molecular sensors or therapeutics. In this talk, I will present recent applications to the simulation of large-scale conformational changes in bi-functional, two-domain protein switches, molecular association kinetics, and how nature might correct for \u201cmistakes\u201d in binding geometry for a model protein-peptide complex.\u003C\/p\u003E","summary":null,"format":"limited_html"}],"field_subtitle":"","field_summary":[{"value":"\u003Cp\u003E\u003Cem\u003EPhysical Chemistry Seminar Series \u003C\/em\u003E\u003C\/p\u003E\u003Cp\u003E\u003Cem\u003E\u0022\u003C\/em\u003EMolecular simulations of protein binding and switching\u0022\u003C\/p\u003E\u003Cp\u003ELillian Chong, PhD - University of Pittsburgh\u003C\/p\u003E","format":"limited_html"}],"field_summary_sentence":[{"value":"Lillian Chong, PhD - University of Pittsburgh"}],"uid":"27195","created_gmt":"2011-04-27 09:39:36","changed_gmt":"2016-10-08 01:54:54","author":"Colly Mitchell","boilerplate_text":"","field_publication":"","field_article_url":"","field_event_time":{"event_time_start":"2011-05-05T17:00:00-04:00","event_time_end":"2011-05-05T18:00:00-04:00","event_time_end_last":"2011-05-05T18:00:00-04:00","gmt_time_start":"2011-05-05 21:00:00","gmt_time_end":"2011-05-05 22:00:00","gmt_time_end_last":"2011-05-05 22:00:00","rrule":null,"timezone":"America\/New_York"},"extras":[],"related_links":[{"url":"http:\/\/www.chem.pitt.edu\/people\/faculty\/lillian-chong","title":"Lillian Chong profile"}],"groups":[{"id":"1292","name":"Parker H. Petit Institute for Bioengineering and Bioscience (IBB)"}],"categories":[],"keywords":[{"id":"12944","name":"Molecular simulations of protein binding and switching"}],"core_research_areas":[],"news_room_topics":[],"event_categories":[{"id":"1795","name":"Seminar\/Lecture\/Colloquium"}],"invited_audience":[],"affiliations":[],"classification":[],"areas_of_expertise":[],"news_and_recent_appearances":[],"phone":[],"contact":[{"value":"\u003Cp\u003EShirley Tomes\u003C\/p\u003E\u003Cp\u003E404-894-0591\u003C\/p\u003E","format":"limited_html"}],"email":[],"slides":[],"orientation":[],"userdata":""}}}