{"598436":{"#nid":"598436","#data":{"type":"event","title":"BioE PhD Defense Presentation- Aditi Sharma","body":[{"value":"\u003Cp\u003E\u003Cstrong\u003EAdvisor: \u003C\/strong\u003E\u003C\/p\u003E\r\n\r\n\u003Cp\u003EAndreas S. Bommarius, Ph.D. (Georgia Institute of Technology)\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u003Cstrong\u003ECo-advisors: \u003C\/strong\u003E\u003C\/p\u003E\r\n\r\n\u003Cp\u003ESven H. Behrens, Ph.D. (Georgia Institute of Technology)\u003C\/p\u003E\r\n\r\n\u003Cp\u003EYury O. Chernoff, Ph.D. (Georgia Institute of Technology)\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u003Cstrong\u003ECommittee members: \u003C\/strong\u003E\u003C\/p\u003E\r\n\r\n\u003Cp\u003EJulie A. Champion, Ph.D. (Georgia Institute of Technology)\u003C\/p\u003E\r\n\r\n\u003Cp\u003EM. G. Finn, Ph.D. (Georgia Institute of Technology)\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u003Cstrong\u003ESTUDIES ON AMYLOID AGGREGATION AND CROSS-SPECIES PRION TRANSMISSION\u003C\/strong\u003E\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\r\n\r\n\u003Cp\u003EProper folding of protein molecules into their native structure is necessary to maintain function. Misfolding of proteins can reduce functionality as well as result in the formation of amorphous aggregates or ordered aggregates like amyloids. Amorphous aggregate formation during production, transport, and storage of protein-based biologics is a cause of concern in the biopharmaceutical industry as it results in a reduction in the efficacy or activity of the active pharmaceutical ingredient. On the other hand, ordered aggregation of proteins into amyloids (and their transmissible versions, prions) has been shown to result in several neurodegenerative diseases in humans and other mammals. While the effect of co-solutes including ions has been extensively studied in the context of measuring the stability of protein formulations and formation of disordered aggregates, there is limited information available on the effect of ions on the formation of ordered amyloid aggregates. In this thesis, we have investigated in detail the effect of presence of ionic co-solutes on the aggregation of amyloids.\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\r\n\r\n\u003Cp\u003EHere, we have studied the efficiency of cross-transmission of the NM fragment of Sup35 protein, from three closely related species of the \u003Cem\u003ESaccharomyces sensu stricto\u003C\/em\u003E group, namely \u003Cem\u003ES. cerevisiae\u003C\/em\u003E,\u003Cem\u003E S. bayanus\u003C\/em\u003E and \u003Cem\u003ES. paradoxus\u003C\/em\u003E, amongst each other. Using ions of the Hofmeister series, we discerned the relative effects of protein sequence, seed conformation, and environment on the cross-species transmission of this protein. Further, investigation of the fibrillation of Amyloid beta-42 (A\u0026beta;\u003Csub\u003E42\u003C\/sub\u003E) and Sup35NM in the presence of anions of the Hofmeister series at pH above and below their isoelectric points uncovered interesting differences in their aggregation behavior pointing to key differences in the aggregation mechanism and the biophysical\/biochemical properties of these proteins. Lastly, we developed a computational model for amyloid aggregation kinetics and used it for global fitting of Sup35NM amyloid aggregation data. In all, this thesis expands the current knowledge of ion-specific effects on aggregation of amyloid proteins as well as the mechanisms of amyloid aggregation.\u003C\/p\u003E\r\n","summary":null,"format":"limited_html"}],"field_subtitle":"","field_summary":[{"value":"\u003Cp\u003EBioE PhD Defense Presentation-\u0026nbsp;\u0026quot;STUDIES ON AMYLOID AGGREGATION AND CROSS-SPECIES PRION TRANSMISSION\u0026quot;- Aditi Sharma\u003C\/p\u003E\r\n","format":"limited_html"}],"field_summary_sentence":[{"value":"\u0022STUDIES ON AMYLOID AGGREGATION AND CROSS-SPECIES PRION TRANSMISSION\u0022"}],"uid":"27917","created_gmt":"2017-11-06 20:37:35","changed_gmt":"2017-11-07 15:22:28","author":"Laura Paige","boilerplate_text":"","field_publication":"","field_article_url":"","field_event_time":{"event_time_start":"2017-11-20T11:00:00-05:00","event_time_end":"2017-11-20T13:00:00-05:00","event_time_end_last":"2017-11-20T13:00:00-05:00","gmt_time_start":"2017-11-20 16:00:00","gmt_time_end":"2017-11-20 18:00:00","gmt_time_end_last":"2017-11-20 18:00:00","rrule":null,"timezone":"America\/New_York"},"extras":[],"groups":[{"id":"65448","name":"Bioengineering Graduate Program"}],"categories":[],"keywords":[{"id":"13974","name":"BioE Program events"},{"id":"6178","name":"BIOE"}],"core_research_areas":[],"news_room_topics":[],"event_categories":[{"id":"1788","name":"Other\/Miscellaneous"}],"invited_audience":[{"id":"78761","name":"Faculty\/Staff"},{"id":"78771","name":"Public"},{"id":"78751","name":"Undergraduate students"}],"affiliations":[],"classification":[],"areas_of_expertise":[],"news_and_recent_appearances":[],"phone":[],"contact":[{"value":"\u003Cp\u003ELaura Paige\u003C\/p\u003E\r\n\r\n\u003Cp\u003E404-385-6655\u003C\/p\u003E\r\n","format":"limited_html"}],"email":[],"slides":[],"orientation":[],"userdata":""}},"598476":{"#nid":"598476","#data":{"type":"event","title":"BioEngineering Program Faculty Meeting","body":[{"value":"\u003Cp\u003E\u003Cem\u003EThe BioEngineering Program faculty meet regularly during the semester to address program policies, events and future research and academic directions.\u003C\/em\u003E\u003C\/p\u003E\r\n","summary":null,"format":"limited_html"}],"field_subtitle":"","field_summary":[{"value":"\u003Cp\u003E\u003Cem\u003EProgram policies, events and directions to be discussed\u003C\/em\u003E\u003C\/p\u003E\r\n","format":"limited_html"}],"field_summary_sentence":[{"value":"\u0022BioEngineering Program Faculty Meeting\u0022"}],"uid":"27917","created_gmt":"2017-11-07 15:27:11","changed_gmt":"2017-11-07 15:27:11","author":"Laura Paige","boilerplate_text":"","field_publication":"","field_article_url":"","field_event_time":{"event_time_start":"2017-12-05T11:00:00-05:00","event_time_end":"2017-12-05T12:00:00-05:00","event_time_end_last":"2017-12-05T12:00:00-05:00","gmt_time_start":"2017-12-05 16:00:00","gmt_time_end":"2017-12-05 17:00:00","gmt_time_end_last":"2017-12-05 17:00:00","rrule":null,"timezone":"America\/New_York"},"extras":[],"groups":[{"id":"65448","name":"Bioengineering Graduate Program"}],"categories":[],"keywords":[],"core_research_areas":[],"news_room_topics":[],"event_categories":[{"id":"1788","name":"Other\/Miscellaneous"}],"invited_audience":[{"id":"78761","name":"Faculty\/Staff"},{"id":"78771","name":"Public"},{"id":"78751","name":"Undergraduate students"}],"affiliations":[],"classification":[],"areas_of_expertise":[],"news_and_recent_appearances":[],"phone":[],"contact":[],"email":[],"slides":[],"orientation":[],"userdata":""}},"598477":{"#nid":"598477","#data":{"type":"event","title":"BioEngineering Graduate Committee Meeting","body":[{"value":"\u003Cp\u003E\u003Cem\u003EThe BioEngineering graduate committee will meet to review\/approve program policies, program faculty applications and submitted student petitions.\u003Cbr \/\u003E\r\n\u003Cbr \/\u003E\r\nStudent Petitions due to\u0026nbsp;\u003Ca href=\u0022mailto:laura.paige@bioengineering.gatech.edu\u0022\u003ELaura Paige\u003C\/a\u003E\u0026nbsp;no later than: 12\/7\/2017.\u003C\/em\u003E\u003C\/p\u003E\r\n","summary":null,"format":"limited_html"}],"field_subtitle":"","field_summary":[{"value":"\u003Cp\u003EBioEngineering Graduate Committee Meeting\u003C\/p\u003E\r\n","format":"limited_html"}],"field_summary_sentence":[{"value":"\u0022BioEngineering Graduate Committee Meeting\u0022"}],"uid":"27917","created_gmt":"2017-11-07 15:32:33","changed_gmt":"2017-11-07 15:32:33","author":"Laura Paige","boilerplate_text":"","field_publication":"","field_article_url":"","field_event_time":{"event_time_start":"2017-12-14T12:00:00-05:00","event_time_end":"2017-12-14T13:00:00-05:00","event_time_end_last":"2017-12-14T13:00:00-05:00","gmt_time_start":"2017-12-14 17:00:00","gmt_time_end":"2017-12-14 18:00:00","gmt_time_end_last":"2017-12-14 18:00:00","rrule":null,"timezone":"America\/New_York"},"extras":[],"groups":[{"id":"65448","name":"Bioengineering Graduate Program"}],"categories":[],"keywords":[],"core_research_areas":[],"news_room_topics":[],"event_categories":[{"id":"1788","name":"Other\/Miscellaneous"}],"invited_audience":[{"id":"78761","name":"Faculty\/Staff"},{"id":"78771","name":"Public"},{"id":"78751","name":"Undergraduate students"}],"affiliations":[],"classification":[],"areas_of_expertise":[],"news_and_recent_appearances":[],"phone":[],"contact":[],"email":[],"slides":[],"orientation":[],"userdata":""}},"593841":{"#nid":"593841","#data":{"type":"event","title":"BioE PhD Proposal presentation- Anish Mukherjee","body":[{"value":"\u003Cp\u003E\u003Cstrong\u003EAdvisor:\u003C\/strong\u003E\u003C\/p\u003E\r\n\r\n\u003Cp\u003EJ. Brandon Dixon, PhD (George W. Woodruff School of Mechanical Engineering, Georgia Institute of Technology)\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u003Cstrong\u003ECommittee:\u003C\/strong\u003E\u003C\/p\u003E\r\n\r\n\u003Cp\u003EMichael J Davis, PhD (Department of Medical Pharmacology \u0026amp; Physiology, University of Missouri)\u003Cbr \/\u003E\r\nHanjoong Jo, PhD (Department of Biomedical Engineering, Georgia Institute of Technology)\u003Cbr \/\u003E\r\nLevi Wood, PhD (School of Mechanical Engineering, Georgia Institute of Technology)\u003Cbr \/\u003E\r\nStanislav Emelianov, PhD (School of Electrical and Computer Engineering, Georgia Institute of Technology)\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u003Cstrong\u003EFunctional Changes in Lymphatic Physiology in Response to Oscillatory Mechanical Stimuli\u003C\/strong\u003E\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u003Cbr \/\u003E\r\nLymphedema, a debilitating disease characterized by excess interstitial fluid accumulation in the extremities of the body, is suspected to be caused by dysfunctions in the lymphatic system. Elevated transmural pressure and wall shear stress in studies on isolated lymphatic vessels have been shown to modify the lymphatic vessel function, although focus have been put on functional changes in response to constant mechanical loading. However the underpinning molecular details and the frequency limitations of the lymphatic vessel response to dynamic pressure and shear stress waveforms are unknown. Hence the present work will try to quantify the effects of oscillatory mechanical forces on the function of lymphatic vessels by 1) Ex vivo quantification of the contractility of isolated lymphatic vessels modified in response to oscillatory shear stresses, 2) In vitro quantification of the calcium dynamics in lymphatic endothelial cells in response to oscillatory shear stress and stretch and 3) In vivo quantification of the change in lymphatic pumping metrics, obtained by NIR imaging, in response to steady and oscillatory external pressure waveforms in a rat model. This work will inform studies on molecular mechanisms leading to mechanosensitivity of lymphangions and will provide experimental evidence for improved physiotherapy techniques for lymphedema.\u003C\/p\u003E\r\n","summary":null,"format":"limited_html"}],"field_subtitle":"","field_summary":[{"value":"\u003Cp\u003EBioE PhD Proposal Presentation-\u0026nbsp;\u0026quot;Functional Changes in Lymphatic Physiology in Response to Oscillatory Mechanical Stimuli\u0026quot;- Anish Mukherjee\u003C\/p\u003E\r\n","format":"limited_html"}],"field_summary_sentence":[{"value":"\u0022Functional Changes in Lymphatic Physiology in Response to Oscillatory Mechanical Stimuli\u0022"}],"uid":"27917","created_gmt":"2017-07-31 12:10:55","changed_gmt":"2017-07-31 12:10:55","author":"Laura Paige","boilerplate_text":"","field_publication":"","field_article_url":"","field_event_time":{"event_time_start":"2017-08-15T14:00:00-04:00","event_time_end":"2017-08-15T16:00:00-04:00","event_time_end_last":"2017-08-15T16:00:00-04:00","gmt_time_start":"2017-08-15 18:00:00","gmt_time_end":"2017-08-15 20:00:00","gmt_time_end_last":"2017-08-15 20:00:00","rrule":null,"timezone":"America\/New_York"},"extras":[],"groups":[{"id":"65448","name":"Bioengineering Graduate Program"}],"categories":[],"keywords":[],"core_research_areas":[],"news_room_topics":[],"event_categories":[{"id":"10377","name":"Career\/Professional development"}],"invited_audience":[{"id":"78761","name":"Faculty\/Staff"},{"id":"78771","name":"Public"},{"id":"78751","name":"Undergraduate students"}],"affiliations":[],"classification":[],"areas_of_expertise":[],"news_and_recent_appearances":[],"phone":[],"contact":[{"value":"\u003Cp\u003ELaura Paige\u003C\/p\u003E\r\n\r\n\u003Cp\u003E404.385.6655\u003C\/p\u003E\r\n","format":"limited_html"}],"email":[],"slides":[],"orientation":[],"userdata":""}},"593631":{"#nid":"593631","#data":{"type":"event","title":"Bioengineering Orientation","body":[{"value":"\u003Cp\u003ECome get the 411 on everything-BioE! Kicking things off with a special poster session and reception, followed by everything you need to know for a great first-year as a BioE grad student.\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u003Cstrong\u003EAGENDA\u003C\/strong\u003E\u003C\/p\u003E\r\n\r\n\u003Cp\u003E12:30 - 2:30 p.m. \u0026nbsp; \u0026nbsp;Poster session and reception - Petit Atrium\u003Cbr \/\u003E\r\n2:30 - 3:30 p.m. \u0026nbsp; \u0026nbsp;BioE Overview - Andr\u0026eacute;s Garc\u0026iacute;a, Ph.D.\u003Cbr \/\u003E\r\n3:30 - 3:45 p.m. \u0026nbsp; \u0026nbsp;Training Grant Information Session\u003C\/p\u003E\r\n\r\n\u003Cul\u003E\r\n\t\u003Cli\u003ECell and Tissue Engineering (CTEng) training grant - Andr\u0026eacute;s Garc\u0026iacute;a, Ph.D.\u003C\/li\u003E\r\n\t\u003Cli\u003EBioMaterials training grant - Christine Payne, Ph.D.\u003C\/li\u003E\r\n\u003C\/ul\u003E\r\n\r\n\u003Cp\u003E3:45\u0026nbsp;- 4:15\u0026nbsp;p.m. Course Advisement - Andr\u0026eacute;s Garc\u0026iacute;a, Ph.D.\u003Cbr \/\u003E\r\n4:15\u0026nbsp;- 4:45 p.m. BioE Student Panel\u003C\/p\u003E\r\n\r\n\u003Cul\u003E\r\n\t\u003Cli\u003EMarcus Walker - ECE\u003C\/li\u003E\r\n\t\u003Cli\u003ESeleipiri Charles - BME\u003C\/li\u003E\r\n\t\u003Cli\u003EKelly Hyland - MSE\u003C\/li\u003E\r\n\t\u003Cli\u003EMichael Hunckler - ME\u003C\/li\u003E\r\n\t\u003Cli\u003EJeffrey Noble - ChBE\u003C\/li\u003E\r\n\u003C\/ul\u003E\r\n\r\n\u003Cp\u003E4:45 - 5:15 p.m. \u0026nbsp; \u0026nbsp;Peer Counseling - current students discuss classes they have taken\u003Cbr \/\u003E\r\n5:30 p.m. \u0026nbsp; \u0026nbsp;Meet in atrium for outing with current BioE students, 5:45 p.m. departure\u003C\/p\u003E\r\n","summary":null,"format":"limited_html"}],"field_subtitle":"","field_summary":"","field_summary_sentence":[{"value":"Open to all new and current BioE grad students"}],"uid":"27195","created_gmt":"2017-07-21 13:03:06","changed_gmt":"2017-07-25 14:21:06","author":"Colly Mitchell","boilerplate_text":"","field_publication":"","field_article_url":"","field_event_time":{"event_time_start":"2017-08-17T13:30:00-04:00","event_time_end":"2017-08-17T18:30:00-04:00","event_time_end_last":"2017-08-17T18:30:00-04:00","gmt_time_start":"2017-08-17 17:30:00","gmt_time_end":"2017-08-17 22:30:00","gmt_time_end_last":"2017-08-17 22:30:00","rrule":null,"timezone":"America\/New_York"},"extras":[],"hg_media":{"547711":{"id":"547711","type":"image","title":"Bioengineering Logo","body":null,"created":"1466784000","gmt_created":"2016-06-24 16:00:00","changed":"1475895341","gmt_changed":"2016-10-08 02:55:41","alt":"Bioengineering Logo","file":{"fid":"92459","name":"parkerpetitinstitutebioengineeringandbioscience-2line-solid-539124.jpeg","image_path":"\/sites\/default\/files\/images\/parkerpetitinstitutebioengineeringandbioscience-2line-solid-539124.jpeg","image_full_path":"http:\/\/www.tlwarc.hg.gatech.edu\/\/sites\/default\/files\/images\/parkerpetitinstitutebioengineeringandbioscience-2line-solid-539124.jpeg","mime":"image\/jpeg","size":7807,"path_740":"http:\/\/www.tlwarc.hg.gatech.edu\/sites\/default\/files\/styles\/740xx_scale\/public\/images\/parkerpetitinstitutebioengineeringandbioscience-2line-solid-539124.jpeg?itok=F9tRfP5I"}}},"media_ids":["547711"],"related_links":[{"url":"http:\/\/bioengineering.gatech.edu\/","title":"BioE website"}],"groups":[{"id":"1292","name":"Parker H. 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Come and talk to the committee chairs, hang with other grad students, and sign up for one (or more!)\u0026nbsp;of the many awesome committees below!\u003Cbr \/\u003E\r\n\u003Cbr \/\u003E\r\nCommittees:\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u003Cstrong\u003EEDUCATION \u0026amp; OUTREACH\u003C\/strong\u003E - Host visitors from local schools and organizations, coordinate educational events such as Buzz on Biotechnology. This is a super-fun, capstone Petit Institute event that requires lots of hands, so sign up to help with hands-on science demos, lab tours, and seminars for eager\/curious high school scientists!\u003Cbr \/\u003E\r\n\u0026nbsp;\u003Cbr \/\u003E\r\n\u003Cstrong\u003ECOMMUNICATIONS\u003C\/strong\u003E - The communications committee is responsible for disseminating information about upcoming BBUGS events via the website, Mailchimp, and maintaining the mailing list.\u0026nbsp;\u003Cbr \/\u003E\r\n\u0026nbsp;\u003Cbr \/\u003E\r\n\u003Cstrong\u003EINDUSTRY\u003C\/strong\u003E - Collaborate with established professionals to host\u0026nbsp;events such as workshops and site-visits to prepare graduate students for a career in industry.\u003Cbr \/\u003E\r\n\u0026nbsp;\u003Cbr \/\u003E\r\n\u003Cstrong\u003EPOLICY\u003C\/strong\u003E - Engaging and increasing the policy interests of graduate students, particularly in areas related to biomedical and bioengineering research, such as public health, healthcare access and regulation of medical devices and therapeutics.\u003Cbr \/\u003E\r\n\u0026nbsp;\u003Cbr \/\u003E\r\n\u003Cstrong\u003EPROFESSIONAL DEVELOPMENT\u003C\/strong\u003E - Seminars and panel presentations to guide individuals at different stages of their careers with topics ranging from advisor selection to interviewing and negotiating job offers.\u003Cbr \/\u003E\r\n\u0026nbsp;\u003Cbr \/\u003E\r\n\u003Cstrong\u003ERESEARCH\u003C\/strong\u003E - Help chairs organize events pertaining to research on campus, networking with clinicians and exposure to the impacts that research brings to hospitals and businesses.\u003Cbr \/\u003E\r\n\u0026nbsp;\u003Cbr \/\u003E\r\n\u003Cstrong\u003ESOCIAL\u003C\/strong\u003E - Events to build community amongst bioengineering and bioscience graduate students through social events (football tailgates, etc.)\u003Cbr \/\u003E\r\n\u0026nbsp;\u003Cbr \/\u003E\r\n\u003Cstrong\u003ESERVICE\u003C\/strong\u003E - Help with various community service activities throughout the year such as informational sessions on the GT Ideas to Serve Competition and volunteering with local groups such as MedShare.\u003Cbr \/\u003E\r\n\u0026nbsp;\u003Cbr \/\u003E\r\n\u003Cem\u003E...something for EVERYONE!\u003C\/em\u003E\u003Cbr \/\u003E\r\n\u0026nbsp;\u003C\/p\u003E\r\n","summary":null,"format":"limited_html"}],"field_subtitle":"","field_summary":"","field_summary_sentence":[{"value":"Calling all Biotech Grad Students!"}],"uid":"27195","created_gmt":"2017-07-21 12:28:20","changed_gmt":"2017-07-21 12:35:16","author":"Colly Mitchell","boilerplate_text":"","field_publication":"","field_article_url":"","field_event_time":{"event_time_start":"2017-08-24T17:00:00-04:00","event_time_end":"2017-08-24T18:30:00-04:00","event_time_end_last":"2017-08-24T18:30:00-04:00","gmt_time_start":"2017-08-24 21:00:00","gmt_time_end":"2017-08-24 22:30:00","gmt_time_end_last":"2017-08-24 22:30:00","rrule":null,"timezone":"America\/New_York"},"extras":["free_food"],"hg_media":{"68922":{"id":"68922","type":"image","title":"Bioengineering \u0026 Bioscience Unified Graduate Students (BBUGS)","body":null,"created":"1449177214","gmt_created":"2015-12-03 21:13:34","changed":"1475894599","gmt_changed":"2016-10-08 02:43:19","alt":"Bioengineering \u0026 Bioscience Unified Graduate Students (BBUGS)","file":{"fid":"192686","name":"bugs_on_grass.png","image_path":"\/sites\/default\/files\/images\/bugs_on_grass_0.png","image_full_path":"http:\/\/www.tlwarc.hg.gatech.edu\/\/sites\/default\/files\/images\/bugs_on_grass_0.png","mime":"image\/png","size":376131,"path_740":"http:\/\/www.tlwarc.hg.gatech.edu\/sites\/default\/files\/styles\/740xx_scale\/public\/images\/bugs_on_grass_0.png?itok=o0GbGwWn"}}},"media_ids":["68922"],"related_links":[{"url":"http:\/\/bbugs.gatech.edu\/","title":"BBUGS website"}],"groups":[{"id":"69452","name":"BBUGS"},{"id":"65448","name":"Bioengineering Graduate Program"},{"id":"1292","name":"Parker H. 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As an interdisciplinary program, BioE faces a unique challenge in unifying students from many different home schools with a wide array of research topics. In order to acknowledge and celebrate this diversity, BioE day incorporates research- and career-focused speeches, competitions, and community-building activities. BioE day is kicked off with a keynote address and is followed by a graduate student being awarded the Chris Ruffin Student Leadership Award for exemplary leadership and involvement in the community. Friendly competitions include a \u0026ldquo;rapid-fire\u0026rdquo; style research presentation session by the BioE graduate students. Faculty act as judges during a poster session that displays the work of a large majority of labs in the program. In addition, BioE Day highlights outstanding members of the community: the recipient of the 2017\u0026nbsp;BioE Outstanding Advisor Award will give a presentation on effective mentoring and the 2017\u0026nbsp;Outstanding Paper recipient will present on her research. The day will conclude with a cookout and games in the courtyard. By displaying the exciting work pioneered by the various disciplines found within the program, BioE day aims to increase awareness of what BioE offers as well as cultivate the camaraderie and interdisciplinary innovative spirit that is the foundation of the program.\u003Cbr \/\u003E\r\n\u003Cbr \/\u003E\r\n\u003Ca href=\u0022http:\/\/bioengineering.gatech.edu\/bioe-day-registration\u0022\u003EREGISTER HERE\u003C\/a\u003E\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u003Cstrong\u003EBioE Day 2017\u0026nbsp;Agenda\u003C\/strong\u003E\u003Cbr \/\u003E\r\n\u003Cem\u003EPetit Biotechnology Building Atrium\u003C\/em\u003E\u003C\/p\u003E\r\n\r\n\u003Cp\u003E12:00 p.m. \u0026nbsp; \u0026nbsp;\u0026nbsp; Keynote Speaker Introduction - \u003Cstrong\u003EAndr\u0026eacute;s Garc\u0026iacute;a, Ph.D.\u0026nbsp;\u003C\/strong\u003E\u003C\/p\u003E\r\n\r\n\u003Cp\u003E12:05 p.m. \u0026nbsp; \u0026nbsp; \u0026nbsp;\u003Cstrong\u003EKeynote Address\u003C\/strong\u003E -\u003Cstrong\u003E\u0026nbsp;Sean Coyer, Ph.D. \u0026nbsp;-\u0026nbsp;W.L. Gore \u0026amp; Associates\u003C\/strong\u003E\u003Cbr \/\u003E\r\n\u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u003Cem\u003E\u0026quot;What\u0026rsquo;s Next? Tips and Tricks to Life after Grad\u0026nbsp;School\u0026quot;\u003C\/em\u003E\u003C\/p\u003E\r\n\r\n\u003Cp\u003E1:00 p.m.\u0026nbsp;\u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp;Lunch\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp;Poster Competition - \u003Cem\u003ESuddath Seminar Room 1128\u003C\/em\u003E\u003C\/p\u003E\r\n\r\n\u003Cp\u003E2:00 p.m.\u0026nbsp;\u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp;Rapid Fire Competition\u003C\/p\u003E\r\n\r\n\u003Cp\u003E3:00 p.m. \u0026nbsp;\u0026nbsp; \u0026nbsp; \u0026nbsp; Coffee break\u003C\/p\u003E\r\n\r\n\u003Cp\u003E3:15 p.m.\u0026nbsp;\u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp;Faculty introduction of the BioE\u0026nbsp;\u0026quot;Outstanding Paper Award\u0026quot; - \u003Cstrong\u003ELaura \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp;O\u0026#39;Farrell, D.V.M.\u003C\/strong\u003E\u003C\/p\u003E\r\n\r\n\u003Cp\u003E3:20 p.m.\u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; Presentation by Outstanding BioE Paper Winner - \u003Cstrong\u003EYogi Patel (Butera Lab)\u003C\/strong\u003E\u003C\/p\u003E\r\n\r\n\u003Cp\u003E3:35 p.m.\u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; Award Presentations\u003C\/p\u003E\r\n\r\n\u003Cp\u003E4:00 p.m. \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp;Presentation by Outstanding BioE Advisor Winner - \u003Cstrong\u003ERoss Ethier, Ph.D.\u003C\/strong\u003E\u003C\/p\u003E\r\n\r\n\u003Cp\u003E4:30 p.m. - 6:30 p.m. \u0026nbsp; Cookout and lawn games - \u003Cem\u003EBioTech Quad\u003C\/em\u003E\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u003Ca href=\u0022http:\/\/bioengineering.gatech.edu\/bioe-day-registration\u0022\u003EREGISTER HERE\u003C\/a\u003E\u003C\/p\u003E\r\n","summary":null,"format":"limited_html"}],"field_subtitle":"","field_summary":"","field_summary_sentence":[{"value":"4th Annual Celebration of BioEngineering Interdisciplinary Graduate Program"}],"uid":"27349","created_gmt":"2017-04-12 13:27:10","changed_gmt":"2017-04-13 21:12:02","author":"Floyd Wood","boilerplate_text":"","field_publication":"","field_article_url":"","field_event_time":{"event_time_start":"2017-05-04T13:00:00-04:00","event_time_end":"2017-05-04T19:30:00-04:00","event_time_end_last":"2017-05-04T19:30:00-04:00","gmt_time_start":"2017-05-04 17:00:00","gmt_time_end":"2017-05-04 23:30:00","gmt_time_end_last":"2017-05-04 23:30:00","rrule":null,"timezone":"America\/New_York"},"extras":[],"hg_media":{"294411":{"id":"294411","type":"image","title":"BioEngineering graduate program at Georgia Tech","body":null,"created":"1449244331","gmt_created":"2015-12-04 15:52:11","changed":"1475894993","gmt_changed":"2016-10-08 02:49:53","alt":"BioEngineering graduate program at Georgia Tech","file":{"fid":"199346","name":"bioe-solid-logo.jpg","image_path":"\/sites\/default\/files\/images\/bioe-solid-logo_0.jpg","image_full_path":"http:\/\/www.tlwarc.hg.gatech.edu\/\/sites\/default\/files\/images\/bioe-solid-logo_0.jpg","mime":"image\/jpeg","size":112514,"path_740":"http:\/\/www.tlwarc.hg.gatech.edu\/sites\/default\/files\/styles\/740xx_scale\/public\/images\/bioe-solid-logo_0.jpg?itok=WYoKuDbB"}}},"media_ids":["294411"],"related_links":[{"url":"http:\/\/www.bioengineering.gatech.edu","title":"Bioengineering Graduate Program"}],"groups":[{"id":"65448","name":"Bioengineering Graduate Program"},{"id":"1292","name":"Parker H. Petit Institute for Bioengineering and Bioscience (IBB)"}],"categories":[],"keywords":[{"id":"13974","name":"BioE Program events"},{"id":"11877","name":"BioE Seminar"},{"id":"248","name":"IBB"}],"core_research_areas":[],"news_room_topics":[],"event_categories":[{"id":"1789","name":"Conference\/Symposium"}],"invited_audience":[{"id":"78761","name":"Faculty\/Staff"},{"id":"78751","name":"Undergraduate students"},{"id":"174045","name":"Graduate students"}],"affiliations":[],"classification":[],"areas_of_expertise":[],"news_and_recent_appearances":[],"phone":[],"contact":[{"value":"\u003Cp\u003E\u003Ca href=\u0022mailto:laura.paige@bioengineering.gatech.edu\u0022\u003ELaura Paige\u003C\/a\u003E - BioE Academic Advisor\u003C\/p\u003E\r\n","format":"limited_html"}],"email":[],"slides":[],"orientation":[],"userdata":""}},"581909":{"#nid":"581909","#data":{"type":"event","title":"BioE PhD Defense Announcement- Caitlin Austin","body":[{"value":"\u003Cp\u003E\u003Cstrong\u003EADVISOR:\u003C\/strong\u003E\u003C\/p\u003E\r\n\r\n\u003Cp\u003ECraig Forest, Ph.D. \u0026nbsp;(Mechanical Engineering)\u0026nbsp;\u003Cbr \/\u003E\r\n\u003Cstrong\u003ECOMMITTEE:\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp; \u003C\/strong\u003E\u003C\/p\u003E\r\n\r\n\u003Cp\u003EBrian Hammer, Ph. D. (Georgia Institute of Technology)\u003C\/p\u003E\r\n\r\n\u003Cp\u003EFaramarz Fekri, Ph. D. (Georgia Institute of Technology)\u003C\/p\u003E\r\n\r\n\u003Cp\u003EMark Styczynski, Ph. D. (Georgia Institute of Technology)\u003C\/p\u003E\r\n\r\n\u003Cp\u003EPeter Hesketh, Ph. D.\u0026nbsp; (Georgia Institute of Technology)\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u003Cstrong\u003EDynamics of molecular communication in bacteria within microfluidic environments\u003C\/strong\u003E\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\r\n\r\n\u003Cp\u003EBiosensors exploiting communication within genetically engineered bacteria are becoming increasingly important for monitoring environmental changes. Recently these sensors have miniaturized towards microfluidics due to the greater control they provide over things such as the population density and dynamic inputs. Although great strides have been made to study a single strain of bacteria in a microfluidic device, there is still a need to be able to study two populations of bacteria communicating with one another. Currently, there are a variety of mathematical models for understanding and predicting how genetically engineered bacteria respond to molecular stimuli in bulk culture environments, but when applied to microfluidics and to complex time-varying inputs, the shortcomings of these models have become apparent. The effects of microfluidic environments such as low oxygen concentration, increased biofilm, diffusion limited molecular distribution, and higher population densities strongly affect rate constants for gene expression not accounted for in previous models. In this work we developed a microfluidic platform capable of housing two bacteria populations to study the bacterial communication with dynamic control of inputs, long-term experimentation, and no cross contamination. We also developed a mathematical model that accurately predicts the biological response of the bacteria populations communicating in the microfluidic environment. This work can serve as a valuable tool in understanding genetically engineered bacteria and improving biosensor design capabilities, opening the door for sensors that adapt to environmental dynamics and communicate with each other.\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\r\n","summary":null,"format":"limited_html"}],"field_subtitle":"","field_summary":[{"value":"\u003Cp\u003EPhD Defense Presentation-\u0026nbsp;\u0026quot;Dynamics of molecular communication in bacteria within microfluidic environments\u0026quot;- Caitlin Austin\u003C\/p\u003E\r\n","format":"limited_html"}],"field_summary_sentence":[{"value":"\u0022Dynamics of molecular communication in bacteria within microfluidic environments\u0022"}],"uid":"27917","created_gmt":"2016-09-29 17:31:19","changed_gmt":"2017-04-13 21:14:28","author":"Laura Paige","boilerplate_text":"","field_publication":"","field_article_url":"","field_event_time":{"event_time_start":"2016-10-20T16:15:00-04:00","event_time_end":"2016-10-20T18:30:00-04:00","event_time_end_last":"2016-10-20T18:30:00-04:00","gmt_time_start":"2016-10-20 20:15:00","gmt_time_end":"2016-10-20 22:30:00","gmt_time_end_last":"2016-10-20 22:30:00","rrule":null,"timezone":"America\/New_York"},"extras":[],"groups":[{"id":"65448","name":"Bioengineering Graduate Program"}],"categories":[],"keywords":[],"core_research_areas":[],"news_room_topics":[],"event_categories":[{"id":"10377","name":"Career\/Professional development"}],"invited_audience":[{"id":"78761","name":"Faculty\/Staff"},{"id":"78751","name":"Undergraduate students"},{"id":"174045","name":"Graduate students"}],"affiliations":[],"classification":[],"areas_of_expertise":[],"news_and_recent_appearances":[],"phone":[],"contact":[{"value":"\u003Cp\u003ELaura Paige 404-385-6655\u003C\/p\u003E\r\n","format":"limited_html"}],"email":[],"slides":[],"orientation":[],"userdata":""}},"527031":{"#nid":"527031","#data":{"type":"event","title":"BioE Day 2016","body":[{"value":"\u003Cp\u003EBioE day is an event specifically designed to foster a sense of community and identity among the BioEngineering Graduate Program\u2019s students and faculty. As an interdisciplinary program, BioE faces a unique challenge in unifying students from many different home schools with a wide array of research topics. In order to acknowledge and celebrate this diversity, BioE day incorporates research- and career-focused speeches, competitions, and community-building activities. BioE day is kicked off with a keynote address and is followed by a graduate student being awarded the Chris Ruffin Student Leadership Award for exemplary leadership and involvement in the community. Friendly competitions include a \u201crapid-fire\u201d style research presentation session by the BioE graduate students. Faculty act as judges during a poster session that displays the work of a large majority of labs in the program. In addition, BioE Day highlights outstanding members of the community: the recipient of the 2016 BioE Outstanding Advisor Award will give a presentation on effective mentoring and the 2016 Outstanding Paper recipient will present on her research. The day will conclude with a cookout and games in the courtyard. By displaying the exciting work pioneered by the various disciplines found within the program, BioE day aims to increase awareness of what BioE offers as well as cultivate the camaraderie and interdisciplinary innovative spirit that is the foundation of the program. \u003Cbr \/\u003E\u003Cbr \/\u003E\u003Ca href=\u0022http:\/\/bioengineering.gatech.edu\/bioe-day-registration\u0022\u003EREGISTER HERE\u003C\/a\u003E\u003C\/p\u003E\u003Cp\u003E\u003Cstrong\u003EBioE Day 2016 Agenda\u003Cbr \/\u003E\u003C\/strong\u003E\u003Cem\u003EPetit Biotechnology Building Atrium\u003C\/em\u003E\u003C\/p\u003E\u003Cp\u003E12:00 \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; Andr\u00e9s Garc\u00eda, Ph.D. introduces Keynote Speaker, Bob Nerem, Ph.D.\u003C\/p\u003E\u003Cp\u003E12:05-12:55 \u0026nbsp; \u003Cstrong\u003EKeynote Address\u003C\/strong\u003E - \u003Cstrong\u003E\u0022\u003C\/strong\u003E\u003Cstrong\u003EBioengineering: Building a New Discipline, a Personal\u003C\/strong\u003E\u003Cbr \/\u003E\u003Cstrong\u003E\u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; Journey\u201d\u003C\/strong\u003E - Bob Nerem, Ph.D., 5-10\u0026nbsp;minutes of Q\u0026amp;A\u003C\/p\u003E\u003Cp\u003E1:00 \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp;Lunch\u003C\/p\u003E\u003Cp\u003E\u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp;Poster Competition - \u003Cem\u003ESuddath Seminar Room 1128\u003C\/em\u003E\u003C\/p\u003E\u003Cp\u003E2:00 \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp;Rapid Fire Competition\u003C\/p\u003E\u003Cp\u003E3:00 \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp;Coffee break\u003C\/p\u003E\u003Cp\u003E3:05 \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp;Wilbur Lam, M.D., Ph.D. introduces student Jordan Ciciliano\u003C\/p\u003E\u003Cp\u003E3:10-3:25 \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp;Presentation by Outstanding BioE Paper Winner (Jordan Ciciliano)\u003C\/p\u003E\u003Cp\u003E3:30-3:45 \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp;Presentation by Outstanding BioE Advisor Winner (Krishnendu Roy, Ph.D.)\u003C\/p\u003E\u003Cp\u003E3:50 \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp;Award Presentations\u003C\/p\u003E\u003Cp\u003E4 - 6:30 p.m. \u0026nbsp;Cookout and lawn games - \u003Cem\u003EBioTech Quad\u003C\/em\u003E\u003C\/p\u003E\u003Cp\u003E\u003Ca href=\u0022http:\/\/bioengineering.gatech.edu\/bioe-day-registration\u0022\u003EREGISTER HERE\u003C\/a\u003E\u003C\/p\u003E","summary":null,"format":"limited_html"}],"field_subtitle":"","field_summary":"","field_summary_sentence":[{"value":"3rd Annual Celebration of BioEngineering Interdisciplinary Graduate Program"}],"uid":"27195","created_gmt":"2016-04-20 10:21:16","changed_gmt":"2017-04-13 21:15:58","author":"Colly Mitchell","boilerplate_text":"","field_publication":"","field_article_url":"","field_event_time":{"event_time_start":"2016-05-12T13:00:00-04:00","event_time_end":"2016-05-12T19:30:00-04:00","event_time_end_last":"2016-05-12T19:30:00-04:00","gmt_time_start":"2016-05-12 17:00:00","gmt_time_end":"2016-05-12 23:30:00","gmt_time_end_last":"2016-05-12 23:30:00","rrule":null,"timezone":"America\/New_York"},"extras":[],"hg_media":{"294411":{"id":"294411","type":"image","title":"BioEngineering graduate program at Georgia Tech","body":null,"created":"1449244331","gmt_created":"2015-12-04 15:52:11","changed":"1475894993","gmt_changed":"2016-10-08 02:49:53","alt":"BioEngineering graduate program at Georgia Tech","file":{"fid":"199346","name":"bioe-solid-logo.jpg","image_path":"\/sites\/default\/files\/images\/bioe-solid-logo_0.jpg","image_full_path":"http:\/\/www.tlwarc.hg.gatech.edu\/\/sites\/default\/files\/images\/bioe-solid-logo_0.jpg","mime":"image\/jpeg","size":112514,"path_740":"http:\/\/www.tlwarc.hg.gatech.edu\/sites\/default\/files\/styles\/740xx_scale\/public\/images\/bioe-solid-logo_0.jpg?itok=WYoKuDbB"}}},"media_ids":["294411"],"related_links":[{"url":"http:\/\/www.bioengineering.gatech.edu\/bioe-day-agenda","title":"BioE Day website"}],"groups":[{"id":"1292","name":"Parker H. Petit Institute for Bioengineering and Bioscience (IBB)"},{"id":"65448","name":"Bioengineering Graduate Program"}],"categories":[],"keywords":[{"id":"13974","name":"BioE Program events"},{"id":"11877","name":"BioE Seminar"},{"id":"248","name":"IBB"}],"core_research_areas":[],"news_room_topics":[],"event_categories":[{"id":"1789","name":"Conference\/Symposium"}],"invited_audience":[{"id":"78751","name":"Undergraduate students"},{"id":"78761","name":"Faculty\/Staff"},{"id":"174045","name":"Graduate students"}],"affiliations":[],"classification":[],"areas_of_expertise":[],"news_and_recent_appearances":[],"phone":[],"contact":[{"value":"\u003Cp\u003E\u003Ca href=\u0022mailto:laura.paige@bioengineering.gatech.edu\u0022\u003ELaura Paige\u003C\/a\u003E - BioE Academic Advisor\u003C\/p\u003E","format":"limited_html"}],"email":[],"slides":[],"orientation":[],"userdata":""}},"557461":{"#nid":"557461","#data":{"type":"event","title":"MS Thesis Defense - Leandro Moretti","body":[{"value":"\u003Cp\u003EAdvisor: \u003Cstrong\u003EThomas H. Barker, Ph.D.\u003C\/strong\u003E (University of Virginia)\u003C\/p\u003E\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\u003Cp\u003E\u003Cstrong\u003ECommittee:\u003C\/strong\u003E\u003C\/p\u003E\u003Cp\u003E\u003Cstrong\u003EAndr\u00e9s\u003C\/strong\u003E\u003Cstrong\u003E Garc\u00eda\u003C\/strong\u003E\u003Cstrong\u003E, Ph.D. \u003C\/strong\u003E(Georgia Institute of Technology)\u003C\/p\u003E\u003Cp\u003E\u003Cstrong\u003ESusan Thomas, Ph.D. \u003C\/strong\u003E(Georgia Institute of Technology)\u003C\/p\u003E\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\u003Cp align=\u0022center\u0022\u003E\u003Cstrong\u003EApproaches to Improve Expression and Specificity of an Antibody Probe Against Fibronectin\u003C\/strong\u003E\u003C\/p\u003E\u003Cp align=\u0022center\u0022\u003E\u0026nbsp;\u003C\/p\u003E\u003Cp\u003EPhage display is a convenient method to select proteins of interest based on binding affinity. The Barker lab recently used this technology to discover an antibody fragment (scFv), termed H5, capable of selectively binding to the integrin binding domain of fibronectin (Fn) under a strained configuration, typically due to forces exerted on the extracellular matrix (ECM) by cells.\u003C\/p\u003E\u003Cp\u003ELarge scale production of H5 scFv is hindered by non-optimized codons and suspected protein toxicity, since the E. coli strain producing the protein grew poorly at normal temperatures. Moreover, the transfected vector containing H5, pIT2, appeared to be degraded in consecutively selected bacterial cultures, as suggested by the isolation of significantly shorter than expect plasmids.\u003C\/p\u003E\u003Cp\u003EAfter significant effort, reconstruction of the pIT2 vector sequence was accomplished from multiple colonies and cross referencing with the provided anti-ubiquitin scFv antibody fragment, and the complete DNA sequence of H5 was recovered. The sequence was codon optimized for expression in an E. coli strain engineered for high levels of scFv production. Furthermore, the H5 DNA was recombined with error prone PCR, to generate a library of random mutants, which was transformed into a stable, E. coli strain. This library will be panned on the targets again through phage display in order to find an improved version of H5, defined by more selective binding to the extended conformation of the integrin binding domain of Fn.\u003C\/p\u003E","summary":null,"format":"limited_html"}],"field_subtitle":"","field_summary":[{"value":"\u003Cp\u003EMS Thesis Defense-\u0026nbsp;\u0022Approaches to Improve Expression and Specificity of an Antibody Probe Against Fibronectin\u0022- Leandro Moretti\u003C\/p\u003E","format":"limited_html"}],"field_summary_sentence":[{"value":"\u0022Approaches to Improve Expression and Specificity of an Antibody Probe Against Fibronectin\u0022"}],"uid":"27917","created_gmt":"2016-08-01 13:45:35","changed_gmt":"2017-04-13 21:15:16","author":"Laura Paige","boilerplate_text":"","field_publication":"","field_article_url":"","field_event_time":{"event_time_start":"2016-08-16T16:00:00-04:00","event_time_end":"2016-08-16T18:00:00-04:00","event_time_end_last":"2016-08-16T18:00:00-04:00","gmt_time_start":"2016-08-16 20:00:00","gmt_time_end":"2016-08-16 22:00:00","gmt_time_end_last":"2016-08-16 22:00:00","rrule":null,"timezone":"America\/New_York"},"extras":[],"groups":[{"id":"65448","name":"Bioengineering Graduate Program"}],"categories":[],"keywords":[],"core_research_areas":[],"news_room_topics":[],"event_categories":[{"id":"1788","name":"Other\/Miscellaneous"}],"invited_audience":[{"id":"78751","name":"Undergraduate students"},{"id":"78761","name":"Faculty\/Staff"},{"id":"174045","name":"Graduate students"}],"affiliations":[],"classification":[],"areas_of_expertise":[],"news_and_recent_appearances":[],"phone":[],"contact":[{"value":"\u003Cp\u003ELaura Paige\u003C\/p\u003E\u003Cp\u003E404-385-6655\u003C\/p\u003E","format":"limited_html"}],"email":[],"slides":[],"orientation":[],"userdata":""}},"553501":{"#nid":"553501","#data":{"type":"event","title":"BioEngineering Graduate Committee Meeting","body":[{"value":"\u003Cp\u003E\u003Cem\u003EThe BioEngineering graduate committee will meet to review\/approve program policies, program faculty applications and submitted student petitions.\u003Cbr \/\u003E\u003Cbr \/\u003EStudent Petitions due to\u0026nbsp;\u003Ca href=\u0022mailto:laura.paige@bioengineering.gatech.edu\u0022\u003ELaura Paige\u003C\/a\u003E\u0026nbsp;no later than: 08\/24\/2016.\u003C\/em\u003E\u003C\/p\u003E","summary":null,"format":"limited_html"}],"field_subtitle":"","field_summary":[{"value":"\u003Cp\u003EBioEngineering Graduate Committee Meeting\u003C\/p\u003E","format":"limited_html"}],"field_summary_sentence":[{"value":"\u0022BioEngineering Graduate Committee Meeting\u0022"}],"uid":"27917","created_gmt":"2016-07-18 09:06:34","changed_gmt":"2017-04-13 21:15:22","author":"Laura Paige","boilerplate_text":"","field_publication":"","field_article_url":"","field_event_time":{"event_time_start":"2016-08-31T09:00:00-04:00","event_time_end":"2016-08-31T10:00:00-04:00","event_time_end_last":"2016-08-31T10:00:00-04:00","gmt_time_start":"2016-08-31 13:00:00","gmt_time_end":"2016-08-31 14:00:00","gmt_time_end_last":"2016-08-31 14:00:00","rrule":null,"timezone":"America\/New_York"},"extras":[],"groups":[{"id":"65448","name":"Bioengineering Graduate Program"}],"categories":[],"keywords":[],"core_research_areas":[],"news_room_topics":[],"event_categories":[{"id":"1788","name":"Other\/Miscellaneous"}],"invited_audience":[{"id":"78751","name":"Undergraduate students"},{"id":"78761","name":"Faculty\/Staff"},{"id":"174045","name":"Graduate students"}],"affiliations":[],"classification":[],"areas_of_expertise":[],"news_and_recent_appearances":[],"phone":[],"contact":[],"email":[],"slides":[],"orientation":[],"userdata":""}},"563111":{"#nid":"563111","#data":{"type":"event","title":"BioE PhD Proposal presentation- Erin Edwards","body":[{"value":"\u003Cp\u003E\u003Cstrong\u003EAdvisor:\u0026nbsp;\u003C\/strong\u003E\u003C\/p\u003E\u003Cp\u003ESusan Thomas, Ph.D. (Georgia Institute of Technology)\u003Cbr \/\u003E \u003Cbr \/\u003E \u003Cstrong\u003ECommittee:\u003C\/strong\u003E\u003Cbr \/\u003E Andr\u00e9s Garc\u00eda, Ph.D. (Georgia Institute of Technology)\u003Cbr \/\u003E Wilbur Lam, Ph.D. (Georgia Institute of Technology \u0026amp; Emory University)\u003Cbr \/\u003E John McDonald, Ph.D. (Georgia Institute of Technology)\u003Cbr \/\u003E Cheng Zhu, Ph.D. (Georgia Institute of Technology)\u003Cbr \/\u003E \u003Cbr \/\u003E ELUCIDATING THE CONTRIBUTIONS OF CELLULAR AND MICROENVIRONMENT CHARACTERISTICS ON CELL ADHESION PROCESSES IN FLOW\u003Cbr \/\u003E \u003Cbr \/\u003E Circulating cell recruitment is critical to a variety of physiological and pathophysiological processes and occurs amidst the high shear environment of the vasculature via a multistep rolling to firm adhesion cascade. Cells initially engage the vascular endothelium through interactions between endothelial-presented selectins and their corresponding ligands presented by circulating cells. These interactions precede firm adhesion and arrest and eventually transmigration across the endothelium for tissue infiltration. Since many cell subtypes including leukocytes and metastatic cancer cells employ this mechanism to facilitate their escape the vasculature, understanding differences in cell-subtype adhesive behavior can inform the development of targeted therapeutics that interfere with metastatic cell transport, while leaving physiologically important immune cell recruitment mechanisms intact. As such, the overall objective of this proposal is to explore how selectin-mediated adhesion 1) is regulated by the biochemical and biophysical microenvironment of the vasculature and 2) varies among different cell subtypes. Through the use of in vitro fluidic methodologies in conjunction with innovative single-cell analyses we expect to elucidate key differences in the selectin-dependent adhesive behavior of metastatic versus leukocytic cells in order to inform targeted drug development and dosing strategies for the cell-subtype selective interference of cell adhesion.\u003C\/p\u003E","summary":null,"format":"limited_html"}],"field_subtitle":"","field_summary":[{"value":"\u003Cp\u003EPhD Proposal Presentation- \u0022ELUCIDATING THE CONTRIBUTIONS OF CELLULAR AND MICROENVIRONMENT CHARACTERISTICS ON CELL ADHESION PROCESSES IN FLOW\u0022 - Erin Edwards\u003C\/p\u003E","format":"limited_html"}],"field_summary_sentence":[{"value":"\u0022ELUCIDATING THE CONTRIBUTIONS OF CELLULAR AND MICROENVIRONMENT CHARACTERISTICS ON CELL ADHESION PROCESSES IN FLOW\u0022"}],"uid":"27917","created_gmt":"2016-08-16 10:20:34","changed_gmt":"2017-04-13 21:15:07","author":"Laura Paige","boilerplate_text":"","field_publication":"","field_article_url":"","field_event_time":{"event_time_start":"2016-09-01T13:00:00-04:00","event_time_end":"2016-09-01T15:00:00-04:00","event_time_end_last":"2016-09-01T15:00:00-04:00","gmt_time_start":"2016-09-01 17:00:00","gmt_time_end":"2016-09-01 19:00:00","gmt_time_end_last":"2016-09-01 19:00:00","rrule":null,"timezone":"America\/New_York"},"extras":[],"groups":[{"id":"65448","name":"Bioengineering Graduate Program"}],"categories":[],"keywords":[],"core_research_areas":[],"news_room_topics":[],"event_categories":[{"id":"1788","name":"Other\/Miscellaneous"}],"invited_audience":[{"id":"78751","name":"Undergraduate students"},{"id":"78761","name":"Faculty\/Staff"},{"id":"174045","name":"Graduate students"}],"affiliations":[],"classification":[],"areas_of_expertise":[],"news_and_recent_appearances":[],"phone":[],"contact":[{"value":"\u003Cp\u003ELaura Paige\u003C\/p\u003E\u003Cp\u003E404.385.6655\u003C\/p\u003E","format":"limited_html"}],"email":[],"slides":[],"orientation":[],"userdata":""}},"565841":{"#nid":"565841","#data":{"type":"event","title":"BioE PhD Proposal presentation- Thomas Easley","body":[{"value":"\u003Cp\u003E\u003Cstrong\u003EAdvisor:\u003C\/strong\u003E\u003Cbr \/\u003E\r\nAjit P. Yoganathan, Ph.D. (Georgia Institute of Technology)\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u003Cstrong\u003ECommittee:\u003C\/strong\u003E\u003C\/p\u003E\r\n\r\n\u003Cul\u003E\r\n\t\u003Cli\u003ECyrus K. Aidun, Ph.D. (Georgia Institute of Technology)\u003C\/li\u003E\r\n\t\u003Cli\u003EWei Sun, Ph.D. (Georgia Institute of Technology)\u003C\/li\u003E\r\n\t\u003Cli\u003EF. Levent Degertekin, Ph.D. (Georgia Institute of Technology)\u003C\/li\u003E\r\n\t\u003Cli\u003EJoseph H. Gorman, M.D. (University of Pennsylvania)\u003C\/li\u003E\r\n\t\u003Cli\u003EVinod H. Thourani, M.D. (Emory University)\u003C\/li\u003E\r\n\u003C\/ul\u003E\r\n","summary":null,"format":"limited_html"}],"field_subtitle":"","field_summary":[{"value":"\u003Cp\u003EPh.D. Proposal Presentation -\u0026nbsp;\u0026quot;Quantitative Assessment of the Effects of Mitral Valve Annular Dynamics and the Risks of Mitral Valve-in-Ring Procedures\u0026quot; - Thomas Easley\u003C\/p\u003E\r\n","format":"limited_html"}],"field_summary_sentence":[{"value":"\u0022Quantitative Assessment of the Effects of Mitral Valve Annular Dynamics and the Risks of Mitral Valve-in-Ring Procedures\u0022"}],"uid":"27917","created_gmt":"2016-08-22 07:33:24","changed_gmt":"2019-06-18 15:05:39","author":"Laura Paige","boilerplate_text":"","field_publication":"","field_article_url":"","field_event_time":{"event_time_start":"2016-09-01T16:00:00-04:00","event_time_end":"2016-09-01T18:00:00-04:00","event_time_end_last":"2016-09-01T18:00:00-04:00","gmt_time_start":"2016-09-01 20:00:00","gmt_time_end":"2016-09-01 22:00:00","gmt_time_end_last":"2016-09-01 22:00:00","rrule":null,"timezone":"America\/New_York"},"extras":[],"groups":[{"id":"65448","name":"Bioengineering Graduate Program"}],"categories":[],"keywords":[],"core_research_areas":[],"news_room_topics":[],"event_categories":[{"id":"1788","name":"Other\/Miscellaneous"}],"invited_audience":[{"id":"78761","name":"Faculty\/Staff"},{"id":"174045","name":"Graduate students"},{"id":"78751","name":"Undergraduate students"}],"affiliations":[],"classification":[],"areas_of_expertise":[],"news_and_recent_appearances":[],"phone":[],"contact":[{"value":"\u003Cp\u003ELaura Paige\u003C\/p\u003E\r\n\r\n\u003Cp\u003E404-385-6655\u003C\/p\u003E\r\n","format":"limited_html"}],"email":[],"slides":[],"orientation":[],"userdata":""}},"567201":{"#nid":"567201","#data":{"type":"event","title":"BioE PhD Proposal presentation- Jordan Ciciliano","body":[{"value":"\u003Cp\u003E\u003Cstrong\u003EAdvisor:\u0026nbsp;\u003C\/strong\u003E\u003C\/p\u003E\u003Cp\u003EWilbur Lam, M.D., Ph.D. (Georgia Institute of Technology \u0026amp; Emory University)\u003C\/p\u003E\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\u003Cp\u003E\u003Cstrong\u003ECommittee:\u003C\/strong\u003E\u003C\/p\u003E\u003Cp\u003EBrandon Dixon, Ph.D. (Georgia Institute of Technology)\u003C\/p\u003E\u003Cp\u003ETodd Sulchek, Ph.D. (Georgia Institute of Technology)\u003C\/p\u003E\u003Cp\u003ESusan Thomas, Ph.D. (Georgia Institute of Technology)\u003C\/p\u003E\u003Cp\u003EHua Wang, Ph.D. (Georgia Institute of Technology)\u003C\/p\u003E\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\u003Cp\u003E\u003Cstrong\u003EDEVELOPING MICROFLUIDIC SYSTEMS TO DECOUPLE BIOPHYSICAL AND BIOCHEMICAL ASPECTS OF HEMATOLOGICAL PROCESSES\u003C\/strong\u003E\u003C\/p\u003E\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\u003Cp\u003ERecent research has revealed that cells dynamically sense and respond to their physical microenvironments. For instance, in hematology specifically, it was shown that shear mediated red blood cell (RBC) deformation results in ATP release, and that platelets attenuate contraction force based on substrate stiffness. The objective of this proposal is thus to create microfluidic systems in which the biophysical and biochemical aspects of hematological processes can be independently investigated. More specifically, this proposal will present novel microfluidic devices: an \u201cendothelial\u201d-ized, T-junction to elucidate the biophysical processes that define the mechanism of action of the ferric chloride thrombosis model; a micropillar array to examine the physical effect of a geometrically relevant, non-biological matrix on platelet and RBC activity; and an electrospun fibrinogen mesh device and a micro-slit device to define the physical parameter space (shear, time of deformation, cell stiffness) that governs RBC fragmentation. Microfluidic platforms allow for real-time, microscopic evaluation of cell response (via brightfield morphology and immunostaining) and precise spatiotemporal control of system inputs and flow characteristics, including shear stress. The knowledge gained by successfully decoupling the biophysical and biological aspects of hematology can result in improved diagnostic assays for blood cell activity and new targets for therapeutics.\u0026nbsp;\u003C\/p\u003E","summary":null,"format":"limited_html"}],"field_subtitle":"","field_summary":[{"value":"\u003Cp\u003EPhD Proposal Presentation-\u0026nbsp;\u0022DEVELOPING MICROFLUIDIC SYSTEMS TO DECOUPLE BIOPHYSICAL AND BIOCHEMICAL ASPECTS OF HEMATOLOGICAL PROCESSES\u0022- Jordan Ciciliano\u003C\/p\u003E","format":"limited_html"}],"field_summary_sentence":[{"value":"\u0022DEVELOPING MICROFLUIDIC SYSTEMS TO DECOUPLE BIOPHYSICAL AND BIOCHEMICAL ASPECTS OF HEMATOLOGICAL PROCESSES\u0022"}],"uid":"27917","created_gmt":"2016-08-24 07:41:25","changed_gmt":"2017-04-13 21:15:00","author":"Laura Paige","boilerplate_text":"","field_publication":"","field_article_url":"","field_event_time":{"event_time_start":"2016-09-06T10:30:00-04:00","event_time_end":"2016-09-06T12:30:00-04:00","event_time_end_last":"2016-09-06T12:30:00-04:00","gmt_time_start":"2016-09-06 14:30:00","gmt_time_end":"2016-09-06 16:30:00","gmt_time_end_last":"2016-09-06 16:30:00","rrule":null,"timezone":"America\/New_York"},"extras":[],"groups":[{"id":"65448","name":"Bioengineering Graduate Program"}],"categories":[],"keywords":[],"core_research_areas":[],"news_room_topics":[],"event_categories":[{"id":"1788","name":"Other\/Miscellaneous"}],"invited_audience":[{"id":"78751","name":"Undergraduate students"},{"id":"78761","name":"Faculty\/Staff"},{"id":"174045","name":"Graduate students"}],"affiliations":[],"classification":[],"areas_of_expertise":[],"news_and_recent_appearances":[],"phone":[],"contact":[{"value":"\u003Cp\u003ELaura Paige\u003C\/p\u003E\u003Cp\u003E404.385.6655\u003C\/p\u003E","format":"limited_html"}],"email":[],"slides":[],"orientation":[],"userdata":""}},"549511":{"#nid":"549511","#data":{"type":"event","title":"BioEngineering Program Faculty Meeting","body":[{"value":"\u003Cp\u003E\u003Cem\u003EThe BioEngineering Program faculty meet regularly during the semester to address program policies, events and future research and academic directions.\u003C\/em\u003E\u003C\/p\u003E\r\n","summary":null,"format":"limited_html"}],"field_subtitle":"","field_summary":[{"value":"\u003Cp\u003E\u003Cem\u003EProgram policies, events and directions to be discussed\u003C\/em\u003E\u003C\/p\u003E\r\n","format":"limited_html"}],"field_summary_sentence":[{"value":":BioEngineering Program Faculty Meeting\u0022"}],"uid":"27917","created_gmt":"2016-06-30 11:01:29","changed_gmt":"2016-11-30 19:55:06","author":"Laura Paige","boilerplate_text":"","field_publication":"","field_article_url":"","field_event_time":{"event_time_start":"2016-09-08T12:00:00-04:00","event_time_end":"2016-09-08T13:00:00-04:00","event_time_end_last":"2016-09-08T13:00:00-04:00","gmt_time_start":"2016-09-08 16:00:00","gmt_time_end":"2016-09-08 17:00:00","gmt_time_end_last":"2016-09-08 17:00:00","rrule":null,"timezone":"America\/New_York"},"extras":[],"groups":[{"id":"65448","name":"Bioengineering Graduate Program"}],"categories":[],"keywords":[],"core_research_areas":[],"news_room_topics":[],"event_categories":[{"id":"1788","name":"Other\/Miscellaneous"}],"invited_audience":[{"id":"78761","name":"Faculty\/Staff"}],"affiliations":[],"classification":[],"areas_of_expertise":[],"news_and_recent_appearances":[],"phone":[],"contact":[{"value":"\u003Cp\u003ELaura Paige\u003C\/p\u003E\r\n\r\n\u003Cp\u003E404-385-6655\u003C\/p\u003E\r\n","format":"limited_html"}],"email":[],"slides":[],"orientation":[],"userdata":""}},"568541":{"#nid":"568541","#data":{"type":"event","title":"BioE PhD Proposal presentation- Joshua Hooks","body":[{"value":"\u003Cp\u003E\u003Cstrong\u003EAdvisor:\u0026nbsp;\u003C\/strong\u003E\u003C\/p\u003E\u003Cp\u003EJ. Brandon Dixon, Ph.D. (ME\/Georgia Institute of Technology)\u003C\/p\u003E\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\u003Cp\u003E\u003Cstrong\u003ECommittee:\u003C\/strong\u003E\u003C\/p\u003E\u003Cp\u003EAndr\u00e9s J. Garc\u00eda, PhD (Georgia Institute of Technology)\u003C\/p\u003E\u003Cp\u003EC. Ross Ethier, PhD (BME\/(Georgia Institute of Technology)\u003C\/p\u003E\u003Cp\u003EMichael Davis, PhD (BME\/Georgia Institute of Technology \u0026amp; Emory University)\u003C\/p\u003E\u003Cp\u003EMariappan Muthuchamy (Medical Physiology\/Texas A\u0026amp;M)\u003C\/p\u003E\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\u003Cp\u003E\u003Cstrong\u003ERole of Mechanical Microenvironment on the Regulation of Lymphatic Function and Health\u003C\/strong\u003E\u003C\/p\u003E\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\u003Cp\u003EFailure of lymph fluid transport plays an important role in pathologies, such as lymphedema and lymphacele after organ donation. The lymphatic system plays a critical role in maintaining fluid homeostasis in all of the soft tissue of the body. Its ability to transport interstitial fluid is partially dependent on the intrinsic pumping capacity of lymphatic smooth muscle cells. Recently, our lab has shown that lymphatic collecting vessels near an injury never return to pre-injury levels of pumping and lymph transport, but factors that impact collecting vessel phenotype are poorly understood. The central hypothesis of this work is that the components of the extracellular matrix (ECM) and mechanics of the lymphatic microenvironment play a central role in the contractile phenotype of lymphatic muscle cells (LMCs).\u0026nbsp;\u003C\/p\u003E","summary":null,"format":"limited_html"}],"field_subtitle":"","field_summary":[{"value":"\u003Cp\u003EBioE PhD Proposal Presentation-\u0026nbsp;\u0022Role of Mechanical Microenvironment on the Regulation of Lymphatic Function and Health\u0022- Joshua Hooks\u003C\/p\u003E","format":"limited_html"}],"field_summary_sentence":[{"value":"\u0022Role of Mechanical Microenvironment on the Regulation of Lymphatic Function and Health\u0022"}],"uid":"27917","created_gmt":"2016-08-26 07:59:53","changed_gmt":"2017-04-13 21:14:57","author":"Laura Paige","boilerplate_text":"","field_publication":"","field_article_url":"","field_event_time":{"event_time_start":"2016-09-09T14:00:00-04:00","event_time_end":"2016-09-09T16:00:00-04:00","event_time_end_last":"2016-09-09T16:00:00-04:00","gmt_time_start":"2016-09-09 18:00:00","gmt_time_end":"2016-09-09 20:00:00","gmt_time_end_last":"2016-09-09 20:00:00","rrule":null,"timezone":"America\/New_York"},"extras":[],"groups":[{"id":"65448","name":"Bioengineering Graduate Program"}],"categories":[],"keywords":[],"core_research_areas":[],"news_room_topics":[],"event_categories":[{"id":"1788","name":"Other\/Miscellaneous"}],"invited_audience":[{"id":"78751","name":"Undergraduate students"},{"id":"78761","name":"Faculty\/Staff"},{"id":"174045","name":"Graduate students"}],"affiliations":[],"classification":[],"areas_of_expertise":[],"news_and_recent_appearances":[],"phone":[],"contact":[{"value":"\u003Cp\u003ELaura Paige\u003C\/p\u003E\u003Cp\u003E404.385.6655\u003C\/p\u003E","format":"limited_html"}],"email":[],"slides":[],"orientation":[],"userdata":""}},"576441":{"#nid":"576441","#data":{"type":"event","title":"BioE PhD Defense Announcement- Tom Bongiorno","body":[{"value":"\u003Cp class=\u0022xmsonormal\u0022\u003E\u003Cstrong\u003EAdvisor:\u0026nbsp;\u003C\/strong\u003ETodd Sulchek, PhD (Georgia Institute of Technology)\u003C\/p\u003E\u003Cp class=\u0022xmsonormal\u0022\u003E\u0026nbsp;\u003C\/p\u003E\u003Cp class=\u0022xmsonormal\u0022\u003E\u003Cstrong\u003ECommittee:\u0026nbsp;\u003C\/strong\u003E\u003C\/p\u003E\u003Cp class=\u0022xmsonormal\u0022\u003EWilbur A. Lam, MD, PhD (Georgia Institute of Technology \u0026amp;\u0026nbsp;Emory University)\u003C\/p\u003E\u003Cp class=\u0022xmsonormal\u0022\u003ETodd C. McDevitt, PhD (Gladstone Institutes)\u003C\/p\u003E\u003Cp class=\u0022xmsonormal\u0022\u003EJohn F. McDonald, PhD (Georgia Institute of Technology)\u003C\/p\u003E\u003Cp class=\u0022xmsonormal\u0022\u003EPaula M. Vertino, PhD (Emory University)\u003C\/p\u003E\u003Cp class=\u0022xmsonormal\u0022\u003E\u0026nbsp;\u003C\/p\u003E\u003Cp class=\u0022xmsonormal\u0022\u003E\u003Cstrong\u003E\u201c\u003C\/strong\u003E\u003Cstrong\u003ECellular Stiffness as a Sorting-compatible Indicator of Stem Cell Potency\u003C\/strong\u003E\u003Cstrong\u003E\u201d\u003C\/strong\u003E\u003C\/p\u003E\u003Cp class=\u0022xmsonormal\u0022\u003E\u0026nbsp;\u003C\/p\u003E\u003Cp class=\u0022xmsonormal\u0022\u003EDue to their characteristic properties of self-renewal and differentiation, stem cells hold the capacity to serve as phenotype-specific cell factories for various regenerative medicine and tissue engineering applications. However, current phenotyping techniques, which typically employ multiple surface protein-specific antibodies, are often insufficient to identify or enrich cells of a target phenotype. An improved technique that could select target cells could be used to purify starting cell populations for directed differentiation protocols or to enrich specific terminally differentiated phenotypes for tissue engineering.\u003C\/p\u003E\u003Cp class=\u0022xmsonormal\u0022\u003E\u0026nbsp;\u003C\/p\u003E\u003Cp class=\u0022xmsonormal\u0022\u003EThe goal of this project is to investigate cellular mechanical parameters as stem cell phenotype markers to complement the currently available biomolecular markers. This objective was accomplished through 1) the establishment of cell stiffness as a single-cell marker of potency in both mesenchymal stem cells, which give rise to cells of the connective tissue, and limbal stem cells, which replenish the cornea, 2) the development of a method to compare cell mechanics and gene expression at the single-cell level, which will enable more detailed studies of the relationships between cell phenotype, mechanics, and structure, and 3) the determination that pluripotent embryonic stem cells, which are softer than their differentiated progeny, can be enriched using a cell stiffness-based microfluidic sorting device, as assessed by potency-related morphological and genetic factors. Ultimately, this project established cell stiffness as a marker of stem cell differentiation in various cell systems, with applications to label-free selection of target cell phenotypes.\u003C\/p\u003E","summary":null,"format":"limited_html"}],"field_subtitle":"","field_summary":[{"value":"\u003Cp\u003EBioE PhD Defense Announcement-\u0026nbsp;\u003C\/p\u003E\u003Cp class=\u0022xmsonormal\u0022\u003E\u003Cstrong\u003E\u201c\u003C\/strong\u003E\u003Cstrong\u003ECellular Stiffness as a Sorting-compatible Indicator of Stem Cell Potency\u003C\/strong\u003E\u003Cstrong\u003E\u201d- Tom Bongiorno\u003C\/strong\u003E\u003C\/p\u003E","format":"limited_html"}],"field_summary_sentence":[{"value":"\u201cCellular Stiffness as a Sorting-compatible Indicator of Stem Cell Potency\u201d"}],"uid":"27917","created_gmt":"2016-09-13 16:16:22","changed_gmt":"2017-04-13 21:14:42","author":"Laura Paige","boilerplate_text":"","field_publication":"","field_article_url":"","field_event_time":{"event_time_start":"2016-09-22T11:00:00-04:00","event_time_end":"2016-09-22T13:00:00-04:00","event_time_end_last":"2016-09-22T13:00:00-04:00","gmt_time_start":"2016-09-22 15:00:00","gmt_time_end":"2016-09-22 17:00:00","gmt_time_end_last":"2016-09-22 17:00:00","rrule":null,"timezone":"America\/New_York"},"extras":[],"groups":[{"id":"65448","name":"Bioengineering Graduate Program"}],"categories":[],"keywords":[],"core_research_areas":[],"news_room_topics":[],"event_categories":[{"id":"1788","name":"Other\/Miscellaneous"}],"invited_audience":[{"id":"78751","name":"Undergraduate students"},{"id":"78761","name":"Faculty\/Staff"},{"id":"174045","name":"Graduate students"}],"affiliations":[],"classification":[],"areas_of_expertise":[],"news_and_recent_appearances":[],"phone":[],"contact":[{"value":"\u003Cp\u003ELaura Paige\u003C\/p\u003E\u003Cp\u003E404.385.6655\u003C\/p\u003E","format":"limited_html"}],"email":[],"slides":[],"orientation":[],"userdata":""}},"549521":{"#nid":"549521","#data":{"type":"event","title":"BioEngineering Program Faculty Meeting","body":[{"value":"\u003Cp\u003E\u003Cem\u003EThe BioEngineering Program faculty meet regularly during the semester to address program policies, events and future research and academic directions.\u003C\/em\u003E\u003C\/p\u003E","summary":null,"format":"limited_html"}],"field_subtitle":"","field_summary":[{"value":"\u003Cp\u003E\u003Cem\u003EProgram policies, events and directions to be discussed\u003C\/em\u003E\u003C\/p\u003E","format":"limited_html"}],"field_summary_sentence":[{"value":"\u0022BioEngineering Program Faculty Meeting\u0022"}],"uid":"27917","created_gmt":"2016-06-30 11:03:31","changed_gmt":"2016-10-08 02:18:15","author":"Laura Paige","boilerplate_text":"","field_publication":"","field_article_url":"","field_event_time":{"event_time_start":"2016-10-11T12:00:00-04:00","event_time_end":"2016-10-11T13:00:00-04:00","event_time_end_last":"2016-10-11T13:00:00-04:00","gmt_time_start":"2016-10-11 16:00:00","gmt_time_end":"2016-10-11 17:00:00","gmt_time_end_last":"2016-10-11 17:00:00","rrule":null,"timezone":"America\/New_York"},"extras":[],"groups":[{"id":"65448","name":"Bioengineering Graduate Program"}],"categories":[],"keywords":[],"core_research_areas":[],"news_room_topics":[],"event_categories":[{"id":"1788","name":"Other\/Miscellaneous"}],"invited_audience":[{"id":"78761","name":"Faculty\/Staff"}],"affiliations":[],"classification":[],"areas_of_expertise":[],"news_and_recent_appearances":[],"phone":[],"contact":[{"value":"\u003Cp\u003ELaura Paige\u003C\/p\u003E\u003Cp\u003E404-385-6655\u003C\/p\u003E","format":"limited_html"}],"email":[],"slides":[],"orientation":[],"userdata":""}},"553511":{"#nid":"553511","#data":{"type":"event","title":"BioEngineering Graduate Committee Meeting","body":[{"value":"\u003Cp\u003E\u003Cem\u003EThe BioEngineering graduate committee will meet to review\/approve program policies, program faculty applications and submitted student petitions.\u003Cbr \/\u003E\u003Cbr \/\u003EStudent Petitions due to\u0026nbsp;\u003Ca href=\u0022mailto:laura.paige@bioengineering.gatech.edu\u0022\u003ELaura Paige\u003C\/a\u003E\u0026nbsp;no later than: 10\/19\/2016.\u003C\/em\u003E\u003C\/p\u003E","summary":null,"format":"limited_html"}],"field_subtitle":"","field_summary":[{"value":"\u003Cp\u003EBioEngineering Graduate Committee Meeting\u003C\/p\u003E","format":"limited_html"}],"field_summary_sentence":[{"value":"\u0022BioEngineering Graduate Committee Meeting\u0022"}],"uid":"27917","created_gmt":"2016-07-18 09:10:00","changed_gmt":"2017-04-13 21:15:22","author":"Laura Paige","boilerplate_text":"","field_publication":"","field_article_url":"","field_event_time":{"event_time_start":"2016-10-26T13:00:00-04:00","event_time_end":"2016-10-26T14:00:00-04:00","event_time_end_last":"2016-10-26T14:00:00-04:00","gmt_time_start":"2016-10-26 17:00:00","gmt_time_end":"2016-10-26 18:00:00","gmt_time_end_last":"2016-10-26 18:00:00","rrule":null,"timezone":"America\/New_York"},"extras":[],"groups":[{"id":"65448","name":"Bioengineering Graduate Program"}],"categories":[],"keywords":[],"core_research_areas":[],"news_room_topics":[],"event_categories":[{"id":"1788","name":"Other\/Miscellaneous"}],"invited_audience":[{"id":"78751","name":"Undergraduate students"},{"id":"78761","name":"Faculty\/Staff"},{"id":"174045","name":"Graduate students"}],"affiliations":[],"classification":[],"areas_of_expertise":[],"news_and_recent_appearances":[],"phone":[],"contact":[],"email":[],"slides":[],"orientation":[],"userdata":""}},"597553":{"#nid":"597553","#data":{"type":"event","title":"BioE PhD Defense Presentation - Olivia Burnsed","body":[{"value":"\u003Cp\u003E\u003Cstrong\u003EAdvisors:\u003C\/strong\u003E\u003C\/p\u003E\r\n\r\n\u003Cp\u003ERobert E. Guldberg, PhD, (School of Mechanical Engineering, Georgia Institute of Technology)\u003C\/p\u003E\r\n\r\n\u003Cp\u003ETodd C. McDevitt, PhD, Gladstone Institutes\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u003Cstrong\u003ECommittee:\u003C\/strong\u003E\u003C\/p\u003E\r\n\r\n\u003Cp\u003EJohnna S. Temenoff, PhD (Department of Biomedical Engineering, Georgia Institute of Technology)\u003C\/p\u003E\r\n\r\n\u003Cp\u003EKrishnendu Roy, PhD (Department of Biomedical Engineering, Georgia Institute of Technology)\u003C\/p\u003E\r\n\r\n\u003Cp\u003ETom Koob, PhD (MiMedx Group, Inc.)\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u003Cstrong\u003EEngineering an Improved Cartilage Repair Strategy Combining Cells and ECM-derived Materials\u003C\/strong\u003E\u003C\/p\u003E\r\n\r\n\u003Cp\u003EOsteoarthritis (OA) is the leading cause of disability in the United States and one in two people are expected to develop symptomatic knee OA by age 85. The avascularity, low cellularity, and slow proliferation of chondrocytes all limit the natural regenerative capacity of cartilage in addition to the inflammation prevalent in the joint space. Cell therapies, such as autologous chondrocyte implantation (ACI), offer promising options for treating persistent cartilage lesions, but the inability to expand chondrocytes to sufficient numbers without adversely affecting their phenotype remains a significant problem for graft success. ACI is not indicated for cartilage damage associated with osteoarthritis (OA) or other inflammatory diseases, however, and this lack of efficacy is attributed to the inflammatory environment cells are exposed to, since multiple inflammatory mediators have been shown to play a pivotal role in the initiation and perpetuation of OA. Anti-inflammatory therapies with single molecular inhibitors are unable to effectively modulate the complex inflammatory environment presented in OA. Thus, novel therapies that are capable of modulating multiple signaling pathways and cell types are an attractive alternative to address OA-associated inflammation.\u003C\/p\u003E\r\n\r\n\u003Cp\u003ETherefore, the objective of this proposal was to engineer an improved cartilage repair strategy by combining cells and ECM materials to address problems with both cartilage repair and OA-associated inflammation. We developed decellularized cartilage microcarriers that retain endogenous extracellular matrix proteins to both expand and deliver chondrocytes while retaining their phenotype. We also characterize the effects of aggregation, culture conditions, and donor variability on the ability of mesenchymal stem cell (MSC) immunomodulation of OA. To this end, we quantified MSC paracrine factor production, suppression of activated synoviocyte inflammation, and therapeutic efficacy in the rat medial meniscal transection (MMT) rat model of OA. Furthermore, we investigated the interaction between MSCs and human amniotic membrane and the influence of cell-cell and cell-ECM therein on the modulation of inflammation, both in vitro and in vivo. Overall, this work broadens current understanding of cartilage tissue engineering and immunomodulation via ECM and stem cell-based therapies, providing valuable information that can be used to develop strategies to improve efficacy of osteoarthritis treatments.\u0026nbsp;\u003C\/p\u003E\r\n","summary":null,"format":"limited_html"}],"field_subtitle":"","field_summary":[{"value":"\u003Cp\u003EBioE PhD Defense Presentation-\u0026nbsp;\u0026quot;Engineering an Improved Cartilage Repair Strategy Combining Cells and ECM-derived Materials\u0026quot;-\u003C\/p\u003E\r\n\r\n\u003Cp\u003EOlivia Burnsed\u003C\/p\u003E\r\n","format":"limited_html"}],"field_summary_sentence":[{"value":"\u0022Engineering an Improved Cartilage Repair Strategy Combining Cells and ECM-derived Materials\u0022"}],"uid":"27917","created_gmt":"2017-10-18 16:28:47","changed_gmt":"2017-10-18 20:59:32","author":"Laura Paige","boilerplate_text":"","field_publication":"","field_article_url":"","field_event_time":{"event_time_start":"2017-11-01T11:00:00-04:00","event_time_end":"2017-11-01T13:00:00-04:00","event_time_end_last":"2017-11-01T13:00:00-04:00","gmt_time_start":"2017-11-01 15:00:00","gmt_time_end":"2017-11-01 17:00:00","gmt_time_end_last":"2017-11-01 17:00:00","rrule":null,"timezone":"America\/New_York"},"extras":[],"groups":[{"id":"65448","name":"Bioengineering Graduate Program"}],"categories":[],"keywords":[],"core_research_areas":[],"news_room_topics":[],"event_categories":[{"id":"1789","name":"Conference\/Symposium"}],"invited_audience":[{"id":"78761","name":"Faculty\/Staff"},{"id":"78771","name":"Public"},{"id":"78751","name":"Undergraduate students"}],"affiliations":[],"classification":[],"areas_of_expertise":[],"news_and_recent_appearances":[],"phone":[],"contact":[{"value":"\u003Cp\u003ELaura Paige\u003C\/p\u003E\r\n\r\n\u003Cp\u003E404-385-6655\u003C\/p\u003E\r\n","format":"limited_html"}],"email":[],"slides":[],"orientation":[],"userdata":""}},"597623":{"#nid":"597623","#data":{"type":"event","title":"BioE PhD Proposal Presentation - Timothy Lee","body":[{"value":"\u003Cp\u003E\u003Cstrong\u003EAdvisor: \u003C\/strong\u003E\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u003Cem\u003ECraig R. Forest, PhD \u003C\/em\u003E\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u003Cem\u003EGeorgia Institute of Technology, G. W. Woodruff School of Mechanical Engineering\u003C\/em\u003E\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u003Cstrong\u003ECommittee:\u003C\/strong\u003E\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u003Cem\u003ER. Clay Reid, MD \u003C\/em\u003E\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u003Cem\u003EAllen Institute for Brain Science\u003C\/em\u003E\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u003Cem\u003EMachelle T. Pardue, PhD\u003C\/em\u003E\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u003Cem\u003EGeorgia Institute of Technology, Coulter Department of Biomedical Engineering\u003C\/em\u003E\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u003Cem\u003EPeter J. Yunker, PhD\u003C\/em\u003E\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u003Cem\u003EGeorgia Institute of Technology, School of Physics\u003C\/em\u003E\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u003Cem\u003ETodd Sulchek, PhD\u003C\/em\u003E\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u003Cem\u003EGeorgia Institute of Technology, G. W. Woodruff School of Mechanical Engineering\u003C\/em\u003E\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u003Cstrong\u003EBatch processing of brain tissue sections for millimeter-scale serial section transmission electron microscopy connectomics\u003C\/strong\u003E\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\r\n\r\n\u003Cp\u003EThe field of connectomics has emerged a promising approach for exploring the nature of neural circuits. A millimeter-scale connectome\u0026mdash;a neuron-to-neuron wiring diagram of a neural circuit\u0026mdash;potentially contains significant information regarding information processing and memory. The field is held back, however, by the difficulty in consistently and rapidly collecting neuroanatomical datasets with serial section transmission electron microscopy (ssTEM). In the cerebral cortex, for instance, a local circuit is contained in a cubic millimeter, but single sections\u0026mdash;obtained by cutting brain samples with a diamond knife\u0026mdash;must be \u0026ldquo;ultrathin\u0026rdquo; (\u0026lt; 40 nanometers), thus requiring 25,000 consecutive sections to be processed. Currently, the processing of ultrathin sections remains an unsolved problem that is necessary for the advancement of ssTEM connectomics. The goals of this proposal are: (1) design, model, and test a novel device that uses hydrodynamic forces and curvature-induced capillary interactions for the transport and trapping of ultrathin sections, (2) design, implement, and characterize batch processing of single sections to enable reliable processing of thousands of serial sections, and (3) design, test, and characterize automated batched section processing, enabling high-throughput and reliable section processing. In total, these aims comprise a novel platform for section processing for millimeter-scale ssTEM connectomics studies.\u003C\/p\u003E\r\n","summary":null,"format":"limited_html"}],"field_subtitle":"","field_summary":[{"value":"\u003Cp\u003EBioE PhD Proposal Presentation-\u0026nbsp;\u0026quot;Batch processing of brain tissue sections for millimeter-scale serial section transmission electron microscopy connectomics\u0026quot;-\u003C\/p\u003E\r\n\r\n\u003Cp\u003ETimothy Lee\u003C\/p\u003E\r\n","format":"limited_html"}],"field_summary_sentence":[{"value":"\u0022Batch processing of brain tissue sections for millimeter-scale serial section transmission electron microscopy connectomics\u0022"}],"uid":"27917","created_gmt":"2017-10-19 16:57:29","changed_gmt":"2017-10-19 17:02:25","author":"Laura Paige","boilerplate_text":"","field_publication":"","field_article_url":"","field_event_time":{"event_time_start":"2017-11-02T15:00:00-04:00","event_time_end":"2017-11-02T17:00:00-04:00","event_time_end_last":"2017-11-02T17:00:00-04:00","gmt_time_start":"2017-11-02 19:00:00","gmt_time_end":"2017-11-02 21:00:00","gmt_time_end_last":"2017-11-02 21:00:00","rrule":null,"timezone":"America\/New_York"},"extras":[],"groups":[{"id":"65448","name":"Bioengineering Graduate Program"}],"categories":[],"keywords":[],"core_research_areas":[],"news_room_topics":[],"event_categories":[{"id":"10377","name":"Career\/Professional development"}],"invited_audience":[{"id":"78761","name":"Faculty\/Staff"},{"id":"78771","name":"Public"},{"id":"78751","name":"Undergraduate students"}],"affiliations":[],"classification":[],"areas_of_expertise":[],"news_and_recent_appearances":[],"phone":[],"contact":[{"value":"\u003Cp\u003ELaura Paige\u003C\/p\u003E\r\n\r\n\u003Cp\u003E404-385-6655\u003C\/p\u003E\r\n","format":"limited_html"}],"email":[],"slides":[],"orientation":[],"userdata":""}},"549531":{"#nid":"549531","#data":{"type":"event","title":"BioEngineering Program Faculty Meeting","body":[{"value":"\u003Cp\u003E\u003Cem\u003EThe BioEngineering Program faculty meet regularly during the semester to address program policies, events and future research and academic directions.\u003C\/em\u003E\u003C\/p\u003E","summary":null,"format":"limited_html"}],"field_subtitle":"","field_summary":[{"value":"\u003Cp\u003E\u003Cem\u003EProgram policies, events and directions to be discussed\u003C\/em\u003E\u003C\/p\u003E","format":"limited_html"}],"field_summary_sentence":[{"value":"\u0022BioEngineering Program Faculty Meeting\u0022"}],"uid":"27917","created_gmt":"2016-06-30 11:05:03","changed_gmt":"2016-10-08 02:18:15","author":"Laura Paige","boilerplate_text":"","field_publication":"","field_article_url":"","field_event_time":{"event_time_start":"2016-11-29T10:00:00-05:00","event_time_end":"2016-11-29T11:00:00-05:00","event_time_end_last":"2016-11-29T11:00:00-05:00","gmt_time_start":"2016-11-29 15:00:00","gmt_time_end":"2016-11-29 16:00:00","gmt_time_end_last":"2016-11-29 16:00:00","rrule":null,"timezone":"America\/New_York"},"extras":[],"groups":[{"id":"65448","name":"Bioengineering Graduate Program"}],"categories":[],"keywords":[],"core_research_areas":[],"news_room_topics":[],"event_categories":[{"id":"1788","name":"Other\/Miscellaneous"}],"invited_audience":[{"id":"78761","name":"Faculty\/Staff"}],"affiliations":[],"classification":[],"areas_of_expertise":[],"news_and_recent_appearances":[],"phone":[],"contact":[{"value":"\u003Cp\u003ELaura Paige\u003C\/p\u003E\u003Cp\u003E404-385-6655\u003C\/p\u003E","format":"limited_html"}],"email":[],"slides":[],"orientation":[],"userdata":""}},"553521":{"#nid":"553521","#data":{"type":"event","title":"BioEngineering Graduate Committee Meeting","body":[{"value":"\u003Cp\u003E\u003Cem\u003EThe BioEngineering graduate committee will meet to review\/approve program policies, program faculty applications and submitted student petitions.\u003Cbr \/\u003E\u003Cbr \/\u003EStudent Petitions due to\u0026nbsp;\u003Ca href=\u0022mailto:laura.paige@bioengineering.gatech.edu\u0022\u003ELaura Paige\u003C\/a\u003E\u0026nbsp;no later than: 04\/28\/2016.\u003C\/em\u003E\u003C\/p\u003E","summary":null,"format":"limited_html"}],"field_subtitle":"","field_summary":[{"value":"\u003Cp\u003EBioEngineering Graduate Committee Meeting\u003C\/p\u003E","format":"limited_html"}],"field_summary_sentence":[{"value":"\u0022BioEngineering Graduate Committee Meeting\u0022"}],"uid":"27917","created_gmt":"2016-07-18 09:11:36","changed_gmt":"2017-04-13 21:15:22","author":"Laura Paige","boilerplate_text":"","field_publication":"","field_article_url":"","field_event_time":{"event_time_start":"2016-12-07T11:00:00-05:00","event_time_end":"2016-12-07T12:00:00-05:00","event_time_end_last":"2016-12-07T12:00:00-05:00","gmt_time_start":"2016-12-07 16:00:00","gmt_time_end":"2016-12-07 17:00:00","gmt_time_end_last":"2016-12-07 17:00:00","rrule":null,"timezone":"America\/New_York"},"extras":[],"groups":[{"id":"65448","name":"Bioengineering Graduate Program"}],"categories":[],"keywords":[],"core_research_areas":[],"news_room_topics":[],"event_categories":[{"id":"1788","name":"Other\/Miscellaneous"}],"invited_audience":[{"id":"78751","name":"Undergraduate students"},{"id":"78761","name":"Faculty\/Staff"},{"id":"174045","name":"Graduate students"}],"affiliations":[],"classification":[],"areas_of_expertise":[],"news_and_recent_appearances":[],"phone":[],"contact":[],"email":[],"slides":[],"orientation":[],"userdata":""}},"360341":{"#nid":"360341","#data":{"type":"event","title":"PhD Proposal Presentation - Sangeetha Srinivasan","body":[{"value":"\u003Cp\u003E\u003Cstrong\u003ETitle:\u0026nbsp;\u003C\/strong\u003E\u003Cstrong\u003EBiomaterial-Based Engineering of Dendritic Cell Environments for Targeted Immune Tolerance Induction\u0026nbsp;\u003C\/strong\u003E\u003C\/p\u003E\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\u003Cp\u003E\u003Cstrong\u003ESummary:\u0026nbsp;\u003C\/strong\u003EAutoimmune disorders are estimated to be among the top ten leading causes of death among women of all ages below 65, for which available treatments include systemic immunosuppressants that cause serious long-term side effects. There is hence a growing interest to engineer mechanisms of inducing target-specific immune tolerance with biomaterials particularly professional antigen presenting cells namely dendritic cells (DCs). DCs previously studied in the context of biomaterials have been discovered to elicit differential responses to biomaterials suggesting that materials on their own have the ability to stimulate specific DC phenotype. As the phenotype of DCs is a key mediator of downstream adaptive immune responses that lead to normal or aberrant immunity, there is increasing interest in delineating the underlying mechanisms of material-cell interaction. In this proposal, we initially investigate the role played by DCs in the adjuvant effect shown by certain materials such as poly lactic-co-glycolic acid (PLGA) and further exploit the differential nature of the response towards agarose compared to PLGA, to develop solely biomaterial-based methods in inducing antigen-specific immune tolerance in an \u003Cem\u003Ein vivo\u003C\/em\u003E mouse model. Moreover, DCs can be locally treated with specific immunomodulators rather than biomaterials to express a tolerogenic phenotype that can trigger antigen-specific immunoregulation. As a second and distinct approach, in this proposal, we examine the possibility of developing the spatiotemporally controlled delivery of immunomodulators from a single implantable biomaterial niche. The design of such a delivery device would call for not only incorporating a strategy for DC phenotype modulation but also a technique for promoting endogenous DC recruitment upon \u003Cem\u003Ein vivo\u003C\/em\u003E implantation; thus it would enable the localized delivery of factors while promoting systemic circulation of in situ primed DCs for effective downstream immune function, a feature commonly lacking in existing treatments of autoimmune diseases. Finally, the efficacy of this technique will be assessed in the context of an autoimmune disease model, to explore its potential use as a therapeutic cure for individuals with autoimmune disorders.\u003C\/p\u003E\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\u003Cp\u003E\u003Cstrong\u003EAdvisor: \u003C\/strong\u003E\u003C\/p\u003E\u003Cp\u003EJulia E. Babensee, PhD\u003C\/p\u003E\u003Cp\u003EWallace C. Coulter Department of Biomedical Engineering\u003C\/p\u003E\u003Cp\u003EGeorgia Institute of Technology and Emory University\u003C\/p\u003E\u003Cp\u003E\u003Cstrong\u003E\u0026nbsp;\u003C\/strong\u003E\u003C\/p\u003E\u003Cp\u003E\u003Cstrong\u003EThesis Committee: \u003C\/strong\u003E\u003C\/p\u003E\u003Cp\u003EJulie Champion, PhD\u003C\/p\u003E\u003Cp\u003ESchool of Chemical and Biomolecular Engineering\u003C\/p\u003E\u003Cp\u003EGeorgia Institute of Technology and Emory University\u003C\/p\u003E\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\u003Cp\u003EEdward Botchwey, PhD\u003C\/p\u003E\u003Cp\u003EWallace C. Coulter Department of Biomedical Engineering\u003C\/p\u003E\u003Cp\u003EGeorgia Institute of Technology and Emory University\u003C\/p\u003E\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\u003Cp\u003ESusan Thomas, PhD\u003C\/p\u003E\u003Cp\u003EGeorge W. Woodruff School of Mechanical Engineering\u003C\/p\u003E\u003Cp\u003EGeorgia Institute of Technology and Emory University\u003C\/p\u003E\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\u003Cp\u003E\u0026nbsp;Krishnendu Roy, PhD\u003C\/p\u003E\u003Cp\u003EWallace C. Coulter Department of Biomedical Engineering\u003C\/p\u003E\u003Cp\u003EGeorgia Institute of Technology and Emory University\u003C\/p\u003E\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E","summary":null,"format":"limited_html"}],"field_subtitle":"","field_summary":[{"value":"\u003Cp\u003EPhD Proposal Presentation-\u0026nbsp;\u0022Biomaterial-Based Engineering of Dendritic Cell Environments for Targeted Immune Tolerance Induction \u0022- Sangeetha Srinivasan\u003C\/p\u003E","format":"limited_html"}],"field_summary_sentence":[{"value":"\u0022Biomaterial-Based Engineering of Dendritic Cell Environments for Targeted Immune Tolerance Induction \u0022"}],"uid":"27917","created_gmt":"2015-01-05 11:46:25","changed_gmt":"2017-04-13 21:20:50","author":"Laura Paige","boilerplate_text":"","field_publication":"","field_article_url":"","field_event_time":{"event_time_start":"2015-01-07T10:00:00-05:00","event_time_end":"2015-01-07T12:00:00-05:00","event_time_end_last":"2015-01-07T12:00:00-05:00","gmt_time_start":"2015-01-07 15:00:00","gmt_time_end":"2015-01-07 17:00:00","gmt_time_end_last":"2015-01-07 17:00:00","rrule":null,"timezone":"America\/New_York"},"extras":[],"groups":[{"id":"65448","name":"Bioengineering Graduate Program"}],"categories":[],"keywords":[],"core_research_areas":[],"news_room_topics":[],"event_categories":[{"id":"1788","name":"Other\/Miscellaneous"}],"invited_audience":[{"id":"78751","name":"Undergraduate students"},{"id":"78761","name":"Faculty\/Staff"},{"id":"174045","name":"Graduate students"}],"affiliations":[],"classification":[],"areas_of_expertise":[],"news_and_recent_appearances":[],"phone":[],"contact":[{"value":"\u003Cp\u003ELaura Paige\u003C\/p\u003E\u003Cp\u003E404-385-6655\u003C\/p\u003E","format":"limited_html"}],"email":[],"slides":[],"orientation":[],"userdata":""}},"355351":{"#nid":"355351","#data":{"type":"event","title":"BioEngineering Program Faculty Meeting","body":[{"value":"\u003Cp\u003E\u003Cem\u003EThe BioEngineering Program faculty meet regularly during the semester to address program policies, events and future research and academic directions.\u003C\/em\u003E\u003C\/p\u003E","summary":null,"format":"limited_html"}],"field_subtitle":"","field_summary":[{"value":"\u003Cp\u003E\u003Cem\u003EProgram policies, events and directions to be discussed\u003C\/em\u003E\u003C\/p\u003E","format":"limited_html"}],"field_summary_sentence":[{"value":"BioEngineering Program Faculty Meeting"}],"uid":"27917","created_gmt":"2014-12-12 15:33:25","changed_gmt":"2016-10-08 02:10:47","author":"Laura Paige","boilerplate_text":"","field_publication":"","field_article_url":"","field_event_time":{"event_time_start":"2015-01-08T10:00:00-05:00","event_time_end":"2015-01-08T11:00:00-05:00","event_time_end_last":"2015-01-08T11:00:00-05:00","gmt_time_start":"2015-01-08 15:00:00","gmt_time_end":"2015-01-08 16:00:00","gmt_time_end_last":"2015-01-08 16:00:00","rrule":null,"timezone":"America\/New_York"},"extras":[],"groups":[{"id":"65448","name":"Bioengineering Graduate Program"}],"categories":[],"keywords":[],"core_research_areas":[],"news_room_topics":[],"event_categories":[{"id":"1788","name":"Other\/Miscellaneous"}],"invited_audience":[{"id":"78761","name":"Faculty\/Staff"}],"affiliations":[],"classification":[],"areas_of_expertise":[],"news_and_recent_appearances":[],"phone":[],"contact":[{"value":"\u003Cp\u003ELaura Paige\u003C\/p\u003E\u003Cp\u003E404-385-6655\u003C\/p\u003E","format":"limited_html"}],"email":[],"slides":[],"orientation":[],"userdata":""}},"358761":{"#nid":"358761","#data":{"type":"event","title":"BioEngineering Graduate Committee Meeting","body":[{"value":"\u003Cp\u003E\u003Cem\u003EThe BioEngineering graduate committee will meet to review\/approve program policies, program faculty applications and submitted student petitions.\u003Cbr \/\u003E\u003Cbr \/\u003EStudent Petitions due to\u0026nbsp;\u003Ca href=\u0022mailto:laura.paige@bioengineering.gatech.edu\u0022\u003ELaura Paige\u003C\/a\u003E\u0026nbsp;no later than: 1\/14\/2015\u003C\/em\u003E\u003C\/p\u003E","summary":null,"format":"limited_html"}],"field_subtitle":"","field_summary":[{"value":"\u003Cp\u003EBioEngineering Graduate Committee Meeting\u003C\/p\u003E","format":"limited_html"}],"field_summary_sentence":[{"value":"\u0022BioEngineering Graduate Committee Meeting\u0022"}],"uid":"27917","created_gmt":"2014-12-18 14:48:07","changed_gmt":"2016-10-08 02:10:51","author":"Laura Paige","boilerplate_text":"","field_publication":"","field_article_url":"","field_event_time":{"event_time_start":"2015-01-28T11:00:00-05:00","event_time_end":"2015-01-28T12:00:00-05:00","event_time_end_last":"2015-01-28T12:00:00-05:00","gmt_time_start":"2015-01-28 16:00:00","gmt_time_end":"2015-01-28 17:00:00","gmt_time_end_last":"2015-01-28 17:00:00","rrule":null,"timezone":"America\/New_York"},"extras":[],"groups":[{"id":"65448","name":"Bioengineering Graduate Program"}],"categories":[],"keywords":[],"core_research_areas":[],"news_room_topics":[],"event_categories":[{"id":"1788","name":"Other\/Miscellaneous"}],"invited_audience":[{"id":"78761","name":"Faculty\/Staff"}],"affiliations":[],"classification":[],"areas_of_expertise":[],"news_and_recent_appearances":[],"phone":[],"contact":[{"value":"\u003Cp\u003ELaura Paige\u0026nbsp;\u003C\/p\u003E\u003Cp\u003E404-385-6655\u003C\/p\u003E","format":"limited_html"}],"email":[],"slides":[],"orientation":[],"userdata":""}},"366741":{"#nid":"366741","#data":{"type":"event","title":"PhD Proposal Presentaion - Timothy Chang","body":[{"value":"\u003Cp class=\u0022p1\u0022\u003E\u003Cstrong\u003EProtein Nanoparticle Vaccines\u003C\/strong\u003E\u003C\/p\u003E\u003Cp class=\u0022p1\u0022\u003E\u003Cstrong\u003E\u003Cbr \/\u003E\u003C\/strong\u003E\u003C\/p\u003E\u003Cp class=\u0022p1\u0022\u003E\u003Cstrong\u003EThesis Committee Members\u003C\/strong\u003E\u003C\/p\u003E\u003Cp class=\u0022p1\u0022\u003E\u003Cstrong\u003EAdvisor:\u003C\/strong\u003E Julie A. Champion, Ph.D. - School of Chemical and Biomolecular Engineering, Georgia Institute of Technology\u003C\/p\u003E\u003Cp class=\u0022p1\u0022\u003EJennifer K. Leavey, Ph.D. - School of Biology, Georgia Institute of Technology\u003C\/p\u003E\u003Cp class=\u0022p1\u0022\u003EKrishnendu Roy, Ph.D. - Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology\u0026nbsp;\u003C\/p\u003E\u003Cp class=\u0022p1\u0022\u003EMark R. Prausnitz, Ph.D. - School of Chemical and Biomolecular Engineering, Georgia Institute of Technology\u003C\/p\u003E\u003Cp class=\u0022p1\u0022\u003EBao-Zhong Wang, Ph.D. - Department of Microbiology and Immunology, Emory University School of Medicine\u003C\/p\u003E\u003Cp class=\u0022p1\u0022\u003E\u0026nbsp;\u003C\/p\u003E\u003Cp class=\u0022p1\u0022\u003EHighly conserved pathogen proteins are essential for broadly cross-protective vaccines, but tend to be poorly immunogenic. Protein nanoparticle vaccines made from conserved influenza matrix protein 2 and hemagglutinin trigger specific, adaptive immune responses that soluble protein cannot. Without excipients or adjuvants, protein nanoparticles eliminate the possibility of off-target immune responses, and their abiotic nature makes them amenable to cold chain-independent storage and use. The mechanisms by which protein nanoparticles enhance component protein immunogenicity are still not well understood. Protein nanoparticles will be made from hen egg ovalbumin and influenza proteins to examine dendritic cell responses in vitro and adaptive immune responses in vivo. The goals of this project are two-fold: to understand the immunological basis behind protein nanoparticle adjuvancy, and to improve this adjuvancy with studies into nanoparticle stability, enhancing endosomal buffering, and molecular adjuvants as nanoparticle coatings. This project aims to assess the viability of protein nanoparticles as a vaccine delivery platform.\u003C\/p\u003E","summary":null,"format":"limited_html"}],"field_subtitle":"","field_summary":[{"value":"\u003Cp\u003EPhD Proposal Presentation -\u0026nbsp;\u0022Protein Nanoparticle Vaccines\u0022 -\u0026nbsp;Timothy Chang\u003C\/p\u003E","format":"limited_html"}],"field_summary_sentence":[{"value":"\u0022Protein Nanoparticle Vaccines\u0022"}],"uid":"27349","created_gmt":"2015-01-22 10:22:16","changed_gmt":"2017-04-13 21:20:33","author":"Floyd Wood","boilerplate_text":"","field_publication":"","field_article_url":"","field_event_time":{"event_time_start":"2015-02-02T12:00:00-05:00","event_time_end":"2015-02-02T14:00:00-05:00","event_time_end_last":"2015-02-02T14:00:00-05:00","gmt_time_start":"2015-02-02 17:00:00","gmt_time_end":"2015-02-02 19:00:00","gmt_time_end_last":"2015-02-02 19:00:00","rrule":null,"timezone":"America\/New_York"},"extras":[],"groups":[{"id":"65448","name":"Bioengineering Graduate Program"}],"categories":[],"keywords":[{"id":"13974","name":"BioE Program events"}],"core_research_areas":[],"news_room_topics":[],"event_categories":[{"id":"1788","name":"Other\/Miscellaneous"}],"invited_audience":[{"id":"78751","name":"Undergraduate students"},{"id":"78761","name":"Faculty\/Staff"},{"id":"174045","name":"Graduate students"}],"affiliations":[],"classification":[],"areas_of_expertise":[],"news_and_recent_appearances":[],"phone":[],"contact":[],"email":[],"slides":[],"orientation":[],"userdata":""}},"369011":{"#nid":"369011","#data":{"type":"event","title":"PhD Proposal Presentation - Jason L. Wang","body":[{"value":"\u003Cp\u003E\u003Cstrong\u003EAdvisor\u003C\/strong\u003E:\u0026nbsp;\u003C\/p\u003E\u003Cp\u003ERobert E. Guldberg, Ph.D. (Georgia Institute of Technology)\u003C\/p\u003E\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\u003Cp\u003E\u003Cstrong\u003ECommittee:\u003C\/strong\u003E\u003C\/p\u003E\u003Cp\u003ERudolph L. Gleason, Ph.D. (Georgia Institute of Technology)\u003C\/p\u003E\u003Cp\u003EManu O. Platt, Ph.D. (Georgia Institute of Technology)\u003C\/p\u003E\u003Cp\u003EJohnna S. Temenoff, Ph.D. (Georgia Institute of Technology)\u003C\/p\u003E\u003Cp\u003EM. Neale Weitzmann, Ph.D. (Emory University)\u003C\/p\u003E\u003Cp align=\u0022center\u0022\u003E\u003Cstrong\u003E\u0026nbsp;\u003C\/strong\u003E\u003C\/p\u003E\u003Cp align=\u0022center\u0022\u003E\u003Cstrong\u003EHIV-1 Protein Effects on Skeletal Development and Bone Tissue Regeneration\u003C\/strong\u003E\u003C\/p\u003E\u003Cp\u003EHIV and AIDS have drastically compromised the quality of life and lifespan for millions of people worldwide. Since its inception in 1996, highly active antiretroviral therapy (HAART) has dramatically increased the life expectancy of those infected with HIV to nearly that of the general population. However, HIV-infected individuals on treatment are now faced with the premature onset of disorders traditionally associated with the natural aging process including cardiovascular disease, neurocognitive decline, and osteoporosis. It is well understood that HIV infection alone is a risk factor for osteopenia and osteoporosis and subsequently for fragility fractures. More recently, studies have established an increase in fracture prevalence in the HIV-infected population. However, the effects of HIV infection, HIV proteins, and antiretroviral drugs on bone are difficult to investigate in the clinical setting. Traditional risk factors for osteoporosis \u2013 such as vitamin D deficiency, drug use, smoking, and alcohol use \u2013 can complicate any observed effects that HIV or HAART drugs may have. Despite the increased risk for fracture and fracture prevalence in the HIV-infected population, few studies have investigated the potential for HIV infection to adversely affect fracture healing. Considering the critical role of immune cells in the fracture healing process, bone repair may be impaired or delayed with HIV infection.\u003C\/p\u003E\u003Cp\u003EThe goal of this project is to determine the effects of HIV-1 proteins on skeletal development and bone tissue regeneration through the use of two HIV-1 transgenic animal models. This will be accomplished through three specific aims:\u003C\/p\u003E\u003Col\u003E\u003Cli\u003E\u003Cstrong\u003EI.\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp; \u003C\/strong\u003EInvestigate the longitudinal skeletal changes in the growing HIV-1 transgenic rat.\u003Col\u003E\u003Cli\u003E\u003Cstrong\u003EII.\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp; \u003C\/strong\u003EDetermine the bone regeneration capacity in the HIV-1 transgenic rat using a BMP-2-mediated segmental bone defect repair model.\u003C\/li\u003E\u003Cli\u003E\u003Cstrong\u003EIII.\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp; \u003C\/strong\u003ECharacterize the skeleton of the HIV-1 transgenic mouse and the effects of HAART drug treatment.\u003C\/li\u003E\u003C\/ol\u003E\u003C\/li\u003E\u003C\/ol\u003E\u003Cp\u003EThis project will contribute to the growing body of knowledge on the effects of HIV infection on skeletal health and present initial investigations into the effects of HIV on the bone repair process. In addition, it will characterize two HIV-1 transgenic animal models as functional surrogates for studying skeletal disorders in the context of HIV.\u003C\/p\u003E\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E","summary":null,"format":"limited_html"}],"field_subtitle":"","field_summary":[{"value":"\u003Cp\u003EPhD Proposal Presentation-\u0026nbsp;\u0022HIV-1 Protein Effects on Skeletal Development and Bone Tissue Regeneration\u0022- Jason L. Wang\u003C\/p\u003E","format":"limited_html"}],"field_summary_sentence":[{"value":"\u0022HIV-1 Protein Effects on Skeletal Development and Bone Tissue Regeneration\u0022"}],"uid":"27917","created_gmt":"2015-01-28 09:17:03","changed_gmt":"2017-04-13 21:20:24","author":"Laura Paige","boilerplate_text":"","field_publication":"","field_article_url":"","field_event_time":{"event_time_start":"2015-02-10T12:00:00-05:00","event_time_end":"2015-02-10T14:00:00-05:00","event_time_end_last":"2015-02-10T14:00:00-05:00","gmt_time_start":"2015-02-10 17:00:00","gmt_time_end":"2015-02-10 19:00:00","gmt_time_end_last":"2015-02-10 19:00:00","rrule":null,"timezone":"America\/New_York"},"extras":[],"related_links":[{"url":"http:\/\/guldberglab.gatech.edu\/","title":"Guldberg Musculoskeletal Research Lab"}],"groups":[{"id":"65448","name":"Bioengineering Graduate Program"}],"categories":[],"keywords":[],"core_research_areas":[],"news_room_topics":[],"event_categories":[{"id":"1788","name":"Other\/Miscellaneous"}],"invited_audience":[{"id":"78751","name":"Undergraduate students"},{"id":"78761","name":"Faculty\/Staff"},{"id":"174045","name":"Graduate students"}],"affiliations":[],"classification":[],"areas_of_expertise":[],"news_and_recent_appearances":[],"phone":[],"contact":[{"value":"\u003Cp\u003ELaura Paige\u0026nbsp;\u003C\/p\u003E\u003Cp\u003E404-385-6655\u003C\/p\u003E","format":"limited_html"}],"email":[],"slides":[],"orientation":[],"userdata":""}},"358771":{"#nid":"358771","#data":{"type":"event","title":"BioEngineering Graduate Committee Meeting","body":[{"value":"\u003Cp\u003E\u003Cem\u003EThe BioEngineering graduate committee will meet to review\/approve program policies, program faculty applications and submitted student petitions.\u003Cbr \/\u003E\u003Cbr \/\u003EStudent Petitions due to\u0026nbsp;\u003Ca href=\u0022mailto:laura.paige@bioengineering.gatech.edu\u0022\u003ELaura Paige\u003C\/a\u003E\u0026nbsp;no later than: 2\/11\/2015\u003C\/em\u003E\u003C\/p\u003E","summary":null,"format":"limited_html"}],"field_subtitle":"","field_summary":[{"value":"\u003Cp\u003EBioEngineering Graduate Committee Meeting\u003C\/p\u003E","format":"limited_html"}],"field_summary_sentence":[{"value":"\u0022BioEngineering Graduate Committee Meeting\u0022"}],"uid":"27917","created_gmt":"2014-12-18 14:50:20","changed_gmt":"2016-10-08 02:10:51","author":"Laura Paige","boilerplate_text":"","field_publication":"","field_article_url":"","field_event_time":{"event_time_start":"2015-02-25T11:00:00-05:00","event_time_end":"2015-02-25T12:00:00-05:00","event_time_end_last":"2015-02-25T12:00:00-05:00","gmt_time_start":"2015-02-25 16:00:00","gmt_time_end":"2015-02-25 17:00:00","gmt_time_end_last":"2015-02-25 17:00:00","rrule":null,"timezone":"America\/New_York"},"extras":[],"groups":[{"id":"65448","name":"Bioengineering Graduate Program"}],"categories":[],"keywords":[],"core_research_areas":[],"news_room_topics":[],"event_categories":[{"id":"1788","name":"Other\/Miscellaneous"}],"invited_audience":[{"id":"78761","name":"Faculty\/Staff"}],"affiliations":[],"classification":[],"areas_of_expertise":[],"news_and_recent_appearances":[],"phone":[],"contact":[{"value":"\u003Cp\u003ELaura Paige\u003C\/p\u003E\u003Cp\u003E404-385-6655\u003C\/p\u003E","format":"limited_html"}],"email":[],"slides":[],"orientation":[],"userdata":""}},"378991":{"#nid":"378991","#data":{"type":"event","title":"BioE PhD Defense Announcement: David Sotto","body":[{"value":"\u003Cp\u003EGang Bao, Ph.D. (Advisor)\u003C\/p\u003E\u003Cp\u003EMichelle Dawson, Ph.D.\u003C\/p\u003E\u003Cp\u003ERaphael Lee, M.D., Sc.D. (University of Chicago)\u0026nbsp;\u003Cbr \/\u003E Todd Sulchek, Ph.D.\u003Cbr \/\u003E Johnna Temenoff, Ph.D.\u003C\/p\u003E\u003Cp\u003EDirecting the Migration of Mesenchymal Stem Cells and Bystander Cells using Superparamagnetic Iron Oxide Nanoparticles\u003C\/p\u003E\u003Cp\u003E\u0026nbsp;Cell migration plays an important role in numerous normal and pathological processes. The physical mechanisms of adhesion, protrusion\/extension, contractions, and polarization can regulate cell migration speed, persistence time, and downstream effects in paracrine and endocrine signaling. Methods for understanding these biophysical and biochemical responses to date have been limited to the use of external forces acting on mechanotransductive receptors. Additionally, as the use of magnetic nanoparticles for cell tracking and cell manipulation studies continues to gain popularity, so does the importance of understanding the cellular response to mechanical forces caused by these magnetic systems.\u003C\/p\u003E\u003Cp\u003EThis thesis work utilizes superparamagnetic iron oxide nanoparticles and static magnets to induce an endogenous magnetic force on the cell membrane. This cell manipulation model is used to better understand the mechanobiologal responses of mesenchymal stem cell to SPIO labeling and endogenous force generation. Directionally persistent motility, cytoskeletal reorganization, and altered pro-migratory cytokine secretion is reported in this thesis as a response to SPIO based cell manipulation.\u003C\/p\u003E\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E","summary":null,"format":"limited_html"}],"field_subtitle":"","field_summary":[{"value":"\u003Cp\u003EPhD Defense Presentation- \u0022Directing the Migration of Mesenchymal Stem Cells and Bystander Cells using Superparamagnetic Iron Oxide Nanoparticles\u0022 David Sotto\u003C\/p\u003E","format":"limited_html"}],"field_summary_sentence":[{"value":"\u0022Directing the Migration of Mesenchymal Stem Cells and Bystander Cells using Superparamagnetic Iron Oxide Nanoparticles\u0022"}],"uid":"27917","created_gmt":"2015-02-17 10:12:30","changed_gmt":"2017-04-13 21:20:03","author":"Laura Paige","boilerplate_text":"","field_publication":"","field_article_url":"","field_event_time":{"event_time_start":"2015-02-27T10:00:00-05:00","event_time_end":"2015-02-27T12:00:00-05:00","event_time_end_last":"2015-02-27T12:00:00-05:00","gmt_time_start":"2015-02-27 15:00:00","gmt_time_end":"2015-02-27 17:00:00","gmt_time_end_last":"2015-02-27 17:00:00","rrule":null,"timezone":"America\/New_York"},"extras":[],"groups":[{"id":"65448","name":"Bioengineering Graduate Program"}],"categories":[],"keywords":[],"core_research_areas":[],"news_room_topics":[],"event_categories":[{"id":"1788","name":"Other\/Miscellaneous"}],"invited_audience":[{"id":"78751","name":"Undergraduate students"},{"id":"78761","name":"Faculty\/Staff"},{"id":"174045","name":"Graduate students"}],"affiliations":[],"classification":[],"areas_of_expertise":[],"news_and_recent_appearances":[],"phone":[],"contact":[{"value":"\u003Cp\u003ELaura Paige\u003C\/p\u003E\u003Cp\u003E404-385-6655\u003C\/p\u003E","format":"limited_html"}],"email":[],"slides":[],"orientation":[],"userdata":""}},"378971":{"#nid":"378971","#data":{"type":"event","title":"BioE PhD Proposal presentation- Mojdeh Faraji","body":[{"value":"\u003Cp\u003EAdvisor: Eberhard O. Voit, Ph.D.\u003C\/p\u003E\u003Cp\u003EWallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology\u003C\/p\u003E\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\u003Cp\u003ECommittee Members:\u003C\/p\u003E\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\u003Cp\u003EAndreas S. Bommarius, Ph.D.\u003C\/p\u003E\u003Cp\u003ESchool of Chemical and Biomolecular Engineering, Georgia Institute of Technology\u003C\/p\u003E\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\u003Cp\u003EMichael J. Leamy, Ph.D.\u003C\/p\u003E\u003Cp\u003EThe George W. Woodruff School of Mechanical Engineering, Georgia Institute of Technology\u003C\/p\u003E\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\u003Cp\u003EPamela Peralta-Yahya, Ph.D.\u003C\/p\u003E\u003Cp\u003ESchool of Chemical and Biomolecular Engineering, Georgia Institute of Technology\u003C\/p\u003E\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\u003Cp\u003EPeng Qiu, Ph.D.\u003C\/p\u003E\u003Cp\u003EWallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology\u003C\/p\u003E\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\u003Cp\u003ETitle:\u0026nbsp;Computational Inference of the Structure and Regulation of the Lignin Pathway in \u003Cem\u003EPanicum virgatum\u003C\/em\u003E\u003C\/p\u003E\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\u003Cp\u003EAbstract:\u0026nbsp;Switchgrass is a prime target for biofuel production from inedible plant parts and has been the subject of numerous investigations in recent years. Yet, one of the main obstacles to effective biofuel production remains to be the major problem of recalcitrance. Recalcitrance emerges in part from the 3-D structure of lignin as a polymer in the secondary cell wall. Lignin limits accessibility of the sugars in the cellulose and hemicellulose polymers to enzymes and ultimately decreases ethanol yield. Monolignols, the building blocks of lignin polymers, are synthesized in the cytosol and translocated to the plant cell wall, where they undergo polymerization. The biosynthetic pathway leading to monolignols in switchgrass is not completely known, and difficulties associated with \u003Cem\u003Ein vivo\u003C\/em\u003E measurements of these intermediates pose a challenge for a true understanding of the functioning of the pathway.\u0026nbsp;The proposed work aims to apply a systems biological modeling approach to address this challenge.\u003C\/p\u003E","summary":null,"format":"limited_html"}],"field_subtitle":"","field_summary":[{"value":"\u003Cp\u003EPhD Proposal Presentation - \u0022Computational Inference of the Structure and Regulation of the Lignin Pathway in \u003Cem\u003EPanicum virgatum\u0022- Mojdeh Faraji\u003C\/em\u003E\u003C\/p\u003E","format":"limited_html"}],"field_summary_sentence":[{"value":"\u0022Computational Inference of the Structure and Regulation of the Lignin Pathway in Panicum virgatum\u0022"}],"uid":"27917","created_gmt":"2015-02-17 10:00:07","changed_gmt":"2017-04-13 21:20:03","author":"Laura Paige","boilerplate_text":"","field_publication":"","field_article_url":"","field_event_time":{"event_time_start":"2015-03-02T13:30:00-05:00","event_time_end":"2015-03-02T15:30:00-05:00","event_time_end_last":"2015-03-02T15:30:00-05:00","gmt_time_start":"2015-03-02 18:30:00","gmt_time_end":"2015-03-02 20:30:00","gmt_time_end_last":"2015-03-02 20:30:00","rrule":null,"timezone":"America\/New_York"},"extras":[],"groups":[{"id":"65448","name":"Bioengineering Graduate Program"}],"categories":[],"keywords":[],"core_research_areas":[],"news_room_topics":[],"event_categories":[{"id":"1788","name":"Other\/Miscellaneous"}],"invited_audience":[{"id":"78751","name":"Undergraduate students"},{"id":"78761","name":"Faculty\/Staff"},{"id":"174045","name":"Graduate students"}],"affiliations":[],"classification":[],"areas_of_expertise":[],"news_and_recent_appearances":[],"phone":[],"contact":[{"value":"\u003Cp\u003ELaura Paige\u0026nbsp;\u003C\/p\u003E\u003Cp\u003E404-385-6655\u003C\/p\u003E","format":"limited_html"}],"email":[],"slides":[],"orientation":[],"userdata":""}},"378981":{"#nid":"378981","#data":{"type":"event","title":"BioE PhD Proposal Presentation- Yogi Patel","body":[{"value":"\u003Cp\u003EAdvisor:\u003C\/p\u003E\u003Cp\u003ERobert J. Butera, Ph.D. (Georgia Institute of Technology, School of ECE and Dept. of BME)\u003C\/p\u003E\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\u003Cp\u003EThesis Committee:\u003C\/p\u003E\u003Cp\u003EChris Rozell, Ph.D. (Georgia Institute of Technology, School of ECE)\u003C\/p\u003E\u003Cp\u003ELaura O Farrell, DVM, Ph.D. (Georgia Institute of Technology, GTRC)\u003C\/p\u003E\u003Cp\u003EArthur English, Ph.D. (Emory University, Dept. of Cell Biology)\u003C\/p\u003E\u003Cp\u003EThomas Burkholder, Ph.D. (Georgia Institute of Technology, School of Applied Physiology)\u003C\/p\u003E\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\u003Cp\u003ENeural modulation of liver function to regulate lipid and glucose metabolism\u003C\/p\u003E\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\u003Cp\u003EMammalian blood glucose concentrations are maintained within well-defined biological limits despite considerable fluctuations in the rate at which glucose is obtained from food and utilized by tissues. Of all homeostatic mechanisms, maintenance of blood glucose levels is finely regulated, and one in which the liver and the central nervous system play a prominent role. The liver can add or remove glucose from circulating blood in accordance with the demands of the body, which are transmitted by both hormonal and neural messaging. The hormonal messaging system is well understood, unlike the neural messaging system. Hormonal messaging is mediated by insulin and glucagon, which have opposite effects on blood glucose levels. Studies have shown that frequency-dependent electrical stimulation of peripheral nerves innervating the liver can lead to increased output of glucose by the liver. Studies have also shown that transection of the peripheral nerves innervating the liver may lead to changes in lipid and glucose metabolism. However, the magnitude and temporal scale with which these effects can be regulated remains unclear. In addition, whether electrical stimulation of peripheral nerves can lead to a decrease in blood glucose levels also remains unclear. The goal of this proposal is to investigate (1) the extent to which activity in peripheral nerves innervating the liver can be altered via electrical stimulation to regulate lipid and glucose metabolism and (2) how blood glucose levels are encoded in peripheral nerve activity for homeostatic regulation by the central nervous system. These goals will be accomplished via three specific aims: First, I will characterize the effects of electrical stimulation in a frequency-dependent manner to excite or inhibit activity in autonomic and somatic peripheral nerves. Second, I will use electrical stimulation to excite or inhibit activity in autonomic nerves innervating the liver and quantify the effects on lipid and blood glucose metabolism. Third, I will use statistical modeling methods to decode autonomic nerve activity communicated to the central nervous system and correlate nerve activity to blood glucose levels. I hypothesize that decoding liver-specific autonomic nerve activity can be used to optimize electrical stimulation, resulting in a closed-loop approach to regulate lipid and glucose metabolism via neural messaging. Together, these experiments will explore the dynamics underlying neural control of lipid and glucose metabolism.\u003C\/p\u003E","summary":null,"format":"limited_html"}],"field_subtitle":"","field_summary":[{"value":"\u003Cp\u003EPhD Proposal Presentation \u0022Neural modulation of liver function to regulate lipid and glucose metabolism\u0022 Yogi Patel\u003C\/p\u003E","format":"limited_html"}],"field_summary_sentence":[{"value":"\u0022Neural modulation of liver function to regulate lipid and glucose metabolism\u0022"}],"uid":"27917","created_gmt":"2015-02-17 10:08:40","changed_gmt":"2017-04-13 21:20:03","author":"Laura Paige","boilerplate_text":"","field_publication":"","field_article_url":"","field_event_time":{"event_time_start":"2015-03-04T08:00:00-05:00","event_time_end":"2015-03-04T10:00:00-05:00","event_time_end_last":"2015-03-04T10:00:00-05:00","gmt_time_start":"2015-03-04 13:00:00","gmt_time_end":"2015-03-04 15:00:00","gmt_time_end_last":"2015-03-04 15:00:00","rrule":null,"timezone":"America\/New_York"},"extras":[],"groups":[{"id":"65448","name":"Bioengineering Graduate Program"}],"categories":[],"keywords":[],"core_research_areas":[],"news_room_topics":[],"event_categories":[{"id":"1788","name":"Other\/Miscellaneous"}],"invited_audience":[{"id":"78751","name":"Undergraduate students"},{"id":"78761","name":"Faculty\/Staff"},{"id":"174045","name":"Graduate students"}],"affiliations":[],"classification":[],"areas_of_expertise":[],"news_and_recent_appearances":[],"phone":[],"contact":[{"value":"\u003Cp\u003ELaura Paige\u003C\/p\u003E\u003Cp\u003E404-385-6655\u003C\/p\u003E","format":"limited_html"}],"email":[],"slides":[],"orientation":[],"userdata":""}},"381241":{"#nid":"381241","#data":{"type":"event","title":"BioE PhD Defense Announcement: Qingfen Pan","body":[{"value":"\u003Cp\u003E\u003Cstrong\u003EAdvisor\u003C\/strong\u003E: Barbara Boyan, Ph.D.\u003C\/p\u003E\u003Cp\u003E\u0026nbsp;\u003Cstrong\u003EThesis Committee Members\u003C\/strong\u003E:\u003C\/p\u003E\u003Cp\u003EJulia Babensee, Ph.D.\u003C\/p\u003E\u003Cp\u003EManu Platt, Ph.D.\u003C\/p\u003E\u003Cp\u003EBrandon Dixon, Ph.D.\u003C\/p\u003E\u003Cp\u003EZvi Schwartz, DMD, Ph.D.\u003C\/p\u003E\u003Cp\u003E\u0026nbsp;\u003Cstrong\u003ETitle: 24R,25-dihydroxyvitamin D3 based Therapy for the Treatment of Knee Osteoarthritis\u003C\/strong\u003E\u003C\/p\u003E\u003Cp\u003EOsteoarthritis (OA) is the most common degenerative joint disease, which according to the center for disease control (CDC), affects nearly 30 million people in the United States. The disease is characterized by joint inflammation, which leads to chondrocyte apoptosis, cartilage matrix degradation, loss of joint function, and eventually total knee replacement. Current drug therapies aim to ease pain and reduce local inflammation; however, no drug exists that effectively alleviates the disease condition without significant side effects that are typical to anti-inflammatory drugs. Therefore, an unmet medical demand exists for development of tissue-engineering strategies to promote articular cartilage repair and regeneration to treat OA. 24R,25-dihydroxyvitamin D3 [24R,25(OH)2D3] is an attractive option for articular cartilage repair because of its anti-apoptotic properties in cartilage cells. The overall objective of this work was to prevent degeneration of articular cartilage through the development of a 24R,25(OH)2D3 based therapy, enhancing chondrocyte survival and cartilage repair. The central hypothesis was that 24R,25(OH)2D3 has therapeutic effects on osteoarthritic articular chondrocytes, reducing cell apoptosis and factors contributing to joint inflammation and\u0026nbsp; cartilage degradation, thus promoting articular cartilage repair and regeneration.\u003C\/p\u003E\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E","summary":null,"format":"limited_html"}],"field_subtitle":"","field_summary":[{"value":"\u003Cp\u003EPhD Defense Presentation-\u0026nbsp;\u002224R,25-dihydroxyvitamin D3 based Therapy for the Treatment of Knee Osteoarthritis\u0022- Qingfen Pan\u003C\/p\u003E","format":"limited_html"}],"field_summary_sentence":[{"value":"\u002224R,25-dihydroxyvitamin D3 based Therapy for the Treatment of Knee Osteoarthritis\u0022"}],"uid":"27917","created_gmt":"2015-02-23 16:07:47","changed_gmt":"2017-04-13 21:19:58","author":"Laura Paige","boilerplate_text":"","field_publication":"","field_article_url":"","field_event_time":{"event_time_start":"2015-03-09T13:00:00-04:00","event_time_end":"2015-03-09T15:00:00-04:00","event_time_end_last":"2015-03-09T15:00:00-04:00","gmt_time_start":"2015-03-09 17:00:00","gmt_time_end":"2015-03-09 19:00:00","gmt_time_end_last":"2015-03-09 19:00:00","rrule":null,"timezone":"America\/New_York"},"extras":[],"groups":[{"id":"65448","name":"Bioengineering Graduate Program"}],"categories":[],"keywords":[],"core_research_areas":[],"news_room_topics":[],"event_categories":[{"id":"1788","name":"Other\/Miscellaneous"}],"invited_audience":[{"id":"78751","name":"Undergraduate students"},{"id":"78761","name":"Faculty\/Staff"},{"id":"174045","name":"Graduate students"}],"affiliations":[],"classification":[],"areas_of_expertise":[],"news_and_recent_appearances":[],"phone":[],"contact":[{"value":"\u003Cp\u003ELaura Paige\u003C\/p\u003E\u003Cp\u003E404-385-6655\u003C\/p\u003E","format":"limited_html"}],"email":[],"slides":[],"orientation":[],"userdata":""}},"384441":{"#nid":"384441","#data":{"type":"event","title":"PhD Defense Presentation- Ivana Parker","body":[{"value":"\u003Cp\u003E\u003Cstrong\u003EIvana Parker\u003C\/strong\u003E\u003C\/p\u003E\u003Cp\u003EBioEngineering PhD Defense Presentation\u003C\/p\u003E\u003Cp\u003EMarch 19, 2015, 3:00 pm\u003C\/p\u003E\u003Cp\u003ESuddath Room, IBB\u003C\/p\u003E\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\u003Cp\u003EAdvisor: Manu Platt, Ph.D.\u003C\/p\u003E\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\u003Cp\u003EThesis Committee Members:\u003C\/p\u003E\u003Cp\u003ERudy Gleason, Ph.D.\u003C\/p\u003E\u003Cp\u003ESuzanne Eskin, Ph.D.\u003C\/p\u003E\u003Cp\u003EW. Robert Taylor, Ph.D.\u003C\/p\u003E\u003Cp\u003ERoy Sutliff, Ph.D.\u003C\/p\u003E\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\u003Cp\u003ETitle: The Role of HIV-1 Tat and Antiretrovirals on Cathepsin Mediated Arterial Remodeling\u003C\/p\u003E\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\u003Cp\u003EMajor advances in highly active antiretroviral therapies (ARVs) have extended the lives of people living with HIV, but there still remains an increased risk of death by cardiovascular diseases (CVD). HIV proteins and ARVs have been shown to contribute to cardiovascular dysfunction with effects on the different cell types that comprise the arterial wall. In particular, HIV-1 transactivating factor, Tat, is a cationic polypeptide that binds to endothelial cells, inducing a range of responses that have been shown to contribute to vascular dysfunction. It is well established that hemodynamics also play an important role in endothelial cell mediated atherosclerotic development where upon exposure to low or oscillatory shear stress, such as that found at branches and bifurcations, endothelial cells contribute to proteolytic vascular remodeling, by upregulating cathepsins, potent elastases and collagenases. Mechanisms to understand the influence of HIV proteins on shear mediated vascular remodeling have not been fully elucidated.\u003C\/p\u003E\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\u003Cp\u003EThe objective of this thesis is to explore the effects of pro-atherogenic shear stress, HIV proteins, and antiretroviral therapies on the vasculature using in vivo and in vitro models. The goals are to determine the effects of pro-atherogenic shear stress conditions coupled with these HIV factors on proteolytic activity\u0026nbsp; and determine downstream regulatory mechanisms using in vitro culture systems and the HIV-transgenic mouse model.\u0026nbsp;\u003C\/p\u003E","summary":null,"format":"limited_html"}],"field_subtitle":"","field_summary":[{"value":"\u003Cp\u003EPhD Defense Presentation-\u0026nbsp;\u0022The Role of HIV-1 Tat and Antiretrovirals on Cathepsin Mediated Arterial Remodeling\u0022- Ivana Parker\u003C\/p\u003E","format":"limited_html"}],"field_summary_sentence":[{"value":"\u0022The Role of HIV-1 Tat and Antiretrovirals on Cathepsin Mediated Arterial Remodeling\u0022"}],"uid":"27917","created_gmt":"2015-03-04 16:43:43","changed_gmt":"2017-04-13 21:19:52","author":"Laura Paige","boilerplate_text":"","field_publication":"","field_article_url":"","field_event_time":{"event_time_start":"2015-03-19T16:00:00-04:00","event_time_end":"2015-03-19T18:00:00-04:00","event_time_end_last":"2015-03-19T18:00:00-04:00","gmt_time_start":"2015-03-19 20:00:00","gmt_time_end":"2015-03-19 22:00:00","gmt_time_end_last":"2015-03-19 22:00:00","rrule":null,"timezone":"America\/New_York"},"extras":[],"related_links":[{"url":"http:\/\/platt.gatech.edu\/","title":"Platt Lab Website"}],"groups":[{"id":"65448","name":"Bioengineering Graduate Program"}],"categories":[],"keywords":[],"core_research_areas":[],"news_room_topics":[],"event_categories":[{"id":"1788","name":"Other\/Miscellaneous"}],"invited_audience":[{"id":"78751","name":"Undergraduate students"},{"id":"78761","name":"Faculty\/Staff"},{"id":"174045","name":"Graduate students"}],"affiliations":[],"classification":[],"areas_of_expertise":[],"news_and_recent_appearances":[],"phone":[],"contact":[{"value":"\u003Cp\u003ELaura Paige\u003C\/p\u003E\u003Cp\u003E404-385-6655\u003C\/p\u003E","format":"limited_html"}],"email":[],"slides":[],"orientation":[],"userdata":""}},"355361":{"#nid":"355361","#data":{"type":"event","title":"BioEngineering Program Faculty Meeting","body":[{"value":"\u003Cp\u003E\u003Cem\u003EThe BioEngineering Program faculty meet regularly during the semester to address program policies, events and future research and academic directions.\u003C\/em\u003E\u003C\/p\u003E","summary":null,"format":"limited_html"}],"field_subtitle":"","field_summary":[{"value":"\u003Cp\u003E\u003Cem\u003EProgram policies, events and directions to be discussed\u003C\/em\u003E\u003C\/p\u003E","format":"limited_html"}],"field_summary_sentence":[{"value":"BioEngineering Program Faculty Meeting"}],"uid":"27917","created_gmt":"2014-12-12 15:40:22","changed_gmt":"2016-10-08 02:10:47","author":"Laura Paige","boilerplate_text":"","field_publication":"","field_article_url":"","field_event_time":{"event_time_start":"2015-03-24T12:00:00-04:00","event_time_end":"2015-03-24T13:00:00-04:00","event_time_end_last":"2015-03-24T13:00:00-04:00","gmt_time_start":"2015-03-24 16:00:00","gmt_time_end":"2015-03-24 17:00:00","gmt_time_end_last":"2015-03-24 17:00:00","rrule":null,"timezone":"America\/New_York"},"extras":[],"groups":[{"id":"65448","name":"Bioengineering Graduate Program"}],"categories":[],"keywords":[],"core_research_areas":[],"news_room_topics":[],"event_categories":[{"id":"1788","name":"Other\/Miscellaneous"}],"invited_audience":[{"id":"78761","name":"Faculty\/Staff"}],"affiliations":[],"classification":[],"areas_of_expertise":[],"news_and_recent_appearances":[],"phone":[],"contact":[{"value":"\u003Cp\u003ELaura Paige\u003C\/p\u003E\u003Cp\u003E404-385-6655\u003C\/p\u003E","format":"limited_html"}],"email":[],"slides":[],"orientation":[],"userdata":""}},"389001":{"#nid":"389001","#data":{"type":"event","title":"2015 BioEngineering Graduate Recruiting Day","body":[{"value":"\u003Cp\u003EWe are delighted to host BioEngineering Graduate recruits from across the country, and have planned an exciting day to include faculty interviews, student panels as well as research and training grant presentations. All BioEngineering faculty and students will be available to meet with prospective students for faculty interviews and a planned graduate student panel.\u003C\/p\u003E\u003Cp\u003E\u003Cstrong\u003E\u003Cbr \/\u003E\u003C\/strong\u003E\u003C\/p\u003E\u003Cp\u003E\u003Cstrong\u003EAGENDA\u003C\/strong\u003E\u003C\/p\u003E\u003Cp\u003E\u003Cstrong\u003EThursday, March 26th , 2015\u003C\/strong\u003E\u003Cbr \/\u003E \u003Cbr \/\u003E2:30-4:30pm Optional Tour of Emory\u003Cbr \/\u003EMeet in IBB Atrium @ 2:15pm\u003Cbr \/\u003E \u003Cbr \/\u003E5:00pm - BioE Social\u003Cbr \/\u003EMarlow\u2019s Tavern\u003Cbr \/\u003E950 West Peachtree Street\u003Cbr \/\u003E*Meet there or walk from IBB lobby @ 4:45pm\u003Cbr \/\u003E \u003Cbr \/\u003E\u003Cstrong\u003EFriday, March 27, 2015\u003C\/strong\u003E\u003Cbr \/\u003E \u003Cbr \/\u003E9:45am - BioEngineering Overview- Andr\u00e9s Garc\u00eda, PhD\u003Cbr \/\u003E \u003Cbr \/\u003E10:45am - BGA (BioEngineering Graduate Association) student panel\u003Cbr \/\u003E \u003Cbr \/\u003E11:30am - Lunch and poster session\u003Cbr \/\u003E \u003Cbr \/\u003E1:00pm - Faculty Interviews\u003Cbr \/\u003E \u003Cbr \/\u003E5:30 - BioE Social\u003Cbr \/\u003ERay\u2019s New York Pizza\u003Cbr \/\u003E26 5th Street NW- Tech Square\u003Cbr \/\u003E*Meet there or walk from IBB lobby @ 5:15pm\u003C\/p\u003E","summary":null,"format":"limited_html"}],"field_subtitle":"","field_summary":"","field_summary_sentence":[{"value":"The Interdisciplinary BioEngineering Graduate program welcomes prospective students to campus"}],"uid":"27349","created_gmt":"2015-03-19 15:33:54","changed_gmt":"2017-04-13 21:19:43","author":"Floyd Wood","boilerplate_text":"","field_publication":"","field_article_url":"","field_event_time":{"event_time_start":"2015-03-27T10:45:00-04:00","event_time_end":"2015-03-27T20:00:00-04:00","event_time_end_last":"2015-03-27T20:00:00-04:00","gmt_time_start":"2015-03-27 14:45:00","gmt_time_end":"2015-03-28 00:00:00","gmt_time_end_last":"2015-03-28 00:00:00","rrule":null,"timezone":"America\/New_York"},"extras":[],"related_links":[{"url":"http:\/\/www.bioengineering.gatech.edu\/","title":"BioEngineering website"}],"groups":[{"id":"65448","name":"Bioengineering Graduate Program"}],"categories":[],"keywords":[{"id":"6178","name":"BIOE"},{"id":"13974","name":"BioE Program events"},{"id":"569","name":"bioengineering"}],"core_research_areas":[],"news_room_topics":[],"event_categories":[{"id":"1788","name":"Other\/Miscellaneous"}],"invited_audience":[{"id":"78751","name":"Undergraduate students"},{"id":"174045","name":"Graduate students"}],"affiliations":[],"classification":[],"areas_of_expertise":[],"news_and_recent_appearances":[],"phone":[],"contact":[{"value":"\u003Cp\u003E\u003Ca href=\u0022mailto:laura.paige@bioengineering.gatech.edu\u0022\u003ELaura Paige\u003C\/a\u003E\u003C\/p\u003E","format":"limited_html"}],"email":[],"slides":[],"orientation":[],"userdata":""}},"387881":{"#nid":"387881","#data":{"type":"event","title":"PhD Proposal Presentation - Caitlin Austin","body":[{"value":"\u003Cp\u003E\u003Cstrong\u003EAdvisor: Craig Forest, PhD\u003C\/strong\u003E \u0026nbsp;(Georgia Institute of Technology)\u003C\/p\u003E\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\u003Cp\u003E\u003Cstrong\u003ECommittee:\u003C\/strong\u003E\u003C\/p\u003E\u003Cp\u003E\u003Cstrong\u003EBrian Hammer, PhD\u003C\/strong\u003E (Georgia Institute of Technology)\u003C\/p\u003E\u003Cp\u003E\u003Cstrong\u003EFaramarz Fekri, PhD\u003C\/strong\u003E (Georgia Institute of Technology)\u003C\/p\u003E\u003Cp\u003E\u003Cstrong\u003EMark Styczynski, PhD\u003C\/strong\u003E (Georgia Institute of Technology)\u003C\/p\u003E\u003Cp\u003E\u003Cstrong\u003EPeter Hesketh, PhD\u003C\/strong\u003E\u0026nbsp; (Georgia Institute of Technology)\u003C\/p\u003E\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\u003Cp align=\u0022center\u0022\u003E\u003Cstrong\u003EDynamics of Molecular Communication in Bacteria within Microfluidic Environments\u003C\/strong\u003E\u003C\/p\u003E\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\u003Ctable border=\u00220\u0022 cellpadding=\u00220\u0022\u003E\u003Ctbody\u003E\u003Ctr\u003E\u003Ctd\u003E\u003Cp\u003EBiosensors exploiting communication within genetically engineered bacteria are becoming increasingly important for monitoring environmental changes. Recently these sensors have miniaturized towards microfluidics due to the greater control they provide over things such as the population density and dynamic inputs. Although great strides have been made to study a single strain of bacteria in a microfluidic device, there is still a need to be able to study two populations of bacteria communicating with one another. Currently, there are a variety of mathematical models for understanding and predicting how genetically engineered bacteria respond to molecular stimuli in bulk culture environments, but when applied to microfluidics and to complex time-varying inputs, the shortcomings of these models have become apparent. The effects of microfluidic environments such as low oxygen concentration, increased biofilm encapsulation, diffusion limited molecular distribution, and higher population densities strongly affect rate constants for gene expression not accounted for in previous models. Thus, the long-term goal of this research is to develop a microfluidic platform capable of housing two bacteria populations to study the bacterial communication with dynamic control the inputs, long-term experimentation, and no cross contamination. We also look to create a mathematical model that accurately predicts the biological response of the bacteria populations communicating in the microfluidic environment.\u003C\/p\u003E\u003C\/td\u003E\u003C\/tr\u003E\u003C\/tbody\u003E\u003C\/table\u003E","summary":null,"format":"limited_html"}],"field_subtitle":"","field_summary":[{"value":"\u003Cp\u003E\u0022Dynamics of Molecular Communication in Bacteria within Microfluidic Environments\u0022- Caitlin Austin\u003C\/p\u003E","format":"limited_html"}],"field_summary_sentence":[{"value":"\u0022Dynamics of Molecular Communication in Bacteria within Microfluidic Environments\u0022"}],"uid":"27917","created_gmt":"2015-03-16 14:00:16","changed_gmt":"2017-04-13 21:19:45","author":"Laura Paige","boilerplate_text":"","field_publication":"","field_article_url":"","field_event_time":{"event_time_start":"2015-03-30T17:00:00-04:00","event_time_end":"2015-03-30T19:00:00-04:00","event_time_end_last":"2015-03-30T19:00:00-04:00","gmt_time_start":"2015-03-30 21:00:00","gmt_time_end":"2015-03-30 23:00:00","gmt_time_end_last":"2015-03-30 23:00:00","rrule":null,"timezone":"America\/New_York"},"extras":[],"related_links":[{"url":"http:\/\/pbl.gatech.edu\/","title":"Forest lab"}],"groups":[{"id":"65448","name":"Bioengineering Graduate Program"}],"categories":[],"keywords":[],"core_research_areas":[],"news_room_topics":[],"event_categories":[{"id":"1788","name":"Other\/Miscellaneous"}],"invited_audience":[{"id":"78751","name":"Undergraduate students"},{"id":"174045","name":"Graduate students"}],"affiliations":[],"classification":[],"areas_of_expertise":[],"news_and_recent_appearances":[],"phone":[],"contact":[{"value":"\u003Cp\u003ELaura Paige\u003C\/p\u003E\u003Cp\u003E404-385-6655\u003C\/p\u003E","format":"limited_html"}],"email":[],"slides":[],"orientation":[],"userdata":""}},"358781":{"#nid":"358781","#data":{"type":"event","title":"BioEngineering Graduate Committee Meeting","body":[{"value":"\u003Cp\u003E\u003Cem\u003EThe BioEngineering graduate committee will meet to review\/approve program policies, program faculty applications and submitted student petitions.\u003Cbr \/\u003E\u003Cbr \/\u003EStudent Petitions due to\u0026nbsp;\u003Ca href=\u0022mailto:laura.paige@bioengineering.gatech.edu\u0022\u003ELaura Paige\u003C\/a\u003E\u0026nbsp;no later than: 3\/31\/2015\u003C\/em\u003E\u003C\/p\u003E","summary":null,"format":"limited_html"}],"field_subtitle":"","field_summary":[{"value":"\u003Cp\u003EBioEngineering Graduate Committee Meeting\u003C\/p\u003E","format":"limited_html"}],"field_summary_sentence":[{"value":"\u0022BioEngineering Graduate Committee Meeting\u0022"}],"uid":"27917","created_gmt":"2014-12-18 14:51:49","changed_gmt":"2016-10-08 02:10:51","author":"Laura Paige","boilerplate_text":"","field_publication":"","field_article_url":"","field_event_time":{"event_time_start":"2015-04-08T13:00:00-04:00","event_time_end":"2015-04-08T14:00:00-04:00","event_time_end_last":"2015-04-08T14:00:00-04:00","gmt_time_start":"2015-04-08 17:00:00","gmt_time_end":"2015-04-08 18:00:00","gmt_time_end_last":"2015-04-08 18:00:00","rrule":null,"timezone":"America\/New_York"},"extras":[],"groups":[{"id":"65448","name":"Bioengineering Graduate Program"}],"categories":[],"keywords":[],"core_research_areas":[],"news_room_topics":[],"event_categories":[{"id":"1788","name":"Other\/Miscellaneous"}],"invited_audience":[{"id":"78761","name":"Faculty\/Staff"}],"affiliations":[],"classification":[],"areas_of_expertise":[],"news_and_recent_appearances":[],"phone":[],"contact":[{"value":"\u003Cp\u003ELaura Paige\u003C\/p\u003E\u003Cp\u003E404-385-6655\u003C\/p\u003E","format":"limited_html"}],"email":[],"slides":[],"orientation":[],"userdata":""}},"390771":{"#nid":"390771","#data":{"type":"event","title":"Ph.D Defense Presentation - Alex Chaulk","body":[{"value":"\u003Cp\u003E\u003Cstrong\u003EAlex Caulk\u003C\/strong\u003E\u003Cbr \/\u003EBioE PhD Defense Presentation\u003Cbr \/\u003EApril 8, 2015, 3:00 PM\u003Cbr \/\u003ESuddath Seminar Room (1128), IBB\u003C\/p\u003E\u003Cp\u003E\u003Cstrong\u003E\u003Cbr \/\u003E\u003C\/strong\u003E\u003C\/p\u003E\u003Cp\u003E\u003Cstrong\u003EAdvisor:\u003C\/strong\u003E Rudy Gleason, Ph.D.\u003C\/p\u003E\u003Cp\u003E\u003Cstrong\u003EThesis Committee Members:\u003C\/strong\u003E\u003Cbr \/\u003EManu Platt, Ph.D.\u003Cbr \/\u003EW. Robert Taylor, MD, Ph.D.\u003Cbr \/\u003ERoy Sutliff, Ph.D.\u003Cbr \/\u003EHanjoong Jo, Ph.D.\u003Cbr \/\u003EJ. Brandon Dixon, Ph.D.\u003C\/p\u003E\u003Cp\u003E\u003Cstrong\u003E\u0026nbsp;\u003C\/strong\u003E\u003Cbr class=\u0022Apple-interchange-newline\u0022 \/\u003E\u003Cstrong\u003EBiomechanics and Modeling Methods for Quantifying Mechanically-mediated Disease Progression in Neglected Populations\u003C\/strong\u003E\u003C\/p\u003E\u003Cp class=\u0022p1\u0022\u003EIt is well known that biological tissue grows and remodels in response to changes in mechanical loading. Arteries and lymphatic vessels share many similar mechanical loads including luminal pressure, axial force, and fluid shear force on the endothelium. Diseases of vascular systems have previously been associated with deviations from a hypothesized \u201cpreferred\u201d homeostatic mechanical environment and maladaptive growth and remodeling. Mechanically-mediated disease development affects many populations, but developing nations face challenges that are unique due to disease burdens that are region-specific. Treatment strategies for HIV have resulted in HIV-positive patients living longer lives, but these patients also suffer from non-AIDS-related comorbidities including vascular remodeling and accelerated progression of cardiovascular disease. Similarly, lymphatic filariasis often leads to lymphedema, a condition characterized by tissue swelling and fibrosis as well as remodeling of the lymphatic vasculature. Disease burden in sub-Saharan Africa is due in large part to pathologies such as these; yet, studies investigating the role of biomechanics in disease development in these populations are limited. Thus, the purpose of this dissertation is to develop novel experimental and theoretical frameworks for the study of mechanically-mediated diseases of the arterial and lymphatic vasculature that are commonly seen in developing nations with the ultimate intention of identifying key parameters that contribute to tissue growth and remodeling leading to disease progression.\u003C\/p\u003E","summary":null,"format":"limited_html"}],"field_subtitle":"","field_summary":[{"value":"\u003Cp\u003EPh.D Defense Presentation - \u0022Biomechanics and Modeling Methods for Quantifying Mechanically-mediated Disease Progression in Neglected Populations\u0022 - Alex Chaulk\u003C\/p\u003E","format":"limited_html"}],"field_summary_sentence":[{"value":"Biomechanics and Modeling Methods for Quantifying Mechanically-mediated Disease Progression in Neglected Populations"}],"uid":"27349","created_gmt":"2015-03-26 08:59:25","changed_gmt":"2017-04-13 21:19:39","author":"Floyd Wood","boilerplate_text":"","field_publication":"","field_article_url":"","field_event_time":{"event_time_start":"2015-04-08T16:00:00-04:00","event_time_end":"2015-04-08T18:30:00-04:00","event_time_end_last":"2015-04-08T18:30:00-04:00","gmt_time_start":"2015-04-08 20:00:00","gmt_time_end":"2015-04-08 22:30:00","gmt_time_end_last":"2015-04-08 22:30:00","rrule":null,"timezone":"America\/New_York"},"extras":[],"groups":[{"id":"65448","name":"Bioengineering Graduate Program"}],"categories":[],"keywords":[{"id":"6178","name":"BIOE"},{"id":"569","name":"bioengineering"}],"core_research_areas":[],"news_room_topics":[],"event_categories":[{"id":"1788","name":"Other\/Miscellaneous"}],"invited_audience":[{"id":"78751","name":"Undergraduate students"},{"id":"78761","name":"Faculty\/Staff"},{"id":"174045","name":"Graduate students"}],"affiliations":[],"classification":[],"areas_of_expertise":[],"news_and_recent_appearances":[],"phone":[],"contact":[{"value":"\u003Cp\u003ELaura Paige\u003Cbr \/\u003E404-385-6655\u003C\/p\u003E","format":"limited_html"}],"email":[],"slides":[],"orientation":[],"userdata":""}},"392471":{"#nid":"392471","#data":{"type":"event","title":"PhD Proposal Presentation - Drew Owen","body":[{"value":"\u003Cp\u003ECommittee:\u003C\/p\u003E\u003Cp\u003E\u0026nbsp; \u0026nbsp; \u0026nbsp;Dr. Peter Hesketh, Chair (ME)\u003C\/p\u003E\u003Cp\u003E\u0026nbsp; \u0026nbsp; Dr. Alexander Alexeev (ME)\u003C\/p\u003E\u003Cp\u003E\u0026nbsp; \u0026nbsp; Dr. J. Brandon Dixon (ME)\u003C\/p\u003E\u003Cp\u003E\u0026nbsp; \u0026nbsp; Dr. Hang Lu (ChBE)\u003C\/p\u003E\u003Cp\u003E\u0026nbsp; \u0026nbsp; \u0026nbsp;Dr. Todd Sulchek (ME)\u003C\/p\u003E\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\u003Cp\u003E\u003Cstrong\u003ETitle: Mixing and Sampling in a Microfluidic Channel Using Rotating Magnetic Microbeads\u003C\/strong\u003E\u003C\/p\u003E\u003Cp\u003EThe objective of this research proposal is to create and study the use of a bed of rotating magnetic microbeads (3\u00b5m diameter) in a channel for mixing in a microfluidic channel and for capturing particles from a dilute fluid sample in a microfluidic channel. Rotation of the magnetic microbeads is created by actuating the beads via magnetized pieces of permalloy, an alloy of nickel and iron. These pieces of permalloy will be patterned onto glass wafers via microfacbrication techniques yielding features less than 10\u00b5m in size. The study will involve quantifying the effectiveness of both mixing and capturing using three different geometrical layouts of these features with multiple channel heights. For each geometry and channel height, multiple flowrates will be measured. Mixing will be characterized using two phase flow and quantified by examining the variance in fluorescent intensity. Capture will be quantified by taking real time videos of captured fluorescent particles. Capture of the fluorescent particles is performed by binding of functionalized proteins on the surface of the microbeads and fluorescent particles. This work will be used to build a higher throughput, multiplexed microfluidic device.\u0026nbsp;\u003C\/p\u003E","summary":null,"format":"limited_html"}],"field_subtitle":"","field_summary":[{"value":"\u003Cp\u003EPhD Proposal Presentation-\u0026nbsp;\u0022Mixing and Sampling in a Microfluidic Channel Using Rotating Magnetic Microbeads\u0022- Drew Owen\u003C\/p\u003E","format":"limited_html"}],"field_summary_sentence":[{"value":"\u0022Mixing and Sampling in a Microfluidic Channel Using Rotating Magnetic Microbeads\u0022"}],"uid":"27917","created_gmt":"2015-04-01 09:17:19","changed_gmt":"2017-04-13 21:19:37","author":"Laura Paige","boilerplate_text":"","field_publication":"","field_article_url":"","field_event_time":{"event_time_start":"2015-04-14T12:00:00-04:00","event_time_end":"2015-04-14T14:00:00-04:00","event_time_end_last":"2015-04-14T14:00:00-04:00","gmt_time_start":"2015-04-14 16:00:00","gmt_time_end":"2015-04-14 18:00:00","gmt_time_end_last":"2015-04-14 18:00:00","rrule":null,"timezone":"America\/New_York"},"extras":[],"groups":[{"id":"65448","name":"Bioengineering Graduate Program"}],"categories":[],"keywords":[],"core_research_areas":[],"news_room_topics":[],"event_categories":[{"id":"1788","name":"Other\/Miscellaneous"}],"invited_audience":[{"id":"78751","name":"Undergraduate students"},{"id":"78761","name":"Faculty\/Staff"},{"id":"174045","name":"Graduate students"}],"affiliations":[],"classification":[],"areas_of_expertise":[],"news_and_recent_appearances":[],"phone":[],"contact":[{"value":"\u003Cp\u003ELaura Paige\u003C\/p\u003E\u003Cp\u003E404.385.6655\u003C\/p\u003E","format":"limited_html"}],"email":[],"slides":[],"orientation":[],"userdata":""}},"393421":{"#nid":"393421","#data":{"type":"event","title":"PhD Proposal Presentation- Daniel Porto","body":[{"value":"\u003Cp\u003E\u003Cstrong\u003EAdvisor:\u003C\/strong\u003E\u003C\/p\u003E\u003Cp\u003EHang Lu, Ph.D. (Chemical and Biomolecular Engineering)\u003C\/p\u003E\u003Cp\u003E\u003Cstrong\u003ECommittee Members:\u003C\/strong\u003E\u003C\/p\u003E\u003Cp\u003ERobert Butera, Ph.D. (Electrical and Computer Engineering)\u003C\/p\u003E\u003Cp\u003EPatrick McGrath, Ph.D. (Biology)\u003C\/p\u003E\u003Cp\u003ELena Ting, Ph.D. (Biomedical Engineering)\u003C\/p\u003E\u003Cp\u003EPatricio Vela, Ph.D. (Electrical and Computer Engineering)\u003C\/p\u003E\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\u003Cp\u003E\u003Cstrong\u003ETitle\u003C\/strong\u003E: All-optical white noise analysis of mechanosensory neural circuits in\u0026nbsp;\u003Cem\u003ECaenorhabditis elegans\u003C\/em\u003E\u003C\/p\u003E\u003Cp\u003EProject Summary:\u003C\/p\u003E\u003Cp\u003EThe human brain is a system that processes sensory information from the environment to output behavioral responses. A fundamental question in neuroscience is how the neural circuitry calculates the appropriate output from a given input, or in terms of systems analysis, what are transfer functions that describe this system\u2019s function? A key challenge in answering this question is the overwhelming complexity of this system. Another challenge is acquiring accurate output measurements while simultaneously controlling the input of the system\u003Cem\u003E. C. elegans\u003C\/em\u003E serves as a useful model organism in answering this question by addressing and overcoming both of these issues. First, the \u003Cem\u003EC. elegans\u003C\/em\u003E\u2019 nervous system contains only 302 neurons, and is the only organism that has its entire connectome mapped. Second, it has easily manipulated genetics, high progeny number, and a transparent body, allowing for high-throughput calcium imaging, optogenetics, and behavior tracking experiments. In my thesis, I will develop a platform that can precisely control neuronal activity with optogenetics, while simultaneously measuring neuronal activity with calcium imaging and behavioral output with computer vision tools in order to perform white-noise analysis. This will allow for estimation of impulse responses that characterize \u003Cem\u003EC. elegans\u003C\/em\u003E neural circuitry, providing accurate models of its function. This method will be applied to two mechanosensory circuits in order to compare their spatial and temporal properties.\u0026nbsp;\u003C\/p\u003E","summary":null,"format":"limited_html"}],"field_subtitle":"","field_summary":[{"value":"\u003Cp\u003EPhD Proposal Presentation-\u0026nbsp;\u0022All-optical white noise analysis of mechanosensory neural circuits in Caenorhabditis elegans\u0022- Daniel Porto\u003C\/p\u003E","format":"limited_html"}],"field_summary_sentence":[{"value":"\u0022All-optical white noise analysis of mechanosensory neural circuits in Caenorhabditis elegans\u0022"}],"uid":"27917","created_gmt":"2015-04-03 08:39:15","changed_gmt":"2017-04-13 21:19:34","author":"Laura Paige","boilerplate_text":"","field_publication":"","field_article_url":"","field_event_time":{"event_time_start":"2015-04-15T10:00:00-04:00","event_time_end":"2015-04-15T12:00:00-04:00","event_time_end_last":"2015-04-15T12:00:00-04:00","gmt_time_start":"2015-04-15 14:00:00","gmt_time_end":"2015-04-15 16:00:00","gmt_time_end_last":"2015-04-15 16:00:00","rrule":null,"timezone":"America\/New_York"},"extras":[],"related_links":[{"url":"http:\/\/www.lulab.gatech.edu\/","title":"Lu lab"}],"groups":[{"id":"65448","name":"Bioengineering Graduate Program"}],"categories":[],"keywords":[],"core_research_areas":[],"news_room_topics":[],"event_categories":[{"id":"1788","name":"Other\/Miscellaneous"}],"invited_audience":[{"id":"78751","name":"Undergraduate students"},{"id":"78761","name":"Faculty\/Staff"},{"id":"174045","name":"Graduate students"}],"affiliations":[],"classification":[],"areas_of_expertise":[],"news_and_recent_appearances":[],"phone":[],"contact":[{"value":"\u003Cp\u003ELaura Paige\u003C\/p\u003E\u003Cp\u003E404-385-6655\u003C\/p\u003E","format":"limited_html"}],"email":[],"slides":[],"orientation":[],"userdata":""}},"394541":{"#nid":"394541","#data":{"type":"event","title":"BioE MS Thesis Presentation- Max Jordan Nguemeni Tiako","body":[{"value":"\u003Cp\u003ECommittee: Chair: Dr. David Ku, (ME, BioE) Georgia Institute of Technology\u003C\/p\u003E\u003Cp\u003E\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp; Dr. Nick Willett (BME, BioE, Department of Orthopedics) Emory University, Georgia Institute of Technology\u003C\/p\u003E\u003Cp\u003E\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp; Dr. Joseph Williams (Department of Surgery) Emory University\u003C\/p\u003E\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\u003Cp\u003EDesign of Maxillofacial Implants for Cosmetic and Reconstructive Procedures \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp;\u0026nbsp;\u003C\/p\u003E\u003Cp\u003EMaxillofacial surgery can be used to help appearance and restore function.\u0026nbsp; Often there is a need to provide additional volume with soft tissue properties. This works explores the use of a new biomaterial invented at GT with soft tissue properties as possible maxillofacial implants to provide volume.\u0026nbsp; The implants are for restoring speech function in cleft palate patients presenting velopharyngeal insufficiency and providing volume to reduce the nasolabial folds in order to create a more youthful appearance.\u0026nbsp;\u003C\/p\u003E\u003Cp\u003EWe have developed facial implants for the nasolabial fold and lip plumping to address low efficiency of the current methods employed for dermal fillers by providing both long-term usage as well as removability. Furthermore, an insertion method and insertion tools were developed to facilitate the implantation for the surgeons.\u003C\/p\u003E\u003Cp\u003ERegarding the reconstructive aspects of the maxillofacial implants, we have developed a pharyngeal implant aiming to reduce the gap between the pharyngeal implant and the velum (soft palate) of 20% of patients presenting a cleft palate. This implant will allow the care team to delay the palatoplasty in order to not hinder palatal growth in patients. The material used for the implants can also be used to better the current obturators by replacing the acrylic, posterior portion. The main current obturators are the nance obturator and custom acrylic obturators, deemed uncomfortable for the patients due to the hardness of the material. The design process for the implants and the novel obturator involved the optimization of material and shape, taking into consideration mechanical properties of the implants\u2019 surrounding tissues, the anatomy of each feature being enhanced as well as potential implantation modes.\u0026nbsp;\u003C\/p\u003E","summary":null,"format":"limited_html"}],"field_subtitle":"","field_summary":[{"value":"\u003Cp\u003EMS Thesis Presentation-\u0026nbsp;\u0022Design of Maxillofacial Implants for Cosmetic and Reconstructive Procedures\u0022- Max Jordan Nguemeni Tiako\u003C\/p\u003E","format":"limited_html"}],"field_summary_sentence":[{"value":"\u0022Design of Maxillofacial Implants for Cosmetic and Reconstructive Procedures\u0022"}],"uid":"27917","created_gmt":"2015-04-08 09:01:04","changed_gmt":"2017-04-13 21:19:31","author":"Laura Paige","boilerplate_text":"","field_publication":"","field_article_url":"","field_event_time":{"event_time_start":"2015-04-20T18:00:00-04:00","event_time_end":"2015-04-20T20:00:00-04:00","event_time_end_last":"2015-04-20T20:00:00-04:00","gmt_time_start":"2015-04-20 22:00:00","gmt_time_end":"2015-04-21 00:00:00","gmt_time_end_last":"2015-04-21 00:00:00","rrule":null,"timezone":"America\/New_York"},"extras":[],"groups":[{"id":"65448","name":"Bioengineering Graduate Program"}],"categories":[],"keywords":[],"core_research_areas":[],"news_room_topics":[],"event_categories":[{"id":"1788","name":"Other\/Miscellaneous"}],"invited_audience":[{"id":"78751","name":"Undergraduate students"},{"id":"78761","name":"Faculty\/Staff"},{"id":"174045","name":"Graduate students"}],"affiliations":[],"classification":[],"areas_of_expertise":[],"news_and_recent_appearances":[],"phone":[],"contact":[{"value":"\u003Cp\u003ELaura Paige\u003C\/p\u003E\u003Cp\u003E404-385-6655\u003C\/p\u003E","format":"limited_html"}],"email":[],"slides":[],"orientation":[],"userdata":""}},"395071":{"#nid":"395071","#data":{"type":"event","title":"PhD Defense Presentation- Michael Weiler","body":[{"value":"\u003Cp\u003E\u003Cstrong\u003EAdvisor: J. Brandon Dixon,\u0026nbsp;PhD\u003C\/strong\u003E\u003C\/p\u003E\u003Cp\u003ESchool of Mechanical Engineering, Georgia Institute of Technology\u003C\/p\u003E\u003Cp\u003E\u003Cstrong\u003ECo-Advisor\u003C\/strong\u003E:\u0026nbsp;\u003Cstrong\u003EEdward Botchwey, Ph.D. -\u0026nbsp;\u003C\/strong\u003EDepartment\u0026nbsp;of Biomedical Engineering, Georgia Institute of Technology\u003C\/p\u003E\u003Cp\u003E\u003Cstrong\u003E\u0026nbsp;\u003C\/strong\u003E\u003C\/p\u003E\u003Cp\u003E\u003Cstrong\u003ECommittee:\u003C\/strong\u003E\u003C\/p\u003E\u003Cp\u003E\u003Cstrong\u003EThomas Barker, Ph.D. -\u003C\/strong\u003E\u0026nbsp;Department\u0026nbsp;of Biomedical Engineering, Georgia Institute of Technology\u003C\/p\u003E\u003Cp\u003E\u003Cstrong\u003EStanley Rockson, M.D. - \u003C\/strong\u003EStanford School of Medicine\u003C\/p\u003E\u003Cp\u003E\u003Cstrong\u003ETodd Sulchek, Ph.D. -\u0026nbsp;\u003C\/strong\u003ESchool of Mechanical Engineering,\u0026nbsp;Georgia Institute of Technology\u003C\/p\u003E\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\u003Cp align=\u0022center\u0022\u003E\u201c\u003Cstrong\u003EDesign and Optimization of Near-Infrared Functional Lymphatic Imaging in Health and Lymphedema\u003C\/strong\u003E\u201d\u003C\/p\u003E\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\u003Cp\u003EThe lymphatic vasculature is present in nearly all tissues of the body and serves three primary functions: (1) regulation of tissue fluid homeostasis through the transport of large proteins and excess interstitial fluid,\u0026nbsp;\u0026nbsp;(2) immune cell trafficking, and (3) lipid transport.\u0026nbsp;\u0026nbsp;When the normal function of the lymphatic system deteriorates, many complications can arise.\u0026nbsp;\u0026nbsp;Loss of lymphatic pump function often leads to tissue fluid accumulation, fibrosis, and lipid deposition \u2013 a disease known as lymphedema.\u0026nbsp;\u0026nbsp;Despite the critical roles that it performs, very little is known about the lymphatic vasculature in comparison to the blood vasculature.\u0026nbsp;\u0026nbsp;One of the main reasons for this knowledge gap may be the lack of in vivo imaging techniques to non-invasively visualize and obtain quantifiable information regarding lymphatic function, both in health and disease.\u0026nbsp;\u0026nbsp;New techniques are needed to better study lymphatic biology, elucidate the functional role of lymphatics and lymphangiogenesis in health and disease conditions, and better diagnose patients with lymphatic disease at an early stage before any resulting tissue damage is permanent.\u003C\/p\u003E\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\u003Cp\u003ENear-infrared (NIR) lymphatic imaging has emerged as a new technology for imaging of lymphatic architecture and quantification of vessel function.\u0026nbsp;\u0026nbsp;Although the technique has shown very exciting early results, the technique remains immature and several enhancements specifically for lymphatic imaging and functional quantification remain necessary.\u0026nbsp;\u0026nbsp;Therefore, we have characterized and optimized NIR imaging specifically for lymphatic vessels through a physical and physiological approach.\u0026nbsp;\u0026nbsp;Furthermore, the enhanced NIR lymphatic imaging technique was performed in the context of a novel rodent model of lymphedema to evaluate and characterize the role of lymphatic vessel function in the progression of the disease.\u003C\/p\u003E","summary":null,"format":"limited_html"}],"field_subtitle":"","field_summary":[{"value":"\u003Cp\u003EPhD Defense Presentation-\u0026nbsp;\u0022Design and Optimization of Near-Infrared Functional Lymphatic Imaging in Health and Lymphedema\u0022- Michael Weiler\u003C\/p\u003E","format":"limited_html"}],"field_summary_sentence":[{"value":"\u0022Design and Optimization of Near-Infrared Functional Lymphatic Imaging in Health and Lymphedema\u0022"}],"uid":"27917","created_gmt":"2015-04-09 14:54:21","changed_gmt":"2017-04-13 21:19:31","author":"Laura Paige","boilerplate_text":"","field_publication":"","field_article_url":"","field_event_time":{"event_time_start":"2015-04-23T16:00:00-04:00","event_time_end":"2015-04-23T18:00:00-04:00","event_time_end_last":"2015-04-23T18:00:00-04:00","gmt_time_start":"2015-04-23 20:00:00","gmt_time_end":"2015-04-23 22:00:00","gmt_time_end_last":"2015-04-23 22:00:00","rrule":null,"timezone":"America\/New_York"},"extras":[],"related_links":[{"url":"http:\/\/llbb.gatech.edu\/Home.html","title":"Dixon lab website"}],"groups":[{"id":"65448","name":"Bioengineering Graduate Program"}],"categories":[],"keywords":[],"core_research_areas":[],"news_room_topics":[],"event_categories":[{"id":"1788","name":"Other\/Miscellaneous"}],"invited_audience":[{"id":"78751","name":"Undergraduate students"},{"id":"78761","name":"Faculty\/Staff"},{"id":"174045","name":"Graduate students"}],"affiliations":[],"classification":[],"areas_of_expertise":[],"news_and_recent_appearances":[],"phone":[],"contact":[{"value":"\u003Cp\u003ELaura Paige\u0026nbsp;\u003C\/p\u003E\u003Cp\u003E404-385-6655\u003C\/p\u003E","format":"limited_html"}],"email":[],"slides":[],"orientation":[],"userdata":""}},"355411":{"#nid":"355411","#data":{"type":"event","title":"BioE Day","body":[{"value":"\u003Cp\u003E\u0026nbsp;BioE Day has been established to celebrate the excellence in science that our students and faculty demonstrate as well as build community between both students and faculty.\u003Cbr \/\u003E\u003Cbr \/\u003ECome and learn about the opportunities and resources available to BioE graduate students at Georgia Tech, such as scholarships, fellowships and joint programs.\u0026nbsp;\u003Cbr \/\u003E\u003Cbr \/\u003EAll students and faculty associated with BioE are invited to attend.\u003C\/p\u003E","summary":null,"format":"limited_html"}],"field_subtitle":"","field_summary":[{"value":"\u003Cp\u003EBioE Day has been established to celebrate the excellence in science that our students and faculty demonstrate as well as build community between both students and faculty. All students and faculty associated with BioE are invited to attend.\u003C\/p\u003E","format":"limited_html"}],"field_summary_sentence":[{"value":"Second annual event is a showcase for science and opportunity to build community between students and faculty"}],"uid":"27917","created_gmt":"2014-12-12 15:54:36","changed_gmt":"2017-04-13 21:20:54","author":"Laura Paige","boilerplate_text":"","field_publication":"","field_article_url":"","field_event_time":{"event_time_start":"2015-04-30T14:00:00-04:00","event_time_end":"2015-04-30T19:00:00-04:00","event_time_end_last":"2015-04-30T19:00:00-04:00","gmt_time_start":"2015-04-30 18:00:00","gmt_time_end":"2015-04-30 23:00:00","gmt_time_end_last":"2015-04-30 23:00:00","rrule":null,"timezone":"America\/New_York"},"extras":[],"groups":[{"id":"65448","name":"Bioengineering Graduate Program"}],"categories":[],"keywords":[{"id":"248","name":"IBB"}],"core_research_areas":[],"news_room_topics":[],"event_categories":[{"id":"10377","name":"Career\/Professional development"},{"id":"1788","name":"Other\/Miscellaneous"},{"id":"1791","name":"Student sponsored"}],"invited_audience":[{"id":"78751","name":"Undergraduate students"},{"id":"78761","name":"Faculty\/Staff"},{"id":"78771","name":"Public"},{"id":"174045","name":"Graduate students"}],"affiliations":[],"classification":[],"areas_of_expertise":[],"news_and_recent_appearances":[],"phone":[],"contact":[],"email":[],"slides":[],"orientation":[],"userdata":""}},"400981":{"#nid":"400981","#data":{"type":"event","title":"PhD Proposal Presentation - Tel Rouse","body":[{"value":"\u003Cp\u003E\u003Cstrong\u003EAdvisor:\u003C\/strong\u003E \u003Cstrong\u003EHang Lu, Ph.D. \u003C\/strong\u003E(Georgia Institute of Technology)\u003C\/p\u003E\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\u003Cp\u003E\u003Cstrong\u003ECommittee: \u003C\/strong\u003E\u003C\/p\u003E\u003Cp\u003E\u003Cstrong\u003EPatrick McGrath, Ph.D.\u003C\/strong\u003E (Georgia Institute of Technology)\u003C\/p\u003E\u003Cp\u003E\u003Cstrong\u003ERobert Butera, Ph.D.\u003C\/strong\u003E (Georgia Institute of Technology)\u003C\/p\u003E\u003Cp\u003E\u003Cstrong\u003EMark Stycyznski, Ph.D.\u003C\/strong\u003E (Georgia Institute of Technology)\u003C\/p\u003E\u003Cp\u003E\u003Cstrong\u003EYun Zhang, Ph.D.\u003C\/strong\u003E (Harvard University)\u003C\/p\u003E\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\u003Cp align=\u0022center\u0022\u003E\u003Cstrong\u003EA High-Throughput Microfluidic Platform for High-Content\u003C\/strong\u003E\u003C\/p\u003E\u003Cp align=\u0022center\u0022\u003E\u003Cstrong\u003ELearning Studies in \u003Cem\u003EC. elegans\u003C\/em\u003E\u003C\/strong\u003E\u003C\/p\u003E\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\u003Cp\u003ELearning is a complex process governed by many genetic and environmental factors. \u003Cem\u003EC. elegans\u003C\/em\u003E serves as a useful model organism for learning studies, as it contains a simple nervous system with only 302 neurons, and yet exhibits a large repertoire of behaviors, including learning and memory. My thesis aims to develop a platform for high-throughput learning-phenotype classification through the extraction and analysis of high-content behavioral data. The platform will consist of a microfluidic behavioral arena to provide a standardized and finely tunable closed-loop assay environment to detect preference changes due to learning. Hardware and software will enable simultaneous multiple-animal behavioral tracking as animals navigate through their environment during the learning assays. Methodologies will be developed to extract relevant behavioral features and subsequently quantify learning phenotypes based on the temporal, feature-rich behavioral data. The platform will be utilized to assess the roles, interactions, and functional effects of a putative insulin-like peptide (ILP) network on pathogenic learning in \u003Cem\u003EC. elegans\u003C\/em\u003E. This platform will improve learning-phenotype classification through advancements in microenvironment standardization, presentation of dynamic spatial stimuli, and the amount of information collected. Additionally, this high-content information can be used to better infer putative biological mechanisms from observed morphologies.\u003C\/p\u003E","summary":null,"format":"limited_html"}],"field_subtitle":"","field_summary":[{"value":"\u003Cp\u003EPhD Proposal Presentation-\u0026nbsp;\u0022A High-Throughput Microfluidic Platform for High-Content Learning Studies in C. elegans\u0022- Tel Rouse\u003C\/p\u003E","format":"limited_html"}],"field_summary_sentence":[{"value":"\u0022A High-Throughput Microfluidic Platform for High-Content Learning Studies in C. elegans\u0022"}],"uid":"27917","created_gmt":"2015-05-01 10:32:43","changed_gmt":"2017-04-13 21:19:22","author":"Laura Paige","boilerplate_text":"","field_publication":"","field_article_url":"","field_event_time":{"event_time_start":"2015-05-13T11:00:00-04:00","event_time_end":"2015-05-13T13:00:00-04:00","event_time_end_last":"2015-05-13T13:00:00-04:00","gmt_time_start":"2015-05-13 15:00:00","gmt_time_end":"2015-05-13 17:00:00","gmt_time_end_last":"2015-05-13 17:00:00","rrule":null,"timezone":"America\/New_York"},"extras":[],"related_links":[{"url":"http:\/\/www.lulab.gatech.edu\/","title":"Lu lab"}],"groups":[{"id":"65448","name":"Bioengineering Graduate Program"}],"categories":[],"keywords":[],"core_research_areas":[],"news_room_topics":[],"event_categories":[{"id":"1788","name":"Other\/Miscellaneous"}],"invited_audience":[{"id":"78751","name":"Undergraduate students"},{"id":"78761","name":"Faculty\/Staff"},{"id":"174045","name":"Graduate students"}],"affiliations":[],"classification":[],"areas_of_expertise":[],"news_and_recent_appearances":[],"phone":[],"contact":[{"value":"\u003Cp\u003ELaura Paige\u003C\/p\u003E","format":"limited_html"}],"email":[],"slides":[],"orientation":[],"userdata":""}},"399251":{"#nid":"399251","#data":{"type":"event","title":"PhD Proposal Presentation - Prem Midha","body":[{"value":"\u003Cp\u003E\u003Cstrong\u003EAdvisor:\u003C\/strong\u003E\u003C\/p\u003E\u003Cp\u003EAjit P. Yoganathan, PhD- Georgia Institute of Technology, Atlanta, GA\u003Cstrong\u003E\u0026nbsp;\u003C\/strong\u003E\u003C\/p\u003E\u003Cp\u003E\u003Cstrong\u003ECommittee Members:\u003C\/strong\u003E\u003C\/p\u003E\u003Cp\u003EVasilis Babaliaros, M.D. Emory University, Atlanta, GA\u003C\/p\u003E\u003Cp\u003EGautam Kumar, M. D.\u003Csup\u003E- \u003C\/sup\u003EAtlanta VA Medical Center, Atlanta, GA.\u003C\/p\u003E\u003Cp\u003EWei Sun, PhD\u003Csup\u003E -\u003C\/sup\u003EGeorgia Institute of Technology, Atlanta, GA\u003C\/p\u003E\u003Cp\u003ECyrus Aidun, PhD-Georgia Institute of Technology, Atlanta, GA\u003C\/p\u003E\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\u003Cp\u003E\u003Cstrong\u003ETitle:\u003C\/strong\u003E A Parametric Investigation of Aortic Valve-in-Valve Performance\u003C\/p\u003E\u003Cp\u003E\u003Cstrong\u003E\u0026nbsp;\u003C\/strong\u003E\u003C\/p\u003E\u003Cp\u003EWith recent advances in transcatheter aortic valve replacement (TAVR), off-label use of these devices is increasing, posing unknown risks to patients.\u0026nbsp; Clinicians who are using these devices in an off-label manner are doing so with limited basis for judgment except experience. In recent years, with an aging population of surgical aortic valve replacement (SAVR) patients, it is becoming increasingly more common to correct a failing bioprosthesis with a TAVR in a procedure known as valve-in-valve (VIV). It should be clearly noted that based on ISO Failure Mode Effect Analysis standards (5840-2,3) and FDA 201X Heart Valve guidelines, the design intent of the current generation of TAVR designs does not address VIV use. Furthermore, the Valve-in-Valve International Data Registry documents a number of hemodynamic and structural complications associated with this type of off-label use, which may compromise patient safety. Providing clinicians with an engineering basis to compliment an otherwise experience-based decision making process could lead to even more favorable patient outcomes. Based on generalized valve characteristics, this study aims to clarify what type, size, and deployment positioning of a TAVR will yield the most favorable performance evaluated by 1) hemodynamic pressures and flows, 2) flow field characterization via high-speed particle image velocimetry (PIV) and particle tracking, 3) level of sinus obstruction via trans-TAVR gradient, 4) valve dynamics via high-speed en face photogrammetry, and 5) migration risk through uniaxial pullout force measurements and elevated cardiac output conditions.\u0026nbsp; The results of this study will help better inform the VIV procedural decision-making process.\u003C\/p\u003E","summary":null,"format":"limited_html"}],"field_subtitle":"","field_summary":[{"value":"\u003Cp\u003EPhD Proposal Presentation-\u0026nbsp;\u0022A Parametric Investigation of Aortic Valve-in-Valve Performance\u0022- Prem Midha\u003C\/p\u003E","format":"limited_html"}],"field_summary_sentence":[{"value":"\u0022A Parametric Investigation of Aortic Valve-in-Valve Performance\u0022"}],"uid":"27917","created_gmt":"2015-04-24 15:32:53","changed_gmt":"2017-04-13 21:19:24","author":"Laura Paige","boilerplate_text":"","field_publication":"","field_article_url":"","field_event_time":{"event_time_start":"2015-05-21T16:00:00-04:00","event_time_end":"2015-05-21T18:00:00-04:00","event_time_end_last":"2015-05-21T18:00:00-04:00","gmt_time_start":"2015-05-21 20:00:00","gmt_time_end":"2015-05-21 22:00:00","gmt_time_end_last":"2015-05-21 22:00:00","rrule":null,"timezone":"America\/New_York"},"extras":[],"related_links":[{"url":"http:\/\/groups.bme.gatech.edu\/groups\/cfmg\/group\/home.htm","title":"Yoganathan lab"}],"groups":[{"id":"65448","name":"Bioengineering Graduate Program"}],"categories":[],"keywords":[],"core_research_areas":[],"news_room_topics":[],"event_categories":[{"id":"1788","name":"Other\/Miscellaneous"}],"invited_audience":[{"id":"78751","name":"Undergraduate students"},{"id":"78761","name":"Faculty\/Staff"},{"id":"174045","name":"Graduate students"}],"affiliations":[],"classification":[],"areas_of_expertise":[],"news_and_recent_appearances":[],"phone":[],"contact":[{"value":"\u003Cp\u003ELaura Paige\u003C\/p\u003E\u003Cp\u003E404.385.6655\u003C\/p\u003E","format":"limited_html"}],"email":[],"slides":[],"orientation":[],"userdata":""}},"403031":{"#nid":"403031","#data":{"type":"event","title":"PhD Proposal Presentation - Gregory Holst","body":[{"value":"\u003Cp\u003E\u003Cstrong\u003EAdvisor\u003C\/strong\u003E: Craig R. Forest, PhD (Georgia Institute of Technology, Mechanical Engineering)\u003C\/p\u003E\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\u003Cp\u003E\u003Cstrong\u003ECommittee Members\u003C\/strong\u003E:\u003C\/p\u003E\u003Cp\u003EGarrett B.\u0026nbsp;Stanley, PhD (Georgia Institute of Technology, Biomedical Engineering)\u003C\/p\u003E\u003Cp\u003ETodd Sulchek, PhD (Georgia Institute of Technology, Mechanical Engineering)\u003C\/p\u003E\u003Cp\u003EHongkui Zeng, PhD (Allen Institute for Brain Science)\u003C\/p\u003E\u003Cp\u003EEdward S. Boyden, PhD \u0026nbsp;(Massachusetts Institute of Technology, Biological Engineering and Brain and Cognitive Sciences)\u003C\/p\u003E\u003Cp\u003ESuhasa B. Kodandaramaiah, PhD (University of Minnesota, Mechanical Engineering)\u003C\/p\u003E\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\u003Cp\u003E\u003Cstrong\u003EIn vivo serial patch clamp robotics for cell type identification in the mouse visual cortex\u003C\/strong\u003E\u003C\/p\u003E\u003Cp\u003EPatch-clamping, the gold standard technique for measuring trans-membrane voltages and currents in neurons, involves delicately resting a 1 \u03bcm diameter pipette against a cell to create an intimate electrical and mechanical connection between the pipette tip and the cell membrane. From there, it is possible to record essentially interference-free single-neuron \u201cspikes\u201d in membrane voltage. These spikes are the primary method of inter-neuronal communication in the nervous system.\u003C\/p\u003E\u003Cp\u003E\u0026nbsp;The experimental procedure to obtain these high-fidelity recordings is considered an art form performed in vivo by a small number of highly trained individuals.\u0026nbsp; Previous work has introduced mechanical and electrical automation techniques, or \u0022autopatching,\u0022 to reduce the cognitive load and the required training to obtain these recordings, but the low yield is still a major limitation and requires many attempts to obtain a single recording. \u0026nbsp;\u003C\/p\u003E\u003Cp\u003E\u0026nbsp;This work introduces additional robotic tools to completely automate serial patch clamp recording attempts.\u0026nbsp; Electrical and mechanical hardware and software algorithms have been developed to automate pipette manipulation, specifically, pneumatic control, electrical control, precise positioning, replacement, filling, wire threading, and storage.\u0026nbsp; Taken together, these tools enable the first completely autonomous, serial patch clamp recording attempts in the living brain.\u003C\/p\u003E\u003Cp\u003E\u0026nbsp;These robotic tools also enable more difficult experiments that combine patch clamp recording with other techniques such as biocytin filling for morphological reconstruction.\u0026nbsp; Progress towards a survey of 50 cells in the visual cortex will be presented to establish cell type identification schemes based on coupled electrophysiology and morphology.\u003C\/p\u003E\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E","summary":null,"format":"limited_html"}],"field_subtitle":"","field_summary":[{"value":"\u003Cp\u003EPhD Proposal Presentation-\u0026nbsp;\u0022In vivo serial patch clamp robotics for cell type identification in the mouse visual cortex\u0022- Gregory Holst\u003C\/p\u003E","format":"limited_html"}],"field_summary_sentence":[{"value":"\u0022In vivo serial patch clamp robotics for cell type identification in the mouse visual cortex\u0022"}],"uid":"27917","created_gmt":"2015-05-08 11:27:29","changed_gmt":"2017-04-13 21:19:21","author":"Laura Paige","boilerplate_text":"","field_publication":"","field_article_url":"","field_event_time":{"event_time_start":"2015-05-21T14:00:00-04:00","event_time_end":"2015-05-21T16:00:00-04:00","event_time_end_last":"2015-05-21T16:00:00-04:00","gmt_time_start":"2015-05-21 18:00:00","gmt_time_end":"2015-05-21 20:00:00","gmt_time_end_last":"2015-05-21 20:00:00","rrule":null,"timezone":"America\/New_York"},"extras":[],"related_links":[{"url":"http:\/\/pbl.gatech.edu\/","title":"Forest lab"}],"groups":[{"id":"65448","name":"Bioengineering Graduate Program"}],"categories":[],"keywords":[],"core_research_areas":[],"news_room_topics":[],"event_categories":[{"id":"1788","name":"Other\/Miscellaneous"}],"invited_audience":[{"id":"78751","name":"Undergraduate students"},{"id":"78761","name":"Faculty\/Staff"},{"id":"174045","name":"Graduate students"}],"affiliations":[],"classification":[],"areas_of_expertise":[],"news_and_recent_appearances":[],"phone":[],"contact":[{"value":"\u003Cp\u003ELaura Paige\u003C\/p\u003E\u003Cp\u003E404-385-6655\u003C\/p\u003E","format":"limited_html"}],"email":[],"slides":[],"orientation":[],"userdata":""}},"355371":{"#nid":"355371","#data":{"type":"event","title":"BioEngineering Program Faculty Meeting","body":[{"value":"\u003Cp\u003E\u003Cem\u003EThe BioEngineering Program faculty meet regularly during the semester to address program policies, events and future research and academic directions.\u003C\/em\u003E\u003C\/p\u003E","summary":null,"format":"limited_html"}],"field_subtitle":"","field_summary":[{"value":"\u003Cp\u003E\u003Cem\u003EProgram policies, events and directions to be discussed\u003C\/em\u003E\u003C\/p\u003E","format":"limited_html"}],"field_summary_sentence":[{"value":"BioEngineering Program Faculty Meeting"}],"uid":"27917","created_gmt":"2014-12-12 15:44:37","changed_gmt":"2016-10-08 02:10:47","author":"Laura Paige","boilerplate_text":"","field_publication":"","field_article_url":"","field_event_time":{"event_time_start":"2015-05-22T12:00:00-04:00","event_time_end":"2015-05-22T13:00:00-04:00","event_time_end_last":"2015-05-22T13:00:00-04:00","gmt_time_start":"2015-05-22 16:00:00","gmt_time_end":"2015-05-22 17:00:00","gmt_time_end_last":"2015-05-22 17:00:00","rrule":null,"timezone":"America\/New_York"},"extras":[],"groups":[{"id":"65448","name":"Bioengineering Graduate Program"}],"categories":[],"keywords":[],"core_research_areas":[],"news_room_topics":[],"event_categories":[{"id":"1788","name":"Other\/Miscellaneous"}],"invited_audience":[{"id":"78761","name":"Faculty\/Staff"}],"affiliations":[],"classification":[],"areas_of_expertise":[],"news_and_recent_appearances":[],"phone":[],"contact":[{"value":"\u003Cp\u003ELaura Paige\u003C\/p\u003E\u003Cp\u003E404-385-6655\u003C\/p\u003E","format":"limited_html"}],"email":[],"slides":[],"orientation":[],"userdata":""}},"404081":{"#nid":"404081","#data":{"type":"event","title":"BioE PhD Defense Announcement: Timothy Kassis","body":[{"value":"\u003Cp\u003E\u003Cstrong\u003EAdvisor: J. Brandon Dixon, Ph.D.\u003C\/strong\u003E (Georgia Institute of Technology)\u003C\/p\u003E\u003Cp\u003E\u003Cstrong\u003ECommittee:\u003C\/strong\u003E\u003C\/p\u003E\u003Cp\u003E\u003Cstrong\u003ELaura O\u2019Farrell, Ph.D.\u003C\/strong\u003E (Georgia Institute of Technology)\u003Cbr \/\u003E \u003Cstrong\u003EW. Robert Taylor, Ph.D., M.D.\u003C\/strong\u003E (Georgia Institute of Technology and Emory University)\u003Cbr \/\u003E \u003Cstrong\u003EPhilip Santangelo, Ph.D.\u003C\/strong\u003E (Georgia Institute of Technology and Emory University)\u003Cbr \/\u003E \u003Cstrong\u003EAnatoliy Gashev, Ph.D., M.D., D.MSci.\u003C\/strong\u003E (Texas A\u0026amp;M University)\u003C\/p\u003E\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\u003Cp align=\u0022center\u0022\u003E\u003Cstrong\u003EQuantifying the Role of Lymphatics in Lipid Transport and Lymphatic Filariasis Using Novel Engineering Approaches\u003C\/strong\u003E\u003C\/p\u003E\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\u003Cp\u003EThe lymphatic system has fundamental physiological roles in maintaining fluid homeostasis, immune cell trafficking and lipid transport from the small intestine to the venous circulation. Lymphatic vessels are the main functional organ responsible for the diverse transport roles the system plays. Unlike the blood vasculature, the lymphatic system does not have a central pump, such as the heart, and relies on a variety of factors to move lymph through. It was long thought that only external factors, such as skeletal muscle contraction and lymph formation, played a role in the functional transport capacity of these vessels. With the advancement of imaging capabilities (both hardware and software), it has become clear in the past two decades or so that the main factor in driving lymph transport is the ability of these vessels to intrinsically contract whereby each vessel is comprised of a chain of `mini pumps\u0027 in series. The functional capacity of these vessels is thus now understood to be primarily determined by this pumping activity that has been shown to be regulated by various mechanical and biochemical cues. Lymphatic vessel dysfunction has been implicated in a variety of diseases including many lipid related pathologies and a neglected tropical disease known as lymphatic filariasis. While it has been possible to study the vessel function in the context of fluid drainage and immune cell trafficking, the capability to understand the role of lymphatic vessels in lipid transport has not been available due to the lack of experimental animal models and acquisition systems. As part of this thesis, we sought to develop an experimental animal model along with hardware and software tools to investigate the interplay between lymphatics and their lipid content. We report the first functional measurements of how vessels respond to elevated lipid loads. We further utilized our engineering expertise to develop an experimental platform allowing us to further understand the parasite known as \u003Cem\u003EB. malayi\u003C\/em\u003E that migrates to and resides in lymphatic vessels.\u003C\/p\u003E","summary":null,"format":"limited_html"}],"field_subtitle":"","field_summary":[{"value":"\u003Cp\u003EPhD Defense Presentation-\u0026nbsp;\u0022Quantifying the Role of Lymphatics in Lipid Transport and Lymphatic Filariasis Using Novel Engineering Approaches\u0022- Timothy Kassis\u003C\/p\u003E","format":"limited_html"}],"field_summary_sentence":[{"value":"\u0022Quantifying the Role of Lymphatics in Lipid Transport and Lymphatic Filariasis Using Novel Engineering Approaches\u0022"}],"uid":"27917","created_gmt":"2015-05-12 15:54:50","changed_gmt":"2017-04-13 21:19:20","author":"Laura Paige","boilerplate_text":"","field_publication":"","field_article_url":"","field_event_time":{"event_time_start":"2015-05-26T16:00:00-04:00","event_time_end":"2015-05-26T18:00:00-04:00","event_time_end_last":"2015-05-26T18:00:00-04:00","gmt_time_start":"2015-05-26 20:00:00","gmt_time_end":"2015-05-26 22:00:00","gmt_time_end_last":"2015-05-26 22:00:00","rrule":null,"timezone":"America\/New_York"},"extras":[],"related_links":[{"url":"http:\/\/llbb.gatech.edu\/Home.html","title":"Dixon lab website"}],"groups":[{"id":"65448","name":"Bioengineering Graduate Program"}],"categories":[],"keywords":[],"core_research_areas":[],"news_room_topics":[],"event_categories":[{"id":"1788","name":"Other\/Miscellaneous"}],"invited_audience":[{"id":"78751","name":"Undergraduate students"},{"id":"78761","name":"Faculty\/Staff"},{"id":"174045","name":"Graduate students"}],"affiliations":[],"classification":[],"areas_of_expertise":[],"news_and_recent_appearances":[],"phone":[],"contact":[{"value":"\u003Cp\u003ELaura Paige\u003C\/p\u003E\u003Cp\u003E404-385-6655\u003C\/p\u003E","format":"limited_html"}],"email":[],"slides":[],"orientation":[],"userdata":""}},"372271":{"#nid":"372271","#data":{"type":"event","title":"PhD Proposal Presentation- Marcus Walker","body":[{"value":"\u003Cp\u003ECommittee Members:\u0026nbsp;\u003C\/p\u003E\u003Cp\u003EAdvisor: Brani Vidakovic, PhD (ISyE\/BME, Georgia Tech)\u003C\/p\u003E\u003Cp\u003ECo-Advisor: Douglas Robertson, MD, PhD (BME, Georgia Tech\/Emory)\u003C\/p\u003E\u003Cp\u003EGary May, PhD (ECE, Georgia Tech)\u003C\/p\u003E\u003Cp\u003EBarbara Boyan, PhD (VCU)\u003C\/p\u003E\u003Cp\u003EJoseph Williams, MD (CHOA)\u003C\/p\u003E\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\u003Cp\u003ETitle:\u0026nbsp;Craniosynostosis developmental quantification and severity assessment\u003C\/p\u003E\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\u003Cp\u003EAbstract:\u003C\/p\u003E\u003Cp\u003EQuantifying disease progression is one the most difficult challenges facing physicians as they look to provide the most effective treatment customized for individual patients especially in the case of surgical intervention. In more severe cases of craniosynostosis, when the cranial sutures between the bone plates prematurely fuse causing a constriction of skull development, surgery is often pursued to correct the deformity, but the optimal timing and technique of this surgery is not well characterized as well as the cause of postoperative complications.\u003C\/p\u003E\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\u003Cp\u003EThe goal of this project is to develop computational algorithms that provide a comprehensive analysis of individual pediatric skulls in preparation for surgery using their CT scans and provide insights into what makes specific cases more severe than others. These same analytics are then used more broadly to evaluate normal and abnormal cranial development in the different forms of craniosynostosis. Then utilizing these cranial features and clinical information from a large patient population, predictive models will be developed for the identification of risk factors and severity markers related to postoperative intracranial pressure and resynostosis of the fused suture or other sutures. These outcomes are especially important because patients with these complications frequently seek successive follow-up surgeries for additional correction.\u003C\/p\u003E\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\u003Cp\u003EThis comprehensive analysis of the skull is proposed through characterizing the intracranial volume asymmetries and measuring the cranial sutures from preoperative CT scans for synostosis differentiation and severity. Then the bone plates, separated by their corresponding sutures, are characterized using maximum intensity projections with wavelet statistical image improvement techniques to help identify signs of high underlying intracranial pressures along with three-dimensional surface fitting and vector analysis to quantify bone thickness around the skull. These techniques combine to provide an extensive assessment of the skull for further understanding of craniosynostosis and an identification of the cases that pose the greatest risk.\u003C\/p\u003E","summary":null,"format":"limited_html"}],"field_subtitle":"","field_summary":[{"value":"\u003Cp\u003EPhD Proposal Presentation-\u0026nbsp;\u0022Craniosynostosis developmental quantification and severity assessment\u0022- Marcus Walker\u003C\/p\u003E","format":"limited_html"}],"field_summary_sentence":[{"value":"\u0022Craniosynostosis developmental quantification and severity assessment\u0022"}],"uid":"27917","created_gmt":"2015-02-03 16:17:17","changed_gmt":"2017-04-13 21:20:12","author":"Laura Paige","boilerplate_text":"","field_publication":"","field_article_url":"","field_event_time":{"event_time_start":"2015-05-26T17:00:00-04:00","event_time_end":"2015-05-26T19:00:00-04:00","event_time_end_last":"2015-05-26T19:00:00-04:00","gmt_time_start":"2015-05-26 21:00:00","gmt_time_end":"2015-05-26 23:00:00","gmt_time_end_last":"2015-05-26 23:00:00","rrule":null,"timezone":"America\/New_York"},"extras":[],"related_links":[{"url":"http:\/\/zoe.bme.gatech.edu\/~bv20\/","title":"Vidakovic Lab"}],"groups":[{"id":"65448","name":"Bioengineering Graduate Program"}],"categories":[],"keywords":[],"core_research_areas":[],"news_room_topics":[],"event_categories":[{"id":"1795","name":"Seminar\/Lecture\/Colloquium"}],"invited_audience":[{"id":"78751","name":"Undergraduate students"},{"id":"174045","name":"Graduate students"}],"affiliations":[],"classification":[],"areas_of_expertise":[],"news_and_recent_appearances":[],"phone":[],"contact":[{"value":"\u003Cp\u003ELaura Paige\u003C\/p\u003E\u003Cp\u003E404-385-6655\u003C\/p\u003E","format":"limited_html"}],"email":[],"slides":[],"orientation":[],"userdata":""}},"405051":{"#nid":"405051","#data":{"type":"event","title":"BioE PhD Defense Announcement: Chanchala Kaddi","body":[{"value":"\u003Cp\u003E\u003Cstrong\u003EAdvisor: May D. Wang, Ph.D. \u003C\/strong\u003E(Georgia Institute of Technology)\u003C\/p\u003E\u003Cp\u003E\u0026nbsp;C\u003Cstrong\u003Eommittee:\u003C\/strong\u003E\u003C\/p\u003E\u003Cp\u003E\u003Cstrong\u003EMelissa Kemp, Ph.D.\u003C\/strong\u003E (Georgia Institute of Technology)\u003C\/p\u003E\u003Cp\u003E\u003Cstrong\u003EDong M. Shin, M.D.\u003C\/strong\u003E (Georgia Institute of Technology, Winship Cancer Institute, Emory University)\u003C\/p\u003E\u003Cp\u003E\u003Cstrong\u003EBrani Vidakovic, Ph.D.\u003C\/strong\u003E (Georgia Institute of Technology)\u003C\/p\u003E\u003Cp\u003E\u003Cstrong\u003EHoward Weiss, Ph.D.\u003C\/strong\u003E (Georgia Institute of Technology)\u003C\/p\u003E\u003Cp align=\u0022center\u0022\u003E\u003Cstrong\u003E\u0026nbsp;\u003C\/strong\u003E\u003Cstrong\u003E\u0026nbsp;\u003C\/strong\u003E\u003C\/p\u003E\u003Cp align=\u0022center\u0022\u003E\u003Cstrong\u003EMathematical Models for Data Mining and System Dynamics to Study Head and Neck Cancer Progression and Chemoprevention\u003C\/strong\u003E\u003C\/p\u003E\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\u003Cp\u003EHead and neck squamous cell carcinoma (HNSCC) is the 6\u003Csup\u003Eth\u003C\/sup\u003E most prevalent cancer worldwide, and more than 12,000 deaths from this disease are anticipated in 2015 in the U.S. alone. The advancement of genomic, transcriptomic, and other \u2013omic data acquisition technologies has enabled deeper exploration of the molecular-level mechanisms behind HNSCC development and progression. The insights gained through data-driven analysis can lead to earlier diagnosis and better treatment strategies, and ultimately can result in better patient outcomes. However, the volume and complexity of \u2013omic data remain great challenges.\u003C\/p\u003E\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\u003Cp\u003EThe goal of this research is to address several key challenges related to applying \u2013omic data for HNSCC research. These are: (1) the lack of modeling tools and systems for discovering biomarkers at the protein and metabolite levels; (2) the lack of effective strategies for integrating heterogeneous types of \u2013omic data for prediction; and (3) the lack of systems-level representations of biomarker knowledge for effectively predicting responses to bioactive agents. Overall, this research accelerates knowledge extraction, enables prediction using \u2013omic data for HNSCC, and delivers a suite of mathematical modeling tools for data mining and system dynamics.\u0026nbsp;\u003C\/p\u003E","summary":null,"format":"limited_html"}],"field_subtitle":"","field_summary":[{"value":"\u003Cp\u003EPhD Defense Presentation-\u0026nbsp;\u0022Mathematical Models for Data Mining and System Dynamics to Study Head and Neck Cancer Progression and Chemoprevention\u0022- Chanchala Kaddi\u003C\/p\u003E","format":"limited_html"}],"field_summary_sentence":[{"value":"\u0022Mathematical Models for Data Mining and System Dynamics to Study Head and Neck Cancer Progression and Chemoprevention\u0022"}],"uid":"27917","created_gmt":"2015-05-17 14:59:19","changed_gmt":"2017-04-13 21:19:18","author":"Laura Paige","boilerplate_text":"","field_publication":"","field_article_url":"","field_event_time":{"event_time_start":"2015-05-29T15:00:00-04:00","event_time_end":"2015-05-29T17:00:00-04:00","event_time_end_last":"2015-05-29T17:00:00-04:00","gmt_time_start":"2015-05-29 19:00:00","gmt_time_end":"2015-05-29 21:00:00","gmt_time_end_last":"2015-05-29 21:00:00","rrule":null,"timezone":"America\/New_York"},"extras":[],"related_links":[{"url":"http:\/\/www.bio-miblab.org\/","title":"May Wang"}],"groups":[{"id":"65448","name":"Bioengineering Graduate Program"}],"categories":[],"keywords":[],"core_research_areas":[],"news_room_topics":[],"event_categories":[{"id":"1788","name":"Other\/Miscellaneous"}],"invited_audience":[{"id":"78751","name":"Undergraduate students"},{"id":"78761","name":"Faculty\/Staff"},{"id":"174045","name":"Graduate students"}],"affiliations":[],"classification":[],"areas_of_expertise":[],"news_and_recent_appearances":[],"phone":[],"contact":[{"value":"\u003Cp\u003ELaura Paige\u0026nbsp;\u003C\/p\u003E\u003Cp\u003E404-385-6655\u003C\/p\u003E","format":"limited_html"}],"email":[],"slides":[],"orientation":[],"userdata":""}},"406681":{"#nid":"406681","#data":{"type":"event","title":"BioE MS Thesis Presentation- Katy Lassahn","body":[{"value":"\u003Cp\u003EAdvisor: Todd McDevitt, PhD, School of Biomedical Engineering\u003Cbr \/\u003E \u003Cbr \/\u003E Committee:\u003C\/p\u003E\u003Cp\u003EAndr\u00e9s Garc\u00eda, PhD\u0026nbsp; School of Mechanical Engineering \u003Cbr \/\u003E Luke Brewster,MD\/ PhD, Emory University School of Medicine\u003Cbr \/\u003E \u003Cbr \/\u003E Title: Delivery of Prolyl Hydroxylase inhibitors to MSC Spheroids for Enhanced Angiogenesis.\u003C\/p\u003E\u003Cp\u003E\u003Cbr \/\u003E Chronic non-healing wounds are a major healthcare concern in the U.S, especially due to the growing diabetic and elderly population. Wound healing is a complex biological process that is dependent on cells at the site of injury to signal and recruit immune cells, fibroblasts, and endothelial cells in order to rebuild damaged vasculature via angiogenesis. MSCs aid in wound healing and revascularization of damaged tissue because of their ability to secrete pro-angiogenic cytokines such as VEGF and IL-6 and recruit immune cells and endothelial cells to the site of injury to form new blood vessels. Hypoxia is known to be a key regulator in the angiogenic response of many cells, including MSCs.\u0026nbsp; Small molecule drugs termed Prolyl Hydroxylase inhibitors (PHDi) are able to cause a hypoxic response in cells can enhance MSCs ability to facilitate angiogenesis. The objective of this project is to investigate and compare the effects of commercially available PHDi on pro-angiogenic factor secretion of MSCs. Additionally, since the response to the drugs is likely short-lived, a method for prolonged delivery or exposure of PHDi to MSCs will be investigated.\u003C\/p\u003E","summary":null,"format":"limited_html"}],"field_subtitle":"","field_summary":[{"value":"\u003Cp\u003EMS Thesis Presentation-\u0026nbsp;\u0022Delivery of Prolyl Hydroxylase inhibitors to MSC Spheroids for Enhanced Angiogenesis\u0022- Katy Lassahn\u003C\/p\u003E","format":"limited_html"}],"field_summary_sentence":[{"value":"\u0022Delivery of Prolyl Hydroxylase inhibitors to MSC Spheroids for Enhanced Angiogenesis\u0022"}],"uid":"27917","created_gmt":"2015-05-21 15:06:19","changed_gmt":"2017-04-13 21:19:17","author":"Laura Paige","boilerplate_text":"","field_publication":"","field_article_url":"","field_event_time":{"event_time_start":"2015-06-03T11:00:00-04:00","event_time_end":"2015-06-03T13:00:00-04:00","event_time_end_last":"2015-06-03T13:00:00-04:00","gmt_time_start":"2015-06-03 15:00:00","gmt_time_end":"2015-06-03 17:00:00","gmt_time_end_last":"2015-06-03 17:00:00","rrule":null,"timezone":"America\/New_York"},"extras":[],"groups":[{"id":"65448","name":"Bioengineering Graduate Program"}],"categories":[],"keywords":[],"core_research_areas":[],"news_room_topics":[],"event_categories":[{"id":"1788","name":"Other\/Miscellaneous"}],"invited_audience":[{"id":"78751","name":"Undergraduate students"},{"id":"78761","name":"Faculty\/Staff"},{"id":"174045","name":"Graduate students"}],"affiliations":[],"classification":[],"areas_of_expertise":[],"news_and_recent_appearances":[],"phone":[],"contact":[{"value":"\u003Cp\u003ELaura Paige\u003C\/p\u003E\u003Cp\u003E404-385-6655\u003C\/p\u003E","format":"limited_html"}],"email":[],"slides":[],"orientation":[],"userdata":""}},"407021":{"#nid":"407021","#data":{"type":"event","title":"BioE PhD Defense Announcement: Lauren Priddy","body":[{"value":"\u003Cp\u003EAdvisor\u003C\/p\u003E\u003Cp\u003ERobert E. Guldberg, Ph.D. (Georgia Institute of Technology)\u003C\/p\u003E\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\u003Cp\u003ECommittee\u003C\/p\u003E\u003Cp\u003EEdward A. Botchwey, PhD. (Georgia Institute of Technology)\u003C\/p\u003E\u003Cp\u003EAndr\u00e9s J. Garc\u00eda, Ph.D. (Georgia Institute of Technology)\u003C\/p\u003E\u003Cp\u003EJohnna S. Temenoff, Ph.D. (Georgia Institute of Technology)\u003C\/p\u003E\u003Cp\u003ELisa Tran, D.D.S., M.D. (Emory University)\u003C\/p\u003E\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\u003Cp\u003EBiomaterial strategies for improved bone healing with bone morphogenetic protein-2 delivery\u003C\/p\u003E\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\u003Cp\u003EMusculoskeletal injuries account for two-thirds of all injuries that occur in the United States annually, and among these injuries, large bone defects are particularly challenging to repair. Although bone morphogenetic protein-2 (BMP-2) delivered on an absorbable collagen sponge (ACS) has shown clinical success in long bone healing, complications associated with the empirical use of supraphysiological doses of BMP-2, including heterotopic mineralization and inflammation, necessitate the development of a biomaterial carrier that localizes growth factors to the site of injury. In the development of bone tissue engineering strategies, another critical design parameter is the timing of delivery vehicle degradation, since bone regeneration may be impeded by the presence of residual biomaterials at the injury site. Further, bioactive, naturally derived extracellular matrix (ECM) products with pro-healing and immunomodulatory properties are attractive therapeutics with rapid translatability that may function to attenuate heterotopic mineralization often observed with high dose BMP-2 treatment.\u003C\/p\u003E\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\u003Cp\u003EThe goal of this work was to investigate hybrid biomaterial systems with controlled strategies for BMP-2 delivery to promote structural and functional restoration of segmental bone defects. Using a critically sized rat segmental bone defect model, we (i) evaluated the effects of alginate hydrogel oxidation on BMP-2 release and bone regeneration, (ii) elucidated the spatiotemporal effects of high dose BMP-2 on bone healing and gene expression, and (iii) investigated the ability of amniotic membrane to attenuate heterotopic mineralization in critically sized bone defects. Modification of the delivery vehicle to modulate growth factor availability may help minimize adverse side effects associated with high dose BMP-2 delivery, while harnessing the healing efficacy of BMP-2 for bone tissue engineering applications.\u003C\/p\u003E","summary":null,"format":"limited_html"}],"field_subtitle":"","field_summary":[{"value":"\u003Cp\u003EPhD Defense Presentation-\u0026nbsp;\u0022Biomaterial strategies for improved bone healing with bone morphogenetic protein-2 delivery\u0022- Lauren Priddy\u003C\/p\u003E","format":"limited_html"}],"field_summary_sentence":[{"value":"\u0022Biomaterial strategies for improved bone healing with bone morphogenetic protein-2 delivery\u0022"}],"uid":"27917","created_gmt":"2015-05-26 08:01:16","changed_gmt":"2017-04-13 21:19:17","author":"Laura Paige","boilerplate_text":"","field_publication":"","field_article_url":"","field_event_time":{"event_time_start":"2015-06-08T14:00:00-04:00","event_time_end":"2015-06-08T16:00:00-04:00","event_time_end_last":"2015-06-08T16:00:00-04:00","gmt_time_start":"2015-06-08 18:00:00","gmt_time_end":"2015-06-08 20:00:00","gmt_time_end_last":"2015-06-08 20:00:00","rrule":null,"timezone":"America\/New_York"},"extras":[],"related_links":[{"url":"http:\/\/guldberglab.gatech.edu\/","title":"Guldberg Musculoskeletal Research Lab"}],"groups":[{"id":"65448","name":"Bioengineering Graduate Program"}],"categories":[],"keywords":[],"core_research_areas":[],"news_room_topics":[],"event_categories":[{"id":"1788","name":"Other\/Miscellaneous"}],"invited_audience":[{"id":"78751","name":"Undergraduate students"},{"id":"78761","name":"Faculty\/Staff"},{"id":"174045","name":"Graduate students"}],"affiliations":[],"classification":[],"areas_of_expertise":[],"news_and_recent_appearances":[],"phone":[],"contact":[{"value":"\u003Cp\u003ELaura Paige\u003C\/p\u003E\u003Cp\u003E404-385-6655\u003C\/p\u003E","format":"limited_html"}],"email":[],"slides":[],"orientation":[],"userdata":""}},"412411":{"#nid":"412411","#data":{"type":"event","title":"BioE PhD Defense Presentation- Po Wei Chen","body":[{"value":"\u003Cp\u003E\u003Cstrong\u003EAdvisor\u003C\/strong\u003E: Eberhard O. Voit, Ph.D. (Georgia Institute of Technology)\u003Cbr \/\u003E \u003Cbr \/\u003E \u003Cstrong\u003ECommittee:\u003C\/strong\u003E\u003C\/p\u003E\u003Cp\u003EEdward A. Botchwey, PhD. (Georgia Institute of Technology)\u003C\/p\u003E\u003Cp\u003EYusuf A. Hannun, M.D. (Stony Brook Cancer Center)\u003Cbr \/\u003E Melissa L. Kemp, Ph.D. (Georgia Institute of Technology)\u003C\/p\u003E\u003Cp\u003EMark P. Styczynski, Ph.D. (Georgia Institute of Technology)\u003C\/p\u003E\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\u003Cp\u003E\u003Cstrong\u003ECharacterization of Sphingolipid-Based Stress Responses in the Yeast Saccharomyces cerevisiae through Reverse Engineering\u003C\/strong\u003E\u003C\/p\u003E\u003Cp\u003E\u0026nbsp;Sphingolipids regulate numerous cell functions through the activation of specific signaling cascades. Although sphingolipids have been investigated for several decades, a detailed mechanistic and systemic understanding of their biosynthesis and utilization is still lacking. As a consequence, it is still impossible to predict with reliability how cells react and adapt to external stresses and which specific roles sphingolipids play in such stress responses.\u0026nbsp;\u0026nbsp;\u003C\/p\u003E\u003Cp\u003EIn this thesis, I develop mathematical and computational approaches that shed light on the regulatory mechanisms with which baker\u2019s yeast responds to two types of stresses: heat and hydroxyurea. Stresses typically mandate the transition of a cellular system from its normal steady state to a different state. Thus, in the first project, I perform a theoretical state transition analysis. Based on this theoretical foundation, I propose in the second project an optimization strategy that appropriately captures the sphingolipid dynamics under 30 minutes of heat stress. This analysis reveals novel cellular response strategies, including a switch from biosynthesis to sphingolipid retrieval from cell membranes. To address the roles of these distinct ceramide variants, which differ in their fatty acyl CoA chain lengths, I propose a model that uses the previous model as boundary conditions. The model reveals interesting patterns of ceramide dynamics that are different for variants with long and very fatty acyl groups. Finally, I analyze long-term exposure of yeast cells to hydroxyurea. This analysis permits the novel identification and characterization of subtle regulatory mechanisms that are based on the cells\u2019 distinction between ceramides with saturated or unsaturated fatty acyl groups.\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u003C\/p\u003E\u003Cp\u003ETaken together, this dissertation work reveals novel control mechanisms with which yeast cells coordinate complex responses to external stresses. Beyond the analysis of sphingolipids, this work demonstrates how innovative techniques of dynamic modeling and optimization can assist in the extraction of detailed information from modern metabolomics data.\u003C\/p\u003E\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E","summary":null,"format":"limited_html"}],"field_subtitle":"","field_summary":[{"value":"\u003Cp\u003EPhD Defense Presentation-\u0026nbsp;\u0022Characterization of Sphingolipid-Based Stress Responses in the Yeast Saccharomyces cerevisiae through Reverse Engineering\u0022- Po Wei Chen\u003C\/p\u003E","format":"limited_html"}],"field_summary_sentence":[{"value":"\u0022Characterization of Sphingolipid-Based Stress Responses in the Yeast Saccharomyces cerevisiae through Reverse Engineering\u0022"}],"uid":"27917","created_gmt":"2015-06-09 11:02:14","changed_gmt":"2017-04-13 21:19:13","author":"Laura Paige","boilerplate_text":"","field_publication":"","field_article_url":"","field_event_time":{"event_time_start":"2015-06-19T16:30:00-04:00","event_time_end":"2015-06-19T18:30:00-04:00","event_time_end_last":"2015-06-19T18:30:00-04:00","gmt_time_start":"2015-06-19 20:30:00","gmt_time_end":"2015-06-19 22:30:00","gmt_time_end_last":"2015-06-19 22:30:00","rrule":null,"timezone":"America\/New_York"},"extras":[],"groups":[{"id":"65448","name":"Bioengineering Graduate Program"}],"categories":[],"keywords":[],"core_research_areas":[],"news_room_topics":[],"event_categories":[{"id":"1788","name":"Other\/Miscellaneous"}],"invited_audience":[{"id":"78751","name":"Undergraduate students"},{"id":"78761","name":"Faculty\/Staff"},{"id":"174045","name":"Graduate students"}],"affiliations":[],"classification":[],"areas_of_expertise":[],"news_and_recent_appearances":[],"phone":[],"contact":[{"value":"\u003Cp\u003ELaura Paige\u003C\/p\u003E\u003Cp\u003E404-385-6655\u003C\/p\u003E","format":"limited_html"}],"email":[],"slides":[],"orientation":[],"userdata":""}},"412471":{"#nid":"412471","#data":{"type":"event","title":"BioE PhD Defense Presentation- Ashley Allen","body":[{"value":"\u003Cp\u003E\u003Cstrong\u003EAdvisor\u003C\/strong\u003E\u003Cbr \/\u003E Robert E. Guldberg, Ph.D. (Georgia Institute of Technology)\u003Cbr \/\u003E \u003Cbr \/\u003E \u003Cstrong\u003ECommittee\u003C\/strong\u003E\u003Cbr \/\u003E Ian B. Copland, PhD. (Emory University)\u003Cbr \/\u003E Andr\u00e9s J. Garc\u00eda, Ph.D. (Georgia Institute of Technology)\u003C\/p\u003E\u003Cp\u003EZulma Gazit, Ph.D. (Cedars-Sinai Medical Center)\u003Cbr \/\u003E Todd C. McDevitt, Ph.D. (Gladstone Institutes)\u003C\/p\u003E\u003Cp align=\u0022center\u0022\u003E\u003Cbr \/\u003E \u003Cstrong\u003EModulation of Stem Cell Delivery Strategy by Platelet Lysate Utilization and Cell Aggregation for Enhanced Bone Regeneration\u003C\/strong\u003E\u003C\/p\u003E\u003Cp align=\u0022center\u0022\u003E\u0026nbsp;\u003C\/p\u003E\u003Cp\u003ELarge bone defects, such as those resulting from trauma or tumor resection, are repaired using graft tissue as the current gold standard. However, limitations of this treatment approach, including limited tissue availability and poor revascularization post-grafting, have motivated the development of cell- and protein-based strategies. Although recombinant human bone morphogenetic protein 2 (rhBMP-2) is clinically utilized to promote bone repair in incidences of non-union, supra-physiologic dosing of rhBMP-2 can result in adverse effects including heterotopic bone formation and systemic inflammation. Mesenchymal stem cell (MSC)-based bone tissue engineering strategies offer several potential advantages over the use of osteoinductive protein alone. However, challenges to control delivered cell behavior remain a significant barrier to the clinical translation of MSC-based therapeutics.\u003C\/p\u003E\u003Cp\u003EHuman platelet lysate (hPL) utilization and cell aggregation have each demonstrated the capacity to modulate a range of MSC outcomes, including cell number, phenotype, and secretome. The goal of this work was to investigate their potential application in MSC-based large bone defect repair. We pursued this objective through development of a bioluminescent cell tracking protocol and subsequent evaluation of these strategies for improved MSC survival and facilitated bone regeneration. Additional to engineering an efficacious MSC-based treatment for bone injury, this research aimed to relate key principles influencing cell-based tissue regeneration more globally.\u003C\/p\u003E","summary":null,"format":"limited_html"}],"field_subtitle":"","field_summary":[{"value":"\u003Cp\u003EPhD Defense Presentation-\u0026nbsp;\u0022Modulation of Stem Cell Delivery Strategy by Platelet Lysate Utilization and Cell Aggregation for Enhanced Bone Regeneration\u0022- Ashley Allen\u003C\/p\u003E","format":"limited_html"}],"field_summary_sentence":[{"value":"\u0022Modulation of Stem Cell Delivery Strategy by Platelet Lysate Utilization and Cell Aggregation for Enhanced Bone Regeneration\u0022"}],"uid":"27917","created_gmt":"2015-06-09 11:18:49","changed_gmt":"2017-04-13 21:19:13","author":"Laura Paige","boilerplate_text":"","field_publication":"","field_article_url":"","field_event_time":{"event_time_start":"2015-06-24T10:00:00-04:00","event_time_end":"2015-06-24T12:00:00-04:00","event_time_end_last":"2015-06-24T12:00:00-04:00","gmt_time_start":"2015-06-24 14:00:00","gmt_time_end":"2015-06-24 16:00:00","gmt_time_end_last":"2015-06-24 16:00:00","rrule":null,"timezone":"America\/New_York"},"extras":[],"related_links":[{"url":"http:\/\/guldberglab.gatech.edu\/","title":"Guldberg Musculoskeletal Research Lab"}],"groups":[{"id":"65448","name":"Bioengineering Graduate Program"}],"categories":[],"keywords":[],"core_research_areas":[],"news_room_topics":[],"event_categories":[{"id":"1788","name":"Other\/Miscellaneous"}],"invited_audience":[{"id":"78751","name":"Undergraduate students"},{"id":"78761","name":"Faculty\/Staff"},{"id":"174045","name":"Graduate students"}],"affiliations":[],"classification":[],"areas_of_expertise":[],"news_and_recent_appearances":[],"phone":[],"contact":[{"value":"\u003Cp\u003ELaura Paige\u003C\/p\u003E\u003Cp\u003E404-385-6655\u003C\/p\u003E","format":"limited_html"}],"email":[],"slides":[],"orientation":[],"userdata":""}},"415061":{"#nid":"415061","#data":{"type":"event","title":"BioE PhD Defense Presentation- Apoorva Salimath","body":[{"value":"\u003Cp\u003E\u003Cstrong\u003EAdvisor\u003C\/strong\u003E:\u0026nbsp;Andr\u00e9s J. Garc\u00eda, Ph.D. (Georgia Institute of Technology)\u003Cbr \/\u003E \u003Cbr \/\u003E \u003Cstrong\u003ECommittee:\u003C\/strong\u003E\u003C\/p\u003E\u003Cp\u003EEdward A. Botchwey, PhD. (Georgia Institute of Technology)\u003C\/p\u003E\u003Cp\u003EThomas J. Burkholder, Ph.D. (Georgia Institute of Technology)\u003Cbr \/\u003E Johnna S. Temenoff, Ph.D. (Georgia Institute of Technology)\u003C\/p\u003E\u003Cp\u003EThomas H. Barker, Ph.D. (Georgia Institute of Technology)\u003C\/p\u003E\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\u003Cp\u003E\u003Cstrong\u003EBiofunctional Hydrogels for Skeletal Muscle Constructs\u003C\/strong\u003E\u003C\/p\u003E\u003Cp\u003E\u0026nbsp; \u0026nbsp; \u0026nbsp;Skeletal muscle tissue damage costs the US government hundreds of billions of dollars annually. Meanwhile, there is great potential to use skeletal muscle as a scalable actuator system, covering wide length scales, frequencies, and force regimes. \u0026nbsp;Hence, the interest in soft robotics and regenerative medicine methods to engineer skeletal muscle has increased in recent years. The challenges to generate a functional muscle strip are typical to those of tissue engineering, where common issues such as cell source, material scaffold, bioreactor method or configuration play key roles. Specifically, it is important to translate the existing body of myogenesis knowledge into engineering muscle constructs by examining the impact of the cell microenvironment on growth, alignment, fusion, and differentiation of skeletal muscle cells.\u0026nbsp;\u003C\/p\u003E\u003Cp\u003E\u0026nbsp; \u0026nbsp; \u0026nbsp;The main motivation behind this thesis was to generate a contractile 3D skeletal muscle construct utilizing organized biochemical and physical cues to guide muscle cell differentiation and maturation. Such a construct is expected to play an important role in medical applications and the development of soft robotics. To do this,\u0026nbsp;3D, swollen hydrogels were chosen to provide tailorable platforms that support cellular activities to similar extents as native matrices. For this work, we utilized an engineered bio-functionalized poly(ethylene glycol)-(PEG)-hydrogel with maleimide (MAL) cross-linking reaction chemistry that gels rapidly with high reaction efficiency under cytocompatible reaction conditions. PEG alone has been shown to have low protein adsorption, a minimal inflammatory profile, well established chemistry, and a long history of safety in vivo. \u0026nbsp;The PEG-MAL system in particular allows \u201cplug-and-play\u201d design variation, control over polymerization time, and small degradation products.\u003C\/p\u003E\u003Cp\u003E\u0026nbsp; \u0026nbsp; \u0026nbsp;To develop an effective soft biomaterial for the development of an aligned, functional muscle construct, we (i) screened\u0026nbsp;hydrogel properties for differentiation, (ii) recreated alignment of skeletal muscle cells, (iii) determined effective generated force upon action of an external agonist.\u0026nbsp;The impact of this study in generating a controllable force actuator will be significant in the construction of biological machines. Concomitantly, this study will provide a unique regenerative solution for skeletal muscle tissue repair and regeneration.\u003C\/p\u003E\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E","summary":null,"format":"limited_html"}],"field_subtitle":"","field_summary":[{"value":"\u003Cp\u003EPhD Defense Presentation-\u0026nbsp;\u0022Biofunctional Hydrogels for Skeletal Muscle Constructs\u0022- Apoorva Salmiath\u003C\/p\u003E","format":"limited_html"}],"field_summary_sentence":[{"value":"\u0022Biofunctional Hydrogels for Skeletal Muscle Constructs\u0022"}],"uid":"27917","created_gmt":"2015-06-16 10:23:30","changed_gmt":"2017-04-13 21:19:11","author":"Laura Paige","boilerplate_text":"","field_publication":"","field_article_url":"","field_event_time":{"event_time_start":"2015-06-29T10:00:00-04:00","event_time_end":"2015-06-29T12:00:00-04:00","event_time_end_last":"2015-06-29T12:00:00-04:00","gmt_time_start":"2015-06-29 14:00:00","gmt_time_end":"2015-06-29 16:00:00","gmt_time_end_last":"2015-06-29 16:00:00","rrule":null,"timezone":"America\/New_York"},"extras":[],"related_links":[{"url":"http:\/\/garcialab.gatech.edu\/","title":"Garcia lab"}],"groups":[{"id":"65448","name":"Bioengineering Graduate Program"}],"categories":[],"keywords":[],"core_research_areas":[],"news_room_topics":[],"event_categories":[{"id":"1788","name":"Other\/Miscellaneous"}],"invited_audience":[{"id":"78751","name":"Undergraduate students"},{"id":"78761","name":"Faculty\/Staff"},{"id":"174045","name":"Graduate students"}],"affiliations":[],"classification":[],"areas_of_expertise":[],"news_and_recent_appearances":[],"phone":[],"contact":[{"value":"\u003Cp\u003ELaura Paige\u003C\/p\u003E\u003Cp\u003E404-385-6655\u003C\/p\u003E","format":"limited_html"}],"email":[],"slides":[],"orientation":[],"userdata":""}},"418831":{"#nid":"418831","#data":{"type":"event","title":"BioE PhD Defense Announcement: Milad Navaei","body":[{"value":"\u003Cp\u003E\u003Cstrong\u003EAdvisor: \u003C\/strong\u003E\u003C\/p\u003E\u003Cp\u003EPeter Hesketh, PhD (Georgia Institute of Technology)\u003C\/p\u003E\u003Cp\u003E\u003Cstrong\u003ECommittee:\u003C\/strong\u003E\u003C\/p\u003E\u003Cp\u003EMostafa Ghiaasiaan, PhD (Georgia Institute of Technology)\u003Cbr \/\u003E Albert Frazier, PhD (Georgia Institute of Technology)\u003Cbr \/\u003E Oliver Brand, PhD (Georgia Institute of Technology)\u003Cbr \/\u003E Jean-Marie Dimanja, PhD (Spelman College)\u003C\/p\u003E\u003Cp\u003ETodd Sulchek, PhD (Georgia Institute of Technology)\u003Cbr \/\u003E \u0026nbsp;\u0026nbsp;\u0026nbsp;\u003C\/p\u003E\u003Cp\u003E\u003Cstrong\u003EIntegration of a Micro-Gas Chromatography System for Detection of Volatile Organic Compounds\u003C\/strong\u003E\u003C\/p\u003E\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\u003Cp\u003EThe focus of this dissertation is on the design and micro-fabrication of an all gas chromatography column with a novel two dimensional resistive heater and its integration with an ultra-low power TCD sensor for fast separation and detection of Volatile Organic Compounds (VOC). The major limitations of the current MEMS-GC column are: direct bonding of silicon to silicon, and peak band broadening due to slow temperature programming. Direct fusion bonding of silicon to silicon is not an effective technique for proper sealing of a high density micro-machined surface such as a GC column. This technique requires extremely smooth and clean surfaces, otherwise small voids and unbonded areas occur. As part of this thesis, a new gold eutectic-fusion bonding technique is developed to improve the sealing of the column. The time and power required to ramp and sustain the column\u2019s temperature are very high for the current GC columns. To reduce the time required to separate the compounds, a new temperature gradient programming heating method was developed to generate temperature gradients along the length of the column. This novel heating method refocuses eluding bands and counteract the part of the chromatographic band spreading. At the end, a low power TCD sensor was designed and integrated for a faster and more accurate measurement of the VOC gases separated with the MEMS GC column. These features enable the MEMS-GC system to analyze live and fast detection of the VOC gases released by pathogenic species of Armellaria fungus.\u0026nbsp;\u003C\/p\u003E","summary":null,"format":"limited_html"}],"field_subtitle":"","field_summary":[{"value":"\u003Cp\u003EPhD Defense Presentation-\u0026nbsp;\u0022Integration of a Micro-Gas Chromatography System for Detection of Volatile Organic Compounds\u0022 - Milad Navaei\u003C\/p\u003E","format":"limited_html"}],"field_summary_sentence":[{"value":"\u0022Integration of a Micro-Gas Chromatography System for Detection of Volatile Organic Compounds\u0022"}],"uid":"27917","created_gmt":"2015-06-26 09:41:25","changed_gmt":"2017-04-13 21:19:10","author":"Laura Paige","boilerplate_text":"","field_publication":"","field_article_url":"","field_event_time":{"event_time_start":"2015-07-21T12:00:00-04:00","event_time_end":"2015-07-21T14:00:00-04:00","event_time_end_last":"2015-07-21T14:00:00-04:00","gmt_time_start":"2015-07-21 16:00:00","gmt_time_end":"2015-07-21 18:00:00","gmt_time_end_last":"2015-07-21 18:00:00","rrule":null,"timezone":"America\/New_York"},"extras":[],"groups":[{"id":"65448","name":"Bioengineering Graduate Program"}],"categories":[],"keywords":[],"core_research_areas":[],"news_room_topics":[],"event_categories":[{"id":"1788","name":"Other\/Miscellaneous"}],"invited_audience":[{"id":"78751","name":"Undergraduate students"},{"id":"78761","name":"Faculty\/Staff"},{"id":"174045","name":"Graduate students"}],"affiliations":[],"classification":[],"areas_of_expertise":[],"news_and_recent_appearances":[],"phone":[],"contact":[{"value":"\u003Cp\u003ELaura Paige\u0026nbsp;\u003C\/p\u003E\u003Cp\u003E404-385-6655\u003C\/p\u003E","format":"limited_html"}],"email":[],"slides":[],"orientation":[],"userdata":""}},"424041":{"#nid":"424041","#data":{"type":"event","title":"BioE PhD Defense Presentation- Chimdimnma Esimai","body":[{"value":"\u003Cp class=\u0022DataField11pt\u0022\u003E\u003Cstrong\u003EAdvisor\u003C\/strong\u003E: Andr\u00e9s J. Garc\u00eda, PhD (Georgia Institute of Technology)\u003C\/p\u003E\u003Cp class=\u0022DataField11pt\u0022\u003E\u0026nbsp;\u003C\/p\u003E\u003Cp class=\u0022DataField11pt\u0022\u003E\u003Cstrong\u003ECommittee\u003C\/strong\u003E: \u003C\/p\u003E\u003Cp class=\u0022DataField11pt\u0022\u003EThomas H. Barker, PhD (Georgia Institute of Technology)\u003C\/p\u003E\u003Cp class=\u0022DataField11pt\u0022\u003EAndrew P. Kowalczyk, PhD (Emory University)\u003C\/p\u003E\u003Cp class=\u0022DataField11pt\u0022\u003ESusan N. Thomas, PhD (Georgia Institute of Technology)\u003C\/p\u003E\u003Cp class=\u0022DataField11pt\u0022\u003ECheng Zhu, PhD (Georgia Institute of Technology)\u003C\/p\u003E\u003Cp class=\u0022DataField11pt\u0022\u003E\u0026nbsp;\u003C\/p\u003E\u003Cp class=\u0022DataField11pt\u0022\u003E\u003Cstrong\u003EQuantitative Analyses for Cadherin-Based Cell-Cell Adhesive Force\u003C\/strong\u003E\u003C\/p\u003E\u003Cp class=\u0022DataField11pt\u0022\u003E\u0026nbsp;\u003C\/p\u003E\u003Cp class=\u0022DataField11pt\u0022\u003ECell adhesion is a critical determinant of tissue architecture and tissue organization. Cadherin proteins mediate cell-cell adhesion in a calcium-dependent manner. The functional roles for cadherin proteins early in development and in adults, as well as the multiple disease phenotypes resulting from cadherin dysregulation, underscore the importance of cadherin proteins. Quantitative assessment of cadherin interaction structure, force, and interaction dynamics is not yet completely understood because of lack of experimental platforms to study cadherin proteins as well as their often-conflicting roles in a tissue-specific manner.\u0026nbsp; Adhesive force measurements promise to meet this challenge of elucidating how cadherin complex assembly and function coheres in a spatiotemporal manner in human health and disease. The goal of this thesis was to engineer adhesive surfaces that support cadherin-based adhesion as a model system to analyze cadherin-dependent forces. We have engineered two different types of surfaces, based on self-assembly monolayers of alkanethiols on gold surfaces as well as micro-fabricated post-array detectors that present isolated and purified vascular endothelial cadherin ligands. The proposed research is significant because it focuses on creating a robust, quantitative experimental platform to study the formation of the cadherin complex in vitro and integrates a quantitative understanding of cell mechanics. Once validated, our approach will provide a strategy to understand the variables that promote the greatest adhesion strength.\u0026nbsp;\u003C\/p\u003E","summary":null,"format":"limited_html"}],"field_subtitle":"","field_summary":[{"value":"\u003Cp\u003EPhD Defense Presentation-\u0026nbsp;\u0022Quantitative Analyses for Cadherin-Based Cell-Cell Adhesive Force\u0022-\u0026nbsp;Chimdimnma Esimai \u0026nbsp;\u0026nbsp;\u003C\/p\u003E","format":"limited_html"}],"field_summary_sentence":[{"value":"\u0022Quantitative Analyses for Cadherin-Based Cell-Cell Adhesive Force\u0022"}],"uid":"27917","created_gmt":"2015-07-13 13:50:49","changed_gmt":"2017-04-13 21:19:06","author":"Laura Paige","boilerplate_text":"","field_publication":"","field_article_url":"","field_event_time":{"event_time_start":"2015-07-27T10:00:00-04:00","event_time_end":"2015-07-27T12:00:00-04:00","event_time_end_last":"2015-07-27T12:00:00-04:00","gmt_time_start":"2015-07-27 14:00:00","gmt_time_end":"2015-07-27 16:00:00","gmt_time_end_last":"2015-07-27 16:00:00","rrule":null,"timezone":"America\/New_York"},"extras":[],"related_links":[{"url":"http:\/\/garcialab.gatech.edu\/","title":"Garcia lab"}],"groups":[{"id":"65448","name":"Bioengineering Graduate Program"}],"categories":[],"keywords":[],"core_research_areas":[],"news_room_topics":[],"event_categories":[{"id":"1788","name":"Other\/Miscellaneous"}],"invited_audience":[{"id":"78751","name":"Undergraduate students"},{"id":"78761","name":"Faculty\/Staff"},{"id":"174045","name":"Graduate students"}],"affiliations":[],"classification":[],"areas_of_expertise":[],"news_and_recent_appearances":[],"phone":[],"contact":[{"value":"\u003Cp\u003ELaura Paige\u003C\/p\u003E\u003Cp\u003E404-385-6655\u003C\/p\u003E","format":"limited_html"}],"email":[],"slides":[],"orientation":[],"userdata":""}},"427721":{"#nid":"427721","#data":{"type":"event","title":"PhD Defense Presentation- He Zheng","body":[{"value":"\u003Cp class=\u0022xmsonormal\u0022\u003E\u003Cstrong\u003EAdvisor:\u003C\/strong\u003E\u0026nbsp;Garrett Stanley, PhD (Georgia Institute of Technology)\u003C\/p\u003E\u003Cp class=\u0022xmsonormal\u0022\u003E\u0026nbsp;\u003C\/p\u003E\u003Cp class=\u0022xmsonormal\u0022\u003E\u003Cstrong\u003ECommittee Members:\u003C\/strong\u003E\u003C\/p\u003E\u003Cp class=\u0022xmsonormal\u0022\u003EDieter Jaeger, PhD (Georgia Institute of Technology \u0026amp; Emory University)\u003C\/p\u003E\u003Cp class=\u0022xmsonormal\u0022\u003ERobert Liu, PhD (Georgia Institute of Technology \u0026amp; Emory University)\u003C\/p\u003E\u003Cp class=\u0022xmsonormal\u0022\u003EChristopher Rozell, PhD (Georgia Institute of Technology \u0026amp; Emory University)\u003C\/p\u003E\u003Cp class=\u0022xmsonormal\u0022\u003EAnna Roe, PhD (Vanderbilt University)\u003C\/p\u003E\u003Cp class=\u0022xmsonormal\u0022\u003E\u0026nbsp;\u003C\/p\u003E\u003Cp class=\u0022xmsonormal\u0022\u003E\u0026nbsp;\u003C\/p\u003E\u003Cp class=\u0022xmsonormal\u0022\u003E\u003Cstrong\u003EState-dependent information processing in the rat vibrissa pathway\u003C\/strong\u003E\u003C\/p\u003E\u003Cp class=\u0022xmsonormal\u0022\u003E\u0026nbsp;\u003C\/p\u003E\u003Cp class=\u0022xmsonormal\u0022\u003ETo navigate the world, we must\u0026nbsp;efficiently extract relevant information from\u0026nbsp;complex sensory inputs\u0026nbsp;to form perceptions and make decisions on a moment-to-moment basis. The efficient encoding of sensory information necessarily relies on the ability of the pathway to dynamically interpret the sensory input according to the context under which external stimuli are processed. Internally, this context is represented by the state of the brain, which can be modulated by bottom-up processes such as sensory adaptation, intrinsic mechanisms such as neuromodulators, and top-down processes such as arousal.\u003C\/p\u003E\u003Cp class=\u0022xmsonormal\u0022\u003E\u0026nbsp;This thesis examines the modulation of brain state induced via bottom-up sensory adaptation and the spontaneous change in brain state, the relationship between brain state and sensory-evoked activity, and the potential implications of brain state modulation for the perception of the stimulus.\u003C\/p\u003E\u003Cp class=\u0022xmsonormal\u0022\u003E\u0026nbsp;Using voltage-sensitive dye imaging in anesthetized rats and the paradigm of detection \/ spatial discrimination task by the ideal observer, I\u0026nbsp;quantified, in the adapted state,\u0026nbsp;how the cortical response to a stimulus in the vibrissa pathway was shaped and how the information for detecting and spatially discriminating the stimulus was differentially optimized. Cortical activation and detection \/ discrimination tradeoff were quantified in relation to the degree of adaptation, which was modulated continuously by the frequency and velocity of the adapting stimulus. I\u0026nbsp;investigated the spontaneous changes in brain state reflected in the frequency content and phase of the pre-stimulus activity and how it modulated sensory evoked response. Finally, I explored the interaction between the intrinsic changes in brain state and sensory adaptation.\u0026nbsp;\u003C\/p\u003E\u003Cp class=\u0022xmsonormal\u0022\u003EThis thesis investigates the regulation of brain state\u0026nbsp;via bottom-up sensory adaptation and spontaneous changes, providing a glimpse into a high-dimensional continuum.\u003C\/p\u003E","summary":null,"format":"limited_html"}],"field_subtitle":"","field_summary":[{"value":"\u003Cp\u003EPhD Defense Presentation-\u0026nbsp;\u0022State-dependent information processing in the rat vibrissa pathway\u0022- He Zheng\u003C\/p\u003E","format":"limited_html"}],"field_summary_sentence":[{"value":"\u0022State-dependent information processing in the rat vibrissa pathway\u0022"}],"uid":"27917","created_gmt":"2015-07-22 13:46:54","changed_gmt":"2017-04-13 21:19:02","author":"Laura Paige","boilerplate_text":"","field_publication":"","field_article_url":"","field_event_time":{"event_time_start":"2015-08-05T10:00:00-04:00","event_time_end":"2015-08-05T12:01:00-04:00","event_time_end_last":"2015-08-05T12:01:00-04:00","gmt_time_start":"2015-08-05 14:00:00","gmt_time_end":"2015-08-05 16:01:00","gmt_time_end_last":"2015-08-05 16:01:00","rrule":null,"timezone":"America\/New_York"},"extras":[],"groups":[{"id":"65448","name":"Bioengineering Graduate Program"}],"categories":[],"keywords":[],"core_research_areas":[],"news_room_topics":[],"event_categories":[{"id":"1788","name":"Other\/Miscellaneous"}],"invited_audience":[{"id":"78751","name":"Undergraduate students"},{"id":"78761","name":"Faculty\/Staff"},{"id":"174045","name":"Graduate students"}],"affiliations":[],"classification":[],"areas_of_expertise":[],"news_and_recent_appearances":[],"phone":[],"contact":[{"value":"\u003Cp\u003ELaura Paige\u003C\/p\u003E\u003Cp\u003E404-385-6655\u003C\/p\u003E","format":"limited_html"}],"email":[],"slides":[],"orientation":[],"userdata":""}},"425181":{"#nid":"425181","#data":{"type":"event","title":"BioEngineering Expo 2015","body":[{"value":"\u003Cp\u003EOpen to new and current BioE students, the BioE Orientation \u0026amp; Expo is the perfect place to get to know the BioE community, learn about the great research being conducted and talk to PIs about their labs!\u003C\/p\u003E\u003Cp\u003E1:00pm\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp; BioE Overview- Andr\u00e9s Garc\u00eda, PhD- Director, Interdisciplinary \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp;BioEngineering Graduate Program\u003C\/p\u003E\u003Cp\u003E2:00pm\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp; Course Advisement- Andr\u00e9s Garc\u00eda, PhD\u003C\/p\u003E\u003Cp\u003E2:30pm\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp; Current BioE Student Panel\u003C\/p\u003E\u003Cp\u003E\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp; \u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp; ECE\/BioE- Aaron Enten\u003C\/p\u003E\u003Cp\u003E\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp; BME\/BioE- Olivia Burnsed\u003C\/p\u003E\u003Cp\u003E\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp; ChBE\/BioE- Jaya Arya\u003C\/p\u003E\u003Cp\u003E\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp; MSE\/BioE- Kirsten Paratt\u003C\/p\u003E\u003Cp\u003E\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp; ME\/BioE- Kevin Hetzendorfer\u003C\/p\u003E\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\u003Cp\u003E3:00pm\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp; Fellowships Office\u003C\/p\u003E\u003Cp\u003E\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp; Center for Career Discovery \u0026amp; Development\u003C\/p\u003E\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\u003Cp\u003E3:15pm\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp; Training Grant Information Session\u003C\/p\u003E\u003Cp\u003E\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp; IGERT, Robert Nerem, PhD\u003C\/p\u003E\u003Cp\u003E\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp; CTEng, Andr\u00e9s Garc\u00eda, PhD\u003C\/p\u003E\u003Cp\u003E\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp; BioMaterials, Julie Champion, PhD\u003C\/p\u003E\u003Cp\u003E\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u003C\/p\u003E\u003Cp\u003E3:30pm\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp; Poster Session \u0026amp; Reception \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp;\u003C\/p\u003E","summary":null,"format":"limited_html"}],"field_subtitle":"","field_summary":[{"value":"\u003Cp\u003EBioEngineering Expo 2015\u003C\/p\u003E","format":"limited_html"}],"field_summary_sentence":[{"value":"Learn about the great research being conducted and talk to PIs about their labs!"}],"uid":"27917","created_gmt":"2015-07-15 15:32:11","changed_gmt":"2017-04-13 21:19:05","author":"Laura Paige","boilerplate_text":"","field_publication":"","field_article_url":"","field_event_time":{"event_time_start":"2015-08-13T14:00:00-04:00","event_time_end":"2015-08-13T18:00:00-04:00","event_time_end_last":"2015-08-13T18:00:00-04:00","gmt_time_start":"2015-08-13 18:00:00","gmt_time_end":"2015-08-13 22:00:00","gmt_time_end_last":"2015-08-13 22:00:00","rrule":null,"timezone":"America\/New_York"},"extras":[],"related_links":[{"url":"http:\/\/bioengineering.gatech.edu\/","title":"BIOE program"}],"groups":[{"id":"65448","name":"Bioengineering Graduate Program"}],"categories":[],"keywords":[{"id":"248","name":"IBB"}],"core_research_areas":[],"news_room_topics":[],"event_categories":[{"id":"1789","name":"Conference\/Symposium"}],"invited_audience":[{"id":"78751","name":"Undergraduate students"},{"id":"78761","name":"Faculty\/Staff"},{"id":"174045","name":"Graduate students"}],"affiliations":[],"classification":[],"areas_of_expertise":[],"news_and_recent_appearances":[],"phone":[],"contact":[{"value":"\u003Cp\u003ELaura Paige\u003C\/p\u003E\u003Cp\u003E404-385-6655\u003C\/p\u003E","format":"limited_html"}],"email":[],"slides":[],"orientation":[],"userdata":""}},"418911":{"#nid":"418911","#data":{"type":"event","title":"BioEngineering Program Faculty Meeting","body":"","field_subtitle":"","field_summary":[{"value":"\u003Cp\u003E\u003Cem\u003EThe BioEngineering Program faculty meet regularly during the semester to address program policies, events and future research and academic directions.\u003C\/em\u003E\u003C\/p\u003E","format":"limited_html"}],"field_summary_sentence":[{"value":"\u0022BioEngineering Program Faculty Meeting\u0022"}],"uid":"27917","created_gmt":"2015-06-26 14:58:30","changed_gmt":"2016-10-08 02:12:22","author":"Laura Paige","boilerplate_text":"","field_publication":"","field_article_url":"","field_event_time":{"event_time_start":"2015-08-27T12:00:00-04:00","event_time_end":"2015-08-27T13:00:00-04:00","event_time_end_last":"2015-08-27T13:00:00-04:00","gmt_time_start":"2015-08-27 16:00:00","gmt_time_end":"2015-08-27 17:00:00","gmt_time_end_last":"2015-08-27 17:00:00","rrule":null,"timezone":"America\/New_York"},"extras":[],"groups":[{"id":"65448","name":"Bioengineering Graduate Program"}],"categories":[],"keywords":[],"core_research_areas":[],"news_room_topics":[],"event_categories":[{"id":"1788","name":"Other\/Miscellaneous"}],"invited_audience":[{"id":"78761","name":"Faculty\/Staff"}],"affiliations":[],"classification":[],"areas_of_expertise":[],"news_and_recent_appearances":[],"phone":[],"contact":[{"value":"\u003Cp\u003ELaura Paige\u003C\/p\u003E\u003Cp\u003E404-385-6655\u003C\/p\u003E","format":"limited_html"}],"email":[],"slides":[],"orientation":[],"userdata":""}},"435781":{"#nid":"435781","#data":{"type":"event","title":"PhD Defense Presentation- Kipp Schoenwald","body":[{"value":"\u003Cp\u003ETodd Sulchek, Ph.D. (Chair and PI), ME, \u0026nbsp;(Georgia Institute of Technology)\u003C\/p\u003E\u003Cp\u003EOliver Brand, Ph.D., ECE, (Georgia Institute of Technology)\u003C\/p\u003E\u003Cp\u003EPeter Hesketh, Ph.D., ME, (Georgia Institute of Technology)\u003C\/p\u003E\u003Cp\u003EWilber A. Lam, MD, Ph.D., BME, (Georgia Institute of Technology)\u003C\/p\u003E\u003Cp\u003EHang Lu, Ph.D., ChBE, (Georgia Institute of Technology)\u003C\/p\u003E\u003Cp align=\u0022center\u0022\u003E\u0026nbsp;\u003C\/p\u003E\u003Cp align=\u0022center\u0022\u003E\u003Cstrong\u003E\u201cToward an Aspirating Force Probe: Microfabrication of a high sensitivity fluidic AFM probe\u201d\u003C\/strong\u003E\u003C\/p\u003E\u003Cp align=\u0022center\u0022\u003E\u003Cstrong\u003E\u0026nbsp;\u003C\/strong\u003E\u003C\/p\u003E\u003Cp\u003EThis work presents significant advancements toward the development of an aspirating force probe or \u0022AFP\u0022. The technology is an elaboration on the canonical AFM probe, targeting added capacity to physically manipulate both adhesive and nonadhesive cells by fluid pressure controlled aspiration at the cantilever terminus.\u0026nbsp; We demonstrate a low stiffness design of a fully integrated fluidic probe.\u0026nbsp; This may be combined with the dynamic loading and high spatial resolution capabilities of any AFM system, as the design requires no modification to a mounting unit.\u0026nbsp; We developed three key microfabrication techniques to achieve this: a low stiffness (k \u0026lt; 100 pN\/nm) nano-fluidic cantilever via a thermally decomposable polynorborne sacrificial layer, fully integrated fluidic system that requires no modification to an AFM probe mount, and two micro to nano-fluidic interfaces for connecting the latter.\u003C\/p\u003E","summary":null,"format":"limited_html"}],"field_subtitle":"","field_summary":[{"value":"\u003Cp\u003EPhD Defense Presentation-\u0026nbsp;\u201cToward an Aspirating Force Probe: Microfabrication of a high sensitivity fluidic AFM probe\u201d- Kipp Schoenwald\u003C\/p\u003E","format":"limited_html"}],"field_summary_sentence":[{"value":"\u201cToward an Aspirating Force Probe: Microfabrication of a high sensitivity fluidic AFM probe\u201d"}],"uid":"27917","created_gmt":"2015-08-18 09:00:49","changed_gmt":"2017-04-13 21:18:46","author":"Laura Paige","boilerplate_text":"","field_publication":"","field_article_url":"","field_event_time":{"event_time_start":"2015-08-31T14:00:00-04:00","event_time_end":"2015-08-31T16:00:00-04:00","event_time_end_last":"2015-08-31T16:00:00-04:00","gmt_time_start":"2015-08-31 18:00:00","gmt_time_end":"2015-08-31 20:00:00","gmt_time_end_last":"2015-08-31 20:00:00","rrule":null,"timezone":"America\/New_York"},"extras":[],"groups":[{"id":"65448","name":"Bioengineering Graduate Program"}],"categories":[],"keywords":[],"core_research_areas":[],"news_room_topics":[],"event_categories":[{"id":"1788","name":"Other\/Miscellaneous"}],"invited_audience":[{"id":"78751","name":"Undergraduate students"},{"id":"78761","name":"Faculty\/Staff"},{"id":"174045","name":"Graduate students"}],"affiliations":[],"classification":[],"areas_of_expertise":[],"news_and_recent_appearances":[],"phone":[],"contact":[{"value":"\u003Cp\u003ELaura Paige\u003C\/p\u003E\u003Cp\u003E404 385-6655\u003C\/p\u003E","format":"limited_html"}],"email":[],"slides":[],"orientation":[],"userdata":""}},"436811":{"#nid":"436811","#data":{"type":"event","title":"PhD Proposal Presentation - Alex Schudel","body":[{"value":"\u003Cp\u003E\u003Cstrong\u003EAdvisor: Susan Thomas, Ph.D. \u003C\/strong\u003E(Georgia Institute of Technology)\u003C\/p\u003E\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\u003Cp\u003E\u003Cstrong\u003ECommittee:\u003C\/strong\u003E\u003C\/p\u003E\u003Cp\u003E\u003Cstrong\u003EM.G. Finn, Ph.D. \u003C\/strong\u003E(Georgia Institute of Technology)\u003C\/p\u003E\u003Cp\u003E\u003Cstrong\u003EBrandon Dixon, Ph.D. \u003C\/strong\u003E(Georgia Institute of Technology)\u003C\/p\u003E\u003Cp\u003E\u003Cstrong\u003EValeria Milam, Ph.D. \u003C\/strong\u003E(Georgia Institute of Technology)\u003C\/p\u003E\u003Cp\u003E\u003Cstrong\u003EMichael Davis, Ph.D. \u003C\/strong\u003E(Georgia Institute of Technology, Emory University)\u003C\/p\u003E\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\u003Cp align=\u0022center\u0022\u003E\u003Cstrong\u003EBIOMATERIALS-BASED NANOTECHNOLOGY FOR LYMPHATIC-TARGETED NITRIC OXIDE MODULATION\u003C\/strong\u003E\u003C\/p\u003E\u003Cp\u003E\u003Cstrong\u003E\u0026nbsp;\u003C\/strong\u003E\u003C\/p\u003E\u003Cp\u003EThe lymphatics play a vital role in the regulation of tissue fluid levels and immune response. Loss of lymphatic function leads to accumulation of interstitial fluid (edema), tissue damage, loss of lipid transport, increased adipocyte differentiation (obesity), and downregulated immune function. Alleviating lymphatic dysfunction therefore represents a critical hurdle in the treatment of many pathologies. Nitric oxide (NO) is among the principal signaling molecules controlling lymphatic function when it is produced in physiological levels, and is also integral in the cytotoxic immune response of leukocytes where it is produced it high concentrations and can react with other inflammatory species. Therefore, corruption of NO signaling is associated with the initiation and\/or propagation of many lymphatic pathologies. Given the importance of the lymphatics and the pronounced effect NO has on lymphatic and immune function, modulation of NO within lymphatics offers a promising means of alleviating lymphatic deficiencies that may arise from loss of function or parasitic infection, and which eventually contribute to many diseases. To date, however, clinical application of NO modulation within lymphatics has been hindered by the lack of adequate vehicles to both deliver and modulate NO levels in a controlled manner. The objective of this proposal is to develop a biomaterials-based approach to improve the efficacy of NO modulation within lymphatic tissues.\u0026nbsp;\u003C\/p\u003E","summary":null,"format":"limited_html"}],"field_subtitle":"","field_summary":[{"value":"\u003Cp\u003EPhD Proposal Presentation-\u0026nbsp;\u0022Biomaterials-based Nanotechnology for Lymphatic - targeted nitric oxide modulation\u0022 - Alex Schudel\u003C\/p\u003E","format":"limited_html"}],"field_summary_sentence":[{"value":"\u0022Biomaterials-based Nanotechnology for Lymphatic - targeted nitric oxide modulation\u0022"}],"uid":"27917","created_gmt":"2015-08-19 08:46:57","changed_gmt":"2017-04-13 21:18:44","author":"Laura Paige","boilerplate_text":"","field_publication":"","field_article_url":"","field_event_time":{"event_time_start":"2015-08-31T14:00:00-04:00","event_time_end":"2015-08-31T16:00:00-04:00","event_time_end_last":"2015-08-31T16:00:00-04:00","gmt_time_start":"2015-08-31 18:00:00","gmt_time_end":"2015-08-31 20:00:00","gmt_time_end_last":"2015-08-31 20:00:00","rrule":null,"timezone":"America\/New_York"},"extras":[],"groups":[{"id":"65448","name":"Bioengineering Graduate Program"}],"categories":[],"keywords":[],"core_research_areas":[],"news_room_topics":[],"event_categories":[{"id":"1788","name":"Other\/Miscellaneous"}],"invited_audience":[{"id":"78751","name":"Undergraduate students"},{"id":"174045","name":"Graduate students"}],"affiliations":[],"classification":[],"areas_of_expertise":[],"news_and_recent_appearances":[],"phone":[],"contact":[{"value":"\u003Cp\u003ELaura Paige\u003C\/p\u003E\u003Cp\u003E404-385-6655\u003C\/p\u003E","format":"limited_html"}],"email":[],"slides":[],"orientation":[],"userdata":""}},"431771":{"#nid":"431771","#data":{"type":"event","title":"BioEngineering Graduate Committee Meeting","body":[{"value":"\u003Cp\u003E\u003Cem\u003EThe BioEngineering graduate committee will meet to review\/approve program policies, program faculty applications and submitted student petitions.\u003Cbr \/\u003E\u003Cbr \/\u003EStudent Petitions due to\u0026nbsp;\u003Ca href=\u0022mailto:laura.paige@bioengineering.gatech.edu\u0022\u003ELaura Paige\u003C\/a\u003E\u0026nbsp;no later than: 9\/8\/2015\u003C\/em\u003E\u003C\/p\u003E","summary":null,"format":"limited_html"}],"field_subtitle":"","field_summary":[{"value":"\u003Cp\u003EBioEngineering Graduate Committee Meeting\u003C\/p\u003E","format":"limited_html"}],"field_summary_sentence":[{"value":"\u0022BioEngineering Graduate Committee Meeting\u0022"}],"uid":"27917","created_gmt":"2015-08-05 14:28:18","changed_gmt":"2016-10-08 02:12:48","author":"Laura Paige","boilerplate_text":"","field_publication":"","field_article_url":"","field_event_time":{"event_time_start":"2015-09-15T11:00:00-04:00","event_time_end":"2015-09-15T12:00:00-04:00","event_time_end_last":"2015-09-15T12:00:00-04:00","gmt_time_start":"2015-09-15 15:00:00","gmt_time_end":"2015-09-15 16:00:00","gmt_time_end_last":"2015-09-15 16:00:00","rrule":null,"timezone":"America\/New_York"},"extras":[],"groups":[{"id":"65448","name":"Bioengineering Graduate Program"}],"categories":[],"keywords":[],"core_research_areas":[],"news_room_topics":[],"event_categories":[{"id":"1789","name":"Conference\/Symposium"}],"invited_audience":[{"id":"78761","name":"Faculty\/Staff"}],"affiliations":[],"classification":[],"areas_of_expertise":[],"news_and_recent_appearances":[],"phone":[],"contact":[],"email":[],"slides":[],"orientation":[],"userdata":""}},"452101":{"#nid":"452101","#data":{"type":"event","title":"BioE PhD Defense Announcement: Shaun Eshraghi","body":[{"value":"\u003Cp\u003E\u003Cstrong\u003EAdvisor: \u003C\/strong\u003E\u003C\/p\u003E\u003Cp\u003ESuman Das, Ph.D. (Georgia Institute of Technology)\u003C\/p\u003E\u003Cp\u003E\u003Cstrong\u003E\u0026nbsp;\u003C\/strong\u003E\u003C\/p\u003E\u003Cp\u003E\u003Cstrong\u003ECommittee:\u003C\/strong\u003E\u003C\/p\u003E\u003Cp\u003EKyriaki Kalaitzidou, Ph.D. (Georgia Institute of Technology)\u003C\/p\u003E\u003Cp\u003EWilbur A. Lam, Ph.D. (Georgia Institute of Technology \u0026amp; Emory University)\u003C\/p\u003E\u003Cp\u003EDavid Ku, Ph.D. (Georgia Institute of Technology \u0026amp; Emory University)\u003C\/p\u003E\u003Cp\u003EJeannette Yen, Ph.D. (Georgia Institute of Technology)\u003C\/p\u003E\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\u003Cp\u003E\u003Cstrong\u003E\u0026nbsp;\u003C\/strong\u003E\u003C\/p\u003E\u003Cp\u003E\u003Cstrong\u003EAdditive Manufacturing of Tissue Engineering Scaffolds for Bone and Cartilage\u003C\/strong\u003E\u003C\/p\u003E\u003Cp align=\u0022center\u0022\u003E\u003Cstrong\u003E\u0026nbsp;\u003C\/strong\u003E\u003C\/p\u003E\u003Cp\u003EBone and cartilage constructs are often plagued with mechanical failure, poor nutrient transport, poor tissue ingrowth, and necrosis of embedded cells. However, advances in computer aided design (CAD) and computational modeling enable the design of scaffolds with complex internal michroarchitectures and the a priori prediction of their transport and mechanical properties, such that the design of constructs satisfying the needs of the tissue environment can be optimized. The goal of this research is to investigate the capability of additive manufacturing technologies to create designed microarchitectured tissue engineering scaffolds for bone and cartilage regeneration. This goal will be achieved by pursuing the following two objectives: (1) the manufacture of bioresorbable thermoplastic scaffolds by selective laser sintering (SLS) (2) and the manufacture of hydrogel scaffolds by large area maskless photopolymerization (LAMP). SLS is a laser based additive manufacturing method in which an object is built layer-by-layer by fusing powdered material using a computer-controlled scanning laser. \u0026nbsp;LAMP is a massively parallel ultraviolet curing-based process that can be used to create hydrogels from a photomonomer on a large-scale (558x558mm) while maintaining extremely high feature resolution (20\u00b5m). In this research, SLS is used to process polycaprolactone (PCL) and composites of PCL with hydroxyapatite (HA) for bone tissue engineering applications while LAMP is used to process polyethylene glycol diacrylate (PEGDA) which can be used for hard and soft tissue applications\u003C\/p\u003E","summary":null,"format":"limited_html"}],"field_subtitle":"","field_summary":[{"value":"\u003Cp\u003EPhD Defense Presentation-\u0026nbsp;\u0022Additive Manufacturing of Tissue Engineering Scaffolds for Bone and Cartilage\u0022- Shaun Eshraghi\u003C\/p\u003E","format":"limited_html"}],"field_summary_sentence":[{"value":"\u0022Additive Manufacturing of Tissue Engineering Scaffolds for Bone and Cartilage\u0022"}],"uid":"27917","created_gmt":"2015-09-25 08:39:04","changed_gmt":"2017-04-13 21:18:09","author":"Laura Paige","boilerplate_text":"","field_publication":"","field_article_url":"","field_event_time":{"event_time_start":"2015-10-13T11:00:00-04:00","event_time_end":"2015-10-13T13:00:00-04:00","event_time_end_last":"2015-10-13T13:00:00-04:00","gmt_time_start":"2015-10-13 15:00:00","gmt_time_end":"2015-10-13 17:00:00","gmt_time_end_last":"2015-10-13 17:00:00","rrule":null,"timezone":"America\/New_York"},"extras":[],"groups":[{"id":"65448","name":"Bioengineering Graduate Program"}],"categories":[],"keywords":[],"core_research_areas":[],"news_room_topics":[],"event_categories":[{"id":"1788","name":"Other\/Miscellaneous"}],"invited_audience":[{"id":"78751","name":"Undergraduate students"},{"id":"78761","name":"Faculty\/Staff"},{"id":"174045","name":"Graduate students"}],"affiliations":[],"classification":[],"areas_of_expertise":[],"news_and_recent_appearances":[],"phone":[],"contact":[{"value":"\u003Cp\u003ELaura Paige\u0026nbsp;\u003C\/p\u003E\u003Cp\u003E404-385-6655\u003C\/p\u003E","format":"limited_html"}],"email":[],"slides":[],"orientation":[],"userdata":""}},"458011":{"#nid":"458011","#data":{"type":"event","title":"PhD Defense Presentation- Jenna Wilson","body":[{"value":"\u003Cp\u003E\u003Cstrong\u003EAdvisor: \u003C\/strong\u003ETodd McDevitt, Ph.D. (Gladstone Institutes)\u003C\/p\u003E\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\u003Cp\u003E\u003Cstrong\u003ECommittee:\u0026nbsp;\u003C\/strong\u003E\u003C\/p\u003E\u003Cp\u003EEdward Botchwey, Ph.D. (Georgia Institute of Technology)\u003C\/p\u003E\u003Cp\u003EKrishnendu Roy, Ph.D.\u0026nbsp;(Georgia Institute of Technology)\u003C\/p\u003E\u003Cp\u003EAthanassios Sambanis, Ph.D.\u003C\/p\u003E\u003Cp\u003EEdmund Waller, M.D., Ph.D. (Emory University)\u0026nbsp;\u003C\/p\u003E\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\u003Cp\u003E\u003Cstrong\u003E\u201cEngineering a Platform to Harness Pluripotent Stem Cell-Derived Paracrine Factors\u201d\u003C\/strong\u003E\u003C\/p\u003E\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\u003Cp\u003EThe results of initial stem cell transplantation studies indicate that many of the observed functional improvements are due to transient paracrine actions of the transplanted stem cells, rather than the stem cells permanently engrafting and replacing the damaged cellular material. Thus, research on the identity and potency of paracrine factors secreted by stem cells has become an increased area of focus in the regenerative medicine field. Due to the mitogenic and morphogenic roles of embryonic stem cells (ESCs) during the early stages of development, they are an underexplored cell population which likely possess a unique and potent secretome. A potential application for the milieu of mitogens and morphogens produced by pluripotent stem cells is the restoration of the proliferative and regenerative capacity of adult stem cell populations, as these multipotent cells have a limited capacity for expansion outside the body and are also negatively regulated by dysfunctional signals in vivo which are implicated in the reduced capacity for regeneration with injury or aging.\u003C\/p\u003E\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\u003Cp\u003ETo take advantage of the stimulatory potential of pluripotent cell-derived signals, the goal of this project was to develop a controlled means of harnessing and delivering soluble factors derived from pluripotent stem cells. This objective was accomplished through the (1) development of a microencapsulation-based culture system for ESC aggregates, (2) design of a novel upstream bioreactor for encapsulated ESC culture which enabled the concentration and delivery of stem cell secreted products, (3) characterization of the global expression profile of ESC-secreted factors, and (4) investigation of the influence of ESC-derived factors on adult stem and progenitor populations. Ultimately, this project established pluripotent stem cells as a unique source of potent growth factors and cytokines which can be regulated and concentrated using engineering design parameters to enable multiple applications in the field of regenerative medicine.\u003C\/p\u003E\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E","summary":null,"format":"limited_html"}],"field_subtitle":"","field_summary":[{"value":"\u003Cp\u003EPhD Defense Presentation-\u0026nbsp;\u0022Engineering a Platform to Harness Pluripotent Stem Cell-Derived Paracrine Factors\u0022- Jenna Wilson\u003C\/p\u003E","format":"limited_html"}],"field_summary_sentence":[{"value":"\u0022Engineering a Platform to Harness Pluripotent Stem Cell-Derived Paracrine Factors\u0022"}],"uid":"27917","created_gmt":"2015-10-12 07:36:51","changed_gmt":"2016-10-08 02:13:57","author":"Laura Paige","boilerplate_text":"","field_publication":"","field_article_url":"","field_event_time":{"event_time_start":"2015-10-26T11:30:00-04:00","event_time_end":"2015-10-26T13:30:00-04:00","event_time_end_last":"2015-10-26T13:30:00-04:00","gmt_time_start":"2015-10-26 15:30:00","gmt_time_end":"2015-10-26 17:30:00","gmt_time_end_last":"2015-10-26 17:30:00","rrule":null,"timezone":"America\/New_York"},"extras":[],"groups":[{"id":"65448","name":"Bioengineering Graduate Program"}],"categories":[],"keywords":[],"core_research_areas":[],"news_room_topics":[],"event_categories":[{"id":"1788","name":"Other\/Miscellaneous"}],"invited_audience":[{"id":"78761","name":"Faculty\/Staff"}],"affiliations":[],"classification":[],"areas_of_expertise":[],"news_and_recent_appearances":[],"phone":[],"contact":[{"value":"\u003Cp\u003ELaura Paige\u003C\/p\u003E\u003Cp\u003E404-385-6655\u003C\/p\u003E","format":"limited_html"}],"email":[],"slides":[],"orientation":[],"userdata":""}},"452191":{"#nid":"452191","#data":{"type":"event","title":"BioEngineering Program Faculty Meeting","body":[{"value":"\u003Cp\u003E\u003Cem\u003EThe BioEngineering Program faculty meet regularly during the semester to address program policies, events and future research and academic directions.\u003C\/em\u003E\u003C\/p\u003E","summary":null,"format":"limited_html"}],"field_subtitle":"","field_summary":[{"value":"\u003Cp\u003E\u003Cem\u003EProgram policies, events and directions to be discussed\u003C\/em\u003E\u003C\/p\u003E","format":"limited_html"}],"field_summary_sentence":[{"value":"BioEngineering Program Faculty Meeting"}],"uid":"27917","created_gmt":"2015-09-25 09:25:29","changed_gmt":"2016-10-08 02:14:01","author":"Laura Paige","boilerplate_text":"","field_publication":"","field_article_url":"","field_event_time":{"event_time_start":"2015-10-29T12:00:00-04:00","event_time_end":"2015-10-29T13:00:00-04:00","event_time_end_last":"2015-10-29T13:00:00-04:00","gmt_time_start":"2015-10-29 16:00:00","gmt_time_end":"2015-10-29 17:00:00","gmt_time_end_last":"2015-10-29 17:00:00","rrule":null,"timezone":"America\/New_York"},"extras":[],"groups":[{"id":"65448","name":"Bioengineering Graduate Program"}],"categories":[],"keywords":[],"core_research_areas":[],"news_room_topics":[],"event_categories":[{"id":"1788","name":"Other\/Miscellaneous"}],"invited_audience":[{"id":"78761","name":"Faculty\/Staff"}],"affiliations":[],"classification":[],"areas_of_expertise":[],"news_and_recent_appearances":[],"phone":[],"contact":[{"value":"\u003Cp\u003ELaura Paige\u003C\/p\u003E\u003Cp\u003E404-385-6655\u003C\/p\u003E","format":"limited_html"}],"email":[],"slides":[],"orientation":[],"userdata":""}},"460401":{"#nid":"460401","#data":{"type":"event","title":"BioE PhD Proposal Presentation- Nathan Rohner","body":[{"value":"\u003Cp\u003E\u003Cstrong\u003EAdvisor: Susan Thomas, Ph.D. \u003C\/strong\u003E(Georgia Institute of Technology)\u003C\/p\u003E\u003Cp\u003E\u003Cstrong\u003ECommittee:\u003C\/strong\u003E\u003C\/p\u003E\u003Cp\u003E\u003Cstrong\u003EKrishnendu Roy, Ph.D. \u003C\/strong\u003E(Georgia Institute of Technology)\u003C\/p\u003E\u003Cp\u003E\u003Cstrong\u003EEdward Botchwey, Ph.D. \u003C\/strong\u003E(Georgia Institute of Technology)\u003C\/p\u003E\u003Cp\u003E\u003Cstrong\u003EFredrik Vannberg, Ph.D. \u003C\/strong\u003E(Georgia Institute of Technology)\u003C\/p\u003E\u003Cp\u003E\u003Cstrong\u003EEdmund Waller, M.D., Ph.D. \u003C\/strong\u003E(Emory University)\u003C\/p\u003E\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\u003Cp align=\u0022center\u0022\u003E\u003Cstrong\u003EROLE OF VASCULAR REMODELING IN THE ACCUMULATION, CLEARANCE, AND BIODISTRIBUTION OF BIOMOLECULAR FACTORS IN LOCAL INFLAMMATORY DISEASE\u003C\/strong\u003E\u003C\/p\u003E\u003Cp\u003E\u003Cstrong\u003E\u0026nbsp;\u003C\/strong\u003E\u003C\/p\u003E\u003Cp\u003ELocal inflammation within tumors and injured joints is implicated in the systemic side effects that precipitate development of more advanced pathologies, such as metastasis and rheumatoid arthritis (RA), respectively. Soluble factors (SF) produced within the tissues of localized disease, including cytokines, exosomes, proteases, and microvesicles, mediate pathological signaling and have emerged as putative therapeutic targets. However, SF bioavailability in distributed tissues and the impact of disease course on their dissemination profiles is poorly defined. This stymies progress towards therapeutic amelioration of SF signaling activities to improve disease outcome and is the critical knowledge gap this proposal seeks to fill. The central hypothesis is that vascular remodeling within diseased tissues redirects the organism-wide signaling activity of locally secreted SF and may negatively contribute to disease burden by altering the bioavailability of molecules important to systemic disease progression. The overall objective of this proposal is to elucidate how local tissue remodeling may lead to pathological signaling within distributed tissues in order to provide insight into the potential for localized disease to exert systemic effects.\u003C\/p\u003E","summary":null,"format":"limited_html"}],"field_subtitle":"","field_summary":[{"value":"\u003Cp\u003EPhD Proposal Presentation-\u0026nbsp;\u0022ROLE OF VASCULAR REMODELING IN THE ACCUMULATION, CLEARANCE, AND BIODISTRIBUTION OF BIOMOLECULAR FACTORS IN LOCAL INFLAMMATORY DISEASE\u0022- Nathan Rohner\u003C\/p\u003E","format":"limited_html"}],"field_summary_sentence":[{"value":"\u0022ROLE OF VASCULAR REMODELING IN THE ACCUMULATION, CLEARANCE, AND BIODISTRIBUTION OF BIOMOLECULAR FACTORS IN LOCAL INFLAMMATORY DISEASE\u0022"}],"uid":"27917","created_gmt":"2015-10-19 11:33:49","changed_gmt":"2017-04-13 21:17:53","author":"Laura Paige","boilerplate_text":"","field_publication":"","field_article_url":"","field_event_time":{"event_time_start":"2015-10-30T14:00:00-04:00","event_time_end":"2015-10-30T16:00:00-04:00","event_time_end_last":"2015-10-30T16:00:00-04:00","gmt_time_start":"2015-10-30 18:00:00","gmt_time_end":"2015-10-30 20:00:00","gmt_time_end_last":"2015-10-30 20:00:00","rrule":null,"timezone":"America\/New_York"},"extras":[],"related_links":[{"url":"http:\/\/thomas.gatech.edu\/","title":"Thomas lab website"}],"groups":[{"id":"65448","name":"Bioengineering Graduate Program"}],"categories":[],"keywords":[],"core_research_areas":[],"news_room_topics":[],"event_categories":[{"id":"1788","name":"Other\/Miscellaneous"}],"invited_audience":[{"id":"78751","name":"Undergraduate students"},{"id":"78761","name":"Faculty\/Staff"},{"id":"174045","name":"Graduate students"}],"affiliations":[],"classification":[],"areas_of_expertise":[],"news_and_recent_appearances":[],"phone":[],"contact":[{"value":"\u003Cp\u003ELaura Paige 404-385-6655\u003C\/p\u003E","format":"limited_html"}],"email":[],"slides":[],"orientation":[],"userdata":""}},"463501":{"#nid":"463501","#data":{"type":"event","title":"PhD Defense Presentation - Adrian Lam","body":[{"value":"\u003Cp\u003E\u003Cstrong\u003EAdvisor:\u0026nbsp;\u003C\/strong\u003E\u003C\/p\u003E\u003Cp\u003EJohn N. Oshinski, Ph.D., Department of Biomedical Engineering, Georgia Tech\u003C\/p\u003E\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\u003Cp\u003E\u003Cstrong\u003ECommittee:\u003C\/strong\u003E\u003C\/p\u003E\u003Cp\u003EXiaoping Hu, Ph.D., Department of Biomedical Engineering, Georgia Tech\u003C\/p\u003E\u003Cp\u003EMichael S. Lloyd, M.D., Division of Cardiology, Department of Medicine, Emory University School of Medicine\u003C\/p\u003E\u003Cp\u003EDavid Ku, Ph.D., Department of Radiology and Imaging Sciences, Emory University School of Medicine\u003C\/p\u003E\u003Cp\u003EOrlando Simonetti, Ph.D., Department of Biomedical Engineering, Ohio State University\u003C\/p\u003E\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\u003Cp\u003E\u003Cstrong\u003EDevelopment of a Combined Angiography and Late Gadolinium Enhancement MR Sequence\u003C\/strong\u003E\u003C\/p\u003E\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\u003Cp\u003EWith the rapid growth of catheter-based interventional cardiology procedures, knowledge of the vasculature surrounding the heart relative to the distribution of scar tissue can provide important information for procedural planning and appropriate patient selection. Two examples of this are: (1) selecting patients for Cardiac Resynchronization Therapy (CRT), or (2) evaluating the outcome for atrial fibrillation (AF) patients who have undergone Pulmonary Vein Isolation (PVI).\u003C\/p\u003E\u003Cp\u003ECRT uses a biventricular pacemaker to restore synchronous myocardial contraction in heart failure patients with evidence of ventricular dyssynchrony. Optimal improvement from therapy necessitates that the left ventricular pacing lead, which is transvenously implanted through the coronary veins, is situated at the latest contracting site that is not predominantly myocardial scar. In order to achieve this, co-registered images of the coronary veins and myocardial scar are necessary. However, current MR imaging protocols use separate sequences to image these features, complicating co-registration.\u0026nbsp;\u003C\/p\u003E\u003Cp\u003EPVI aims to circumferentially ablate around the pulmonary veins to electrically isolate triggers from reaching the left atrium. In order to evaluate ablation effectiveness, segmentation of the atrial wall is necessary. Yet, the thin nature of the atrial wall and low contrast at the blood-atrial wall interface make segmentation a challenge. While angiography images clearly delineate the inner atrial wall, co-registration is still necessary to the scar images.\u003C\/p\u003E\u003Cp\u003EThese examples benefit from co-registration between MR angiography and scar images yet use different MR sequences making image registration cumbersome, preventing a unified display. The overall goal of this project was to develop a sequence that would produce inherently co-registered angiography and scar images using a single acquisition sequence and create image processing methods for a combined display. This sequence uses a slow infusion of gadolinium with a centric-ordered k-space acquisition scheme for angiographic imaging. Central k-space will be re-acquired at the end of the sequence (~10 mins after injection) and share outer k-space from the initial angiographic k-space to create inherently co-registered scar images. This sequence will be validated by imaging porcine hearts and then tested on two patient groups: (1) patients with known previous myocardial infarct (MI), and (2) patients with AF who have undergone PVI, to use LGE to evaluate ablation effectiveness. Algorithms will be developed to combine coronary vein and myocardial scar displays to allow LV lead planning. In addition, the concept of a pulmonary vein bullseye will be created to allow quantification of the extent of circumferential ablation in post-PVI patients.\u003C\/p\u003E","summary":null,"format":"limited_html"}],"field_subtitle":"","field_summary":[{"value":"\u003Cp\u003EPhD Defense Presentation-\u0026nbsp;\u0022Development of a Combined Angiography and Late Gadolinium Enhancement MR Sequence\u0022- Adrian Lam\u003C\/p\u003E","format":"limited_html"}],"field_summary_sentence":[{"value":"\u0022Development of a Combined Angiography and Late Gadolinium Enhancement MR Sequence\u0022"}],"uid":"27917","created_gmt":"2015-10-28 10:42:39","changed_gmt":"2017-04-13 21:17:49","author":"Laura Paige","boilerplate_text":"","field_publication":"","field_article_url":"","field_event_time":{"event_time_start":"2015-11-10T13:00:00-05:00","event_time_end":"2015-11-10T15:00:00-05:00","event_time_end_last":"2015-11-10T15:00:00-05:00","gmt_time_start":"2015-11-10 18:00:00","gmt_time_end":"2015-11-10 20:00:00","gmt_time_end_last":"2015-11-10 20:00:00","rrule":null,"timezone":"America\/New_York"},"extras":[],"groups":[{"id":"65448","name":"Bioengineering Graduate Program"}],"categories":[],"keywords":[],"core_research_areas":[],"news_room_topics":[],"event_categories":[{"id":"1789","name":"Conference\/Symposium"}],"invited_audience":[{"id":"78751","name":"Undergraduate students"},{"id":"78761","name":"Faculty\/Staff"},{"id":"174045","name":"Graduate students"}],"affiliations":[],"classification":[],"areas_of_expertise":[],"news_and_recent_appearances":[],"phone":[],"contact":[{"value":"\u003Cp\u003ELaura Paige\u003C\/p\u003E\u003Cp\u003E404-385-6655\u003C\/p\u003E","format":"limited_html"}],"email":[],"slides":[],"orientation":[],"userdata":""}},"467471":{"#nid":"467471","#data":{"type":"event","title":"BioEngineering Graduate Committee Meeting","body":[{"value":"\u003Cp\u003E\u003Cem\u003EThe BioEngineering graduate committee will meet to review\/approve program policies, program faculty applications and submitted student petitions.\u003Cbr \/\u003E\u003Cbr \/\u003EStudent Petitions due to\u0026nbsp;\u003Ca href=\u0022mailto:laura.paige@bioengineering.gatech.edu\u0022\u003ELaura Paige\u003C\/a\u003E\u0026nbsp;no later than: 11\/11\/2015\u003C\/em\u003E\u003C\/p\u003E","summary":null,"format":"limited_html"}],"field_subtitle":"","field_summary":[{"value":"\u003Cp\u003EBioEngineering Graduate Committee Meeting\u003C\/p\u003E","format":"limited_html"}],"field_summary_sentence":[{"value":"\u0022BioEngineering Graduate Committee Meeting\u0022"}],"uid":"27917","created_gmt":"2015-11-09 10:49:31","changed_gmt":"2017-04-13 21:17:42","author":"Laura Paige","boilerplate_text":"","field_publication":"","field_article_url":"","field_event_time":{"event_time_start":"2015-11-16T15:00:00-05:00","event_time_end":"2015-11-16T16:00:00-05:00","event_time_end_last":"2015-11-16T16:00:00-05:00","gmt_time_start":"2015-11-16 20:00:00","gmt_time_end":"2015-11-16 21:00:00","gmt_time_end_last":"2015-11-16 21:00:00","rrule":null,"timezone":"America\/New_York"},"extras":[],"groups":[{"id":"65448","name":"Bioengineering Graduate Program"}],"categories":[],"keywords":[],"core_research_areas":[],"news_room_topics":[],"event_categories":[{"id":"1789","name":"Conference\/Symposium"}],"invited_audience":[{"id":"78751","name":"Undergraduate students"},{"id":"174045","name":"Graduate students"}],"affiliations":[],"classification":[],"areas_of_expertise":[],"news_and_recent_appearances":[],"phone":[],"contact":[],"email":[],"slides":[],"orientation":[],"userdata":""}},"465611":{"#nid":"465611","#data":{"type":"event","title":"BioE PhD Proposal presentation- Olivia Burnsed","body":[{"value":"\u003Cp\u003E\u003Cstrong\u003EThesis Committee\u003C\/strong\u003E\u003C\/p\u003E\u003Cp\u003ERobert E. Guldberg, Ph.D. (ME, Georgia Institute of Technology) (Advisor)\u003C\/p\u003E\u003Cp\u003ETodd C. McDevitt, Ph.D. (Gladstone Institute of Cardiovascular Disease)\u003C\/p\u003E\u003Cp\u003EThomas J. Koob, Ph. D. (Chief Scientific Officer, MiMedx Group, Inc.)\u003C\/p\u003E\u003Cp\u003EJohnna S. Temenoff, Ph.D. (BME, Georgia Institute of Technology)\u003C\/p\u003E\u003Cp\u003EKrishnendu Roy, Ph. D. (BME, Georgia Institute of Technology)\u003C\/p\u003E\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\u003Cp\u003E\u003Cstrong\u003ETitle:\u0026nbsp;\u003C\/strong\u003EEngineering an Improved Cartilage Repair Strategy Combining Cells and ECM-derived Materials\u003C\/p\u003E\u003Cp class=\u0022xmsonormal\u0022\u003E\u0026nbsp;\u003C\/p\u003E\u003Cp\u003E\u003Cstrong\u003EAbstract\u003C\/strong\u003E\u003C\/p\u003E\u003Cp\u003ECartilage has a limited capacity to heal and regenerate due to its low cellularity and avascular nature. As a result, osteoarthritis (OA) affects nearly 27 million adults in the US and there are no clinically proven disease modifying therapies, leading to nearly half a million total knee replacements annually. Autologous chondrocyte implantation is the only clinically approved cellular therapy for chondral defects in the US, but\u0026nbsp;the inability to expand chondrocytes to sufficient numbers without adversely affecting their phenotype remains a significant problem. Additionally, the multiple inflammatory mediators involved in the initiation and perpetuation of OA hinder the efficacy of cellular therapies.\u0026nbsp;The inherent immunomodulatory capabilities of MSCs offer a potent alternative to conventional drug treatment regimens due to their ability to regulate multiple signaling pathways and cell types of innate and adaptive immunity. The primary objective of this study is to engineer an improved cartilage repair strategy by combining cells and extracellular matrix(ECM)-derived materials.\u0026nbsp;Specifically, this work will (i) develop cartilage-derived microcarriers for chondrocyte expansion (ii) determine the effect of tissue-specific ECM-derived materials on the chondrogenesis, cell expansion, and secretion of anti-inflammatory factors, and (iii) characterize the effect of MSC delivery format, via single cells, spheroids, or ECM-derived microcarriers, on OA progression in a\u0026nbsp;\u0026nbsp;post-traumatic small animal model. This work will increase the scientific community\u0027s understanding of the role of ECM-derived materials in influencing cell phenotype and expansion as well as the effect of culture format and delivery on MSC-mediated immunomodulatory activity.\u003C\/p\u003E","summary":null,"format":"limited_html"}],"field_subtitle":"","field_summary":[{"value":"\u003Cp\u003EBioE PhD Proposal presentation-\u0026nbsp;\u0022Engineering an Improved Cartilage Repair Strategy Combining Cells and ECM-derived Materials\u0022- Olivia Burnsed\u003C\/p\u003E","format":"limited_html"}],"field_summary_sentence":[{"value":"\u0022Engineering an Improved Cartilage Repair Strategy Combining Cells and ECM-derived Materials\u0022"}],"uid":"27917","created_gmt":"2015-11-03 10:21:20","changed_gmt":"2016-10-08 02:14:39","author":"Laura Paige","boilerplate_text":"","field_publication":"","field_article_url":"","field_event_time":{"event_time_start":"2015-11-17T17:30:00-05:00","event_time_end":"2015-11-17T19:30:00-05:00","event_time_end_last":"2015-11-17T19:30:00-05:00","gmt_time_start":"2015-11-17 22:30:00","gmt_time_end":"2015-11-18 00:30:00","gmt_time_end_last":"2015-11-18 00:30:00","rrule":null,"timezone":"America\/New_York"},"extras":[],"related_links":[{"url":"http:\/\/guldberglab.gatech.edu\/","title":"Guldberg Musculoskeletal Research Lab"}],"groups":[{"id":"65448","name":"Bioengineering Graduate Program"}],"categories":[],"keywords":[],"core_research_areas":[],"news_room_topics":[],"event_categories":[{"id":"1789","name":"Conference\/Symposium"}],"invited_audience":[{"id":"78761","name":"Faculty\/Staff"}],"affiliations":[],"classification":[],"areas_of_expertise":[],"news_and_recent_appearances":[],"phone":[],"contact":[{"value":"\u003Cp\u003ELaura Paige 404.385.6655\u003C\/p\u003E","format":"limited_html"}],"email":[],"slides":[],"orientation":[],"userdata":""}},"456691":{"#nid":"456691","#data":{"type":"event","title":"BioEngineering Program Faculty Meeting","body":[{"value":"\u003Cp\u003E\u003Cem\u003EThe BioEngineering Program faculty meet regularly during the semester to address program policies, events and future research and academic directions.\u003C\/em\u003E\u003C\/p\u003E","summary":null,"format":"limited_html"}],"field_subtitle":"","field_summary":[{"value":"\u003Cp\u003E\u003Cem\u003EProgram policies, events and directions to be discussed\u003C\/em\u003E\u003C\/p\u003E","format":"limited_html"}],"field_summary_sentence":[{"value":"\u0022BioEngineering Program Faculty Meeting\u0022"}],"uid":"27917","created_gmt":"2015-10-07 10:17:51","changed_gmt":"2016-10-08 02:14:14","author":"Laura Paige","boilerplate_text":"","field_publication":"","field_article_url":"","field_event_time":{"event_time_start":"2015-12-01T10:00:00-05:00","event_time_end":"2015-12-01T11:00:00-05:00","event_time_end_last":"2015-12-01T11:00:00-05:00","gmt_time_start":"2015-12-01 15:00:00","gmt_time_end":"2015-12-01 16:00:00","gmt_time_end_last":"2015-12-01 16:00:00","rrule":null,"timezone":"America\/New_York"},"extras":[],"groups":[{"id":"65448","name":"Bioengineering Graduate Program"}],"categories":[],"keywords":[],"core_research_areas":[],"news_room_topics":[],"event_categories":[{"id":"1788","name":"Other\/Miscellaneous"}],"invited_audience":[{"id":"78761","name":"Faculty\/Staff"}],"affiliations":[],"classification":[],"areas_of_expertise":[],"news_and_recent_appearances":[],"phone":[],"contact":[{"value":"\u003Cp\u003ELaura Paige\u003C\/p\u003E\u003Cp\u003E404-385-6655\u003C\/p\u003E","format":"limited_html"}],"email":[],"slides":[],"orientation":[],"userdata":""}},"472821":{"#nid":"472821","#data":{"type":"event","title":"PhD Proposal Presentation - Kathleen Bates","body":[{"value":"\u003Cp\u003E\u003Cstrong\u003EAdvisor: Hang Lu, Ph.D.\u003C\/strong\u003E (Georgia Institute of Technology)\u003C\/p\u003E\u003Cp\u003E\u003Cstrong\u003ECommittee: \u003C\/strong\u003E\u003C\/p\u003E\u003Cp\u003E\u003Cstrong\u003EJennifer Curtis, Ph.D. (\u003C\/strong\u003EGeorgia Institute of Technology)\u003C\/p\u003E\u003Cp\u003E\u003Cstrong\u003EDaniel Goldman, Ph.D. (\u003C\/strong\u003EGeorgia Institute of Technology)\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u003C\/p\u003E\u003Cp\u003E\u003Cstrong\u003EPatrick McGrath, Ph.D. (\u003C\/strong\u003EGeorgia Institute of Technology)\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u003C\/p\u003E\u003Cp\u003E\u003Cstrong\u003ELe Song, Ph.D. (\u003C\/strong\u003EGeorgia Institute of Technology)\u0026nbsp;\u0026nbsp; \u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u003C\/p\u003E\u003Cp\u003E\u003Cstrong\u003EMark Styczynski, Ph.D.\u003C\/strong\u003E \u003Cstrong\u003E(\u003C\/strong\u003EGeorgia Institute of Technology)\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u003C\/p\u003E\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\u003Cp align=\u0022center\u0022\u003E\u003Cstrong\u003EAn automated and low-cost microfluidic platform for behavioral phenotyping of \u003Cem\u003ECaenorhabditis elegans\u003C\/em\u003E\u003C\/strong\u003E\u003C\/p\u003E\u003Cp\u003E\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp; Animal behavior results from a multitude of factors, including external stimuli and internal neural state, as well as past experiences. Behavior is therefore highly variable and dependent on developmental trajectory. This plays clear roles in disease, including psychiatric disorders and diseases that span a continuum, such as autism spectrum disorder. At the same time, these disorders are partially heritable, and usually this heritability is multigenic. In order to address how genes and the environment interact to regulate variability, large-scale experiments with high repeatability are requisite. \u003Cem\u003ECaenorhabditis elegans\u003C\/em\u003E, a small roundworm, significantly simplifies genetic experiments through ease of isogenic culture.\u0026nbsp; However, no technology currently exists that can provide continuous temporal monitoring and behavioral analysis of \u003Cem\u003EC. elegans\u003C\/em\u003E for days-long timescales. In this thesis, a low-cost microscopy and analysis system will be developed to enable scalable implementation of a dynamically controlled microfluidic environment. A general-purpose behavior analysis system will be implemented to evaluate behavioral flexibility across biologically relevant physical and chemical environments. This same analysis technique will then be used to compare the behavior of a library of recombinant inbred \u003Cem\u003EC. elegans\u003C\/em\u003E lines, with the goal to map quantitative behavioral traits to a set of genetic loci and begin addressing the complex question of gene-environment interactions in relation to behavior. This system will also be useful for other large-scale behavioral applications, including drug screening and associative learning.\u0026nbsp;\u003C\/p\u003E","summary":null,"format":"limited_html"}],"field_subtitle":"","field_summary":[{"value":"\u003Cp\u003EPhD Proposal Presentation-\u0026nbsp;\u0022An automated and low-cost microfluidic platform for behavioral phenotyping of Caenorhabditis elegans\u0022- Kathleen Bates\u003C\/p\u003E","format":"limited_html"}],"field_summary_sentence":[{"value":"\u0022An automated and low-cost microfluidic platform for behavioral phenotyping of Caenorhabditis elegans\u0022"}],"uid":"27917","created_gmt":"2015-11-24 08:45:39","changed_gmt":"2017-04-13 21:17:34","author":"Laura Paige","boilerplate_text":"","field_publication":"","field_article_url":"","field_event_time":{"event_time_start":"2015-12-07T13:30:00-05:00","event_time_end":"2015-12-07T15:30:00-05:00","event_time_end_last":"2015-12-07T15:30:00-05:00","gmt_time_start":"2015-12-07 18:30:00","gmt_time_end":"2015-12-07 20:30:00","gmt_time_end_last":"2015-12-07 20:30:00","rrule":null,"timezone":"America\/New_York"},"extras":[],"groups":[{"id":"65448","name":"Bioengineering Graduate Program"}],"categories":[],"keywords":[],"core_research_areas":[],"news_room_topics":[],"event_categories":[{"id":"1789","name":"Conference\/Symposium"}],"invited_audience":[{"id":"78751","name":"Undergraduate students"},{"id":"78761","name":"Faculty\/Staff"},{"id":"174045","name":"Graduate students"}],"affiliations":[],"classification":[],"areas_of_expertise":[],"news_and_recent_appearances":[],"phone":[],"contact":[{"value":"\u003Cp\u003ELaura Paige\u003C\/p\u003E\u003Cp\u003E404.385.6655\u003C\/p\u003E","format":"limited_html"}],"email":[],"slides":[],"orientation":[],"userdata":""}},"481411":{"#nid":"481411","#data":{"type":"event","title":"PhD Defense Presentation- Jennifer Lei","body":[{"value":"\u003Cp\u003E\u003Cstrong\u003EAdvisor:\u003C\/strong\u003E\u003C\/p\u003E\u003Cp\u003EJohnna S. Temenoff, Ph.D.\u0026nbsp;(Georgia Institute of Technology)\u003C\/p\u003E\u003Cp\u003E\u003Cstrong\u003ECommittee:\u003C\/strong\u003E\u003C\/p\u003E\u003Cp\u003EEdward A. Botchwey, Ph.D.\u0026nbsp;(Georgia Institute of Technology)\u003Cbr \/\u003E Robert E. Guldberg, Ph.D.\u0026nbsp;(Georgia Institute of Technology)\u003Cbr \/\u003E Todd C. McDevitt, Ph.D.\u0026nbsp;(The Gladstone Institutes)\u003Cbr \/\u003E William L. Murphy, Ph.D. (University of Wisconsin-Madison)\u003C\/p\u003E\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\u003Cp align=\u0022center\u0022\u003E\u003Cstrong\u003EThe Development of Glycosaminoglycan Coatings for Mesenchymal Stem Cell-Based Culture Applications\u003C\/strong\u003E\u003C\/p\u003E\u003Cp align=\u0022center\u0022\u003E\u003Cstrong\u003E\u0026nbsp;\u003C\/strong\u003E\u003C\/p\u003E\u003Cp\u003EMesenchymal stem cells are multipotent cells that have the ability to differentiate down multiple lineages as well as secrete trophic and anti-inflammatory factors. These qualities make MSCs a promising cell source for cell-based therapies to treat a variety of injuries and pathologies. Biomaterials are often used to control and direct stem cell behavior by engineering a desired environment around the cells. Recent research has focused on using the naturally derived sulfated glycosaminoglycan (GAG), heparin as a biomaterial due to its negative charge and ability to sequester and bind positively charged growth factors. Engineering a heparin coating that can mimic the native heparan sulfate proteoglycan structure found at cell surfaces can be used as a novel platform to present GAGs to cells to direct cell behavior. The overall goal of this dissertation was to develop GAG-based coatings on MSC spheroids in order to study the role of heparin and its derivatives on MSC culture applications.\u003C\/p\u003E\u003Cp\u003ETo investigate the role of heparin in coating form on MSC behavior, the ability of the coating to sequester positively charged growth factors was characterized. Given the role of sulfation in the negative charge density of heparin and growth factor interactions, a desulfated heparin coating was develop and used to examine how presentation of coatings with native and no sulfation levels could potentiate response to growth factors in the surrounding environment. Additionally, heparin and growth factor binding in coating presentation was explored to develop a novel platform to assemble MSC-based microtissues. Together these studies provided valuable insight into a novel approach to direct cell behavior by engineering a coating that harnesses heparin interactions with the surrounding environment.\u003C\/p\u003E\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E","summary":null,"format":"limited_html"}],"field_subtitle":"","field_summary":[{"value":"\u003Cp\u003EPhD Defense Presentation-\u0026nbsp;\u0022The Development of Glycosaminoglycan Coatings for Mesenchymal Stem Cell-Based Culture Applications\u0022- Jennifer Lei\u003C\/p\u003E","format":"limited_html"}],"field_summary_sentence":[{"value":"\u0022The Development of Glycosaminoglycan Coatings for Mesenchymal Stem Cell-Based Culture Applications\u0022"}],"uid":"27917","created_gmt":"2016-01-04 08:28:20","changed_gmt":"2017-04-13 21:17:20","author":"Laura Paige","boilerplate_text":"","field_publication":"","field_article_url":"","field_event_time":{"event_time_start":"2016-01-15T13:00:00-05:00","event_time_end":"2016-01-15T15:00:00-05:00","event_time_end_last":"2016-01-15T15:00:00-05:00","gmt_time_start":"2016-01-15 18:00:00","gmt_time_end":"2016-01-15 20:00:00","gmt_time_end_last":"2016-01-15 20:00:00","rrule":null,"timezone":"America\/New_York"},"extras":[],"groups":[{"id":"65448","name":"Bioengineering Graduate Program"}],"categories":[],"keywords":[],"core_research_areas":[],"news_room_topics":[],"event_categories":[{"id":"1789","name":"Conference\/Symposium"}],"invited_audience":[{"id":"78751","name":"Undergraduate students"},{"id":"78761","name":"Faculty\/Staff"},{"id":"174045","name":"Graduate students"}],"affiliations":[],"classification":[],"areas_of_expertise":[],"news_and_recent_appearances":[],"phone":[],"contact":[{"value":"\u003Cp\u003ELaura Paige\u003C\/p\u003E\u003Cp\u003E404-385-6655\u003C\/p\u003E","format":"limited_html"}],"email":[],"slides":[],"orientation":[],"userdata":""}},"479831":{"#nid":"479831","#data":{"type":"event","title":"BioEngineering Graduate Committee Meeting","body":[{"value":"\u003Cp\u003E\u003Cem\u003EThe BioEngineering graduate committee will meet to review\/approve program policies, program faculty applications and submitted student petitions.\u003Cbr \/\u003E\u003Cbr \/\u003EStudent Petitions due to\u0026nbsp;\u003Ca href=\u0022mailto:laura.paige@bioengineering.gatech.edu\u0022\u003ELaura Paige\u003C\/a\u003E\u0026nbsp;no later than: 1\/14\/2016\u003C\/em\u003E\u003C\/p\u003E","summary":null,"format":"limited_html"}],"field_subtitle":"","field_summary":[{"value":"\u003Cp\u003EBioEngineering Graduate Committee Meeting\u003C\/p\u003E","format":"limited_html"}],"field_summary_sentence":[{"value":"\u0022BioEngineering Graduate Committee Meeting\u0022"}],"uid":"27917","created_gmt":"2015-12-17 10:27:29","changed_gmt":"2016-10-08 02:15:18","author":"Laura Paige","boilerplate_text":"","field_publication":"","field_article_url":"","field_event_time":{"event_time_start":"2016-01-13T17:00:00-05:00","event_time_end":"2016-01-13T18:00:00-05:00","event_time_end_last":"2016-01-13T18:00:00-05:00","gmt_time_start":"2016-01-13 22:00:00","gmt_time_end":"2016-01-13 23:00:00","gmt_time_end_last":"2016-01-13 23:00:00","rrule":null,"timezone":"America\/New_York"},"extras":[],"groups":[{"id":"65448","name":"Bioengineering Graduate Program"}],"categories":[],"keywords":[],"core_research_areas":[],"news_room_topics":[],"event_categories":[{"id":"1788","name":"Other\/Miscellaneous"}],"invited_audience":[{"id":"78761","name":"Faculty\/Staff"}],"affiliations":[],"classification":[],"areas_of_expertise":[],"news_and_recent_appearances":[],"phone":[],"contact":[{"value":"\u003Cp\u003ELaura Paige\u003C\/p\u003E\u003Cp\u003E404-385-6655\u003C\/p\u003E","format":"limited_html"}],"email":[],"slides":[],"orientation":[],"userdata":""}},"513371":{"#nid":"513371","#data":{"type":"event","title":"PhD Defense Presentation- Amy Clark","body":[{"value":"\u003Cp\u003E\u003Cstrong\u003EAdvisor\u003C\/strong\u003E: Andr\u00e9s J. Garc\u00eda, PhD, ME, Georgia Tech\u003C\/p\u003E\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\u003Cp\u003E\u003Cstrong\u003ECommittee\u003C\/strong\u003E:\u003C\/p\u003E\u003Cp\u003EThomas Barker, PhD,(BME, Georgia Tech)\u003C\/p\u003E\u003Cp\u003EEdward Botchwey, PhD (BME, Georgia Tech)\u003C\/p\u003E\u003Cp\u003ERobert Guldberg, PhD (ME, Georgia Tech)\u003C\/p\u003E\u003Cp\u003ETodd McDevitt, PhD (Gladstone Institutes)\u003C\/p\u003E\u003Cp\u003E\u0026nbsp;\u003Csup\u003E\u0026nbsp;\u003C\/sup\u003E\u003C\/p\u003E\u003Cp align=\u0022center\u0022\u003E\u003Cstrong\u003EIntegrin Specificity as a Novel Strategy for Enhancing Transplanted Stem Cell Survival and Tissue Repair in Vivo\u003C\/strong\u003E\u003C\/p\u003E\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\u003Cp\u003EDespite the promising clinical results for the use of human mesenchymal stem cells (hMSC) in musculoskeletal defect treatment, inadequate control of cell survival, engraftment and fate limits the success of this cell-based therapy. Integrin-mediated cell adhesion plays a central role in tissue formation, maintenance, and repair by providing anchorage forces and triggering signals that regulate cell function. We hypothesize that biomaterials presenting integrin-specific adhesive motifs will direct hMSC engraftment and function to improve bone repair. The objective of this project is to engineer bioartificial hydrogels presenting integrin-specific ligands as biomimetic cell delivery vehicles for enhanced \u003Cem\u003Ein vivo\u003C\/em\u003E engraftment and function \u2013 an innovative strategy as it focuses on engineering specificity to integrin receptors to promote survival and cell-based repair \u003Cem\u003Ewithout\u003C\/em\u003E the use of exogenous growth factors.\u003C\/p\u003E\u003Cp\u003EWe investigated the performance of a cell-mediated degradable hydrogel functionalized with integrin-specific ligands in supporting the survival of transplanted hMSC and tissue repair in a segmental bone defect. This was accomplished by incorporating the adhesive a2b1 integrin-specific GFOGER ligand, adhesive avb3 integrin-specific RGD ligand, non-adhesive RDG peptide, or non-adhesive GAOGER peptide combined with human mesenchymal stem cells in a protease-degradable PEG-maleimide hydrogel. Cell survival was tracked through transgenic luciferase expression and bone repair was monitored by microcomputer tomography. We hypothesized that hydrogel delivery vehicles that promoted cell viability in combination with the pro-osteogenic properties of the carrier would result in superior bone repair. We found that \u03b12\u03b21-specific GFOGER-functionalized hydrogels promoted enhanced hMSC survival and bone repair, with differential expression of vascularization and inflammation-related genes \u003Cem\u003Ein vivo\u003C\/em\u003E compared to RGD- or RDG-functionalized hydrogels, highlighting integrin-specificity as an important consideration in the design of cell delivery vehicles for engraftment and tissue repair. We have generated new insights into transplanted hMSC survival, engraftment and function in a bone repair model allowing for direct correlations among hydrogel formulation and integrin specificity, transplanted cell survival, and bone repair outcomes. This work is significant and innovative because improved design of cell delivery vehicles may improve efficacy of current hMSC therapies in the clinic.\u0026nbsp;\u003C\/p\u003E\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E","summary":null,"format":"limited_html"}],"field_subtitle":"","field_summary":[{"value":"\u003Cp\u003EPhD Defense Presentation-\u0026nbsp;\u0022Integrin Specificity as a Novel Strategy for Enhancing Transplanted Stem Cell Survival and Tissue Repair in Vivo\u0022- Amy Clark\u003C\/p\u003E","format":"limited_html"}],"field_summary_sentence":[{"value":"\u0022Integrin Specificity as a Novel Strategy for Enhancing Transplanted Stem Cell Survival and Tissue Repair in Vivo\u0022"}],"uid":"27917","created_gmt":"2016-03-15 08:44:56","changed_gmt":"2017-04-13 21:16:19","author":"Laura Paige","boilerplate_text":"","field_publication":"","field_article_url":"","field_event_time":{"event_time_start":"2016-03-30T15:00:00-04:00","event_time_end":"2016-03-30T17:00:00-04:00","event_time_end_last":"2016-03-30T17:00:00-04:00","gmt_time_start":"2016-03-30 19:00:00","gmt_time_end":"2016-03-30 21:00:00","gmt_time_end_last":"2016-03-30 21:00:00","rrule":null,"timezone":"America\/New_York"},"extras":[],"related_links":[{"url":"http:\/\/garcialab.gatech.edu\/","title":"Garcia lab"}],"groups":[{"id":"65448","name":"Bioengineering Graduate Program"}],"categories":[],"keywords":[],"core_research_areas":[],"news_room_topics":[],"event_categories":[{"id":"1788","name":"Other\/Miscellaneous"}],"invited_audience":[{"id":"78751","name":"Undergraduate students"},{"id":"78761","name":"Faculty\/Staff"},{"id":"174045","name":"Graduate students"}],"affiliations":[],"classification":[],"areas_of_expertise":[],"news_and_recent_appearances":[],"phone":[],"contact":[{"value":"\u003Cp\u003ELaura Paige\u003C\/p\u003E\u003Cp\u003E404-385-6655\u003C\/p\u003E","format":"limited_html"}],"email":[],"slides":[],"orientation":[],"userdata":""}},"524821":{"#nid":"524821","#data":{"type":"event","title":"BioE PhD Proposal Presentation- Yoshitaka Sei","body":[{"value":"\u003Cp\u003E\u003Cstrong\u003EAdvisor: YongTae Kim, \u003C\/strong\u003E\u003Cstrong\u003EPh.D.\u003C\/strong\u003E\u0026nbsp;(Georgia Institute of Technology)\u003C\/p\u003E\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\u003Cp\u003E\u003Cstrong\u003ECommittee:\u003C\/strong\u003E\u003C\/p\u003E\u003Cp\u003E\u003Cstrong\u003EJulie A. Champion,\u003C\/strong\u003E\u003Cstrong\u003E Ph.D.\u003C\/strong\u003E\u0026nbsp;(Georgia Institute of Technology)\u003C\/p\u003E\u003Cp\u003E\u003Cstrong\u003EJ. Brandon Dixon,\u003C\/strong\u003E \u003Cstrong\u003EPh.D.\u003C\/strong\u003E\u0026nbsp;(Georgia Institute of Technology)\u003C\/p\u003E\u003Cp\u003E\u003Cstrong\u003EAndr\u00e9s Garc\u00eda,\u003C\/strong\u003E \u003Cstrong\u003EPh.D.\u003C\/strong\u003E\u0026nbsp;(Georgia Institute of Technology)\u003C\/p\u003E\u003Cp\u003E\u003Cstrong\u003EHanjoong Jo,\u003C\/strong\u003E \u003Cstrong\u003EPh.D.\u003C\/strong\u003E\u0026nbsp;(Georgia Institute of Technology)\u003C\/p\u003E\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\u003Cp align=\u0022center\u0022\u003E\u003Cstrong\u003EMicrofluidics for translating multifunctional nanomaterials\u003C\/strong\u003E\u003C\/p\u003E\u003Cp\u003ECardiovascular disease (CVD) remains as one of the most impactful diseases in the western hemisphere. Atherosclerosis, the underlying pathology for CVD, is the stiffening and occlusion of arteries that may ultimately cause heart attacks or strokes. While there are many therapeutic options available to treat the pathological symptoms, there is a large unmet need for synergistic approaches that actively address the regression of atherosclerosis rather than progression preventative focuses. MicroRNAs may help to address this need as short RNA sequences that play active roles in multiple disease pathways. In particular, inhibiting the microRNA mmu-miR-712 (miR-712) in atherosclerotic mice using anti-miR-712 (am712) results in atherosclerotic plaque reduction. However, its effectiveness may benefit from the addition of a specific method of delivery to the target site. This study will screen for the \u003Cem\u003Ein vitro \u003C\/em\u003Eeffects of delivering am712 using targeted nanomaterials derived from high-density lipoproteins (HDL), which have been known to be an endogenous transporter of microRNAs through blood circulation. To do so involves the engineering of HDL-derived nanomaterials to incorporate am712 (HDL-am712), the implementation of a microfluidic device to mimic and screen HDL-am712 effects on the inflamed endothelium\u003Cem\u003E in vitro\u003C\/em\u003E, and the \u003Cem\u003Ein vivo \u003C\/em\u003Evalidation of the findings with a mouse model.\u0026nbsp;\u003C\/p\u003E","summary":null,"format":"limited_html"}],"field_subtitle":"","field_summary":[{"value":"\u003Cp\u003EPhD Proposal Presentation-\u0026nbsp;\u0022Microfluidics for translating multifunctional nanomaterials\u0022- Yoshitaka Sei\u003C\/p\u003E","format":"limited_html"}],"field_summary_sentence":[{"value":"\u0022Microfluidics for translating multifunctional nanomaterials\u0022"}],"uid":"27917","created_gmt":"2016-04-14 14:32:13","changed_gmt":"2017-04-13 21:16:00","author":"Laura Paige","boilerplate_text":"","field_publication":"","field_article_url":"","field_event_time":{"event_time_start":"2016-04-27T12:30:00-04:00","event_time_end":"2016-04-27T14:30:00-04:00","event_time_end_last":"2016-04-27T14:30:00-04:00","gmt_time_start":"2016-04-27 16:30:00","gmt_time_end":"2016-04-27 18:30:00","gmt_time_end_last":"2016-04-27 18:30:00","rrule":null,"timezone":"America\/New_York"},"extras":[],"groups":[{"id":"65448","name":"Bioengineering Graduate Program"}],"categories":[],"keywords":[],"core_research_areas":[],"news_room_topics":[],"event_categories":[{"id":"1789","name":"Conference\/Symposium"}],"invited_audience":[{"id":"78751","name":"Undergraduate students"},{"id":"78761","name":"Faculty\/Staff"},{"id":"174045","name":"Graduate students"}],"affiliations":[],"classification":[],"areas_of_expertise":[],"news_and_recent_appearances":[],"phone":[],"contact":[{"value":"\u003Cp\u003ELaura Paige\u003C\/p\u003E\u003Cp\u003E404.385.6655\u003C\/p\u003E","format":"limited_html"}],"email":[],"slides":[],"orientation":[],"userdata":""}},"512801":{"#nid":"512801","#data":{"type":"event","title":"BioEngineering Graduate Committee Meeting","body":[{"value":"\u003Cp\u003E\u003Cem\u003EThe BioEngineering graduate committee will meet to review\/approve program policies, program faculty applications and submitted student petitions.\u003Cbr \/\u003E\u003Cbr \/\u003EStudent Petitions due to\u0026nbsp;\u003Ca href=\u0022mailto:laura.paige@bioengineering.gatech.edu\u0022\u003ELaura Paige\u003C\/a\u003E\u0026nbsp;no later than: 04\/28\/2016.\u003C\/em\u003E\u003C\/p\u003E","summary":null,"format":"limited_html"}],"field_subtitle":"","field_summary":[{"value":"\u003Cp\u003EBioEngineering Graduate Committee Meeting\u003C\/p\u003E","format":"limited_html"}],"field_summary_sentence":[{"value":"\u0022BioEngineering Graduate Committee Meeting\u0022"}],"uid":"27917","created_gmt":"2016-03-14 08:38:25","changed_gmt":"2017-04-13 21:16:20","author":"Laura Paige","boilerplate_text":"","field_publication":"","field_article_url":"","field_event_time":{"event_time_start":"2016-05-04T13:00:00-04:00","event_time_end":"2016-05-04T14:00:00-04:00","event_time_end_last":"2016-05-04T14:00:00-04:00","gmt_time_start":"2016-05-04 17:00:00","gmt_time_end":"2016-05-04 18:00:00","gmt_time_end_last":"2016-05-04 18:00:00","rrule":null,"timezone":"America\/New_York"},"extras":[],"groups":[{"id":"65448","name":"Bioengineering Graduate Program"}],"categories":[],"keywords":[{"id":"11877","name":"BioE Seminar"}],"core_research_areas":[],"news_room_topics":[],"event_categories":[{"id":"1788","name":"Other\/Miscellaneous"}],"invited_audience":[{"id":"78751","name":"Undergraduate students"},{"id":"78761","name":"Faculty\/Staff"},{"id":"174045","name":"Graduate students"}],"affiliations":[],"classification":[],"areas_of_expertise":[],"news_and_recent_appearances":[],"phone":[],"contact":[],"email":[],"slides":[],"orientation":[],"userdata":""}},"527521":{"#nid":"527521","#data":{"type":"event","title":"BioE PhD Defense Announcement- Drew Owen","body":[{"value":"\u003Cp\u003E\u003Cstrong\u003EAdvisor:\u003C\/strong\u003E\u0026nbsp; Peter Hesketh, PhD (Georgia Institute of Technology, Mechanical Engineering)\u003C\/p\u003E\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\u003Cp\u003E\u003Cstrong\u003ECommittee:\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp; \u003C\/strong\u003E\u003C\/p\u003E\u003Cp\u003E\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;Alexander Alexeev , PhD (Georgia Institute of Technology, Mechanical Engineering)\u003C\/p\u003E\u003Cp\u003E\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp; J. Brandon Dixon, PhD (Georgia Institute of Technology, Mechanical Engineering)\u003C\/p\u003E\u003Cp\u003E\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;Hang Lu, PhD (Georgia Institute of Technology, Chemical and Biomolecular Engineering)\u003C\/p\u003E\u003Cp\u003E\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;Todd Sulchek, PhD (Georgia Institute of Technology, Mechanical Engineering)\u003C\/p\u003E\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\u003Cp\u003E\u003Cstrong\u003EMixing and Sampling in a Microfluidic Channel Using Rotating Magnetic Microbeads\u003C\/strong\u003E\u003C\/p\u003E\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\u003Cp\u003EThis work presents a novel microsystem utilizing an array of rotating magnetic beads inside a microfluidic channel. The magnetic beads are actuated via a rotating magnetic field. The work demonstrates the fabrication of this device using non-standard MEMS fabrication materials.\u003C\/p\u003E\u003Cp\u003EThe physical operational limits of the device are demonstrated and quantified. The effectiveness of this system is experimentally evaluated in two separate common microfluidic operations. The first operation is the ability for these beads to mix fluids inside a microfluidic channel. This is done by measuring the mixing of two streams of fluid as they flow over the rotating array of beads. The interaction between the speed of the bulk fluid and the speed of the rotating magnetic beads is studied as well as the effect of the path of the bead. The second operation is the capacity to capture particles from the microfluidic channel. This capturing is accomplished via protein-protein bond between the surface functionalizations of the magnetic bead and the particle. In capture experiments, the interplay between density of beads per channel length, channel height and bead rotational speed are studied.\u003C\/p\u003E","summary":null,"format":"limited_html"}],"field_subtitle":"","field_summary":[{"value":"\u003Cp\u003EPhD Defense Presentation-\u0026nbsp;\u0022Mixing and Sampling in a Microfluidic Channel Using Rotating Magnetic Microbeads\u0022- Drew Owen\u003C\/p\u003E","format":"limited_html"}],"field_summary_sentence":[{"value":"\u0022Mixing and Sampling in a Microfluidic Channel Using Rotating Magnetic Microbeads\u0022"}],"uid":"27917","created_gmt":"2016-04-21 09:48:43","changed_gmt":"2017-04-13 21:15:58","author":"Laura Paige","boilerplate_text":"","field_publication":"","field_article_url":"","field_event_time":{"event_time_start":"2016-05-05T10:00:00-04:00","event_time_end":"2016-05-05T12:00:00-04:00","event_time_end_last":"2016-05-05T12:00:00-04:00","gmt_time_start":"2016-05-05 14:00:00","gmt_time_end":"2016-05-05 16:00:00","gmt_time_end_last":"2016-05-05 16:00:00","rrule":null,"timezone":"America\/New_York"},"extras":[],"groups":[{"id":"65448","name":"Bioengineering Graduate Program"}],"categories":[],"keywords":[],"core_research_areas":[],"news_room_topics":[],"event_categories":[{"id":"1788","name":"Other\/Miscellaneous"}],"invited_audience":[{"id":"78751","name":"Undergraduate students"},{"id":"78761","name":"Faculty\/Staff"},{"id":"174045","name":"Graduate students"}],"affiliations":[],"classification":[],"areas_of_expertise":[],"news_and_recent_appearances":[],"phone":[],"contact":[{"value":"\u003Cp\u003ELaura Paige\u003C\/p\u003E\u003Cp\u003E404.385.6655\u003C\/p\u003E","format":"limited_html"}],"email":[],"slides":[],"orientation":[],"userdata":""}},"524851":{"#nid":"524851","#data":{"type":"event","title":"BioEngineering Program Faculty Meeting","body":[{"value":"\u003Cp\u003E\u003Cem\u003EThe BioEngineering Program faculty meet regularly during the semester to address program policies, events and future research and academic directions.\u003C\/em\u003E\u003C\/p\u003E","summary":null,"format":"limited_html"}],"field_subtitle":"","field_summary":[{"value":"\u003Cp\u003E\u003Cem\u003EProgram policies, events and directions to be discussed\u003C\/em\u003E\u003C\/p\u003E","format":"limited_html"}],"field_summary_sentence":[{"value":"\u0022BioEngineering Program Faculty Meeting\u0022"}],"uid":"27917","created_gmt":"2016-04-14 14:49:22","changed_gmt":"2016-10-08 02:17:29","author":"Laura Paige","boilerplate_text":"","field_publication":"","field_article_url":"","field_event_time":{"event_time_start":"2016-05-10T12:00:00-04:00","event_time_end":"2016-05-10T13:00:00-04:00","event_time_end_last":"2016-05-10T13:00:00-04:00","gmt_time_start":"2016-05-10 16:00:00","gmt_time_end":"2016-05-10 17:00:00","gmt_time_end_last":"2016-05-10 17:00:00","rrule":null,"timezone":"America\/New_York"},"extras":[],"groups":[{"id":"65448","name":"Bioengineering Graduate Program"}],"categories":[],"keywords":[],"core_research_areas":[],"news_room_topics":[],"event_categories":[{"id":"1788","name":"Other\/Miscellaneous"}],"invited_audience":[{"id":"78761","name":"Faculty\/Staff"}],"affiliations":[],"classification":[],"areas_of_expertise":[],"news_and_recent_appearances":[],"phone":[],"contact":[{"value":"\u003Cp\u003ELaura Paige\u003C\/p\u003E\u003Cp\u003E404.385.6655\u003C\/p\u003E","format":"limited_html"}],"email":[],"slides":[],"orientation":[],"userdata":""}},"535591":{"#nid":"535591","#data":{"type":"event","title":"BioE PhD Proposal presentation- Kirsten Parratt","body":[{"value":"\u003Cp\u003E\u003Cstrong\u003EAdvisor\u003C\/strong\u003E: Krishnendu Roy,\u0026nbsp;Ph.D.\u0026nbsp;(Biomedical Engineering-Georgia Institute of Technology and Emory University)\u003C\/p\u003E\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\u003Cp\u003E\u003Cstrong\u003ECommittee:\u003C\/strong\u003E\u003C\/p\u003E\u003Cp\u003ERobert Guldberg,\u0026nbsp;Ph.D.\u0026nbsp;(Mechanical Engineering-Georgia Institute of Technology)\u003C\/p\u003E\u003Cp\u003EHang Lu,\u0026nbsp;Ph.D.\u0026nbsp;(Chemical Engineering-Georgia Institute of Technology)\u003C\/p\u003E\u003Cp\u003EValarie Milam,\u0026nbsp;Ph.D.\u0026nbsp;(Materials Science and Engineering-Georgia Institute of Technology)\u003C\/p\u003E\u003Cp\u003EJohnna Temenoff,\u0026nbsp;Ph.D.\u0026nbsp;(Biomedical Engineering-Georgia Institute of Technology and Emory University)\u003C\/p\u003E\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\u003Cp align=\u0022center\u0022\u003E\u003Cstrong\u003EHigh throughput, high replicate screening of materials using flow cytometry\u003C\/strong\u003E\u003C\/p\u003E\u003Cp\u003E\u0026nbsp; Due to challenges inherent in biological research, the study of how material structure contributes to cell function is plagued by high variability and non-reproducible data, which leads to waste of time and resources. In order to bring the statistical power of a study to an acceptable level, the best solution often is to miniaturize samples while increasing replicate number. However, this introduces new organizational challenges during both experimentation and analysis, and still does not resolve the limitations of population-based analyses. Currently there is no widely accessible system for high replicate, high-throughput, non-destructive screening of material-encapsulated cells and this limits our ability to study how material structure can be engineered to control cell function.\u003C\/p\u003E\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\u003Cp\u003E\u0026nbsp; Flow cytometry can be used to solve this problem. The technology allows for the automated collection of a large number of unique events in a short time period, which can be combined to characterize a large population. By multiplexing microparticle shape, size, and fluorescence as variables in flow cytometry, a high-throughput, high replicate, rapid assay system will be developed. This will enable the simultaneous study of many parameters, reduce experimental variability, and provide population data with single cell resolution. Due to their history in the field of tissue engineering, polymeric hydrogels for the differentiation of bone marrow stem cells into chondrocytes were chosen as a model system. The proposed project will compare the potentials of many materials for chondrogenic differentiation and demonstrate a high-throughput materials screening platform that will be widely applicable to other areas of research.\u003C\/p\u003E","summary":null,"format":"limited_html"}],"field_subtitle":"","field_summary":[{"value":"\u003Cp\u003EBio PhD Proposal Presentation-\u0026nbsp;\u0022High throughput, high replicate screening of materials using flow cytometry\u0022- Kirsten Parratt\u003C\/p\u003E","format":"limited_html"}],"field_summary_sentence":[{"value":"\u0022High throughput, high replicate screening of materials using flow cytometry\u0022"}],"uid":"27917","created_gmt":"2016-05-11 08:12:31","changed_gmt":"2017-04-13 21:15:53","author":"Laura Paige","boilerplate_text":"","field_publication":"","field_article_url":"","field_event_time":{"event_time_start":"2016-05-24T10:00:00-04:00","event_time_end":"2016-05-24T12:00:00-04:00","event_time_end_last":"2016-05-24T12:00:00-04:00","gmt_time_start":"2016-05-24 14:00:00","gmt_time_end":"2016-05-24 16:00:00","gmt_time_end_last":"2016-05-24 16:00:00","rrule":null,"timezone":"America\/New_York"},"extras":[],"groups":[{"id":"65448","name":"Bioengineering Graduate Program"}],"categories":[],"keywords":[],"core_research_areas":[],"news_room_topics":[],"event_categories":[{"id":"1788","name":"Other\/Miscellaneous"}],"invited_audience":[{"id":"78751","name":"Undergraduate students"},{"id":"78761","name":"Faculty\/Staff"},{"id":"174045","name":"Graduate students"}],"affiliations":[],"classification":[],"areas_of_expertise":[],"news_and_recent_appearances":[],"phone":[],"contact":[{"value":"\u003Cp\u003ELaura Paige\u003C\/p\u003E\u003Cp\u003E404-385-6655\u003C\/p\u003E","format":"limited_html"}],"email":[],"slides":[],"orientation":[],"userdata":""}},"529341":{"#nid":"529341","#data":{"type":"event","title":"BioE PhD Proposal presentation- Efrain Cermeno","body":[{"value":"\u003Cp\u003E\u003Cstrong\u003ECo-advisors:\u003C\/strong\u003E\u0026nbsp;\u0026nbsp;\u003C\/p\u003E\u003Cp\u003EAndr\u00e9s J Garc\u00eda, Ph.D. (Georgia Institute of Technology, Mechanical Engineering)\u003Cbr \/\u003E Susan N. Thomas, Ph.D. (Georgia Institute of Technology, Mechanical Engineering)\u003C\/p\u003E\u003Cp\u003E\u003Cstrong\u003ECommittee:\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u003C\/strong\u003E\u003C\/p\u003E\u003Cp\u003EEmina H. Huang, M.D. (Cleveland Clinic,\u0026nbsp;\u0026nbsp;Lerner College of Medicine of Case Western Reserve University)\u003Cbr \/\u003E Hang Lu, Ph.D. (Georgia Institute of Technology, Chemical Engineering)\u003Cbr \/\u003E Todd C. McDevitt, Ph.D. (Gladstone Institute of Cardiovascular Disease, UCSF)\u003Cbr \/\u003E \u0026nbsp;\u003C\/p\u003E\u003Cp align=\u0022center\u0022\u003E\u0026nbsp;\u003C\/p\u003E\u003Cp align=\u0022center\u0022\u003E\u003Cstrong\u003EAdhesion Signature Based Enrichment of Tumor Initiating Cells\u003C\/strong\u003E\u003C\/p\u003E\u003Cp\u003E\u0026nbsp; \u0026nbsp;\u0026nbsp;\u003C\/p\u003E\u003Cp\u003E\u0026nbsp; \u0026nbsp; \u0026nbsp; In spite of major therapeutic advances, cancer relapse and low rates of patient response to cancer therapeutics persist. This failure is due in part to a small subpopulation of tumor initiating cells (TICs) with stem cell-like properties that are responsible for the growth of the tumor and the progression of metastasis. These cells are capable of surviving chemotherapy, rendering them highly resistant to conventional cancer therapies. Although the question of whether TICs are stem cells remains a controversial topic in the cancer field, it has become increasingly evident that a better understanding of their biology and function is necessary to effectively treat cancer and eradicate tumors without allowing for relapse to occur.\u003Cbr \/\u003E \u0026nbsp; \u0026nbsp; \u0026nbsp; This project aims to develop an objective, label-free, fast, and scalable method for TIC enrichment based on the adhesion strength signature of these cells. Currently, no efficient and reliable methods to isolate TICs exist. Although many in the field rely on surface marker expression profiles, these are variable and subjective, which hinders the study of TIC biology. Our lab has developed a technology to isolate cells based on their unique adhesion binding strength to a matrix. The novel technology (micro-Stem cell High- Efficiency Adhesion based Recovery [\u03bcSHEAR]) consists of a microfluidic device that applies varying degrees of detachment shear forces to adherent cells. Using this device, human pluripotent stem cells and their progeny have been isolated with high reproducibility, yield (\u0026gt;97%), purity (95-99%), and survival (\u0026gt;95%) rates (Singh et al, Nature Methods 2013). The process is fast (\u0026lt;10 min), label free, and scalable. Our hypothesis is that subtypes of cancer cells will exhibit distinct \u2018adhesive force signatures\u2019 that can be exploited to selectively purify TICs with high efficiency using the \u03bcSHEAR technology. The significance of this work is the development of a novel platform for objective, reliable, and scalable TIC purification\u0026nbsp;\u003C\/p\u003E","summary":null,"format":"limited_html"}],"field_subtitle":"","field_summary":[{"value":"\u003Cp\u003EPhD Proposal Presentation-\u0026nbsp;\u0022Adhesion Signature Based Enrichment of Tumor Initiating Cells\u0022- Efrain Cermeno\u003C\/p\u003E","format":"limited_html"}],"field_summary_sentence":[{"value":"\u0022Adhesion Signature Based Enrichment of Tumor Initiating Cells\u0022"}],"uid":"27917","created_gmt":"2016-04-26 08:01:06","changed_gmt":"2017-04-13 21:15:56","author":"Laura Paige","boilerplate_text":"","field_publication":"","field_article_url":"","field_event_time":{"event_time_start":"2016-05-10T13:00:00-04:00","event_time_end":"2016-05-10T15:00:00-04:00","event_time_end_last":"2016-05-10T15:00:00-04:00","gmt_time_start":"2016-05-10 17:00:00","gmt_time_end":"2016-05-10 19:00:00","gmt_time_end_last":"2016-05-10 19:00:00","rrule":null,"timezone":"America\/New_York"},"extras":[],"groups":[{"id":"65448","name":"Bioengineering Graduate Program"}],"categories":[],"keywords":[],"core_research_areas":[],"news_room_topics":[],"event_categories":[{"id":"1789","name":"Conference\/Symposium"}],"invited_audience":[{"id":"78751","name":"Undergraduate students"},{"id":"78761","name":"Faculty\/Staff"},{"id":"174045","name":"Graduate students"}],"affiliations":[],"classification":[],"areas_of_expertise":[],"news_and_recent_appearances":[],"phone":[],"contact":[{"value":"\u003Cp\u003ELaura Paige\u003C\/p\u003E\u003Cp\u003E404.385.6655\u003C\/p\u003E","format":"limited_html"}],"email":[],"slides":[],"orientation":[],"userdata":""}},"477001":{"#nid":"477001","#data":{"type":"event","title":"BioE PhD Proposal presentation- Jose Garcia","body":[{"value":"\u003Cp\u003E\u003Cstrong\u003EThesis Committee:\u003C\/strong\u003E\u0026nbsp;\u003C\/p\u003E\u003Cp\u003EAndr\u00e9s J. Garc\u00eda, Ph.D. (Georgia Institute of Technology)-Chair\u003C\/p\u003E\u003Cp\u003EEdward A. Botchwey, Ph.D. (Georgia Institute of Technology)\u003C\/p\u003E\u003Cp\u003ERobert E. Guldberg, Ph.D. (Georgia Institute of Technology)\u003C\/p\u003E\u003Cp\u003EW. Robert Taylor, M.D., Ph.D. (Emory University, Georgia Institute of Technology)\u003C\/p\u003E\u003Cp\u003EAlberto Fern\u00e1ndez-Nieves, Ph.D. (Georgia Institute of Technology)\u003C\/p\u003E\u003Cp\u003E\u003Cstrong\u003ETitle:\u0026nbsp;Vascularization of constructs for Improved Survival of Human Mesenchymal Stem Cells for Bone Repair\u003C\/strong\u003E\u003C\/p\u003E\u003Cp\u003E\u003Cstrong\u003EAbstract:\u003C\/strong\u003E\u003C\/p\u003E\u003Cp\u003ERepair of non-healing bone defects through tissue engineering strategies remains a challenging feat in the clinic due to the aversive microenvironment surrounding the injured tissue. The vascular damage that occurs following a bone injury causes extreme ischemia and a loss of circulating cells that contribute to regeneration. Tissue engineered constructs aimed at regenerating the injured bone suffer from complications based on the slow progression of endogenous vascular repair and often fail at bridging the bone defect. Furthermore, stem cell-based strategies aimed at regenerating the critical-size defect routinely demonstrate subpar performance due to the extreme ischemic environment causing massive loss of implanted cell viability. To that end, various strategies have been explored to increase blood vessel regeneration within defects to facilitate both tissue engineered and natural repair processes.\u003C\/p\u003E\u003Cp\u003E\u0026nbsp;This project aims to engineer biomaterials that understand and accelerate the vascularization of critical-size defects for the purposes of enhanced bone regeneration and heightened implanted stem-cell survival. We have engineered polyethylene-glycol (PEG)-based hydrogels that can be functionalized with differing cell adhesive ligands and proteins through a facile Michael-addition reaction between a maleimide moiety on the PEG macromer and a free thiol on the biological molecule. These protease-degradable hydrogels have been previously shown to have the ability to incorporate vascular endothelial growth factor (VEGF) for enhanced vascularization when implanted subcutaneously in mice. We propose to utilize this platform to investigate how integrin-specificity affects vascularization within critical-size defects and how incorporation of VEGF or small molecules to increase expression of hypxoxia inducible factor 1-alpha work in conjunction with integrin-specificity to promote vascularization. Our \u003Cem\u003Ehypothesis \u003C\/em\u003Eis that integrin-specificity plays a role in vascularization of tissue engineered constructs. By exploiting the role integrins play in vascularization, the efficacy of other strategies such as protein or small molecule delivery can be enhanced and vasculogenesis increased. The \u003Cem\u003Esignificance \u003C\/em\u003Eof this work is the development of synthetic biomaterials that allow for increased stem cell survival and enhance the efficacy of stem cell-mediated therapies.\u0026nbsp;\u003C\/p\u003E\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E","summary":null,"format":"limited_html"}],"field_subtitle":"","field_summary":[{"value":"\u003Cp\u003EPhD Proposal Presentation-\u0026nbsp;\u0022Vascularization of constructs for Improved Survival of Human Mesenchymal Stem Cells for Bone Repair\u0022- Jose Garcia\u003C\/p\u003E","format":"limited_html"}],"field_summary_sentence":[{"value":"\u0022Vascularization of constructs for Improved Survival of Human Mesenchymal Stem Cells for Bone Repair\u0022"}],"uid":"27917","created_gmt":"2015-12-08 10:23:32","changed_gmt":"2017-04-13 21:17:30","author":"Laura Paige","boilerplate_text":"","field_publication":"","field_article_url":"","field_event_time":{"event_time_start":"2015-12-14T15:00:00-05:00","event_time_end":"2015-12-14T17:00:00-05:00","event_time_end_last":"2015-12-14T17:00:00-05:00","gmt_time_start":"2015-12-14 20:00:00","gmt_time_end":"2015-12-14 22:00:00","gmt_time_end_last":"2015-12-14 22:00:00","rrule":null,"timezone":"America\/New_York"},"extras":[],"groups":[{"id":"65448","name":"Bioengineering Graduate Program"}],"categories":[],"keywords":[],"core_research_areas":[],"news_room_topics":[],"event_categories":[{"id":"1788","name":"Other\/Miscellaneous"}],"invited_audience":[{"id":"78751","name":"Undergraduate students"},{"id":"78761","name":"Faculty\/Staff"},{"id":"174045","name":"Graduate students"}],"affiliations":[],"classification":[],"areas_of_expertise":[],"news_and_recent_appearances":[],"phone":[],"contact":[{"value":"\u003Cp\u003ELaura Paige\u003C\/p\u003E\u003Cp\u003E404-385-6655\u003C\/p\u003E","format":"limited_html"}],"email":[],"slides":[],"orientation":[],"userdata":""}},"526001":{"#nid":"526001","#data":{"type":"event","title":"BioE PhD Defense Announcement- Yunfeng Chen","body":[{"value":"\u003Cp\u003E\u003Cstrong\u003EAdvisor:\u003C\/strong\u003E\u003C\/p\u003E\u003Cp\u003EDr. Cheng Zhu (BioE, Gatech)\u003C\/p\u003E\u003Cp\u003E\u003Cstrong\u003ECommittee:\u003C\/strong\u003E\u003C\/p\u003E\u003Cp\u003EDr. Larry McIntire (BioE, Gatech)\u003Cbr \/\u003E Dr. Wilbur Lam (BioE, Gatech)\u003Cbr \/\u003E Dr. Xiaoping Du (University of Illinois at Chicago)\u003Cbr \/\u003E Dr. Renhao Li (Emory University)\u003C\/p\u003E\u003Cp align=\u0022center\u0022\u003E\u0026nbsp;\u003C\/p\u003E\u003Cp\u003E\u201c\u003Cstrong\u003EPlatelet Mechanosensing via Surface Receptors GPIb\u03b1 and Integrin \u003C\/strong\u003E\u003Cstrong\u003E\u03b1\u003C\/strong\u003E\u003Cstrong\u003E\u003Csub\u003EIIb\u003C\/sub\u003E\u003C\/strong\u003E\u003Cstrong\u003E\u03b2\u003C\/strong\u003E\u003Cstrong\u003E\u003Csub\u003E3\u003C\/sub\u003E\u003C\/strong\u003E\u201d\u003C\/p\u003E\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\u003Cp\u003EIn hemostasis and thrombosis, platelet adhesion and signaling play key roles. Two platelet receptors, glycoprotein Ib\u03b1 (GPIb\u03b1) and integrin \u03b1\u003Csub\u003EIIb\u003C\/sub\u003E\u03b2\u003Csub\u003E3\u003C\/sub\u003E, mediate the early and mid-stages of platelet adhesion in arterial environments. GPIb\u03b1 is part of the GPIb\u03b1-V-IX complex that constitutes the receptor for von Willebrand factor (VWF). Its binding to VWF A1 domain enables rolling of platelets on the sites of vascular injury. \u03b1\u003Csub\u003EIIb\u003C\/sub\u003E\u03b2\u003Csub\u003E3\u003C\/sub\u003E, upon activation, allows for platelet stable adhesion to the sub-endothelial surface and facilitates the platelets aggregation by cross-linking via soluble fibrinogen, fibronectin and VWF. GPIb\u03b1 and \u03b1\u003Csub\u003EIIb\u003C\/sub\u003E\u03b2\u003Csub\u003E3\u003C\/sub\u003E has been reported to trigger outside-in mechano-activating signals upon ligand engagement in a sequential fashion, but exactly how the extracellular mechano-signals are transduced and translated to intracellular chemical signals remains unknown. In my PhD thesis research, I study GPIb\u03b1 and \u03b1\u003Csub\u003EIIb\u003C\/sub\u003E\u03b2\u003Csub\u003E3\u003C\/sub\u003E in the context of platelet adhesion and signal initiation. I conduct single-molecule and single-cell level experiments to investigate 1) the conformational and functional dynamics of integrin molecules under mechanical forces; and 2) the relation between mechanical signals received by GPIb\u03b1 and \u03b1\u003Csub\u003EIIb\u003C\/sub\u003E\u03b2\u003Csub\u003E3\u003C\/sub\u003E and platelet activation readouts, including intraplatelet Ca\u003Csup\u003E2+\u003C\/sup\u003E signals, \u03b2\u003Csub\u003E3\u003C\/sub\u003E integrins up-regulation, P-selectin expression and more, and decode the signaling transduction process step-by-step.\u003C\/p\u003E","summary":null,"format":"limited_html"}],"field_subtitle":"","field_summary":[{"value":"\u003Cp\u003EPhD Defense Presentation-\u0026nbsp;\u003C\/p\u003E\u003Cp\u003E\u201c\u003Cstrong\u003EPlatelet Mechanosensing via Surface Receptors GPIb\u03b1 and Integrin \u003C\/strong\u003E\u003Cstrong\u003E\u03b1\u003C\/strong\u003E\u003Cstrong\u003E\u003Csub\u003EIIb\u003C\/sub\u003E\u003C\/strong\u003E\u003Cstrong\u003E\u03b2\u003C\/strong\u003E\u003Cstrong\u003E\u003Csub\u003E3\u003C\/sub\u003E\u003C\/strong\u003E\u201d- Yunfeng Chen\u003C\/p\u003E","format":"limited_html"}],"field_summary_sentence":[{"value":"\u201cPlatelet Mechanosensing via Surface Receptors GPIb\u03b1 and Integrin \u03b1IIb\u03b23\u201d"}],"uid":"27917","created_gmt":"2016-04-18 08:05:55","changed_gmt":"2017-04-13 21:15:59","author":"Laura Paige","boilerplate_text":"","field_publication":"","field_article_url":"","field_event_time":{"event_time_start":"2016-05-23T11:00:00-04:00","event_time_end":"2016-05-23T13:00:00-04:00","event_time_end_last":"2016-05-23T13:00:00-04:00","gmt_time_start":"2016-05-23 15:00:00","gmt_time_end":"2016-05-23 17:00:00","gmt_time_end_last":"2016-05-23 17:00:00","rrule":null,"timezone":"America\/New_York"},"extras":[],"groups":[{"id":"65448","name":"Bioengineering Graduate Program"}],"categories":[],"keywords":[],"core_research_areas":[],"news_room_topics":[],"event_categories":[{"id":"1788","name":"Other\/Miscellaneous"}],"invited_audience":[{"id":"78751","name":"Undergraduate students"},{"id":"78761","name":"Faculty\/Staff"},{"id":"174045","name":"Graduate students"}],"affiliations":[],"classification":[],"areas_of_expertise":[],"news_and_recent_appearances":[],"phone":[],"contact":[{"value":"\u003Cp\u003ELaura Paige\u003C\/p\u003E\u003Cp\u003E404.385.6655\u003C\/p\u003E","format":"limited_html"}],"email":[],"slides":[],"orientation":[],"userdata":""}},"475961":{"#nid":"475961","#data":{"type":"event","title":"BioEngineering Program Faculty Meeting","body":[{"value":"\u003Cp\u003E\u003Cem\u003EThe BioEngineering Program faculty meet regularly during the semester to address program policies, events and future research and academic directions.\u003C\/em\u003E\u003C\/p\u003E","summary":null,"format":"limited_html"}],"field_subtitle":"","field_summary":[{"value":"\u003Cp\u003E\u003Cem\u003EProgram policies, events and directions to be discussed\u003C\/em\u003E\u003C\/p\u003E","format":"limited_html"}],"field_summary_sentence":[{"value":"\u0022BioEngineering Program Faculty Meeting\u0022"}],"uid":"27917","created_gmt":"2015-12-04 13:05:42","changed_gmt":"2016-10-08 02:15:06","author":"Laura Paige","boilerplate_text":"","field_publication":"","field_article_url":"","field_event_time":{"event_time_start":"2016-01-26T15:00:00-05:00","event_time_end":"2016-01-26T16:00:00-05:00","event_time_end_last":"2016-01-26T16:00:00-05:00","gmt_time_start":"2016-01-26 20:00:00","gmt_time_end":"2016-01-26 21:00:00","gmt_time_end_last":"2016-01-26 21:00:00","rrule":null,"timezone":"America\/New_York"},"extras":[],"groups":[{"id":"65448","name":"Bioengineering Graduate Program"}],"categories":[],"keywords":[],"core_research_areas":[],"news_room_topics":[],"event_categories":[{"id":"1788","name":"Other\/Miscellaneous"}],"invited_audience":[{"id":"78761","name":"Faculty\/Staff"}],"affiliations":[],"classification":[],"areas_of_expertise":[],"news_and_recent_appearances":[],"phone":[],"contact":[{"value":"\u003Cp\u003ELaura Paige\u003C\/p\u003E\u003Cp\u003E404-385-6655\u003C\/p\u003E","format":"limited_html"}],"email":[],"slides":[],"orientation":[],"userdata":""}},"489761":{"#nid":"489761","#data":{"type":"event","title":"PhD Proposal Presentation - Albert Cheng","body":[{"value":"\u003Cp\u003E\u003Cstrong\u003EAdvisor: Robert E. Guldberg, Ph.D.\u003C\/strong\u003E (Georgia Institute of Technology)\u003C\/p\u003E\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\u003Cp\u003E\u003Cstrong\u003ECommittee:\u003C\/strong\u003E\u003C\/p\u003E\u003Cp\u003E\u003Cstrong\u003EJohnna S. Temenoff, Ph.D.\u003C\/strong\u003E (Georgia Institute of Technology)\u003C\/p\u003E\u003Cp\u003E\u003Cstrong\u003EKrishnendu Roy, Ph.D.\u003C\/strong\u003E (Georgia Institute of Technology)\u003C\/p\u003E\u003Cp\u003E\u003Cstrong\u003EGreg Gibson, Ph.D.\u003C\/strong\u003E (Georgia Institute of Technology)\u003C\/p\u003E\u003Cp\u003E\u003Cstrong\u003ESteven L. Stice, Ph.D.\u003C\/strong\u003E (University of Georgia)\u003C\/p\u003E\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\u003Cp align=\u0022center\u0022\u003E\u003Cstrong\u003EPatient-specific Approaches to Bone Regeneration\u003C\/strong\u003E\u003C\/p\u003E\u003Cp align=\u0022center\u0022\u003E\u003Cstrong\u003E\u0026nbsp;\u003C\/strong\u003E\u003C\/p\u003E\u003Cp\u003EThe first recorded bone grafting procedure was performed by Dr. Job van Meekeren in 1668, who transplanted a fragment of dog skull into the skull of a wounded soldier. Today, bone is the second-most transplanted tissue after blood with more than 1.6 million bone grafting procedures performed annually in the US at a cost of over $5 billion. Treatment of large bone defects in particular remains one of the most challenging problems faced by orthopedic surgeons. Current therapies include bone grafts and\/or delivery of osteoinductive proteins such as bone morphogenetic protein 2 (BMP-2). Despite advances in surgical technique and medical care, many of these treatment options still exhibit high variability in patient outcomes, suggesting that patient-specific factors, such as age, treatment timing, and immune status, may play a much more pivotal role in long-term treatment success than previously thought. Thus, the need to account for these patient-specific factors with more sophisticated treatment strategies has become increasingly apparent.\u003C\/p\u003E\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\u003Cp\u003E\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp; The main objective of this project is to use preclinical animal models to investigate how patient-specific factors influence biomaterial-mediated bone regeneration. Preliminary work suggests that better understanding of these factors will motivate a targeted immunomodulatory therapy for improving bone regeneration. The impact of age on large bone defect healing will be elucidated using an established bone injury model along with delivery of rhBMP-2 in a collagen sponge, which is the current clinical standard. These results may provide valuable insight on a controversial subject: the use of rhBMP-2 in pediatric patients. Additionally, this work will identify some of the key mechanisms that lead to nonunion, a significant clinical problem that affects up to 10% of patients with long bone injuries. Along the way, a chronic nonunion model will be developed that can potentially serve as a more rigorous and clinically relevant platform for testing new technologies and therapeutics. Finally, the issue of trauma-induced immune dysregulation will be explored and the novel approach of immunomodulation to enhance bone repair will be assessed. Collectively, these studies will advance our understanding of the factors that affect bone regeneration and represent a critical step towards improved, more personalized care and management of patients recovering from orthopedic trauma.\u003C\/p\u003E","summary":null,"format":"limited_html"}],"field_subtitle":"","field_summary":[{"value":"\u003Cp\u003EPhD Proposal Presentation-\u0026nbsp;\u0022Patient-specific Approaches to Bone Regeneration\u0022- Albert Cheng\u003C\/p\u003E","format":"limited_html"}],"field_summary_sentence":[{"value":"\u0022Patient-specific Approaches to Bone Regeneration\u0022"}],"uid":"27917","created_gmt":"2016-01-25 08:33:31","changed_gmt":"2017-04-13 21:16:58","author":"Laura Paige","boilerplate_text":"","field_publication":"","field_article_url":"","field_event_time":{"event_time_start":"2016-02-09T12:00:00-05:00","event_time_end":"2016-02-09T14:00:00-05:00","event_time_end_last":"2016-02-09T14:00:00-05:00","gmt_time_start":"2016-02-09 17:00:00","gmt_time_end":"2016-02-09 19:00:00","gmt_time_end_last":"2016-02-09 19:00:00","rrule":null,"timezone":"America\/New_York"},"extras":[],"groups":[{"id":"65448","name":"Bioengineering Graduate Program"}],"categories":[],"keywords":[],"core_research_areas":[],"news_room_topics":[],"event_categories":[{"id":"1788","name":"Other\/Miscellaneous"}],"invited_audience":[{"id":"78751","name":"Undergraduate students"},{"id":"78761","name":"Faculty\/Staff"},{"id":"174045","name":"Graduate students"}],"affiliations":[],"classification":[],"areas_of_expertise":[],"news_and_recent_appearances":[],"phone":[],"contact":[{"value":"\u003Cp\u003ELaura Paige\u0026nbsp;\u003C\/p\u003E\u003Cp\u003E404.385.6655\u003C\/p\u003E","format":"limited_html"}],"email":[],"slides":[],"orientation":[],"userdata":""}},"491221":{"#nid":"491221","#data":{"type":"event","title":"PhD Proposal Presentation - Morris Huang","body":[{"value":"\u003Cp\u003E\u003Cstrong\u003EAdvisor\u003C\/strong\u003E: Stephen Sprigle, PhD (APPH)\u003C\/p\u003E\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\u003Cp\u003E\u003Cstrong\u003ECommittee\u003C\/strong\u003E:\u003C\/p\u003E\u003Cp\u003EAldo Ferri, PhD (Mechanical Engineering)\u003Cbr \/\u003E Jun Ueda, PhD (Mechanical Engineering)\u003Cbr \/\u003E Maysam Ghovanloo,PhD (Electrical and Computer Engineering)\u003Cbr \/\u003E Young-Hui Chang, PhD (APPH)\u003Cbr \/\u003E Mark Greig (Industry)\u003C\/p\u003E\u003Cp align=\u0022center\u0022\u003E\u003Cstrong\u003EDevelopment of a Dynamic Wheelchair Model with Empirical Validation by a Robotic Testbed\u003C\/strong\u003E\u003C\/p\u003E\u003Cp\u003E\u003Cbr \/\u003E For the 1.6 million wheelchair users who live in the United States, the wheelchair forms the foundation for all of their academic, vocational, and societal activities. Amongst these users, 94% own manual wheelchairs, a mobility device that relies on the occupant for propulsive force. Less mechanically efficient wheelchairs require these users to exert greater instantaneous force and total effort for accomplishing desired travel. Greater propulsion effort can lead to difficulty in achieving desired speeds, a higher probability of fatigue over long bouts of mobility, and difficulty negotiating inclines. The accumulation of this greater effort can also increase the potential for injury in the upper extremities. Regretfully, despite the risks associated with low performance wheelchairs, modern wheelchair design is hinged upon hitting arbitrary weight cutoffs that determine the amount of government medical coverage.\u003Cbr \/\u003E \u003Cbr \/\u003E Systems-level dynamic wheelchair models would offer the ability to analytically investigate how different components and designs influence efficiency. To date, models have been developed by the wheelchair community, but are limited to straight-line motion, lack accurate modeling of kinetics, or do not have sufficient empirical validation. Therefore, \u003Cstrong\u003Ethe objective of the proposed research will be to develop a family of dynamic models that define the relationship between wheelchair properties and their respective impacts on wheelchair performance\u003C\/strong\u003E. The novelty of this modeling approach will stem from the use of a wheelchair-propelling robotic test bed for model validation, as well as custom-designed measurement tools that characterize inertial and resistive wheelchair properties for model input. \u003Cstrong\u003EThe proposed approach will 1) model wheelchair kinematics to characterize and partition the system kinetic energy, 2) develop a dynamic wheelchair model to partition resistive energy losses, and 3) generate a cost of transport function for optimizing manual wheelchair design.\u003C\/strong\u003E\u003Cbr \/\u003E \u003Cbr \/\u003E Specifically, these models will illustrate how mechanical design parameters impact the complex interactions between inertia and energy loss during wheelchair maneuvers. By developing accurate dynamic models for manual wheelchairs, manufacturers will be given the capacity to optimize wheelchair design based on objective performance metrics. Furthermore, users and clinicians will be better informed about selecting wheelchair configurations to best meet the needs of users.\u003C\/p\u003E","summary":null,"format":"limited_html"}],"field_subtitle":"","field_summary":[{"value":"\u003Cp\u003EPhD Proposal Presentation-\u0026nbsp;\u0022Development of a Dynamic Wheelchair Model with Empirical Validation by a Robotic Testbed\u0022- Morris Huang\u003C\/p\u003E","format":"limited_html"}],"field_summary_sentence":[{"value":"\u0022Development of a Dynamic Wheelchair Model with Empirical Validation by a Robotic Testbed\u0022"}],"uid":"27917","created_gmt":"2016-01-27 08:36:31","changed_gmt":"2017-04-13 21:16:55","author":"Laura Paige","boilerplate_text":"","field_publication":"","field_article_url":"","field_event_time":{"event_time_start":"2016-02-09T16:00:00-05:00","event_time_end":"2016-02-09T18:00:00-05:00","event_time_end_last":"2016-02-09T18:00:00-05:00","gmt_time_start":"2016-02-09 21:00:00","gmt_time_end":"2016-02-09 23:00:00","gmt_time_end_last":"2016-02-09 23:00:00","rrule":null,"timezone":"America\/New_York"},"extras":[],"groups":[{"id":"65448","name":"Bioengineering Graduate Program"}],"categories":[],"keywords":[],"core_research_areas":[],"news_room_topics":[],"event_categories":[{"id":"1788","name":"Other\/Miscellaneous"}],"invited_audience":[{"id":"78751","name":"Undergraduate students"},{"id":"78761","name":"Faculty\/Staff"},{"id":"174045","name":"Graduate students"}],"affiliations":[],"classification":[],"areas_of_expertise":[],"news_and_recent_appearances":[],"phone":[],"contact":[{"value":"\u003Cp\u003ELaura Paige\u003C\/p\u003E\u003Cp\u003E404.385.6655\u003C\/p\u003E","format":"limited_html"}],"email":[],"slides":[],"orientation":[],"userdata":""}},"490931":{"#nid":"490931","#data":{"type":"event","title":"BioE PhD Proposal presentation- Rachel Simmons","body":[{"value":"\u003Cp\u003E\u003Cstrong\u003EAdvisor: Hanjoong Jo, Ph.D.\u003C\/strong\u003E\u0026nbsp;(Georgia Institute of Technology \u0026amp; Emory University)\u003C\/p\u003E\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\u003Cp\u003E\u003Cstrong\u003ECommittee:\u003C\/strong\u003E\u003C\/p\u003E\u003Cp\u003E\u003Cstrong\u003EMichael Davis, Ph.D. (\u003C\/strong\u003EGeorgia Institute of Technology \u0026amp; Emory University)\u003C\/p\u003E\u003Cp\u003E\u003Cstrong\u003ECharles Searles Jr., M.D.\u003C\/strong\u003E\u0026nbsp;(Emory School of Medicine)\u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp;\u0026nbsp;\u003C\/p\u003E\u003Cp\u003E\u003Cstrong\u003ELoren Williams, Ph.D. (\u003C\/strong\u003EGeorgia Institute of Technology)\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u003C\/p\u003E\u003Cp\u003E\u003Cstrong\u003EYounan Xia, Ph.D. (\u003C\/strong\u003EGeorgia Institute of Technology)\u0026nbsp;\u0026nbsp; \u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u003C\/p\u003E\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\u003Cp align=\u0022center\u0022\u003E\u003Cstrong\u003EmiR-744 Modulation by Disturbed Flow and Role in Endothelial Dysfunction and Atherosclerosis\u003C\/strong\u003E\u003C\/p\u003E\u003Cp\u003E\u0026nbsp;Atherosclerosis is the leading cause of death worldwide despite the use of cholesterol-lowering statins and anti-platelet drugs. The disease localizes to arterial regions exposed to disturbed flow due to the effect of low-magnitude and oscillating shear stress (OS) on endothelial gene expression. However, there are no treatment options to target hemodynamic-mediated mechanisms due to a lack of mechanistic understanding. \u003Cstrong\u003EThe objective of this proposal is to elucidate the effects of d-flow-induced miRNAs on endothelial gene expression and the mechanisms initiating endothelial dysfunction and atherosclerosis.\u003C\/strong\u003E Recently, our lab reported that miR-663 is highly upregulated by OS in human endothelial cells and potentially induces endothelial inflammation. Interestingly, preliminary studies indicate that another miR-663 family member, miR-744, which has a common seed sequence with miR-663, is also upregulated by OS, and may also induce inflammation. \u003Cstrong\u003ETherefore, the overall hypothesis is that overexpression of miR-744 by OS causes endothelial dysfunction and atherosclerosis.\u003C\/strong\u003E \u0026nbsp;To test the hypothesis, miR-744 modulation of OS-induced endothelial dysfunction will be assessed \u003Cem\u003Ein vitro\u003C\/em\u003E, the therapeutic effect of miR-744 inhibition on atherosclerosis development will be assessed \u003Cem\u003Ein vivo\u003C\/em\u003E, and relevant direct targets will be determined.\u0026nbsp;\u003C\/p\u003E\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E","summary":null,"format":"limited_html"}],"field_subtitle":"","field_summary":[{"value":"\u003Cp\u003EBioE PhD Proposal Presentation-\u0026nbsp;\u0022miR-744 Modulation by Disturbed Flow and Role in Endothelial Dysfunction and Atherosclerosis\u0022- Rachel Simmons\u003C\/p\u003E","format":"limited_html"}],"field_summary_sentence":[{"value":"\u0022miR-744 Modulation by Disturbed Flow and Role in Endothelial Dysfunction and Atherosclerosis\u0022"}],"uid":"27917","created_gmt":"2016-01-26 14:17:47","changed_gmt":"2017-04-13 21:16:56","author":"Laura Paige","boilerplate_text":"","field_publication":"","field_article_url":"","field_event_time":{"event_time_start":"2016-02-18T09:00:00-05:00","event_time_end":"2016-02-18T11:00:00-05:00","event_time_end_last":"2016-02-18T11:00:00-05:00","gmt_time_start":"2016-02-18 14:00:00","gmt_time_end":"2016-02-18 16:00:00","gmt_time_end_last":"2016-02-18 16:00:00","rrule":null,"timezone":"America\/New_York"},"extras":[],"groups":[{"id":"65448","name":"Bioengineering Graduate Program"}],"categories":[],"keywords":[],"core_research_areas":[],"news_room_topics":[],"event_categories":[{"id":"1788","name":"Other\/Miscellaneous"}],"invited_audience":[{"id":"78751","name":"Undergraduate students"},{"id":"78761","name":"Faculty\/Staff"},{"id":"174045","name":"Graduate students"}],"affiliations":[],"classification":[],"areas_of_expertise":[],"news_and_recent_appearances":[],"phone":[],"contact":[{"value":"\u003Cp\u003ELaura Paige\u003C\/p\u003E\u003Cp\u003E404.385.6655\u003C\/p\u003E","format":"limited_html"}],"email":[],"slides":[],"orientation":[],"userdata":""}},"490941":{"#nid":"490941","#data":{"type":"event","title":"BioEngineering Graduate Committee Meeting","body":[{"value":"\u003Cp\u003E\u003Cem\u003EThe BioEngineering graduate committee will meet to review\/approve program policies, program faculty applications and submitted student petitions.\u003Cbr \/\u003E\u003Cbr \/\u003EStudent Petitions due to\u0026nbsp;\u003Ca href=\u0022mailto:laura.paige@bioengineering.gatech.edu\u0022\u003ELaura Paige\u003C\/a\u003E\u0026nbsp;no later than: 2\/24\/2016.\u003C\/em\u003E\u003C\/p\u003E","summary":null,"format":"limited_html"}],"field_subtitle":"","field_summary":[{"value":"\u003Cp\u003EBioEngineering Graduate Committee Meeting\u003C\/p\u003E","format":"limited_html"}],"field_summary_sentence":[{"value":"\u0022BioEngineering Graduate Committee Meeting\u0022"}],"uid":"27917","created_gmt":"2016-01-26 14:26:26","changed_gmt":"2016-10-08 02:15:58","author":"Laura Paige","boilerplate_text":"","field_publication":"","field_article_url":"","field_event_time":{"event_time_start":"2016-03-02T11:30:00-05:00","event_time_end":"2016-03-02T12:30:00-05:00","event_time_end_last":"2016-03-02T12:30:00-05:00","gmt_time_start":"2016-03-02 16:30:00","gmt_time_end":"2016-03-02 17:30:00","gmt_time_end_last":"2016-03-02 17:30:00","rrule":null,"timezone":"America\/New_York"},"extras":[],"groups":[{"id":"65448","name":"Bioengineering Graduate Program"}],"categories":[],"keywords":[],"core_research_areas":[],"news_room_topics":[],"event_categories":[{"id":"1788","name":"Other\/Miscellaneous"}],"invited_audience":[{"id":"78761","name":"Faculty\/Staff"}],"affiliations":[],"classification":[],"areas_of_expertise":[],"news_and_recent_appearances":[],"phone":[],"contact":[{"value":"\u003Cp\u003ELaura Paige\u0026nbsp;\u003C\/p\u003E\u003Cp\u003E404-385-6655\u003C\/p\u003E","format":"limited_html"}],"email":[],"slides":[],"orientation":[],"userdata":""}},"503801":{"#nid":"503801","#data":{"type":"event","title":"PhD Proposal Presentation - Susan Hastings","body":[{"value":"\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\u003Cp\u003E\u003Cstrong\u003EAdvisor:\u003C\/strong\u003E David Ku, M.D., Ph.D. (Georgia\u0026nbsp;Institute\u0026nbsp;of Technology)\u003C\/p\u003E\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\u003Cp\u003E\u003Cstrong\u003ECommittee:\u003C\/strong\u003E\u003C\/p\u003E\u003Cp\u003EWilbur Lam M.D., Ph.D. (Georgia Institute of Technology, Emory University)\u003C\/p\u003E\u003Cp\u003EJulia Babensee, Ph.D. (Georgia Institute of Technology)\u003C\/p\u003E\u003Cp\u003ELakshmi Sankar, Ph.D. (Georgia Institute of Technology)\u003C\/p\u003E\u003Cp\u003EKevin Maher, M.D. (Emory University, Children\u0027s Healthcare of Atlanta)\u003C\/p\u003E\u003Cp\u003EShriprasad Deshpande, M.D. (Emory\u0026nbsp;University, Children\u0027s Healthcare of Atlanta)\u003C\/p\u003E\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\u003Cp align=\u0022center\u0022\u003E\u0026nbsp;\u003C\/p\u003E\u003Cp align=\u0022center\u0022\u003E\u003Cstrong\u003EDetermination of Thrombogenicity of Materials Under Flow for Improved Device Design\u003C\/strong\u003E\u003C\/p\u003E\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\u003Cp\u003EMedical devices are burdened with complications of thrombosis and hemorrhage. The combined interaction of material surface, local hemodynamics (in particular shear rate), and large-scale thrombosis is poorly understood.\u0026nbsp;\u003C\/p\u003E\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\u003Cp\u003EFirst, basic science studies will attempt to deduce the relative importance of material surface and shear rate for large-scale bulk thrombus formation in an in vitro setup. Next, a model will be built from those results to predict thrombus surface coverage, growth rate, and time to occlusion. Finally, a selection of current blood-contacting devices will be modified based on these results. My goal is to demonstrate reduction in thrombogenicity in an in vitro simulation.\u003C\/p\u003E\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\u003Cp\u003EThis approach may provide quantitative predictions of clinical thrombogenicity to allow for future systematic design of medical devices to avoid thrombogenic material and flow combinations, as well as improve risk and outcomes for current devices.\u003C\/p\u003E\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E","summary":null,"format":"limited_html"}],"field_subtitle":"","field_summary":[{"value":"\u003Cp\u003EPhD Proposal Presentation-\u0026nbsp;\u0022Determination of Thrombogenicity of Materials Under Flow for Improved Device Design\u0022- Susan Hastings\u003C\/p\u003E","format":"limited_html"}],"field_summary_sentence":[{"value":"\u0022Determination of Thrombogenicity of Materials Under Flow for Improved Device Design\u0022"}],"uid":"27917","created_gmt":"2016-02-19 15:11:22","changed_gmt":"2017-04-13 21:16:32","author":"Laura Paige","boilerplate_text":"","field_publication":"","field_article_url":"","field_event_time":{"event_time_start":"2016-03-04T09:00:00-05:00","event_time_end":"2016-03-04T11:00:00-05:00","event_time_end_last":"2016-03-04T11:00:00-05:00","gmt_time_start":"2016-03-04 14:00:00","gmt_time_end":"2016-03-04 16:00:00","gmt_time_end_last":"2016-03-04 16:00:00","rrule":null,"timezone":"America\/New_York"},"extras":[],"groups":[{"id":"65448","name":"Bioengineering Graduate Program"}],"categories":[],"keywords":[],"core_research_areas":[],"news_room_topics":[],"event_categories":[{"id":"1788","name":"Other\/Miscellaneous"}],"invited_audience":[{"id":"78751","name":"Undergraduate students"},{"id":"174045","name":"Graduate students"}],"affiliations":[],"classification":[],"areas_of_expertise":[],"news_and_recent_appearances":[],"phone":[],"contact":[{"value":"\u003Cp\u003ELaura Paige\u003C\/p\u003E\u003Cp\u003E404-385-6655\u003C\/p\u003E","format":"limited_html"}],"email":[],"slides":[],"orientation":[],"userdata":""}},"479821":{"#nid":"479821","#data":{"type":"event","title":"BioEngineering Program Faculty Meeting","body":[{"value":"\u003Cp\u003E\u003Cem\u003EThe BioEngineering Program faculty meet regularly during the semester to address program policies, events and future research and academic directions.\u003C\/em\u003E\u003C\/p\u003E","summary":null,"format":"limited_html"}],"field_subtitle":"","field_summary":[{"value":"\u003Cp\u003E\u003Cem\u003EProgram policies, events and directions to be discussed\u003C\/em\u003E\u003C\/p\u003E","format":"limited_html"}],"field_summary_sentence":[{"value":"\u0022BioEngineering Program Faculty Meeting\u0022"}],"uid":"27917","created_gmt":"2015-12-17 10:16:44","changed_gmt":"2016-10-08 02:15:18","author":"Laura Paige","boilerplate_text":"","field_publication":"","field_article_url":"","field_event_time":{"event_time_start":"2016-03-07T15:00:00-05:00","event_time_end":"2016-03-07T16:00:00-05:00","event_time_end_last":"2016-03-07T16:00:00-05:00","gmt_time_start":"2016-03-07 20:00:00","gmt_time_end":"2016-03-07 21:00:00","gmt_time_end_last":"2016-03-07 21:00:00","rrule":null,"timezone":"America\/New_York"},"extras":[],"groups":[{"id":"65448","name":"Bioengineering Graduate Program"}],"categories":[],"keywords":[],"core_research_areas":[],"news_room_topics":[],"event_categories":[{"id":"1788","name":"Other\/Miscellaneous"}],"invited_audience":[{"id":"78761","name":"Faculty\/Staff"}],"affiliations":[],"classification":[],"areas_of_expertise":[],"news_and_recent_appearances":[],"phone":[],"contact":[{"value":"\u003Cp\u003ELaura Paige\u003C\/p\u003E\u003Cp\u003E404-385-6655\u003C\/p\u003E","format":"limited_html"}],"email":[],"slides":[],"orientation":[],"userdata":""}},"515721":{"#nid":"515721","#data":{"type":"event","title":"BioE PhD Defense Announcement- Jaya Arya","body":[{"value":"\u003Cp\u003E\u003Cstrong\u003EAdvisor: \u003C\/strong\u003EMark R. Prausnitz, PhD, ChBE, Georgia Tech\u003C\/p\u003E\u003Cp\u003E\u003Cstrong\u003ECommittee:\u003C\/strong\u003E\u003C\/p\u003E\u003Cp\u003EJulie A. Champion, PhD, (ChBE, Georgia Tech)\u003C\/p\u003E\u003Cp\u003EJonathan S. Colton, PhD, (ME, Georgia Tech)\u003C\/p\u003E\u003Cp\u003EKrishnendu Roy, PhD, (BME, Georgia Tech)\u003C\/p\u003E\u003Cp\u003EWilliam C. Weldon, PhD, (Centers for Disease Control and Prevention)\u003C\/p\u003E\u003Cp align=\u0022center\u0022\u003E\u003Cstrong\u003EFormulation and clinical translation of microneedles for vaccination in developing countries\u003C\/strong\u003E\u003C\/p\u003E\u003Cp\u003EMost vaccines are currently administered by healthcare personnel using a needle and syringe. This delivery method poses significant hurdles in vaccine delivery, especially in developing countries. We propose dissolving microneedle patches to be a suitable alternative to needle and syringe vaccination in developing countries. Dissolving microneedle patches contain micron sized needles made out of water-soluble biodegradable polymers that dissolve in the skin to deliver the vaccine. They offer the simplicity of patch application and the possibility to mitigate the logistical and safety challenges associated with conventional hypodermic needles.\u003C\/p\u003E\u003Cp\u003EThe overall goal of this thesis was to develop dissolving microneedle patches to further clinical translation of this technology in the context of vaccinations in developing countries. We studied two specific scenarios, development of microneedle patches for rabies vaccination of dogs and assessment of dissolving microneedle patches in human subjects. Human rabies is eliminated in most developed countries by employing control measures of vaccinations in animals. However, dogs account for nearly all human rabies infections in developing countries and vaccinations are difficult to employ in animals due to the need of a needle and syringe and the cost of administration. While microneedle patches are in pre-clinical development for different vaccines, limited information is available about their use in human subjects, which will be important for clinical translation.\u003C\/p\u003E\u003Cp\u003EThe central hypothesis was that rabies vaccine can be stabilized in a dissolving microneedle patch and be at least as immunogenic as conventional needle and syringe while enabling simple administration and that dissolving microneedle patches could be easily administered without the need of an applicator, be well tolerated in the skin and preferred over needle and syringe administration. This was assessed by engineering patches for veterinary rabies vaccination and evaluating immune response in dogs and determining tolerability, usability and acceptability of placebo microneedle patches in human subjects. Altogether, the results from this thesis should further clinical translation of microneedles for vaccination in developing countries.\u003C\/p\u003E","summary":null,"format":"limited_html"}],"field_subtitle":"","field_summary":[{"value":"\u003Cp\u003EPhD Defense Presentation -\u0026nbsp;\u0022Formulation and clinical translation of microneedles for vaccination in developing countries\u0022- Jaya Arya\u003C\/p\u003E","format":"limited_html"}],"field_summary_sentence":[{"value":"\u0022Formulation and clinical translation of microneedles for vaccination in developing countries\u0022"}],"uid":"27917","created_gmt":"2016-03-21 10:21:37","changed_gmt":"2017-04-13 21:16:16","author":"Laura Paige","boilerplate_text":"","field_publication":"","field_article_url":"","field_event_time":{"event_time_start":"2016-04-05T10:00:00-04:00","event_time_end":"2016-04-05T12:00:00-04:00","event_time_end_last":"2016-04-05T12:00:00-04:00","gmt_time_start":"2016-04-05 14:00:00","gmt_time_end":"2016-04-05 16:00:00","gmt_time_end_last":"2016-04-05 16:00:00","rrule":null,"timezone":"America\/New_York"},"extras":[],"groups":[{"id":"65448","name":"Bioengineering Graduate Program"}],"categories":[],"keywords":[],"core_research_areas":[],"news_room_topics":[],"event_categories":[{"id":"1788","name":"Other\/Miscellaneous"}],"invited_audience":[{"id":"78751","name":"Undergraduate students"},{"id":"78761","name":"Faculty\/Staff"},{"id":"174045","name":"Graduate students"}],"affiliations":[],"classification":[],"areas_of_expertise":[],"news_and_recent_appearances":[],"phone":[],"contact":[{"value":"\u003Cp\u003ELaura Paige\u003C\/p\u003E\u003Cp\u003E404-385-6655\u003C\/p\u003E","format":"limited_html"}],"email":[],"slides":[],"orientation":[],"userdata":""}},"515731":{"#nid":"515731","#data":{"type":"event","title":"BioE PhD Proposal presentation- Andrew Miller","body":[{"value":"\u003Cp\u003E\u003Cstrong\u003EAdvisor: Robert E. Guldberg, Ph.D.\u003C\/strong\u003E\u0026nbsp;(Georgia Institute of Technology)\u003C\/p\u003E\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\u003Cp\u003E\u003Cstrong\u003ECommittee:\u003C\/strong\u003E\u003C\/p\u003E\u003Cp\u003E\u003Cstrong\u003EKen Gall, Ph.D.\u003C\/strong\u003E\u0026nbsp;(Duke University)\u003C\/p\u003E\u003Cp\u003E\u003Cstrong\u003EJohnna S. Temenoff, Ph.D.\u003C\/strong\u003E\u0026nbsp;(Georgia Institute of Technology)\u003C\/p\u003E\u003Cp\u003E\u003Cstrong\u003ENick J. Willett, Ph.D.\u003C\/strong\u003E\u0026nbsp;(Georgia Institute of Technology)\u003C\/p\u003E\u003Cp\u003E\u003Cstrong\u003EMeisha L. Shofner, Ph.D.\u003C\/strong\u003E\u0026nbsp;(Georgia Institute of Technology)\u003C\/p\u003E\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\u003Cp align=\u0022center\u0022\u003E\u003Cstrong\u003EFatigue and Cyclic Loading of 3D Printed Soft Polymers for Orthopedic Applications\u003C\/strong\u003E\u003C\/p\u003E\u003Cp align=\u0022center\u0022\u003E\u003Cstrong\u003E\u0026nbsp;\u003C\/strong\u003E\u003C\/p\u003E\u003Cp\u003EThe use of soft materials in orthopedic applications has largely been stalled due to a lack of biocompatible materials with sufficient fatigue resistance. Silicone was once touted as a potentially suitable material for the replacement of arthritic joints, however numerous studies since have documented cases of failed implants when silicone is used in hand, foot, wrist, and spinal applications. The failure of these implants is generally attributed to fracture, compressive deformation, and wear leading to inflammation, arthritis, foreign body response, and loss of function. More recently there has been a large push for polyurethanes in soft orthopedic devices, specifically polycarbonate urethane (PCU). PCU has been used in applications such as intervertebral disc replacements, acetabular cup bearing surfaces, and meniscal implants, among others. Early clinical data for these devices is promising, with some already in use overseas or in US clinical trials. However, a literature search turns up a surprising lack of fundamental knowledge pertaining to the fatigue and cyclic loading response of PCU. In a more general sense, the relationships between soft polymer structure\/processing and fatigue performance are largely understudied.\u003C\/p\u003E\u003Cp\u003EWith the studies proposed, we hope to provide fundamental knowledge as to the relationships between soft polymer structure and processing and fatigue performance. We will start by investigating relationships between soft polymer structure and compressive fatigue performance for an array of soft synthetic polymers, which we will compare to native soft tissue. From there, we will focus our efforts on polycarbonate urethane (PCU), which has recently shown great promise in vivo. Studies on PCU will include examining the effects of hard segment content as well as 3D printing, and a 3D printed topography, on the resulting fatigue properties. Such studies will provide fundamental knowledge useful for the use and optimization of soft polymers in fatigue prone applications.\u003C\/p\u003E\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E","summary":null,"format":"limited_html"}],"field_subtitle":"","field_summary":[{"value":"\u003Cp\u003EBioE PhD Proposal Presentation-\u0026nbsp;\u0022Fatigue and Cyclic Loading of 3D Printed Soft Polymers for Orthopedic Applications\u0022- Andrew Miller\u003C\/p\u003E","format":"limited_html"}],"field_summary_sentence":[{"value":"\u0022Fatigue and Cyclic Loading of 3D Printed Soft Polymers for Orthopedic Applications\u0022"}],"uid":"27917","created_gmt":"2016-03-21 10:24:30","changed_gmt":"2017-04-13 21:16:16","author":"Laura Paige","boilerplate_text":"","field_publication":"","field_article_url":"","field_event_time":{"event_time_start":"2016-04-21T12:00:00-04:00","event_time_end":"2016-04-21T14:00:00-04:00","event_time_end_last":"2016-04-21T14:00:00-04:00","gmt_time_start":"2016-04-21 16:00:00","gmt_time_end":"2016-04-21 18:00:00","gmt_time_end_last":"2016-04-21 18:00:00","rrule":null,"timezone":"America\/New_York"},"extras":[],"groups":[{"id":"65448","name":"Bioengineering Graduate Program"}],"categories":[],"keywords":[],"core_research_areas":[],"news_room_topics":[],"event_categories":[{"id":"1788","name":"Other\/Miscellaneous"}],"invited_audience":[{"id":"78751","name":"Undergraduate students"},{"id":"78761","name":"Faculty\/Staff"},{"id":"174045","name":"Graduate students"}],"affiliations":[],"classification":[],"areas_of_expertise":[],"news_and_recent_appearances":[],"phone":[],"contact":[{"value":"\u003Cp\u003ELaura Paige\u0026nbsp;\u003C\/p\u003E\u003Cp\u003E404-385-6655\u003C\/p\u003E","format":"limited_html"}],"email":[],"slides":[],"orientation":[],"userdata":""}},"535561":{"#nid":"535561","#data":{"type":"event","title":"BioE PhD Proposal presentation- Scott Thourson","body":[{"value":"\u003Cp\u003E\u003Cstrong\u003EAdvisor\u003C\/strong\u003E: Christine K. Payne,\u0026nbsp;PhD (CHEM, Georgia Tech)\u003C\/p\u003E\u003Cp\u003E\u003Cstrong\u003ECo-Advisor\u003C\/strong\u003E: Craig R. Forest,\u0026nbsp;PhD (ME, Georgia Tech)\u003C\/p\u003E\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\u003Cp\u003E\u003Cstrong\u003ECommittee\u003C\/strong\u003E:\u003C\/p\u003E\u003Cp\u003ETodd A. Sulchek,\u0026nbsp;PhD (ME, Georgia Tech)\u0026nbsp;\u003C\/p\u003E\u003Cp\u003EMaysam Ghovanloo,\u0026nbsp;PhD\u0026nbsp;(ECE, Georgia Tech)\u003C\/p\u003E\u003Cp\u003EGarrett B. Stanley,\u0026nbsp;PhD\u0026nbsp;(BME, Georgia Tech)\u003C\/p\u003E\u003Cp\u003E\u0026nbsp;\u003Csup\u003E\u0026nbsp;\u003C\/sup\u003E\u003C\/p\u003E\u003Cp align=\u0022center\u0022\u003E\u003Cstrong\u003EConductive Polymer Nanowires for Single Cell Electrical Stimulation\u003C\/strong\u003E\u003C\/p\u003E\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\u003Cp\u003E\u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp;The interface between electrical devices and biological systems mediates the interaction between the human body and modern technology. Biomedical applications include neural recording, deep brain stimulation, bionic implants, pacemakers, cochlear implants, artificial vision, biological assembly, and regenerative medicine. There is currently no feasible method to interact with multiple neurons in the human brain simultaneously and selectively. Emerging technology aims to scale down electrodes into microelectrode arrays to improve current capabilities. However, this approach greatly reduces surface area and leads to relatively low charge injection, thus making microelectrodes inefficient for selective single cell stimulation \u003Cem\u003Ein vivo\u003C\/em\u003E. Furthermore, conventional fabrication methods for microelectrode arrays produce stiff electrodes that induce tissue damage from post-implantation micromotion.\u003Cbr \/\u003E \u003Cbr \/\u003E We propose the use of conductive polymer nanowires as an alternative interfacial material for electrical stimulation at the single cell level. Conductive polymers have excellent potential to mediate bioelectrical communication due to their high-conductivity, large charge injection, mechanical flexibility, and biocompatibility. These material properties are further enhanced when polymers are grown as high-aspect ratio nanowires. It is hypothesized that these polymer nanowires can provide a more flexible means for single cell electrical stimulation. It is expected that nanowire electrodes will lower interfacial electrical impedance, minimize voltage-induced tissue damage, improve biocompatibility, and extend chronic stability for future \u003Cem\u003Ein vivo \u003C\/em\u003Eapplications.\u003C\/p\u003E","summary":null,"format":"limited_html"}],"field_subtitle":"","field_summary":[{"value":"\u003Cp\u003EBioE PhD Presentation-\u0026nbsp;\u0022Conductive Polymer Nanowires for Single Cell Electrical Stimulation\u0022- Scott Thourson\u003C\/p\u003E","format":"limited_html"}],"field_summary_sentence":[{"value":"\u0022Conductive Polymer Nanowires for Single Cell Electrical Stimulation\u0022"}],"uid":"27917","created_gmt":"2016-05-11 08:09:09","changed_gmt":"2017-04-13 21:15:53","author":"Laura Paige","boilerplate_text":"","field_publication":"","field_article_url":"","field_event_time":{"event_time_start":"2016-05-17T11:00:00-04:00","event_time_end":"2016-05-17T13:00:00-04:00","event_time_end_last":"2016-05-17T13:00:00-04:00","gmt_time_start":"2016-05-17 15:00:00","gmt_time_end":"2016-05-17 17:00:00","gmt_time_end_last":"2016-05-17 17:00:00","rrule":null,"timezone":"America\/New_York"},"extras":[],"groups":[{"id":"65448","name":"Bioengineering Graduate Program"}],"categories":[],"keywords":[],"core_research_areas":[],"news_room_topics":[],"event_categories":[{"id":"1788","name":"Other\/Miscellaneous"}],"invited_audience":[{"id":"78751","name":"Undergraduate students"},{"id":"78761","name":"Faculty\/Staff"},{"id":"174045","name":"Graduate students"}],"affiliations":[],"classification":[],"areas_of_expertise":[],"news_and_recent_appearances":[],"phone":[],"contact":[{"value":"\u003Cp\u003ELaura Paige\u003C\/p\u003E\u003Cp\u003E404-385-6655\u003C\/p\u003E","format":"limited_html"}],"email":[],"slides":[],"orientation":[],"userdata":""}},"534971":{"#nid":"534971","#data":{"type":"event","title":"BioE PhD Proposal presentation - Mohammad Mahdi Hasani Sadrabadi","body":[{"value":"\u003Cp\u003E\u003Cstrong\u003EAdvisor\u003C\/strong\u003E\u003C\/p\u003E\u003Cp\u003EKarl I. Jacob (Georgia Institute of Technology, School of Materials Science and Engineering)\u003C\/p\u003E\u003Cp\u003E\u003Cstrong\u003ECommittee\u003C\/strong\u003E\u003C\/p\u003E\u003Cp\u003ELuke Brewster, MD, PhD (Emory University School of Medicine)\u003C\/p\u003E\u003Cp\u003EJ. Brandon Dixon, PhD (Georgia Institute of Technology, George Woodruff School of Mechanical Engineering)\u003C\/p\u003E\u003Cp\u003EMostafa A. El-Sayed, PhD (Georgia Institute of Technology, School of Chemistry \u0026amp; Biochemistry)\u003C\/p\u003E\u003Cp\u003EKrishnendu Roy, PhD (Georgia Institute of Technology, Wallace H. Coulter Department of Biomedical Engineering)\u003C\/p\u003E\u003Cp\u003E\u003Cstrong\u003E\u0026nbsp;\u003C\/strong\u003E\u003C\/p\u003E\u003Cp align=\u0022center\u0022\u003E\u003Cstrong\u003EMicrofluidic generation of cancer nanomedicines\u003C\/strong\u003E\u003C\/p\u003E\u003Cp\u003EThe goal of this proposal is to develop a technological foundation to synthesize and evaluate cancer therapeutic polymer-based nanomedicines using microfluidic platform and to optimize, and characterize it for the controlled drug release within tumor environment. The project will be done in three phases; In\u0026nbsp;\u003Cem\u003Ephase I\u003C\/em\u003E, the main goal would be evaluating the ability of on-chip nanoparticle (NP) formation on controlling the physical properties of prepared NPs. Size, polydispersity, morphology, and surface charge of NPs will be characterized in this phase. In\u0026nbsp;\u003Cem\u003Ephase II\u003C\/em\u003E, we will focus on development of complex NPs to address the requirements of next-generation nanomedicine. The main goal will be synthesis of hybrid (organic-inorganic and organic-organic) NPs, multilayer NPs as well as ligand-coated NPs. For hybrid NPs, encapsulation of gold and magnetic NPs inside polymeric particles will be examined for the theranostic applications. In the case of multilayer NPs the main goal is to protect NPs from\u0026nbsp;\u003Cem\u003Ein vivo\u003C\/em\u003E\u0026nbsp;degradation (e.g. in oral delivery) as well as on-target unmasking of the coated NPs. We will also try to make electrostatic ligand-coated NPs for active targeting of cancerous cells. Full sets of mentioned evaluations will be done to characterize the developed complex NPs as well. In\u0026nbsp;\u003Cem\u003Ephase III\u003C\/em\u003E, we will mainly focus on the biological behavior of microfluidic-directed synthezied NPs.\u0026nbsp;\u003Cem\u003EIn vitro\u003C\/em\u003E\u0026nbsp;release profile of drug-loaded NPs will be evaluated. Using two-dimensional cultures of cancer cell lines and subsequently cellular spheroids, NPs-cell interactions, cellular toxicity, and cellular uptake of NPs will be assessed.\u0026nbsp;Tumor-on-chip model will be tried as a real-time analytical method to evaluate the NP accumulation at simulated physiological flow condition. The specific goal of this phase is to design a miniaturized tumor microenvironment on a chip using microfluidics technique to recapitulate the key parameters acting\u0026nbsp;\u003Cem\u003Ein vivo\u003C\/em\u003E\u0026nbsp;including 3D tumor environment, cancer cell aggregates, physiological scaling and flow rates. Such results will be achieved through the possibility for optical window to real-time evaluation and sampling from the designed chambers on the microfluidic platforms. Overall we expect that this research will provide us with broad information on how NP design can affect and control the efficacy of cancer therapeutic nanomedicine.\u003C\/p\u003E","summary":null,"format":"limited_html"}],"field_subtitle":"","field_summary":[{"value":"\u003Cp\u003EBioE PhD Proposal Presentation-\u0026nbsp;\u0022Microfluidic generation of cancer nanomedicines\u0022- Mohammad Mahdi Hasani Sadrabadi\u003C\/p\u003E","format":"limited_html"}],"field_summary_sentence":[{"value":"\u0022Microfluidic generation of cancer nanomedicines\u0022"}],"uid":"27917","created_gmt":"2016-05-10 07:42:56","changed_gmt":"2017-04-13 21:15:53","author":"Laura Paige","boilerplate_text":"","field_publication":"","field_article_url":"","field_event_time":{"event_time_start":"2016-05-25T15:00:00-04:00","event_time_end":"2016-05-25T17:00:00-04:00","event_time_end_last":"2016-05-25T17:00:00-04:00","gmt_time_start":"2016-05-25 19:00:00","gmt_time_end":"2016-05-25 21:00:00","gmt_time_end_last":"2016-05-25 21:00:00","rrule":null,"timezone":"America\/New_York"},"extras":[],"groups":[{"id":"65448","name":"Bioengineering Graduate Program"}],"categories":[],"keywords":[],"core_research_areas":[],"news_room_topics":[],"event_categories":[{"id":"1789","name":"Conference\/Symposium"}],"invited_audience":[{"id":"78751","name":"Undergraduate students"},{"id":"78761","name":"Faculty\/Staff"},{"id":"174045","name":"Graduate students"}],"affiliations":[],"classification":[],"areas_of_expertise":[],"news_and_recent_appearances":[],"phone":[],"contact":[{"value":"\u003Cp\u003ELaura Paige\u003C\/p\u003E\u003Cp\u003E404.385.6655\u003C\/p\u003E","format":"limited_html"}],"email":[],"slides":[],"orientation":[],"userdata":""}},"292811":{"#nid":"292811","#data":{"type":"event","title":"Breakfast Club Seminar","body":[{"value":"\u003Cp\u003E\u003Cstrong\u003E\u0022Autonomous Mobile Robots for Personalized Caregiving\u0022\u003Cbr \/\u003E\u003Cbr \/\u003ECharlie Kemp, PhD\u003C\/strong\u003E\u003Cbr \/\u003E\u003Cstrong\u003EAssociate Professor\u003C\/strong\u003E\u003Cbr \/\u003E\u003Cstrong\u003EWallace H. Coulter Department of Biomedical Engineering\u003C\/strong\u003E\u003Cbr \/\u003E\u003Cstrong\u003EGeorgia Tech\u003Cbr \/\u003E\u003Cbr \/\u003E\u003C\/strong\u003E\u003C\/p\u003E\u003Cp\u003EMobile robots with autonomous capabilities have the potential to provide 24\/7 personalized care, dramatically improving the quality of life of people with motor impairments. I will first provide an overview of opportunities for robots to provide beneficial physical assistance in the context of healthcare. I will then focus on my lab\u2019s research to enable people with severe motor impairments to perform everyday tasks for themselves using mobile robots. In particular, I will focus on our work with Henry Evans, who has severe impairments due to a brainstem stroke. Through our research, Henry has been able to perform a number of tasks for himself for the first time in 10 years, such as pulling a blanket over himself, shaving himself, and operating mechanisms in his home. A key aspect of our work has been giving robots the ability to intelligently regulate the forces they apply while providing assistance.\u003Cbr \/\u003E\u003Cbr \/\u003ECharles C. Kemp (Charlie) is an Associate Professor at the Georgia Institute of Technology in the Department of Biomedical Engineering at Georgia Tech and Emory and is an adjunct faculty member of the School of Interactive Computing and the School of Electrical and Computer Engineering. He earned a doctorate in Electrical Engineering and Computer Science (2005), an MEng, and BS from MIT. In 2007, he founded the Healthcare Robotics Lab at Georgia Tech (\u003Ca href=\u0022http:\/\/healthcare-robotics.com\u0022 title=\u0022http:\/\/healthcare-robotics.com\u0022\u003Ehttp:\/\/healthcare-robotics.com\u003C\/a\u003E), which focuses on mobile manipulation and human-robot interaction. He is an active member of Georgia Tech\u2019s Institute for Robotics \u0026amp; Intelligent Machines and its multi-disciplinary Robotics Ph.D. program. He has received the 3M Non-tenured Faculty Award, the Georgia Tech Research Corporation Robotics Award, and the NSF CAREER award. His research has been covered extensively by the popular media, including the New York Times, Technology Review, ABC, and CNN.\u003C\/p\u003E\u003Cp\u003E\u003Cstrong\u003E\u003Cbr \/\u003E\u003C\/strong\u003E\u003C\/p\u003E","summary":null,"format":"limited_html"}],"field_subtitle":"","field_summary":[{"value":"\u003Cp\u003EThe Petit Institute Breakfast Club seminar series was started with the spirit of the Institute\u0027s interdisciplinary mission in mind and started to feature local Petit Institute faculty member\u0027s research in a seminar format. Faculty are often asked to speak at other universities and conferences, but rarely present at their home institution, this seminar series is an attempt to close that gap. The Petit Institute Breakfast Club is open to anyone in the bio-community.\u003C\/p\u003E","format":"limited_html"}],"field_summary_sentence":[{"value":"\u0022Autonomous Mobile Robots for Personalized Caregiving\u0022 - Charlie Kemp, PhD - Georgia Tech"}],"uid":"27195","created_gmt":"2014-04-23 14:14:20","changed_gmt":"2017-04-13 21:22:40","author":"Colly Mitchell","boilerplate_text":"","field_publication":"","field_article_url":"","field_event_time":{"event_time_start":"2014-08-12T13:30:00-04:00","event_time_end":"2014-08-12T14:30:00-04:00","event_time_end_last":"2014-08-12T14:30:00-04:00","gmt_time_start":"2014-08-12 17:30:00","gmt_time_end":"2014-08-12 18:30:00","gmt_time_end_last":"2014-08-12 18:30:00","rrule":null,"timezone":"America\/New_York"},"extras":[],"related_links":[{"url":"http:\/\/www.hsi.gatech.edu\/cckemp\/index.shtml","title":"Kemp lab website"}],"groups":[{"id":"1292","name":"Parker H. Petit Institute for Bioengineering and Bioscience (IBB)"}],"categories":[],"keywords":[{"id":"11879","name":"BK Club"},{"id":"248","name":"IBB"}],"core_research_areas":[],"news_room_topics":[],"event_categories":[{"id":"1795","name":"Seminar\/Lecture\/Colloquium"}],"invited_audience":[{"id":"78751","name":"Undergraduate students"},{"id":"78761","name":"Faculty\/Staff"},{"id":"174045","name":"Graduate students"}],"affiliations":[],"classification":[],"areas_of_expertise":[],"news_and_recent_appearances":[],"phone":[],"contact":[{"value":"\u003Cp\u003EColly Mitchell\u003C\/p\u003E","format":"limited_html"}],"email":[],"slides":[],"orientation":[],"userdata":""}},"293341":{"#nid":"293341","#data":{"type":"event","title":"BioEngineering Orientation \u0026 Expo 2014","body":[{"value":"\u003Cp\u003EOpen to new and current BioE students, the BioE Orientation \u0026amp; Expo is the perfect place to get to know the BioE community, learn about the great research being conducted and talk to PIs about their labs!\u0026nbsp;\u003Cbr \/\u003E\u003Cbr \/\u003E\u003Cstrong\u003EAGENDA\u003Cbr \/\u003E\u003C\/strong\u003E\u003C\/p\u003E\u003Cp\u003E1:00pm \u0026nbsp; BioE Overview \u2013 Andr\u00e9s Garc\u00eda, PhD \u2013 Director, Interdisciplinary BioEngineering Graduate Program \u003Cbr \/\u003E\u003Cbr \/\u003E2:00pm \u0026nbsp; Student Panel:\u0026nbsp;\u003C\/p\u003E\u003Cul\u003E\u003Cli\u003EHarrison Norman \u2013 BioE\/ECE\u0026nbsp;\u003C\/li\u003E\u003Cli\u003EAdrian Lam \u2013 BioE\/BME\u0026nbsp;\u003C\/li\u003E\u003Cli\u003EKirsten Parratt \u2013 BioE\/MSE\u0026nbsp;\u003C\/li\u003E\u003Cli\u003EJosh Hooks \u2013 BioE\/ME\u0026nbsp;\u003C\/li\u003E\u003Cli\u003EJaya Arya \u2013 BioE\/ChBE\u0026nbsp;\u003C\/li\u003E\u003C\/ul\u003E\u003Cp\u003E\u003Cbr \/\u003E2:30pm \u0026nbsp; Course Advisement \u2013 Andr\u00e9s Garc\u00eda, PhD \u003Cbr \/\u003E\u003Cbr \/\u003E3:00pm \u0026nbsp; Opportunities for Professional Development\u003C\/p\u003E\u003Cul\u003E\u003Cli\u003EFellowships Office \u2013 Kathryn Meehan, PhD \u2013 Director of Fellowship Office\u0026nbsp;\u003C\/li\u003E\u003Cli\u003ECenter for Career Discovery \u0026amp; Development \u2013 Robbie Ouzts- Graduate Career Specialist and Ken Little \u2013 Assistant Director, Graduate Co-op Program\u0026nbsp;\u003C\/li\u003E\u003C\/ul\u003E\u003Cp\u003E\u003Cbr \/\u003E3:15pm \u0026nbsp; Training Grant Info Session IGERT \u2013 Tom Bongiorno CTEng \u2013 Andr\u00e9s Garc\u00eda, PhD BioMaterials \u2013 Andr\u00e9s Garc\u00eda, PhD \u003Cbr \/\u003E\u003Cbr \/\u003E3:30pm \u0026nbsp; Poster Session \u0026amp; Reception - Petit Institute atrium \u003Cbr \/\u003E\u003Cbr \/\u003E5:30pm \u0026nbsp; Outing with current BioE students \u2013 Delia\u2019s Chicken Sausage \u003Cbr \/\u003E\u003Cem\u003EPlease meet in Petit Institute atrium at 5:30pm to depart at 5:45pm\u003C\/em\u003E\u003C\/p\u003E\u003Cp\u003E\u003Cstrong\u003E\u003Ca href=\u0022http:\/\/bioengineering.gatech.edu\/bioe-expo-registration\u0022\u003EREGISTER\u003Cbr \/\u003E\u003Cbr \/\u003E\u003C\/a\u003E\u003C\/strong\u003E\u003C\/p\u003E","summary":null,"format":"limited_html"}],"field_subtitle":"","field_summary":[{"value":"\u003Cp\u003EBioEngineerng Expo 2014\u003C\/p\u003E","format":"limited_html"}],"field_summary_sentence":[{"value":"Learn about the great research being conducted and talk to PIs about their labs!"}],"uid":"27917","created_gmt":"2014-04-25 15:03:14","changed_gmt":"2017-04-13 21:22:39","author":"Laura Paige","boilerplate_text":"","field_publication":"","field_article_url":"","field_event_time":{"event_time_start":"2014-08-15T17:00:00-04:00","event_time_end":"2014-08-15T22:00:00-04:00","event_time_end_last":"2014-08-15T22:00:00-04:00","gmt_time_start":"2014-08-15 21:00:00","gmt_time_end":"2014-08-16 02:00:00","gmt_time_end_last":"2014-08-16 02:00:00","rrule":null,"timezone":"America\/New_York"},"extras":[],"related_links":[{"url":"http:\/\/bioengineering.gatech.edu\/","title":"BIOE program"}],"groups":[{"id":"65448","name":"Bioengineering Graduate Program"}],"categories":[],"keywords":[{"id":"248","name":"IBB"}],"core_research_areas":[],"news_room_topics":[],"event_categories":[{"id":"1788","name":"Other\/Miscellaneous"}],"invited_audience":[{"id":"78751","name":"Undergraduate students"},{"id":"78761","name":"Faculty\/Staff"},{"id":"174045","name":"Graduate students"}],"affiliations":[],"classification":[],"areas_of_expertise":[],"news_and_recent_appearances":[],"phone":[],"contact":[{"value":"\u003Cp\u003E\u003Ca href=\u0022mailto:Laura.Paige@bioengineering.gatech.edu\u0022\u003ELaura Paige\u003C\/a\u003E\u003C\/p\u003E","format":"limited_html"}],"email":[],"slides":[],"orientation":[],"userdata":""}},"311381":{"#nid":"311381","#data":{"type":"event","title":"BioEngineering Program Faculty Meeting","body":[{"value":"\u003Cp\u003E\u003Cem\u003EThe BioEngineering Program faculty meet regularly during the semester to address program policies, events and future research and academic directions.\u003C\/em\u003E\u003C\/p\u003E","summary":null,"format":"limited_html"}],"field_subtitle":"","field_summary":[{"value":"\u003Cp\u003E\u003Cem\u003EProgram policies, events and directions to be discussed\u003C\/em\u003E\u003C\/p\u003E","format":"limited_html"}],"field_summary_sentence":[{"value":"BioEngineering Program Faculty Meeting"}],"uid":"27917","created_gmt":"2014-07-29 13:46:48","changed_gmt":"2016-10-08 02:08:27","author":"Laura Paige","boilerplate_text":"","field_publication":"","field_article_url":"","field_event_time":{"event_time_start":"2014-08-20T12:00:00-04:00","event_time_end":"2014-08-20T13:00:00-04:00","event_time_end_last":"2014-08-20T13:00:00-04:00","gmt_time_start":"2014-08-20 16:00:00","gmt_time_end":"2014-08-20 17:00:00","gmt_time_end_last":"2014-08-20 17:00:00","rrule":null,"timezone":"America\/New_York"},"extras":[],"groups":[{"id":"65448","name":"Bioengineering Graduate Program"}],"categories":[],"keywords":[],"core_research_areas":[],"news_room_topics":[],"event_categories":[{"id":"1788","name":"Other\/Miscellaneous"}],"invited_audience":[{"id":"78761","name":"Faculty\/Staff"}],"affiliations":[],"classification":[],"areas_of_expertise":[],"news_and_recent_appearances":[],"phone":[],"contact":[],"email":[],"slides":[],"orientation":[],"userdata":""}},"288851":{"#nid":"288851","#data":{"type":"event","title":"Bioengineering Seminar Series","body":[{"value":"\u003Cp\u003E\u003Cstrong\u003E\u0022Joining Forces with Biology: A Bioengineering Perspective on Cell Migration\u0022\u003Cbr \/\u003E\u003Cbr \/\u003EKonstantinos Konstantopoulos, PhD\u003C\/strong\u003E\u003Cbr \/\u003E\u003Cstrong\u003EProfessor \u0026amp; Chair\u003C\/strong\u003E\u003Cbr \/\u003E\u003Cstrong\u003EDepartment of Chemical and Biomolecular Engineering\u003C\/strong\u003E\u003Cbr \/\u003E\u003Cstrong\u003EJohns Hopkins University\u003Cbr \/\u003E\u003Cbr \/\u003E\u003C\/strong\u003EThe human body represents an exquisite feat of bioengineering. Physical and biochemical stimuli actively regulate cell responses. Therefore, elucidating the biophysical and molecular nature of physiologically relevant cellular processes requires the integration of engineering and microtechnology fundamental with biophysical models and concepts from biochemistry and molecular cell biology.\u003C\/p\u003E\u003Cp\u003EOur research in Molecular and Cellular Bioengineering is directed at understanding how mechanical forces regulate cell responses pertinent to cancer metastasis and inflammation using physiologically relevant in vitro and in vivo models. This is accomplished through the synthesis of engineering and microtehcnology principles with quantitative modeling and concepts from biophysics, biochemistry, and molecular cell biology. Some of our key research contributions are the discovery of novel adhesion molecules (i.e., selection ligands) that mediate tumor cell adhesion in the vasculature, the biophysical characterization of these adhesive interactions at the single-molecule level, and the elucidation of novel signaling mechanisms during migration through physically confined micro environments. The ultimate goal of our research program is to develop molecular-targetded therapies to combat cancer and inflammatory disorders using a directed multi-disciplinary approach.\u003Cbr \/\u003E\u003Cbr \/\u003E\u003Cbr \/\u003E\u003C\/p\u003E","summary":null,"format":"limited_html"}],"field_subtitle":"","field_summary":[{"value":"\u003Cp\u003EThe Bioengineering Seminar Series is a joint seminar series between the Petit Institute and the Biomedical Engineering department. Seminars are held on Tuesdays or Thursdays between 11am-12pm in Petit Institute, room 1128, unless otherwise indicated.\u003C\/p\u003E\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E","format":"limited_html"}],"field_summary_sentence":[{"value":"\u0022Joining Forces with Biology: A Bioengineering Perspective on Cell Migration\u0022 - Konstantinos Konstantopoulos, PhD - Johns Hopkins University"}],"uid":"27959","created_gmt":"2014-04-07 13:23:43","changed_gmt":"2017-04-13 21:22:45","author":"Karen Ethier","boilerplate_text":"","field_publication":"","field_article_url":"","field_event_time":{"event_time_start":"2014-09-04T16:00:00-04:00","event_time_end":"2014-09-04T17:00:00-04:00","event_time_end_last":"2014-09-04T17:00:00-04:00","gmt_time_start":"2014-09-04 20:00:00","gmt_time_end":"2014-09-04 21:00:00","gmt_time_end_last":"2014-09-04 21:00:00","rrule":null,"timezone":"America\/New_York"},"extras":[],"related_links":[{"url":"http:\/\/web1.johnshopkins.edu\/kostaslab\/","title":"Konstantopoulos Lab"}],"groups":[{"id":"1292","name":"Parker H. Petit Institute for Bioengineering and Bioscience (IBB)"},{"id":"65448","name":"Bioengineering Graduate Program"}],"categories":[],"keywords":[{"id":"11877","name":"BioE Seminar"},{"id":"248","name":"IBB"}],"core_research_areas":[],"news_room_topics":[],"event_categories":[{"id":"1795","name":"Seminar\/Lecture\/Colloquium"}],"invited_audience":[{"id":"78751","name":"Undergraduate students"},{"id":"78761","name":"Faculty\/Staff"},{"id":"174045","name":"Graduate students"}],"affiliations":[],"classification":[],"areas_of_expertise":[],"news_and_recent_appearances":[],"phone":[],"contact":[{"value":"\u003Cp\u003EFaculty host: \u003Ca href=\u0022%20susan.thomas@gatech.edu\u0022\u003ESusan N. Thomas, PhD\u003C\/a\u003E\u003C\/p\u003E","format":"limited_html"}],"email":[],"slides":[],"orientation":[],"userdata":""}},"301651":{"#nid":"301651","#data":{"type":"event","title":"Breakfast Club Seminar","body":[{"value":"\u003Cp\u003E\u003Cstrong\u003E\u0022RNA and Protein: A Match Made in the Hadean\u0022\u003Cbr \/\u003E\u003Cbr \/\u003E\u003C\/strong\u003E\u003Cstrong\u003ELoren Williams, PhD\u003Cbr \/\u003E\u003C\/strong\u003E\u003Cstrong\u003EDirector, NASA-NAI RiboEvo Center\u003Cbr \/\u003E\u003C\/strong\u003E\u003Cstrong\u003EProfessor\u003Cbr \/\u003E\u003C\/strong\u003E\u003Cstrong\u003ESchool of Chemistry \u0026amp; Biochemistry\u003Cbr \/\u003E\u003C\/strong\u003E\u003Cstrong\u003EGeorgia Tech\u003C\/strong\u003E\u003C\/p\u003E\u003Cp\u003EThe Williams lab studies RNA, using synthetic biology, phylogeny, biophysical chemistry, bioinformatics, molecular biology and paleogeology. They construct models of ancient ribosomes in silico, in vitro and in vivo. They deconstruct and reverse engineer the ribosome providing tools for understanding the origin of life and for discovery of new antibiotics. They study DNA interactions with ions, anti-cancer drugs and proteins.\u003C\/p\u003E\u003Cp\u003ELoren Williams was born in Seattle, Washington. In 1981 he received his B.Sc. in Chemistry from the University of Washington where he worked in the laboratory of Martin Gouterman. In 1985 he received his Ph.D. in Physical Chemistry from Duke University, where he worked the laboratory of Barbara Shaw. He was an American Cancer Society Postdoctoral Fellow first at Duke then at Harvard. From 1988 to 1992 he was an NIH Postdoctoral Fellow with Alex Rich in the Department of Biology at MIT. He joined the School of Chemistry and Biochemistry at Georgia Tech in 1992 where is he currently a professor. Loren received an NSF CAREER Award in 1995, and a Sigma Xi Award for best paper from Georgia Tech in 1996. He is director of the NASA Astrobiology Institute funded Ribo Evo Center. The goal of the Center is to rewind the \u201ctape of life\u201d, to understand and recapitulate macromolecular synthesis, folding, assembly and catalysis of primodial biological systems. The Center uses biology\u0027s translation system, which contains an interpretable molecular record of the deep and distant evolutionary past, to understand biology before LUCA.\u003C\/p\u003E","summary":null,"format":"limited_html"}],"field_subtitle":"","field_summary":[{"value":"\u003Cp\u003EThe Petit Institute Breakfast Club seminar series was started with the spirit of the Institute\u0027s interdisciplinary mission in mind and started to feature local Petit Institute faculty member\u0027s research in a seminar format. Faculty are often asked to speak at other universities and conferences, but rarely present at their home institution, this seminar series is an attempt to close that gap. The Petit Institute Breakfast Club is open to anyone in the bio-community.\u003C\/p\u003E","format":"limited_html"}],"field_summary_sentence":[{"value":"\u0022RNA and Protein: A Match Made in the Hadean\u0022 - Loren Williams, PhD - Georgia Tech"}],"uid":"27195","created_gmt":"2014-06-05 13:15:21","changed_gmt":"2017-04-13 21:22:28","author":"Colly Mitchell","boilerplate_text":"","field_publication":"","field_article_url":"","field_event_time":{"event_time_start":"2014-09-09T09:30:00-04:00","event_time_end":"2014-09-09T10:30:00-04:00","event_time_end_last":"2014-09-09T10:30:00-04:00","gmt_time_start":"2014-09-09 13:30:00","gmt_time_end":"2014-09-09 14:30:00","gmt_time_end_last":"2014-09-09 14:30:00","rrule":null,"timezone":"America\/New_York"},"extras":[],"hg_media":{"70917":{"id":"70917","type":"image","title":"Breakfast Club Seminar Series","body":null,"created":"1449177328","gmt_created":"2015-12-03 21:15:28","changed":"1475894625","gmt_changed":"2016-10-08 02:43:45","alt":"Breakfast Club Seminar Series","file":{"fid":"193471","name":"logobldg_graphic.png","image_path":"\/sites\/default\/files\/images\/logobldg_graphic_0.png","image_full_path":"http:\/\/www.tlwarc.hg.gatech.edu\/\/sites\/default\/files\/images\/logobldg_graphic_0.png","mime":"image\/png","size":241588,"path_740":"http:\/\/www.tlwarc.hg.gatech.edu\/sites\/default\/files\/styles\/740xx_scale\/public\/images\/logobldg_graphic_0.png?itok=x84xf3Mz"}}},"media_ids":["70917"],"related_links":[{"url":"http:\/\/astrobiology.gatech.edu\/","title":"Center for Ribosomal Origins and Evolution"},{"url":"http:\/\/www.ibb.gatech.edu\/breakfast-club","title":"IBB Breakfast Club"},{"url":"http:\/\/ww2.chemistry.gatech.edu\/~williams\/","title":"Williams lab"}],"groups":[{"id":"1292","name":"Parker H. Petit Institute for Bioengineering and Bioscience (IBB)"}],"categories":[],"keywords":[{"id":"11879","name":"BK Club"},{"id":"248","name":"IBB"}],"core_research_areas":[],"news_room_topics":[],"event_categories":[{"id":"1795","name":"Seminar\/Lecture\/Colloquium"}],"invited_audience":[{"id":"78751","name":"Undergraduate students"},{"id":"78761","name":"Faculty\/Staff"},{"id":"174045","name":"Graduate students"}],"affiliations":[],"classification":[],"areas_of_expertise":[],"news_and_recent_appearances":[],"phone":[],"contact":[{"value":"\u003Cp\u003E\u003Ca href=\u0022mailto:colly.mitchell@ibb.gatech.edu\u0022\u003EColly Mitchell\u003C\/a\u003E\u003Cbr \/\u003EProgram Coordinator\u003C\/p\u003E","format":"limited_html"}],"email":[],"slides":[],"orientation":[],"userdata":""}},"311331":{"#nid":"311331","#data":{"type":"event","title":"BioEngineering Graduate Committee Meeting","body":[{"value":"\u003Cp\u003E\u003Cem\u003EBioEngineering Graduate Committee Meeting - Program policies, faculty applications and student petitions to be discussed\u003C\/em\u003E\u003C\/p\u003E","summary":null,"format":"limited_html"}],"field_subtitle":"","field_summary":[{"value":"\u003Cp\u003EThe BioEngineering graduate committee will meet to review\/approve program policies, program faculty applications and submitted student petitions.\u003Cbr \/\u003E\u003Cbr \/\u003EStudent Petitions due to\u0026nbsp;\u003Ca href=\u0022mailto:laura.paige@bioengineering.gatech.edu\u0022\u003ELaura Paige\u003C\/a\u003E\u0026nbsp;no later than:\u0026nbsp;\u003C\/p\u003E\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\u003Cp\u003E9\/3\/14\u003C\/p\u003E","format":"limited_html"}],"field_summary_sentence":[{"value":"BioEngineering Graduate Committee Meeting"}],"uid":"27917","created_gmt":"2014-07-29 13:16:16","changed_gmt":"2016-10-08 02:08:27","author":"Laura Paige","boilerplate_text":"","field_publication":"","field_article_url":"","field_event_time":{"event_time_start":"2014-09-10T12:30:00-04:00","event_time_end":"2014-09-10T13:30:00-04:00","event_time_end_last":"2014-09-10T13:30:00-04:00","gmt_time_start":"2014-09-10 16:30:00","gmt_time_end":"2014-09-10 17:30:00","gmt_time_end_last":"2014-09-10 17:30:00","rrule":null,"timezone":"America\/New_York"},"extras":[],"groups":[{"id":"65448","name":"Bioengineering Graduate Program"}],"categories":[],"keywords":[],"core_research_areas":[],"news_room_topics":[],"event_categories":[{"id":"1788","name":"Other\/Miscellaneous"}],"invited_audience":[{"id":"78761","name":"Faculty\/Staff"}],"affiliations":[],"classification":[],"areas_of_expertise":[],"news_and_recent_appearances":[],"phone":[],"contact":[],"email":[],"slides":[],"orientation":[],"userdata":""}},"290111":{"#nid":"290111","#data":{"type":"event","title":"Bioengineering Seminar Series","body":[{"value":"\u003Cp\u003E\u003Cstrong\u003E\u201cInterrogating Cell-to-Cell Heterogeneity by Stochastic Profiling\u201d\u003Cbr \/\u003E\u003Cbr \/\u003EKevin Janes, PhD\u003C\/strong\u003E\u003Cbr \/\u003E\u003Cstrong\u003EAssistant Professor\u003C\/strong\u003E\u003Cbr \/\u003E\u003Cstrong\u003EDepartment of Biomedical Engineering\u003C\/strong\u003E\u003Cbr \/\u003E\u003Cstrong\u003EUniversity of Virginia\u003Cbr \/\u003E\u003Cbr \/\u003E\u003C\/strong\u003ERegulated changes in gene expression underlie many biological processes, but globally profiling cell-to-cell variations in transcriptional regulation is problematic when measuring single cells.\u0026nbsp; The Janes lab has developed an approach, called stochastic profiling, that applies probability theory to transcriptome-wide measurements of small pools of cells to identify single-cell regulatory heterogeneities (Nat Methods 7:311-7 [2010]).\u0026nbsp; In the first half of the talk, Janes will discuss a two-state regulatory circuit that was identified by stochastic profiling (Nat Cell Biol 16:345-56 [2014]).\u0026nbsp; The circuit involves TGFb-family signaling and the junD transcription factor, which are asynchronously activated in 3D breast epithelial cultures to coordinate normal morphogenesis.\u0026nbsp; The circuit also appears to be re-initiated during the early stages of basal-like breast cancer, contributing to the mosaicked expression patterns observed clinically by histology.\u0026nbsp; In the second half of the talk, Janes will talk about work in progress that applies stochastic profiling as a tool for uncovering the mechanistic basis of phenotypes that are incompletely penetrant.\u0026nbsp; Regulatory-state frequencies are matched to downstream phenotype frequencies to converge upon a tractable set of candidate states worthy of follow-up experimentation.\u0026nbsp; Using the ErbB2 oncoprotein as a model trigger for an incompletely penetrant phenotype, they identify a handful of surprising candidates that significantly affect penetrance when perturbed.\u0026nbsp; Stochastic profiling remains the only method compatible with cells microdissected in situ and thereby opens exciting opportunities in the areas of tissue morphogenesis and cancer\u003Cstrong\u003E.\u003C\/strong\u003E\u003C\/p\u003E","summary":null,"format":"limited_html"}],"field_subtitle":"","field_summary":[{"value":"\u003Cp\u003EThe Bioengineering Seminar Series is a joint seminar series between the Petit Institute and the Biomedical Engineering department. Seminars are held on Tuesdays or Thursdays between 11am-12pm in Petit Institute, room 1128, unless otherwise indicated.\u003C\/p\u003E","format":"limited_html"}],"field_summary_sentence":[{"value":"\u201cInterrogating Cell-to-Cell Heterogeneity by Stochastic Profiling\u201d - Kevin Janes, PhD - University of Virginia"}],"uid":"27959","created_gmt":"2014-04-11 13:38:42","changed_gmt":"2017-04-13 21:22:42","author":"Karen Ethier","boilerplate_text":"","field_publication":"","field_article_url":"","field_event_time":{"event_time_start":"2014-09-23T16:00:00-04:00","event_time_end":"2014-09-23T17:00:00-04:00","event_time_end_last":"2014-09-23T17:00:00-04:00","gmt_time_start":"2014-09-23 20:00:00","gmt_time_end":"2014-09-23 21:00:00","gmt_time_end_last":"2014-09-23 21:00:00","rrule":null,"timezone":"America\/New_York"},"extras":[],"related_links":[{"url":"http:\/\/bme.virginia.edu\/janes\/index.html","title":"Janes lab website"}],"groups":[{"id":"1292","name":"Parker H. Petit Institute for Bioengineering and Bioscience (IBB)"},{"id":"65448","name":"Bioengineering Graduate Program"}],"categories":[],"keywords":[{"id":"11877","name":"BioE Seminar"},{"id":"248","name":"IBB"}],"core_research_areas":[],"news_room_topics":[],"event_categories":[{"id":"1795","name":"Seminar\/Lecture\/Colloquium"}],"invited_audience":[{"id":"78751","name":"Undergraduate students"},{"id":"78761","name":"Faculty\/Staff"},{"id":"174045","name":"Graduate students"}],"affiliations":[],"classification":[],"areas_of_expertise":[],"news_and_recent_appearances":[],"phone":[],"contact":[{"value":"\u003Cp\u003EFaculty host: \u003Ca href=\u0022%20melissa.kemp@bme.gatech.edu\u0022\u003EMelissa Kemp, PhD\u003C\/a\u003E\u003C\/p\u003E","format":"limited_html"}],"email":[],"slides":[],"orientation":[],"userdata":""}},"213331":{"#nid":"213331","#data":{"type":"event","title":"Bioengineering Seminar Series","body":[{"value":"\u003Cp\u003E\u003Cstrong\u003E\u003Cstrong\u003E\u003Cstrong\u003E\u003Cstrong\u003E\u003Cstrong\u003E\u0022From Signals to Shapes in Tissue Morphogenesis\u0022\u003C\/strong\u003E\u003C\/strong\u003E\u003C\/strong\u003E\u003C\/strong\u003E\u003Cbr \/\u003E\u003Cbr \/\u003EStanislav Y. Shvartsman, PhD\u003C\/strong\u003E\u003Cbr \/\u003E\u003Cstrong\u003EProfessor\u0026nbsp;of Chemical and Biological Engineering \u003Cbr \/\u003EPrinceton University\u003C\/strong\u003E\u003Cbr \/\u003E\u003Cbr \/\u003ERegulated folding of two-dimensional cell sheets (epithelia) is one of the main mechanisms underlying the emergence of three-dimensional structures of tissues and organs. Mechanisms of epithelial morphogenesis have been highly conserved in evolution and can be largely driven by two-dimensional patterning of mechanical properties of cells comprising the epithelium. My group is interested in establishing quantitative models of epithelial morphogenesis, accounting for multiple layers of regulation, from gene sequence to tissue architecture. I will present some of our recent results in this area, focusing on imaging, modeling, and computational analysis of two-dimensional pattern formation and three-dimensional morphogenesis in the developing Drosophila egg, a powerful system for studying how chemical signals induce complex three-dimensional structures.\u003Cbr \/\u003E\u003Cbr \/\u003EThe main focus of our work is on the quantitative analysis of development. Our goal is to establish models that connect multiple levels of description, from gene sequence to pattern formation and morphogenesis. We emphasize close coupling between genetic experiments, computations, and theory, and use the fruit fly as an experimental system for model validation.\u003C\/p\u003E\u003Cp\u003E\u003Cbr \/\u003EFaculty host: \u003Ca href=\u0022mailto:hang.lu@gatech.edu\u0022\u003EHang Lu\u003C\/a\u003E\u003C\/p\u003E","summary":null,"format":"limited_html"}],"field_subtitle":"","field_summary":[{"value":"\u003Cp\u003EThe Bioengineering Seminar Series is a joint seminar series between Petit Institute and the Wallace H. Coulter Department of Biomedical Engineering. Seminars\u0026nbsp;are held on Tuesdays or Thursdays between 11am-12pm in Petit Institute 1128 unless otherwise indicated.\u003C\/p\u003E","format":"limited_html"}],"field_summary_sentence":[{"value":"\u0022From Signals to Shapes in Tissue Morphogenesis\u0022 - Stanislav Y. Shvartsman, PhD - Princeton University"}],"uid":"27691","created_gmt":"2013-05-16 08:56:58","changed_gmt":"2017-04-13 21:24:03","author":"Karen Cannon","boilerplate_text":"","field_publication":"","field_article_url":"","field_event_time":{"event_time_start":"2014-10-07T12:00:00-04:00","event_time_end":"2014-10-07T13:00:00-04:00","event_time_end_last":"2014-10-07T13:00:00-04:00","gmt_time_start":"2014-10-07 16:00:00","gmt_time_end":"2014-10-07 17:00:00","gmt_time_end_last":"2014-10-07 17:00:00","rrule":null,"timezone":"America\/New_York"},"extras":[],"hg_media":{"213341":{"id":"213341","type":"image","title":"Yanislav Y. Shvartsman, PhD","body":null,"created":"1449180076","gmt_created":"2015-12-03 22:01:16","changed":"1475894876","gmt_changed":"2016-10-08 02:47:56","alt":"Yanislav Y. 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Petit Institute for Bioengineering and Bioscience (IBB)"}],"categories":[],"keywords":[{"id":"11877","name":"BioE Seminar"},{"id":"36591","name":"Bioengeneering Seminar Series"},{"id":"248","name":"IBB"},{"id":"167798","name":"Stas Shvartsman"}],"core_research_areas":[],"news_room_topics":[],"event_categories":[{"id":"1795","name":"Seminar\/Lecture\/Colloquium"}],"invited_audience":[{"id":"78751","name":"Undergraduate students"},{"id":"78761","name":"Faculty\/Staff"},{"id":"174045","name":"Graduate students"}],"affiliations":[],"classification":[],"areas_of_expertise":[],"news_and_recent_appearances":[],"phone":[],"contact":[{"value":"\u003Cp\u003E\u003Ca href=\u0022mailto:hang.lu@gatech.edu\u0022\u003EHang Lu, PhD -\u0026nbsp;faculty host\u003C\/a\u003E\u003C\/p\u003E","format":"limited_html"}],"email":[],"slides":[],"orientation":[],"userdata":""}},"311391":{"#nid":"311391","#data":{"type":"event","title":"BioEngineering Program Faculty Meeting","body":[{"value":"\u003Cp\u003E\u003Cem\u003EThe BioEngineering Program faculty meet regularly during the semester to address program policies, events and future research and academic directions.\u003C\/em\u003E\u003C\/p\u003E","summary":null,"format":"limited_html"}],"field_subtitle":"","field_summary":[{"value":"\u003Cp\u003E\u003Cem\u003EProgram policies, events and directions to be discussed\u003C\/em\u003E\u003C\/p\u003E\u0026nbsp;\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E","format":"limited_html"}],"field_summary_sentence":[{"value":"BioEngineering Program Faculty Meeting"}],"uid":"27917","created_gmt":"2014-07-29 13:50:03","changed_gmt":"2016-10-08 02:08:27","author":"Laura Paige","boilerplate_text":"","field_publication":"","field_article_url":"","field_event_time":{"event_time_start":"2014-10-09T12:00:00-04:00","event_time_end":"2014-10-09T13:00:00-04:00","event_time_end_last":"2014-10-09T13:00:00-04:00","gmt_time_start":"2014-10-09 16:00:00","gmt_time_end":"2014-10-09 17:00:00","gmt_time_end_last":"2014-10-09 17:00:00","rrule":null,"timezone":"America\/New_York"},"extras":[],"groups":[{"id":"65448","name":"Bioengineering Graduate Program"}],"categories":[],"keywords":[],"core_research_areas":[],"news_room_topics":[],"event_categories":[{"id":"1788","name":"Other\/Miscellaneous"}],"invited_audience":[{"id":"78761","name":"Faculty\/Staff"}],"affiliations":[],"classification":[],"areas_of_expertise":[],"news_and_recent_appearances":[],"phone":[],"contact":[],"email":[],"slides":[],"orientation":[],"userdata":""}},"301671":{"#nid":"301671","#data":{"type":"event","title":"Breakfast Club Seminar","body":[{"value":"\u003Cp\u003E\u003Cstrong\u003E\u201cThe Spinal Cord: Parallel\/Distributed Processor Regulating Limb Mechanics\u201d\u003C\/strong\u003E\u003C\/p\u003E\u003Cp\u003E\u003Cstrong\u003ET. Richard Nichols, PhD\u003C\/strong\u003E\u003Cbr \/\u003E\u003Cstrong\u003EProfessor \u0026amp; Chair\u003C\/strong\u003E\u003Cbr \/\u003E\u003Cstrong\u003ESchool of Applied Physiology\u003C\/strong\u003E\u003Cbr \/\u003E\u003Cstrong\u003EGeorgia Tech\u003C\/strong\u003E\u003C\/p\u003E\u003Cp\u003EThe work in the Neurophysiology Laboratory is focused on mechanisms underlying motor coordination in mammalian systems. These mechanisms are to be found in the structure and dynamic properties of the musculoskeletal system as well as in the organization of neuronal circuits in the central nervous system. Our work concerns the interactions between the musculoskeletal system and spinal cord that give rise to normal and abnormal movement and posture, and in the manner in which central pattern-generating networks are modified for specific motor tasks. Their studies have applications in several movement disorders, including spinal cord injury. The experimental approaches span a number of levels, from mechanical studies of isolated muscle cells to kinematic measurements of natural behavior in quadrupeds.\u003C\/p\u003E","summary":null,"format":"limited_html"}],"field_subtitle":"","field_summary":[{"value":"\u003Cp\u003EThe Petit Institute Breakfast Club seminar series was started with the spirit of the Institute\u0027s interdisciplinary mission in mind and started to feature local Petit Institute faculty member\u0027s research in a seminar format. Faculty are often asked to speak at other universities and conferences, but rarely present at their home institution, this seminar series is an attempt to close that gap. The Petit Institute Breakfast Club is open to anyone in the bio-community.\u003C\/p\u003E","format":"limited_html"}],"field_summary_sentence":[{"value":"\u201cThe Spinal Cord: Parallel\/Distributed Processor Regulating Limb Mechanics\u201d  - T. Richard Nichols, PhD - Georgia Tech"}],"uid":"27195","created_gmt":"2014-06-05 13:21:23","changed_gmt":"2017-04-13 21:22:28","author":"Colly Mitchell","boilerplate_text":"","field_publication":"","field_article_url":"","field_event_time":{"event_time_start":"2014-10-14T09:30:00-04:00","event_time_end":"2014-10-14T10:30:00-04:00","event_time_end_last":"2014-10-14T10:30:00-04:00","gmt_time_start":"2014-10-14 13:30:00","gmt_time_end":"2014-10-14 14:30:00","gmt_time_end_last":"2014-10-14 14:30:00","rrule":null,"timezone":"America\/New_York"},"extras":[],"hg_media":{"70917":{"id":"70917","type":"image","title":"Breakfast Club Seminar Series","body":null,"created":"1449177328","gmt_created":"2015-12-03 21:15:28","changed":"1475894625","gmt_changed":"2016-10-08 02:43:45","alt":"Breakfast Club Seminar Series","file":{"fid":"193471","name":"logobldg_graphic.png","image_path":"\/sites\/default\/files\/images\/logobldg_graphic_0.png","image_full_path":"http:\/\/www.tlwarc.hg.gatech.edu\/\/sites\/default\/files\/images\/logobldg_graphic_0.png","mime":"image\/png","size":241588,"path_740":"http:\/\/www.tlwarc.hg.gatech.edu\/sites\/default\/files\/styles\/740xx_scale\/public\/images\/logobldg_graphic_0.png?itok=x84xf3Mz"}}},"media_ids":["70917"],"related_links":[{"url":"http:\/\/www.ap.gatech.edu\/Nichols\/NeurophysiologyLab.php","title":"Neurophysiology Lab"},{"url":"http:\/\/www.ibb.gatech.edu\/breakfast-club","title":"IBB Breakfast Club"}],"groups":[{"id":"1292","name":"Parker H. Petit Institute for Bioengineering and Bioscience (IBB)"}],"categories":[],"keywords":[{"id":"11879","name":"BK Club"},{"id":"248","name":"IBB"}],"core_research_areas":[],"news_room_topics":[],"event_categories":[{"id":"1795","name":"Seminar\/Lecture\/Colloquium"}],"invited_audience":[{"id":"78751","name":"Undergraduate students"},{"id":"78761","name":"Faculty\/Staff"},{"id":"174045","name":"Graduate students"}],"affiliations":[],"classification":[],"areas_of_expertise":[],"news_and_recent_appearances":[],"phone":[],"contact":[{"value":"\u003Cp\u003E\u003Ca href=\u0022mailto:colly.mitchell@ibb.gatech.edu\u0022\u003EColly Mitchell\u003C\/a\u003E\u003Cbr \/\u003EProgram Coordinator\u003Cbr \/\u003E\u003Cbr \/\u003E\u003C\/p\u003E","format":"limited_html"}],"email":[],"slides":[],"orientation":[],"userdata":""}},"311351":{"#nid":"311351","#data":{"type":"event","title":"BioEngineering Graduate Committee Meeting","body":[{"value":"\u003Cp\u003E\u003Cem\u003EThe BioEngineering graduate committee will meet to review\/approve program policies, program faculty applications and submitted student petitions.\u003Cbr \/\u003E\u003Cbr \/\u003EStudent Petitions due to\u0026nbsp;\u003Ca href=\u0022mailto:laura.paige@bioengineering.gatech.edu\u0022\u003ELaura Paige\u003C\/a\u003E\u0026nbsp;no later than: 10\/8\/2014\u003C\/em\u003E\u003C\/p\u003E\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E","summary":null,"format":"limited_html"}],"field_subtitle":"","field_summary":[{"value":"\u003Cp\u003E\u003Cem\u003EBioEngineering Graduate Committee Meeting\u003C\/em\u003E\u003C\/p\u003E","format":"limited_html"}],"field_summary_sentence":[{"value":"BioEngineering Graduate Committee Meeting"}],"uid":"27917","created_gmt":"2014-07-29 13:32:45","changed_gmt":"2016-10-08 02:08:27","author":"Laura Paige","boilerplate_text":"","field_publication":"","field_article_url":"","field_event_time":{"event_time_start":"2014-10-15T12:30:00-04:00","event_time_end":"2014-10-15T13:30:00-04:00","event_time_end_last":"2014-10-15T13:30:00-04:00","gmt_time_start":"2014-10-15 16:30:00","gmt_time_end":"2014-10-15 17:30:00","gmt_time_end_last":"2014-10-15 17:30:00","rrule":null,"timezone":"America\/New_York"},"extras":[],"groups":[{"id":"65448","name":"Bioengineering Graduate Program"}],"categories":[],"keywords":[],"core_research_areas":[],"news_room_topics":[],"event_categories":[{"id":"1788","name":"Other\/Miscellaneous"}],"invited_audience":[{"id":"78761","name":"Faculty\/Staff"}],"affiliations":[],"classification":[],"areas_of_expertise":[],"news_and_recent_appearances":[],"phone":[],"contact":[],"email":[],"slides":[],"orientation":[],"userdata":""}},"333061":{"#nid":"333061","#data":{"type":"event","title":"PhD Proposal Presentation - Aditi Sharma","body":[{"value":"\u003Cp\u003EAdvisor:\u003C\/p\u003E\u003Cp\u003EAndreas S. Bommarius, Ph.D. (Georgia Institute of Technology)\u003C\/p\u003E\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\u003Cp\u003ECo-Advisors:\u003C\/p\u003E\u003Cp\u003ESven H. Behrens, Ph.D. (Georgia Institute of Technology) Yury O. Chernoff, Ph.D. (Georgia Institute of Technology)\u003C\/p\u003E\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\u003Cp\u003ECommittee:\u003C\/p\u003E\u003Cp\u003EM. G. Fin, Ph.D. (Georgia Institute of Technology)\u003C\/p\u003E\u003Cp\u003EJulie A. Champion, Ph.D. (Georgia Institute of Technology)\u003C\/p\u003E\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\u003Cp\u003EStudies on Amyloid Aggregation and Cross-Species Prion Transmission\u003C\/p\u003E\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\u003Cp\u003EAmyloids are an important class of proteins because of their involvement in a number of neurodegenerative diseases such as Alzheimer\u2019s disease, Parkinson\u2019s disease, and Huntington\u2019s disease. Notably, these proteins have a tendency to acquire a stable alternate conformation rich in beta-sheets and associate with each other to form fibrous ordered aggregates. Due to their unique properties and involvement in a number of fatal diseases there is a lot of interest in studying this class of proteins. Another characteristic of amyloidogenic proteins is that a given protein may adopt many distinct conformations, known as \u201cvariants\u201d or \u201cstrains\u201d. Once formed, a strain is efficiently reproduced under the same conditions on addition of the same prion protein. On the other hand, cross species transmission of prions is less efficient due to a \u201cspecies barrier\u201d which prevents the transmission of the prion state between prion proteins from different species with divergent sequences. The molecular basis of prion transmission and mechanisms of prion strain formation are not yet fully understood.\u003C\/p\u003E\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E","summary":null,"format":"limited_html"}],"field_subtitle":"","field_summary":[{"value":"\u003Cp\u003EPhD Proposal Presentation-\u0026nbsp;\u0022Studies on Amyloid Aggregation and Cross-Species Prion Transmission \u0022 Aditi Sharma\u003C\/p\u003E","format":"limited_html"}],"field_summary_sentence":[{"value":"\u0022Studies on Amyloid Aggregation and Cross-Species Prion Transmission \u0022"}],"uid":"27917","created_gmt":"2014-10-10 13:31:20","changed_gmt":"2017-04-13 21:21:27","author":"Laura Paige","boilerplate_text":"","field_publication":"","field_article_url":"","field_event_time":{"event_time_start":"2014-10-24T15:00:00-04:00","event_time_end":"2014-10-24T17:00:00-04:00","event_time_end_last":"2014-10-24T17:00:00-04:00","gmt_time_start":"2014-10-24 19:00:00","gmt_time_end":"2014-10-24 21:00:00","gmt_time_end_last":"2014-10-24 21:00:00","rrule":null,"timezone":"America\/New_York"},"extras":[],"groups":[{"id":"65448","name":"Bioengineering Graduate Program"}],"categories":[],"keywords":[],"core_research_areas":[],"news_room_topics":[],"event_categories":[{"id":"1788","name":"Other\/Miscellaneous"}],"invited_audience":[{"id":"78751","name":"Undergraduate students"},{"id":"78761","name":"Faculty\/Staff"},{"id":"174045","name":"Graduate students"}],"affiliations":[],"classification":[],"areas_of_expertise":[],"news_and_recent_appearances":[],"phone":[],"contact":[{"value":"\u003Cp\u003ELaura Paige\u003C\/p\u003E","format":"limited_html"}],"email":[],"slides":[],"orientation":[],"userdata":""}},"333031":{"#nid":"333031","#data":{"type":"event","title":"PhD Defense Presentation- Stephen Goldman","body":[{"value":"\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\u003Cp\u003E\u003Cstrong\u003EAdvisor: \u003C\/strong\u003E\u003C\/p\u003E\u003Cp\u003EGilda Barabino, Ph.D. (BME)\u003C\/p\u003E\u003Cp\u003E\u0026nbsp;\u003Cstrong\u003ECommittee:\u003C\/strong\u003E\u003C\/p\u003E\u003Cp\u003EEdward Botchwey, Ph.D. (BME)\u003C\/p\u003E\u003Cp\u003ERobert Guldberg, Ph.D. (ME)\u003C\/p\u003E\u003Cp\u003ESpero Karas, M.D. (Emory University)\u003C\/p\u003E\u003Cp\u003EAthanassios Sambanis, Ph.D. (ChBE)\u003C\/p\u003E\u003Cp\u003EJohnna Temenoff, Ph.D. (BME)\u003C\/p\u003E\u003Cp\u003EDue to the inability of intra-articular injuries to adequately self-heal, current therapies are largely focused on palliative care and restoration of joint function rather than true regeneration.\u0026nbsp; Subsequently tissue engineering of chondral and osteochondral tissue constructs has emerged as a promising strategy for the repair of partial and full-thickness intra-articular defects. \u0026nbsp;Unfortunately, the fabrication of large tissue constructs is plagued by poor nutrient transport to the interior of the tissue resulting in poor tissue growth and necrosis.\u0026nbsp; Further, for the specific case of osteochondral grafts, the presence of two distinct tissue types offers additional challenges related to cell sourcing, scaffolding strategies, and bioprocessing. To overcome these constraints, this dissertation was focused on the development and validation of a microfluidic hydrogel platform which reduces nutrient transport limitations within an engineered tissue construct through a serpentine microfluidic network embedded within the developing tissue.\u0026nbsp; To this end, a microfluidic hydrogel was designed to meet the nutrition requirements of a developing tissue and validated through the cultivation of chondral tissue constructs of clinically relevant thicknesses.\u0026nbsp; Additionally, optimal bioprocessing conditions with respect to morphogen delivery and hydrodynamic loading were pursued for the production of bony and cartilaginous tissue from bone marrow derived mesenchymal stem cells.\u0026nbsp; Finally, the optimal bioprocessing conditions were implemented within MSC laden microfluidic hydrogels to spatially engineer the matrix composition of a biphasic osteochondral graft through directed differentiation.\u003C\/p\u003E","summary":null,"format":"limited_html"}],"field_subtitle":"","field_summary":[{"value":"\u003Cp\u003EPhD Defense Presentation-\u0026nbsp;\u0022Development \u0026amp; Validation of a Microfluidic Hydrogel Platform For Osteochondral Tissue Engineering\u0022 Stephen Goldman\u003C\/p\u003E","format":"limited_html"}],"field_summary_sentence":[{"value":"\u0022Development \u0026 Validation of a Microfluidic Hydrogel Platform For Osteochondral Tissue Engineering\u0022"}],"uid":"27917","created_gmt":"2014-10-10 13:02:25","changed_gmt":"2017-04-13 21:21:27","author":"Laura Paige","boilerplate_text":"","field_publication":"","field_article_url":"","field_event_time":{"event_time_start":"2014-10-31T10:00:00-04:00","event_time_end":"2014-10-31T12:00:00-04:00","event_time_end_last":"2014-10-31T12:00:00-04:00","gmt_time_start":"2014-10-31 14:00:00","gmt_time_end":"2014-10-31 16:00:00","gmt_time_end_last":"2014-10-31 16:00:00","rrule":null,"timezone":"America\/New_York"},"extras":[],"groups":[{"id":"65448","name":"Bioengineering Graduate Program"}],"categories":[],"keywords":[],"core_research_areas":[],"news_room_topics":[],"event_categories":[{"id":"1788","name":"Other\/Miscellaneous"}],"invited_audience":[{"id":"78751","name":"Undergraduate students"},{"id":"78761","name":"Faculty\/Staff"},{"id":"174045","name":"Graduate students"}],"affiliations":[],"classification":[],"areas_of_expertise":[],"news_and_recent_appearances":[],"phone":[],"contact":[],"email":[],"slides":[],"orientation":[],"userdata":""}},"335611":{"#nid":"335611","#data":{"type":"event","title":"Neural Engineering Center Seminar","body":[{"value":"\u003Cp\u003E\u003Cstrong\u003E\u0022Softening Polymer Substrates for Chronically Soft Neural Interfaces\u0022\u003C\/strong\u003E\u003Cbr \/\u003E\u003Cbr \/\u003E\u003Cstrong\u003EWalter Voit, PhD\u003C\/strong\u003E\u003Cbr \/\u003E\u003Cstrong\u003EAssistant Professor of Mechanical Engineering\u003C\/strong\u003E\u003Cbr \/\u003E\u003Cstrong\u003EMaterial Science \u0026amp; Engineering\u003C\/strong\u003E\u003Cbr \/\u003E\u003Cstrong\u003EUniversity of Texas at Dallas\u003Cbr \/\u003E\u003Cbr \/\u003E\u003C\/strong\u003EWe describe smart engineered shape memory polymer (SMP) substrates, which have been proposed for use in biomedical devices extensively over the past decade. Specifically, the paradigm of softening bioelectronics medicines enables devices such as neural interfaces to be implanted while mechanically rigid and subsequently soften in physiological conditions. Harris et al. have demonstrated softening intracortical electrodes based on the significant swelling of thermally and water sensitive polymer substrates. Building upon this work, we have further demonstrated the fabrication, characterization and demonstration of softening neural interfaces with 5 micron minimum feature sizes patterned using full-\u0026shy;\u2010photolithography reaching temperature up to 85\u00b0C on softening substrates with minimal swelling. SMP substrates are thiol-\u0026shy;\u2010 ene\/acrylate copolymers designed to position the glass transition temperature (Tg) to near 55\u00b0C, such that after plasticization in fluid, the Tg shifts 20\u00b0C triggering softening. This paradigm allows surgeons adequate time for implantation, and maintains sub 3% swelling of the substrate to minimize abiotic device failure and delamination of the patterned Parylene-\u0026shy;\u2010C barrier coating. We balance mechanical buckling forces, created by modulus mismatches between the device modulus at insertion and that of both agarose gel (in vitro experimental model) and the cortex of a laboratory rat. Other studies have shown how higher modulus materials, such as silicon, tungsten, Parylene-\u0026shy;\u2010C and polyimides maintain sufficient stiffness to allow implantation into tissue. Our devices match these supra 1 GPa insertion properties, but chronically behave mechanically more similarly to polydimethylsiloxane.\u003C\/p\u003E\u003Cp\u003EFaculty Host: \u003Ca href=\u0022mailto:rbutera@gatech.edu\u0022\u003ERobert Butera, Ph.D.\u003C\/a\u003E\u003C\/p\u003E\u003Cp\u003ETrainee Host: \u003Ca href=\u0022mailto:yapatel@gatech.edu\u0022\u003EYogi Patel\u003C\/a\u003E\u003C\/p\u003E\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E","summary":null,"format":"limited_html"}],"field_subtitle":"","field_summary":"","field_summary_sentence":[{"value":"\u0022Softening Polymer Substrates for Chronically Soft Neural Interfaces\u0022 - Walter Voit, PhD - University of Texas at Dallas"}],"uid":"27960","created_gmt":"2014-10-20 15:31:06","changed_gmt":"2017-04-13 21:21:23","author":"Chris Calleri","boilerplate_text":"","field_publication":"","field_article_url":"","field_event_time":{"event_time_start":"2014-10-31T13:00:00-04:00","event_time_end":"2014-10-31T14:00:00-04:00","event_time_end_last":"2014-10-31T14:00:00-04:00","gmt_time_start":"2014-10-31 17:00:00","gmt_time_end":"2014-10-31 18:00:00","gmt_time_end_last":"2014-10-31 18:00:00","rrule":null,"timezone":"America\/New_York"},"extras":[],"hg_media":{"335781":{"id":"335781","type":"image","title":"Walter Voit, PhD - University of Texas at Dallas","body":null,"created":"1449245201","gmt_created":"2015-12-04 16:06:41","changed":"1475895048","gmt_changed":"2016-10-08 02:50:48","alt":"Walter Voit, PhD - University of Texas at Dallas","file":{"fid":"200501","name":"voit-2013-12_0.jpg","image_path":"\/sites\/default\/files\/images\/voit-2013-12_0_0.jpg","image_full_path":"http:\/\/www.tlwarc.hg.gatech.edu\/\/sites\/default\/files\/images\/voit-2013-12_0_0.jpg","mime":"image\/jpeg","size":229370,"path_740":"http:\/\/www.tlwarc.hg.gatech.edu\/sites\/default\/files\/styles\/740xx_scale\/public\/images\/voit-2013-12_0_0.jpg?itok=tp1cfXYh"}},"335791":{"id":"335791","type":"image","title":"Neural Engineering Center Seminar","body":null,"created":"1449245201","gmt_created":"2015-12-04 16:06:41","changed":"1475895048","gmt_changed":"2016-10-08 02:50:48","alt":"Neural Engineering Center Seminar","file":{"fid":"200502","name":"neuralengineering-solid-2lines-539874.jpg","image_path":"\/sites\/default\/files\/images\/neuralengineering-solid-2lines-539874_0.jpg","image_full_path":"http:\/\/www.tlwarc.hg.gatech.edu\/\/sites\/default\/files\/images\/neuralengineering-solid-2lines-539874_0.jpg","mime":"image\/jpeg","size":91127,"path_740":"http:\/\/www.tlwarc.hg.gatech.edu\/sites\/default\/files\/styles\/740xx_scale\/public\/images\/neuralengineering-solid-2lines-539874_0.jpg?itok=4JYGla8c"}}},"media_ids":["335781","335791"],"related_links":[{"url":"http:\/\/voitlab.com\/","title":"Voit lab"},{"url":"http:\/\/www.neuro.gatech.edu\/","title":"Neuro@Tech website"}],"groups":[{"id":"1254","name":"Wallace H. Coulter Dept. of Biomedical Engineering"}],"categories":[],"keywords":[{"id":"1612","name":"BME"},{"id":"248","name":"IBB"},{"id":"166896","name":"seminar"}],"core_research_areas":[],"news_room_topics":[],"event_categories":[{"id":"1795","name":"Seminar\/Lecture\/Colloquium"}],"invited_audience":[{"id":"78751","name":"Undergraduate students"},{"id":"78761","name":"Faculty\/Staff"},{"id":"174045","name":"Graduate students"}],"affiliations":[],"classification":[],"areas_of_expertise":[],"news_and_recent_appearances":[],"phone":[],"contact":[{"value":"\u003Cp\u003EFaculty Host:\u0026nbsp;\u003Ca href=\u0022mailto:rbutera@gatech.edu\u0022\u003ERobert Butera, Ph.D.\u003C\/a\u003E\u003C\/p\u003E\u003Cp\u003ETrainee Host:\u0026nbsp;\u003Ca href=\u0022mailto:yapatel@gatech.edu\u0022\u003EYogi Patel\u003C\/a\u003E\u003C\/p\u003E","format":"limited_html"}],"email":[],"slides":[],"orientation":[],"userdata":""}},"335451":{"#nid":"335451","#data":{"type":"event","title":"PhD Defense Presentation- Mei Zhan","body":[{"value":"\u003Cp\u003ECommittee Members:\u003C\/p\u003E\u003Cp\u003EHang Lu, Ph.D. (Georgia Institute of Technology) - Thesis Advisor\u003C\/p\u003E\u003Cp\u003EQueelim Ch\u0027ng, Ph.D. (MRC Centre for Developmental Neurobiology, Kings College London)\u003C\/p\u003E\u003Cp\u003ERobert Butera, Ph.D. (Georgia Institute of Technology)\u003C\/p\u003E\u003Cp\u003EPhilip J. Santangelo, Ph.D. (Georgia Institute of Technology)\u003C\/p\u003E\u003Cp\u003EHarold Kim, Ph.D. (Georgia Institute of Technology)\u003C\/p\u003E\u003Cp\u003EPatrick McGrath, Ph.D. (Georgia Institute of Technology)\u003C\/p\u003E\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\u003Cp\u003ETitle:\u0026nbsp;\u003C\/p\u003E\u003Cp\u003ENew Toolsets to Understand Environmental Sensation and Variability in the Aging Process\u003C\/p\u003E\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\u003Cp\u003EAbstract\/Summary:\u003C\/p\u003E\u003Cp\u003EAging is a complex process by which a combination of environmental, genetic and stochastic factors generate whole-system changes that modify organ and tissue function and alter physiological processes. Over the last few decades, many genetic and environmental modulators of aging have been found to be highly conserved between humans and a diverse group of model organisms. Yet, an integrative understanding of how these environmental and genetic variables interact over time in a whole organism to modulate the systemic changes involved in aging is lacking. The goal of this thesis project is to advance a systems perspective of aging by providing the experimental tools and conceptual framework for dissecting the regulatory connection between environmental inputs, molecular outputs and long term aging phenotypes in \u003Cem\u003EC. elegans\u003C\/em\u003E, an experimentally tractable multi-cellular model for aging.\u0026nbsp;\u003C\/p\u003E\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\u003Cp\u003ESpecifically, this work advances the quantitative imaging toolsets available to biologists by developing and refining microfluidic, hardware, computer vision, and software integration tools for high-throughput, high-content imaging of \u003Cem\u003EC. elegans\u003C\/em\u003E. As a result of these technological advances, new roles for the TGF-beta and serotonin signalling pathways in encoding environmental food signals to influence longevity were uncovered and quantitatively characterized. Moreover, this work develops and integrates new microfluidic technologies with off-chip support systems to establish a platform for long-term tracking of the health and longevity trajectories of large numbers of individual \u003Cem\u003EC. elegans\u003C\/em\u003E. The capabilities of this platform have the potential to address many important questions in aging including addressing environmental determinants of aging, the sources of inter-individual variability, the time course of aging-related declines and the effects of interventional strategies to improve health outcomes. Together, the toolsets for quantitative imaging and the long-term culture platform permit the large-scale investigation of both the internal state and long-term behavioral and health outputs of an important multicellular model organism for aging.\u003C\/p\u003E\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E","summary":null,"format":"limited_html"}],"field_subtitle":"","field_summary":[{"value":"\u003Cp\u003EPhD Defense Presentation- \u0022New Toolsets to Understand Environmental Sensation and Variability in the Aging Process\u0022- Mei Zhan\u003C\/p\u003E","format":"limited_html"}],"field_summary_sentence":[{"value":"\u0022New Toolsets to Understand Environmental Sensation and Variability in the Aging Process\u0022"}],"uid":"27917","created_gmt":"2014-10-20 14:12:44","changed_gmt":"2017-04-13 21:21:23","author":"Laura Paige","boilerplate_text":"","field_publication":"","field_article_url":"","field_event_time":{"event_time_start":"2014-11-07T14:00:00-05:00","event_time_end":"2014-11-07T16:00:00-05:00","event_time_end_last":"2014-11-07T16:00:00-05:00","gmt_time_start":"2014-11-07 19:00:00","gmt_time_end":"2014-11-07 21:00:00","gmt_time_end_last":"2014-11-07 21:00:00","rrule":null,"timezone":"America\/New_York"},"extras":[],"groups":[{"id":"65448","name":"Bioengineering Graduate Program"}],"categories":[],"keywords":[],"core_research_areas":[],"news_room_topics":[],"event_categories":[{"id":"1788","name":"Other\/Miscellaneous"}],"invited_audience":[{"id":"78751","name":"Undergraduate students"},{"id":"78761","name":"Faculty\/Staff"},{"id":"174045","name":"Graduate students"}],"affiliations":[],"classification":[],"areas_of_expertise":[],"news_and_recent_appearances":[],"phone":[],"contact":[{"value":"\u003Cp\u003ELaura Paige\u003C\/p\u003E","format":"limited_html"}],"email":[],"slides":[],"orientation":[],"userdata":""}},"337261":{"#nid":"337261","#data":{"type":"event","title":"PhD Defense Presentation - Patricia M. Pacheco","body":[{"value":"\u003Cp class=\u0022p1\u0022\u003E\u003Cstrong\u003EFc Coated Micro\/nanoparticles for Humoral Immune System Modulation\u003C\/strong\u003E\u003C\/p\u003E\u003Cp class=\u0022p1\u0022\u003E\u003Cstrong\u003EAdvisor:\u003C\/strong\u003E\u003C\/p\u003E\u003Cp class=\u0022p2\u0022\u003E\u003Cstrong\u003ETodd Sulchek, Ph.D\u003C\/strong\u003E., Mechanical Engineering, Georgia Institute of Technology\u003C\/p\u003E\u003Cp class=\u0022p2\u0022\u003E\u003Cstrong\u003ECommittee:\u003C\/strong\u003E\u003C\/p\u003E\u003Cp class=\u0022p2\u0022\u003E\u003Cstrong\u003EJulia Babensee, Ph.D.\u003C\/strong\u003E, Biomedical Engineering, Georgia Institute of Technology\u003C\/p\u003E\u003Cp class=\u0022p2\u0022\u003E\u003Cstrong\u003EJulie Champion, Ph.D.,\u003C\/strong\u003E Chemical and Biomolecular Engineering, Georgia Institute of Technology\u003C\/p\u003E\u003Cp class=\u0022p2\u0022\u003E\u003Cstrong\u003E\u0026nbsp;Andr\u00e9s Garc\u00eda, Ph.D.,\u003C\/strong\u003E Mechanical Engineering, Georgia Institute of Technology\u003C\/p\u003E\u003Cp class=\u0022p2\u0022\u003E\u003Cstrong\u003EDavid M. White, D.V.M., Ph.D., DACVM,\u003C\/strong\u003E United States Department of Agriculture\u0026nbsp;\u003C\/p\u003E\u003Cp class=\u0022p2\u0022\u003E\u0026nbsp;\u003C\/p\u003E\u003Cp class=\u0022p1\u0022\u003EThe body\u2019s humoral immune response plays a larger role beyond screening for invading pathogens as it is also vital for tissue regeneration, drug delivery, and vaccine processing. The immune system operates within a sophisticated feedback loops, and as such, reagents which may alter it in a tunable manner offer promise to study the immune system as well as engineer specific responses for therapeutic effect. While a strong initial input can sway the response to one of two extremes (pro- or anti-inflammatory), an extreme response is not always required or desired in the case of immunocompromised patients. Therefore, we set out to derive a novel biomaterials platform to alter the immune response in a tunable manner. Antibodies are not only the workhorses of the adaptive immune response but are also powerful immunomodulators through their Fc (constant fragment) regions. By coating microparticles with Fc ligands in variable surface densities, we were able to utilize the sensitivity of multivalent signaling to tune the response of the immune response. Microparticle size was also varied to decouple the effects of physical versus biochemical signaling.\u003C\/p\u003E\u003Cp class=\u0022p2\u0022\u003E\u0026nbsp;The goal of this thesis was to analyze the effects of Fc coated particles on two major components of the humoral immune responses: macrophages and the complement system. We first looked at the mechanical response of macrophages through phagocytosis and found that both Fc density and microparticle size had significant impacts on macrophage phagocytosis. These results also provide a particle delivery \u201ctoolbox\u201d for future applications. We then analyzed the downstream effects of Fc particles on macrophage phenotype and on phenotype plasticity. This showed that the addition of Fc particles lead to increased production of TNF\u03b1 and IL-12 and inverted the response of LPS treated macrophages. Finally, we applied our particles to activate the complement system, an often overlooked cascade of serum protein activation that results in bacterial cell lysis. Cleaved components of the complement system are also powerful chemokines and can act as a vaccine adjuvant. Fc density on particles played a large role in complement system activation, both through the classical and alternative pathway, as it lead to a binary response for smaller particles and a tunable response for larger particles. We then applied these results to create a novel form of antibiotic by using Fc particles to direct complement-mediated bacterial cytotoxicity. The use of immune activation by Fc particles was also applied to better understand and improve the tuberculosis vaccine. Our findings are significant to the biomaterials and immunology fields as we showed that Fc microparticles can generally be used to alter the immune response in a tunable manner for a broad range of applications, as well answering fundamental immunology questions.\u003C\/p\u003E","summary":null,"format":"limited_html"}],"field_subtitle":"","field_summary":[{"value":"\u003Cp\u003EPhD Defense Presentation -\u0026nbsp;Fc Coated Micro\/nanoparticles for Humoral Immune System Modulation - Patricia M. Pacheco\u003C\/p\u003E","format":"limited_html"}],"field_summary_sentence":[{"value":"Fc Coated Micro\/nanoparticles for Humoral Immune System Modulation"}],"uid":"27349","created_gmt":"2014-10-27 11:30:35","changed_gmt":"2017-04-13 21:21:21","author":"Floyd Wood","boilerplate_text":"","field_publication":"","field_article_url":"","field_event_time":{"event_time_start":"2014-11-10T08:00:00-05:00","event_time_end":"2014-11-10T11:00:00-05:00","event_time_end_last":"2014-11-10T11:00:00-05:00","gmt_time_start":"2014-11-10 13:00:00","gmt_time_end":"2014-11-10 16:00:00","gmt_time_end_last":"2014-11-10 16:00:00","rrule":null,"timezone":"America\/New_York"},"extras":[],"groups":[{"id":"65448","name":"Bioengineering Graduate Program"}],"categories":[],"keywords":[{"id":"6178","name":"BIOE"},{"id":"569","name":"bioengineering"}],"core_research_areas":[],"news_room_topics":[],"event_categories":[{"id":"1788","name":"Other\/Miscellaneous"}],"invited_audience":[{"id":"78751","name":"Undergraduate students"},{"id":"78761","name":"Faculty\/Staff"},{"id":"174045","name":"Graduate students"}],"affiliations":[],"classification":[],"areas_of_expertise":[],"news_and_recent_appearances":[],"phone":[],"contact":[{"value":"\u003Cp\u003E\u003Ca href=\u0022mailto:%20laura.paige@bioengineering.gatech.edu\u0022\u003ELaura Paige\u003C\/a\u003E\u003C\/p\u003E","format":"limited_html"}],"email":[],"slides":[],"orientation":[],"userdata":""}},"301611":{"#nid":"301611","#data":{"type":"event","title":"Breakfast Club Seminar","body":[{"value":"\u003Cp\u003E\u003Cstrong\u003E\u0022Mechanoreception of Adhesion and Signaling Molecules on the Cell Surface\u0022\u003C\/strong\u003E\u003Cbr \/\u003E\u003Cbr \/\u003E\u003Cstrong\u003ECheng Zhu, PhD\u003C\/strong\u003E\u003C\/p\u003E\u003Cp\u003E\u003Cstrong\u003EExecutive Director for International Programs\u003C\/strong\u003E\u003Cbr \/\u003E\u003Cstrong\u003EJ. Erskine Love Endowed Chair in Engineering\u003C\/strong\u003E\u003Cbr \/\u003E\u003Cstrong\u003ERegents\u0027 Professor\u003C\/strong\u003E\u003Cbr \/\u003E\u003Cstrong\u003EWallace H. Coulter Dept. of Biomedical Engineering\u003C\/strong\u003E\u003Cbr \/\u003E\u003Cstrong\u003EGeorgia Tech\u003Cbr \/\u003E\u003Cbr \/\u003E\u003C\/strong\u003E\u003C\/p\u003E\u003Cp\u003ECellular and Molecular Biomechanics Laboratory (CMBL)\u003C\/p\u003E\u003Cp\u003EThe CMBL\u0027s interests lie in the adhesion and signaling molecules of the immune system as well as those involved in platelet adhesion and aggregation. They are primarily focused on early cell surface interaction kinetics and their primary signaling responses, as these are critical in determining how a cell will ultimately respond upon contact with another cell. The majority of their work ranges from single molecule interaction studies using atomic force microscopy, molecular dynamics simulations, or biomembrane force probe assays to single cell studies using micropipette adhesions assays, fluorescence imaging techniques, or real-time confocal microscopy. These assays focus on the mechanics and kinetics of receptor-ligand binding and their downstream signaling effects within cells. T cell receptors, selectins, integrins, and their respective ligands are some of the cell surface molecules currently under investigation in our lab. Understanding the initial interaction between molecules such as these and their subsequent early signaling processes is crucial to elucidating the response mechanisms of these physiological systems. Ultimately, the CMBL\u0027s research strives to help better understand the mechanisms within these systems for possible medical applications in autoimmunity, allergy, transplant rejection, and thrombotic disorders.\u003C\/p\u003E\u003Cp\u003E\u003Cstrong\u003E\u003Cbr \/\u003E\u003C\/strong\u003E\u003C\/p\u003E","summary":null,"format":"limited_html"}],"field_subtitle":"","field_summary":[{"value":"\u003Cp\u003EThe Petit Institute Breakfast Club seminar series was started with the spirit of the Institute\u0027s interdisciplinary mission in mind and started to feature local Petit Institute faculty member\u0027s research in a seminar format. Faculty are often asked to speak at other universities and conferences, but rarely present at their home institution, this seminar series is an attempt to close that gap. The Petit Institute Breakfast Club is open to anyone in the bio-community.\u003C\/p\u003E","format":"limited_html"}],"field_summary_sentence":[{"value":"\u0022Mechanoreception of Adhesion and Signaling Molecules on the Cell Surface\u0022 - Cheng Zhu, PhD - Georgia Tech"}],"uid":"27195","created_gmt":"2014-06-05 12:59:37","changed_gmt":"2017-04-13 21:22:28","author":"Colly Mitchell","boilerplate_text":"","field_publication":"","field_article_url":"","field_event_time":{"event_time_start":"2014-11-11T07:30:00-05:00","event_time_end":"2014-11-11T08:30:00-05:00","event_time_end_last":"2014-11-11T08:30:00-05:00","gmt_time_start":"2014-11-11 12:30:00","gmt_time_end":"2014-11-11 13:30:00","gmt_time_end_last":"2014-11-11 13:30:00","rrule":null,"timezone":"America\/New_York"},"extras":[],"hg_media":{"70917":{"id":"70917","type":"image","title":"Breakfast Club Seminar Series","body":null,"created":"1449177328","gmt_created":"2015-12-03 21:15:28","changed":"1475894625","gmt_changed":"2016-10-08 02:43:45","alt":"Breakfast Club Seminar Series","file":{"fid":"193471","name":"logobldg_graphic.png","image_path":"\/sites\/default\/files\/images\/logobldg_graphic_0.png","image_full_path":"http:\/\/www.tlwarc.hg.gatech.edu\/\/sites\/default\/files\/images\/logobldg_graphic_0.png","mime":"image\/png","size":241588,"path_740":"http:\/\/www.tlwarc.hg.gatech.edu\/sites\/default\/files\/styles\/740xx_scale\/public\/images\/logobldg_graphic_0.png?itok=x84xf3Mz"}}},"media_ids":["70917"],"related_links":[{"url":"http:\/\/groups.bme.gatech.edu\/groups\/zhu\/","title":"Zhu lab website"},{"url":"http:\/\/ibb.gatech.edu\/breakfast-club","title":"Breakfast Club series schedule"}],"groups":[{"id":"1292","name":"Parker H. Petit Institute for Bioengineering and Bioscience (IBB)"}],"categories":[],"keywords":[{"id":"11879","name":"BK Club"},{"id":"248","name":"IBB"}],"core_research_areas":[],"news_room_topics":[],"event_categories":[{"id":"1795","name":"Seminar\/Lecture\/Colloquium"}],"invited_audience":[{"id":"78751","name":"Undergraduate students"},{"id":"78761","name":"Faculty\/Staff"},{"id":"174045","name":"Graduate students"}],"affiliations":[],"classification":[],"areas_of_expertise":[],"news_and_recent_appearances":[],"phone":[],"contact":[{"value":"\u003Cp\u003E\u003Ca href=\u0022mailto:colly.mitchell@ibb.gatech.edu\u0022\u003EColly Mitchell\u003C\/a\u003E\u003Cbr \/\u003EProgram Coordinator\u003C\/p\u003E","format":"limited_html"}],"email":[],"slides":[],"orientation":[],"userdata":""}},"311361":{"#nid":"311361","#data":{"type":"event","title":"BioEngineering Graduate Committee Meeting","body":[{"value":"\u003Cp\u003E\u003Cem\u003EThe BioEngineering graduate committee will meet to review\/approve program policies, program faculty applications and submitted student petitions.\u003Cbr \/\u003E\u003Cbr \/\u003EStudent Petitions due to\u0026nbsp;\u003Ca href=\u0022mailto:laura.paige@bioengineering.gatech.edu\u0022\u003ELaura Paige\u003C\/a\u003E\u0026nbsp;no later than:\u0026nbsp;\u003C\/em\u003E\u003C\/p\u003E\u003Cp\u003E\u003Cem\u003E\u0026nbsp;\u003C\/em\u003E\u003C\/p\u003E\u003Cp\u003E\u003Cem\u003E11\/5\/2014\u003C\/em\u003E\u003C\/p\u003E","summary":null,"format":"limited_html"}],"field_subtitle":"","field_summary":[{"value":"\u003Cp\u003E\u003Cem\u003EBioEngineering Graduate Committee Meeting\u003C\/em\u003E\u003C\/p\u003E","format":"limited_html"}],"field_summary_sentence":[{"value":"BioEngineering Graduate Committee Meeting"}],"uid":"27917","created_gmt":"2014-07-29 13:38:06","changed_gmt":"2016-10-08 02:08:27","author":"Laura Paige","boilerplate_text":"","field_publication":"","field_article_url":"","field_event_time":{"event_time_start":"2014-11-12T10:30:00-05:00","event_time_end":"2014-11-12T11:30:00-05:00","event_time_end_last":"2014-11-12T11:30:00-05:00","gmt_time_start":"2014-11-12 15:30:00","gmt_time_end":"2014-11-12 16:30:00","gmt_time_end_last":"2014-11-12 16:30:00","rrule":null,"timezone":"America\/New_York"},"extras":[],"groups":[{"id":"65448","name":"Bioengineering Graduate Program"}],"categories":[],"keywords":[],"core_research_areas":[],"news_room_topics":[],"event_categories":[{"id":"1788","name":"Other\/Miscellaneous"}],"invited_audience":[{"id":"78761","name":"Faculty\/Staff"}],"affiliations":[],"classification":[],"areas_of_expertise":[],"news_and_recent_appearances":[],"phone":[],"contact":[],"email":[],"slides":[],"orientation":[],"userdata":""}},"290121":{"#nid":"290121","#data":{"type":"event","title":"Bioengineering Seminar Series","body":[{"value":"\u003Cp\u003E\u003Cstrong\u003E\u0022Mass Transfer Regulation of Blood Clot Growth and Stability\u0022\u003Cbr \/\u003E\u003Cbr \/\u003EKeith Neeves, PhD\u003C\/strong\u003E\u003Cbr \/\u003E\u003Cstrong\u003EAssociate Professor\u003C\/strong\u003E\u003Cbr \/\u003E\u003Cstrong\u003EDepartment of Chemical and Biological Engineering\u003C\/strong\u003E\u003Cbr \/\u003E\u003Cstrong\u003EColorado School of Mines\u003Cbr \/\u003EDepartment of Pediatrics, University of Colorado, Denver\u003Cbr \/\u003E\u003Cbr \/\u003E\u003C\/strong\u003E\u003C\/p\u003E\u003Cp\u003EThe formation of a clot is an exquisitely regulated biological process in which a complex \u003Cbr \/\u003Efluid, blood, undergoes a rapid transformation into a densely packed porous medium at \u003Cbr \/\u003Ethe site of a vascular injury. In this talk Keith Neeves will review the biophysical mechanisms that regulate the formation of a blood clot, with a focus on mass transfer limitations of platelet \u003Cbr \/\u003Eagonists and inhibitors, coagulation and fibrin formation. Measurements made in \u003Cbr \/\u003Emicrofluidic models of vascular injury reveal that these mass transfer limitation have \u003Cbr \/\u003Eimportant implications in the pathophysiology of bleeding and thrombotic disorders.\u003C\/p\u003E","summary":null,"format":"limited_html"}],"field_subtitle":"","field_summary":[{"value":"\u003Cp\u003EThe Bioengineering Seminar Series is a joint seminar series between the Petit Institute and the Biomedical Engineering department. Seminars are held on Tuesdays or Thursdays between 11am-12pm in Petit Institute, room 1128, unless otherwise indicated.\u003C\/p\u003E","format":"limited_html"}],"field_summary_sentence":[{"value":"\u0022Mass Transfer Regulation of Blood Clot Growth and Stability\u0022 - Keith Neeves, PhD - Colorado School of Mines \u0026 University of Colorado, Denver"}],"uid":"27959","created_gmt":"2014-04-11 13:53:49","changed_gmt":"2017-04-13 21:22:42","author":"Karen Ethier","boilerplate_text":"","field_publication":"","field_article_url":"","field_event_time":{"event_time_start":"2014-11-13T15:00:00-05:00","event_time_end":"2014-11-13T16:00:00-05:00","event_time_end_last":"2014-11-13T16:00:00-05:00","gmt_time_start":"2014-11-13 20:00:00","gmt_time_end":"2014-11-13 21:00:00","gmt_time_end_last":"2014-11-13 21:00:00","rrule":null,"timezone":"America\/New_York"},"extras":[],"related_links":[{"url":"http:\/\/chemeng.mines.edu\/faculty\/kneeves\/","title":"Neeves profile"}],"groups":[{"id":"1292","name":"Parker H. Petit Institute for Bioengineering and Bioscience (IBB)"},{"id":"65448","name":"Bioengineering Graduate Program"}],"categories":[],"keywords":[{"id":"11877","name":"BioE Seminar"},{"id":"248","name":"IBB"}],"core_research_areas":[],"news_room_topics":[],"event_categories":[{"id":"1795","name":"Seminar\/Lecture\/Colloquium"}],"invited_audience":[{"id":"78751","name":"Undergraduate students"},{"id":"78761","name":"Faculty\/Staff"},{"id":"174045","name":"Graduate students"}],"affiliations":[],"classification":[],"areas_of_expertise":[],"news_and_recent_appearances":[],"phone":[],"contact":[{"value":"\u003Cp\u003EFaculty host: \u003Ca href=\u0022%20wilbur.lam@emory.edu\u0022\u003EWilbur Lam, MD, PhD\u003C\/a\u003E\u003C\/p\u003E","format":"limited_html"}],"email":[],"slides":[],"orientation":[],"userdata":""}},"290081":{"#nid":"290081","#data":{"type":"event","title":"Bioengineering Seminar Series","body":[{"value":"\u003Cp\u003E\u003Cstrong\u003E\u0022How is Load-bearing Tissue Built? A Case for Mechanical \u0027Allostery\u0027 in Animal Structure Formation\u0022\u003Cbr \/\u003E\u003Cbr \/\u003EJeffrey Ruberti, PhD \u003Cbr \/\u003EAssociate Professor\u003Cbr \/\u003EChemical Engineering, Mechanical and Industrial Engineering\u003Cbr \/\u003EDirector, Extracellular Matrix Engineering Research Laboratory (EMERL)\u003Cbr \/\u003ENortheastern University\u003Cbr \/\u003E\u003C\/strong\u003E\u003C\/p\u003E\u003Cp\u003EHow is load-bearing tissue built? A case for mechanical \u201callostery\u201d in animal structure formation Abstract Jeffrey W. Ruberti, Ph.D. Northeastern University Boston Shockingly, there exists no established model that can explain how a cluster of vertebrate cells which are expressing matrix proteins manage to produce, refine and grow load-bearing structures that are organized over much longer length scales than the cells themselves. The current best guess model, which was proposed in the mid-1980s by David Birk and Robert Trelstad (subsequently carried forward by Karl Kadler\u2019s group) suggests that cells extrude formed collagen fibrils into the extracellular space via structures which are termed \u201cfibripositors.\u201d Thus, one imagines that the cells, working together, somehow weave the collagen into the matrix, thread by thread with the necessary exposed loose ends finding each other and fusing to form long-range, organized connective tissue. However, gathering evidence to support this model is severely hampered because it is nearly impossible to observe cells in the act of producing matrix while observing the collagen fibril deposition directly at the nanoscale (but we sure are trying to do that in the lab). In addition, the fibripositor model does not contemplate either matrix refinement or growth. Thus, we are not only in need of experimental evidence to support the fibripositor theory, we are short of a comprehensive testable hypothesis in general for how tissue is built. To address this dearth, we have chosen to make a simple (and risky) assumption: We reject the idea that the cells directly manipulate collagen monomers or fibrils to make tissue. Instead, we assume the cell has spent much of its time (~billion years) refining specific molecular systems (secretomes) that are designed to \u201csettle\u201d into their appropriate configuration simply by \u201creading\u201d the energetic landscape. To generate load-bearing connective tissues, we suggest that the cells provide appropriate geometry by self-organizing and then produce an appropriate secretome that has been designed to assemble in opposition to the locally and globally applied mechanical forces which threaten to dissipate animal structure. In effect, we predict that mechanical strain is actually a long-range structure producing signal which works via mechanical allostery to modulate both collagen fibril assembly and retention. Because collagen is generally found resisting tension in load-bearing soft-connective tissue, we expect that the mechanical environment directly shifts the molecular energetics such that collagen\u2019s inherent stability and assembly kinetics are enhanced in the direction of applied tensile forces. I will present the current state and limitations of our investigation of this risky assumption and entertain your thoughts, concerns and comments.\u003C\/p\u003E\u003Cp\u003ERuberti is a Professor of Bioengineering at Northeastern University and Chair of the Bioengineering Graduate Ph.D. program. He earned a BSE in Biomedical Engineering in 1986 from Tulane University and somehow managed to find work in Industry even though no one knew what a Biomedical Engineer was. After enduring multiple entry level engineering positions at Sikorsky aircraft, the Southwest Foundation for Biomedical Research and Hamilton Standard Space and Sea Systems, he returned to Tulane in the form of a doctoral student. He received his Ph.D. in 1998 in Biomedical Engineering, again from Tulane University, and conducted postdoctoral research at the Massachusetts Institute of Technology through 2000, and at the Department of Biomedical Engineering, Northwestern University through 2001. He has served as an associate consultant at Cambridge Polymer Group between 2001 and 2004, as Lecturer at the Massachusetts Eye and Ear Infirmary at Harvard University and as an Adjunct Scientist at the Schepen\u2019s Eye Research Institute at Harvard University. He has painfully and slowly helped produce a little over 45 scientific papers, reviews and book chapters, as well as over 90 national and international conference presentations. His research has also resulted in the issuance of 12 patents with four more pending. He has participated in the extraction of a total of $8.0 M in research grant funding from the National Science Foundation (NSF), the Department of Defense, and the National Institutes of Health (NIH). He has served as a reviewer for the NIH and the NSF, and as a reviewer for many scientific journals in the areas of ophthalmology, materials, biomechanical engineering, biophysics, and cell and tissue engineering. Ruberti is currently an associate editor for the \u003Cem\u003EJournal of Biomechanical Engineering\u003C\/em\u003E and swims a lot in a futile attempt to slow down the inevitable disassembly of his matrix.\u003C\/p\u003E","summary":null,"format":"limited_html"}],"field_subtitle":"","field_summary":[{"value":"\u003Cp\u003EThe Bioengineering Seminar Series is a joint seminar series between the Petit Institute and the Biomedical Engineering department. Seminars are held on Tuesdays or Thursdays between 11am-12pm in Petit Institute, room 1128, unless otherwise indicated.\u003C\/p\u003E\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E","format":"limited_html"}],"field_summary_sentence":[{"value":"\u0022Mechanochemistry of Collagen: Designed to Resist\u0022 - Jeff Ruberti, PhD - Northeastern University"}],"uid":"27959","created_gmt":"2014-04-11 11:58:55","changed_gmt":"2017-04-13 21:22:42","author":"Karen Ethier","boilerplate_text":"","field_publication":"","field_article_url":"","field_event_time":{"event_time_start":"2014-11-18T15:00:00-05:00","event_time_end":"2014-11-18T16:00:00-05:00","event_time_end_last":"2014-11-18T16:00:00-05:00","gmt_time_start":"2014-11-18 20:00:00","gmt_time_end":"2014-11-18 21:00:00","gmt_time_end_last":"2014-11-18 21:00:00","rrule":null,"timezone":"America\/New_York"},"extras":[],"related_links":[{"url":"http:\/\/www1.coe.neu.edu\/~jeffr\/jeff.htm","title":"Ruberti lab website"}],"groups":[{"id":"1292","name":"Parker H. Petit Institute for Bioengineering and Bioscience (IBB)"},{"id":"65448","name":"Bioengineering Graduate Program"}],"categories":[],"keywords":[{"id":"11877","name":"BioE Seminar"},{"id":"248","name":"IBB"}],"core_research_areas":[],"news_room_topics":[],"event_categories":[{"id":"1795","name":"Seminar\/Lecture\/Colloquium"}],"invited_audience":[{"id":"78751","name":"Undergraduate students"},{"id":"78761","name":"Faculty\/Staff"},{"id":"174045","name":"Graduate students"}],"affiliations":[],"classification":[],"areas_of_expertise":[],"news_and_recent_appearances":[],"phone":[],"contact":[{"value":"\u003Cp\u003EFaculty host: \u003Ca href=\u0022%20ross.ethier@bme.gatech.edu\u0022\u003ERoss Ethier, PhD\u003C\/a\u003E\u003C\/p\u003E","format":"limited_html"}],"email":[],"slides":[],"orientation":[],"userdata":""}},"342781":{"#nid":"342781","#data":{"type":"event","title":"MS Thesis Defense Presentation- Adam Blake Dunaway","body":[{"value":"\u003Cp\u003EAdvisor:\u003C\/p\u003E\u003Cp\u003EValeria T. Milam, PhD\u003C\/p\u003E\u003Cp\u003ESchool of Materials Science and Engineering\u003C\/p\u003E\u003Cp\u003EGeorgia Institute of Technology, GA\u003C\/p\u003E\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\u003Cp\u003ECommittee:\u003C\/p\u003E\u003Cp\u003EJohnna S. Temenoff, PhD\u003C\/p\u003E\u003Cp\u003EDepartment of Biomedical Engineering\u003C\/p\u003E\u003Cp\u003EGeorgia Institute of Technology, GA\u003C\/p\u003E\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\u003Cp\u003EDong Qin, PhD\u003C\/p\u003E\u003Cp\u003ESchool of Materials Science and Engineering\u003C\/p\u003E\u003Cp\u003EGeorgia Institute of Technology, GA\u003C\/p\u003E\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\u003Cp\u003E\u003Cstrong\u003ECharacterization of the Binding Activity of Immobilized DNA Aptamers for Nucleotide and Non-nucleotide Targets\u003C\/strong\u003E\u003C\/p\u003E\u003Cp\u003EDeoxyribonucleic acid (DNA) aptamers are oligonucleotides with high specificity and affinity for non-nucleotide targets ranging from molecular species to cellular proteins. Their high affinity, rapid synthesis, and the ease with which they can be chemically modified to include convenient chemical groups (e.g. amine group on 5\u2019 end) make them excellent adaptable ligands for use in colloidal drug delivery vehicles for both uptake and release of therapeutic agents. This work uses pre-identified aptamers for vascular endothelial growth factor (VEGF) to investigate the design of one such vehicle for controlled uptake and release of target therapeutics and analyzes the ability of particle-immobilized aptamers to bind both nucleotide and non-nucleotide targets. Aptamer sequences are immobilized on colloidal microspheres and binding activity of both the primary DNA and protein targets are directly monitored using flow cytometry. Additionally, the dual nature of aptamer-target binding is further investigated by evaluating the effects of simultaneous and serial incubation of the primary targets. Finally, the ability to recover the functionality of the aptamer is evaluated after displacement of the primary DNA target through DNA mediated interactions.\u0026nbsp; It has been shown that the nature of aptamer-target interactions are complex in nature, requiring optimization for each species incorporated into a delivery vehicle; however, partial recovery of aptamer functionality was achieved after hybridization with the primary DNA target.\u0026nbsp;\u003C\/p\u003E","summary":null,"format":"limited_html"}],"field_subtitle":"","field_summary":[{"value":"\u003Cp\u003EMS Defense Presentation-\u0026nbsp;\u0022Characterization of the Binding Activity of Immobilized DNA Aptamers for Nucleotide and Non-nucleotide Targets\u0022- Adam Blake Dunaway\u003C\/p\u003E","format":"limited_html"}],"field_summary_sentence":[{"value":"\u0022Characterization of the Binding Activity of Immobilized DNA Aptamers for Nucleotide and Non-nucleotide Targets\u0022"}],"uid":"27917","created_gmt":"2014-11-07 11:06:16","changed_gmt":"2017-04-13 21:21:14","author":"Laura Paige","boilerplate_text":"","field_publication":"","field_article_url":"","field_event_time":{"event_time_start":"2014-11-20T12:30:00-05:00","event_time_end":"2014-11-20T14:30:00-05:00","event_time_end_last":"2014-11-20T14:30:00-05:00","gmt_time_start":"2014-11-20 17:30:00","gmt_time_end":"2014-11-20 19:30:00","gmt_time_end_last":"2014-11-20 19:30:00","rrule":null,"timezone":"America\/New_York"},"extras":[],"groups":[{"id":"65448","name":"Bioengineering Graduate Program"}],"categories":[],"keywords":[],"core_research_areas":[],"news_room_topics":[],"event_categories":[{"id":"1788","name":"Other\/Miscellaneous"}],"invited_audience":[{"id":"78751","name":"Undergraduate students"},{"id":"78761","name":"Faculty\/Staff"},{"id":"174045","name":"Graduate students"}],"affiliations":[],"classification":[],"areas_of_expertise":[],"news_and_recent_appearances":[],"phone":[],"contact":[{"value":"\u003Cp\u003ELaura Paige\u003C\/p\u003E\u003Cp\u003E404-385-6655\u003C\/p\u003E","format":"limited_html"}],"email":[],"slides":[],"orientation":[],"userdata":""}},"342791":{"#nid":"342791","#data":{"type":"event","title":"MS Thesis Defense Presentation- Harrison Norman","body":[{"value":"\u003Cp\u003E\u003Cstrong\u003EA Device for the Graded Mechanostimulation of Cultured Neurons\u003C\/strong\u003E\u003C\/p\u003E\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\u003Cp\u003EGlaucoma, the second leading cause of blindness world-wide, affects c. 2.8 million people in the US, of which 130,000 are legally blind. Vision loss during glaucoma is due to damage to, and the eventual death of, retinal ganglion cells (RGCs), neurons that carry visual information from the eye to the brain. One current theory hypothesizes that the mechanism of RGC death during glaucoma is due to changes to the local mechanical environment of the RGCs, specifically the existence of additional stresses and strains acting on the axons of the RGCs, resulting in their dysfunction. As this environment is difficult to access in vivo, little is known about the pathway from mechanical insult to RGC dysfunction.\u003C\/p\u003E\u003Cp\u003EThis work presents an in vitro platform for studying the effects of physiologically relevant, axonally applied mechanical insult to neurons in culture. Design considerations are presented, and finite element studies are shown to establish proof of concept. The mold for creating the device was microfabricated in a cleanroom for use in the replica molding of the device. The process of fabricating the final device is then detailed. Initial biocompatibility assays are presented, and experiments for characterizing the function of the device are proposed.\u0026nbsp;\u003C\/p\u003E","summary":null,"format":"limited_html"}],"field_subtitle":"","field_summary":[{"value":"\u003Cp\u003EMS Defense Presentation-\u0026nbsp;\u0022A Device for the Graded Mechanostimulation of Cultured Neurons\u0022- Harrison Norman\u003C\/p\u003E","format":"limited_html"}],"field_summary_sentence":[{"value":"\u0022A Device for the Graded Mechanostimulation of Cultured Neurons\u0022"}],"uid":"27917","created_gmt":"2014-11-07 11:16:07","changed_gmt":"2017-04-13 21:21:14","author":"Laura Paige","boilerplate_text":"","field_publication":"","field_article_url":"","field_event_time":{"event_time_start":"2014-11-21T07:00:00-05:00","event_time_end":"2014-11-21T09:00:00-05:00","event_time_end_last":"2014-11-21T09:00:00-05:00","gmt_time_start":"2014-11-21 12:00:00","gmt_time_end":"2014-11-21 14:00:00","gmt_time_end_last":"2014-11-21 14:00:00","rrule":null,"timezone":"America\/New_York"},"extras":[],"related_links":[{"url":"http:\/\/ethier.gatech.edu\/","title":"Ethier lab"}],"groups":[{"id":"65448","name":"Bioengineering Graduate Program"}],"categories":[],"keywords":[],"core_research_areas":[],"news_room_topics":[],"event_categories":[{"id":"1788","name":"Other\/Miscellaneous"}],"invited_audience":[{"id":"78751","name":"Undergraduate students"},{"id":"78761","name":"Faculty\/Staff"},{"id":"174045","name":"Graduate students"}],"affiliations":[],"classification":[],"areas_of_expertise":[],"news_and_recent_appearances":[],"phone":[],"contact":[{"value":"\u003Cp\u003ELaura Paige\u003C\/p\u003E\u003Cp\u003E404-385-6655\u003C\/p\u003E","format":"limited_html"}],"email":[],"slides":[],"orientation":[],"userdata":""}},"345831":{"#nid":"345831","#data":{"type":"event","title":"PhD Proposal Presentation - Milad Navaei","body":[{"value":"\u003Ctable width=\u0022790\u0022 border=\u00220\u0022 cellpadding=\u00220\u0022\u003E\u003Ctbody\u003E\u003Ctr\u003E\u003Ctd valign=\u0022top\u0022 width=\u002220%\u0022\u003E\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\u003C\/td\u003E\u003Ctd width=\u002279%\u0022\u003E\u003Cp\u003EDr. Peter Hesketh, Chair (ME) \u003Cbr \/\u003E Dr. Todd Sulchek (ME) \u003Cbr \/\u003E Dr. Mostafa Ghiaasiaan (ME) \u003Cbr \/\u003E Dr. Albert Frazier (ECE) \u003Cbr \/\u003E Dr. Oliver Brand (ECE)\u003C\/p\u003E\u003Cp\u003EDr. Jean-Marie Dimanja (Spelman college)\u003C\/p\u003E\u003C\/td\u003E\u003C\/tr\u003E\u003C\/tbody\u003E\u003C\/table\u003E\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\u003Ctable width=\u0022790\u0022 border=\u00220\u0022 cellpadding=\u00220\u0022\u003E\u003Ctbody\u003E\u003Ctr\u003E\u003Ctd valign=\u0022top\u0022\u003E\u0026nbsp;\u003C\/td\u003E\u003Ctd\u003E\u003Cp\u003E\u003Cstrong\u003EIntegrated Micro- Gas Chromatography System for Detection of VOC gases\u003C\/strong\u003E\u003C\/p\u003E\u003C\/td\u003E\u003C\/tr\u003E\u003C\/tbody\u003E\u003C\/table\u003E\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\u003Cp\u003EThe focus of this work is on the design and micro-fabrication of a gas chromatography column with a novel two dimensional resistance heater for fast separation of Volatile Organic Compounds (VOC). A new bonding technique is developed for proper sealing of the column. These features enable the MEMS-GC column to perform live and fast separation of the VOC gases released by pathogenic species of \u003Cem\u003EArmelaria\u003C\/em\u003E fungus to prevent the rapid spread of the fungus agents. \u0026nbsp;The major limitations of the current MEMS-GC systems are:\u0026nbsp; 1. direct fusion bonding of silicon to silicon is not an effective technique for proper bonding of a high density micro-machined surface such as the GC column.\u0026nbsp; This technique requires very smooth and clean surfaces, otherwise small voids and unbonded areas occur 2. the time and power required to ramp and sustain the column\u2019s temperature are very high for the current resistance heaters. \u0026nbsp;In this work, three enabling designs and micro-fabrication techniques are developed and validated: \u0026nbsp;three and two meters long circular GC columns are fabricated. \u2013 The aim is to design and perform both analytical and experimental validation of all silicon gas chromatograph (GC) System for high resolution separation of compounds with a gas inlet in the center and an outlet on the side. Column separation performance is first studied as a function of the length of the column and further investigated for different widths by a numerical analysis, design and experimental validation follow. A gold eutectic-fusion bonding technique is developed to improve the sealing of the column; the proper sealing of the micro-machined GC column is a critical step in GC fabrication.\u2013 The aim is to create a fabrication process for proper sealing of the GC columns using a gold eutectic bonding technique for silicon-silicon bonding; Finally, a new temperature-programming heater is developed to generate temperature gradients along the length of the column to refocus eluding bands and counteract the part of the chromatographic band spreading. Both analytical and experimental validation on the temperature gradient along the column and isothermal temperature are performed. In order to demonstrate the biological utility, the GC column is integrated into a portable GC system and the chromatograph is compared with a conventional GC column.\u003C\/p\u003E\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E","summary":null,"format":"limited_html"}],"field_subtitle":"","field_summary":[{"value":"\u003Cp\u003EPhD Proposal Presentation-\u0026nbsp;\u0022Integrated Micro- Gas Chromatography System for Detection of VOC gases\u0022- Milad Navaei\u003C\/p\u003E","format":"limited_html"}],"field_summary_sentence":[{"value":"\u0022Integrated Micro- Gas Chromatography System for Detection of VOC gases\u0022"}],"uid":"27917","created_gmt":"2014-11-14 06:42:18","changed_gmt":"2017-04-13 21:21:07","author":"Laura Paige","boilerplate_text":"","field_publication":"","field_article_url":"","field_event_time":{"event_time_start":"2014-12-04T14:00:00-05:00","event_time_end":"2014-12-04T16:00:00-05:00","event_time_end_last":"2014-12-04T16:00:00-05:00","gmt_time_start":"2014-12-04 19:00:00","gmt_time_end":"2014-12-04 21:00:00","gmt_time_end_last":"2014-12-04 21:00:00","rrule":null,"timezone":"America\/New_York"},"extras":[],"groups":[{"id":"65448","name":"Bioengineering Graduate Program"}],"categories":[],"keywords":[],"core_research_areas":[],"news_room_topics":[],"event_categories":[{"id":"1788","name":"Other\/Miscellaneous"}],"invited_audience":[{"id":"78751","name":"Undergraduate students"},{"id":"78761","name":"Faculty\/Staff"},{"id":"174045","name":"Graduate students"}],"affiliations":[],"classification":[],"areas_of_expertise":[],"news_and_recent_appearances":[],"phone":[],"contact":[{"value":"\u003Cp\u003ELaura Paige\u003C\/p\u003E\u003Cp\u003E404-385-6655\u003C\/p\u003E","format":"limited_html"}],"email":[],"slides":[],"orientation":[],"userdata":""}},"340611":{"#nid":"340611","#data":{"type":"event","title":"PhD Defense Presentation- Maria Restrepo Pelaez","body":[{"value":"\u003Cp\u003EAdvisor:\u003C\/p\u003E\u003Cp\u003EAjit P. Yoganathan Ph.D.\u003C\/p\u003E\u003Cp\u003EDepartment of Biomedical Engineering\u003C\/p\u003E\u003Cp\u003EGeorgia Institute of Technology, GA\u003C\/p\u003E\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\u003Cp\u003ECommittee\u003C\/p\u003E\u003Cp\u003EMark A. Fogel, MD.\u003C\/p\u003E\u003Cp\u003EDivision of Cardiology\u003C\/p\u003E\u003Cp\u003EChildren\u2019s Hospital of Philadelphia, PA\u003C\/p\u003E\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\u003Cp\u003EPedro J. del Nido, MD.\u003C\/p\u003E\u003Cp\u003EDepartment of Cardiovascular Surgery\u003C\/p\u003E\u003Cp\u003EChildren\u0027s Hospital Boston, MA\u003C\/p\u003E\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\u003Cp\u003EAlessandro Veneziani, Ph.D.\u003C\/p\u003E\u003Cp\u003EDepartment of Mathematics and Computer Science\u003C\/p\u003E\u003Cp\u003EEmory University, GA\u003C\/p\u003E\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\u003Cp\u003EJ. Brandon Dixon, Ph.D.\u003C\/p\u003E\u003Cp\u003EDepartment of Mechanical Engineering\u003C\/p\u003E\u003Cp\u003EGeorgia Institute of Technology, GA\u003C\/p\u003E\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\u003Cp\u003EDon P. Giddens, Ph.D.\u003C\/p\u003E\u003Cp\u003EDepartment of Biomedical Engineering\u003C\/p\u003E\u003Cp\u003EGeorgia Institute of Technology, GA\u003C\/p\u003E\u003Cp\u003E\u003Cem\u003E\u0026nbsp;\u003C\/em\u003E\u003C\/p\u003E\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\u003Cp align=\u0022center\u0022\u003E\u003Cstrong\u003EDevelopment of a Coupled Geometrical Multiscale Solver and Application to Single Ventricle Surgical Planning\u003C\/strong\u003E\u003C\/p\u003E\u003Cp\u003E\u003Cstrong\u003E\u0026nbsp;\u003C\/strong\u003E\u003C\/p\u003E\u003Cp\u003ESingle ventricle heart defects are present in two of every 1000 live births in the US. In this condition the systemic and pulmonary blood flow mix in the functioning ventricle, resulting in insufficient blood oxygenation to sustain life. As part of the palliation of these defects, the staged surgical procedure, known as the Fontan procedure, is performed. Here, the venous returns are directed to the pulmonary arteries, bypassing the right heart and forming the Total Cavopulmonary Connection (TCPC). Even though the palliation improves life expectancy, there are numerous long-term complications that become more prevalent as patients reach adulthood. Many of these complications have been related to the function of the single ventricle circulation, especially to the abnormal TCPC hemodynamics, for which this has been the focus of research throughout the years. Recent progress has been made with the availability of improved medical imaging techniques and computational modeling tools; however, there is limited information on how these evolve in time.\u003C\/p\u003E\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\u003Cp\u003EIn order to improve the Fontan palliation, image-based surgical planning has been used in the most complex cases to prospectively design the TCPC, aiming to improve the hemodynamics. Even though this paradigm has shown promising results, improvement is needed to provide more realistic predictions of the post-operative outcomes. To address this, in this thesis we have developed a novel surgical planning framework that allows us to: (i) model the interaction of the TCPC and global circulation hemodynamics, and (ii) assess the robustness of the surgical option proposed. Here, the single ventricle circulation is modeled using a lumped parameter model, coupled to a computational fluid solver to describe the local TCPC hemodynamics. With this framework, we can predict the immediate post-operative state, model various physiological scenarios, and assess the impact on the local hemodynamics and global circulation. This will allow us to provide information on the effect on the global hemodynamics to the clinical team. In addition to the surgical planning advancements obtained in this thesis, we have performed the largest longitudinal Fontan study to date in which we have evaluated the evolution of the Fontan physiology in time and the effect it has on the energy efficiency of the TCPC.\u0026nbsp;\u003C\/p\u003E\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\u003Cp\u003EIn this thesis, we have studied the short and long-term effects that geometrical and physiological changes have on the Fontan hemodynamics. With this, we have improved the understanding of the Fontan physiology in terms of the short-term effects of Fontan palliation and the long-term deterioration of the changing single ventricle physiology.\u003C\/p\u003E\u003Cp\u003E\u003Cstrong\u003E\u0026nbsp;\u003C\/strong\u003E\u003C\/p\u003E","summary":null,"format":"limited_html"}],"field_subtitle":"","field_summary":[{"value":"\u003Cp\u003EPhD Defense Presentation-\u0026nbsp;\u0022Development of a Coupled Geometrical Multiscale Solver and Application to Single Ventricle Surgical Planning\u0022- Maria Restrepo Pelaez\u003C\/p\u003E\u003Cp align=\u0022center\u0022\u003E\u0026nbsp;\u003C\/p\u003E","format":"limited_html"}],"field_summary_sentence":[{"value":"\u0022Development of a Coupled Geometrical Multiscale Solver and Application to Single Ventricle Surgical Planning\u0022"}],"uid":"27917","created_gmt":"2014-11-04 15:41:13","changed_gmt":"2017-04-13 21:21:15","author":"Laura Paige","boilerplate_text":"","field_publication":"","field_article_url":"","field_event_time":{"event_time_start":"2014-11-21T11:00:00-05:00","event_time_end":"2014-11-21T13:00:00-05:00","event_time_end_last":"2014-11-21T13:00:00-05:00","gmt_time_start":"2014-11-21 16:00:00","gmt_time_end":"2014-11-21 18:00:00","gmt_time_end_last":"2014-11-21 18:00:00","rrule":null,"timezone":"America\/New_York"},"extras":[],"groups":[{"id":"65448","name":"Bioengineering Graduate Program"}],"categories":[],"keywords":[],"core_research_areas":[],"news_room_topics":[],"event_categories":[{"id":"1788","name":"Other\/Miscellaneous"}],"invited_audience":[{"id":"78751","name":"Undergraduate students"},{"id":"78761","name":"Faculty\/Staff"},{"id":"174045","name":"Graduate students"}],"affiliations":[],"classification":[],"areas_of_expertise":[],"news_and_recent_appearances":[],"phone":[],"contact":[{"value":"\u003Cp\u003ELaura Paige\u003C\/p\u003E","format":"limited_html"}],"email":[],"slides":[],"orientation":[],"userdata":""}},"311401":{"#nid":"311401","#data":{"type":"event","title":"BioEngineering Program Faculty Meeting","body":[{"value":"\u003Cp\u003E\u003Cem\u003EThe BioEngineering Program faculty meet regularly during the semester to address program policies, events and future research and academic directions.\u003C\/em\u003E\u003C\/p\u003E","summary":null,"format":"limited_html"}],"field_subtitle":"","field_summary":[{"value":"\u003Cp\u003E\u003Cem\u003EProgram policies, events and directions to be discussed\u003C\/em\u003E\u003C\/p\u003E","format":"limited_html"}],"field_summary_sentence":[{"value":"BioEngineering Program Faculty Meeting"}],"uid":"27917","created_gmt":"2014-07-29 13:51:41","changed_gmt":"2016-10-08 02:08:27","author":"Laura Paige","boilerplate_text":"","field_publication":"","field_article_url":"","field_event_time":{"event_time_start":"2014-12-05T10:00:00-05:00","event_time_end":"2014-12-05T11:00:00-05:00","event_time_end_last":"2014-12-05T11:00:00-05:00","gmt_time_start":"2014-12-05 15:00:00","gmt_time_end":"2014-12-05 16:00:00","gmt_time_end_last":"2014-12-05 16:00:00","rrule":null,"timezone":"America\/New_York"},"extras":[],"groups":[{"id":"65448","name":"Bioengineering Graduate Program"}],"categories":[],"keywords":[],"core_research_areas":[],"news_room_topics":[],"event_categories":[{"id":"1788","name":"Other\/Miscellaneous"}],"invited_audience":[{"id":"78761","name":"Faculty\/Staff"}],"affiliations":[],"classification":[],"areas_of_expertise":[],"news_and_recent_appearances":[],"phone":[],"contact":[],"email":[],"slides":[],"orientation":[],"userdata":""}},"348941":{"#nid":"348941","#data":{"type":"event","title":"PhD Defense Presentation- Anh Nguyen","body":[{"value":"\u003Cp\u003E\u003Cstrong\u003ECOMMITTEE\u003C\/strong\u003E:\u003C\/p\u003E\u003Cp\u003ETodd McDevitt, Ph.D. (Advisor)\u003C\/p\u003E\u003Cp\u003EThomas Barker, Ph.D.\u003C\/p\u003E\u003Cp\u003EAndr\u00e9s Garcia, Ph.D. \u003Cbr \/\u003E Manu Platt, Ph.D.\u003Cbr \/\u003E Chunhui Xu, Ph.D. (Emory University)\u003C\/p\u003E\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\u003Cp align=\u0022center\u0022\u003E\u003Cstrong\u003EProteolytically Degradable Microparticles for Engineering the Extracellular Microenvironment of Pluripotent Stem Cell Aggregates\u003C\/strong\u003E\u003C\/p\u003E\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\u003Cp\u003EEmbryonic stem cells (ESCs) offer tremendous promise for tissue engineering and regenerative medicine applications due to their pluripotent capacity to generate all bodily cell types. ESCs are typically differentiated as 3-dimensional aggregates, termed embryoid bodies (EBs), which recapitulate many biomolecular and biochemical events that occur during embryogenesis and facilitate the extracellular matrix production present in \u003Cem\u003Ein vivo \u003C\/em\u003Etissues that aid in stem cell regulation. However, EB differentiation is very heterogeneous, and manipulation of the EB microenvironment is increasingly being investigated to promote lineage specific differentiation, especially the potential of biomaterials to engineer the complex properties of the extracellular milieu. Incorporation of biomaterial microparticles (MPs) within EBs has demonstrated that materials are able to modulate stem cell pluripotency and differentiation, even in the absence of delivered biomolecules, however the mechanisms are not well known. Previous studies have demonstrated that introduction of proteolytically degradable materials within cellular environments have enhanced proteolytic activity specific to the introduced substrate. Additionally, protease activity has been highly implicated during stem cell differentiation, notably during the formation of all 3 germ lineages. The objective of this work was to engineer gelatin microparticles with tunable degradation rates and analyze their ability to modulate MMP activity and cellular differentiation. The central hypothesis was that incorporation of degradable gelatin MPs within EBs would enhance the proteolytic activity of the spheroids and would lead to enhanced mesodermal induction.\u003C\/p\u003E\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E","summary":null,"format":"limited_html"}],"field_subtitle":"","field_summary":[{"value":"\u003Cp\u003EPhD Defense Presentation-\u0026nbsp;\u0022Proteolytically Degradable Microparticles for Engineering the Extracellular Microenvironment of Pluripotent Stem Cell Aggregates\u0022- Anh Nguyen\u003C\/p\u003E","format":"limited_html"}],"field_summary_sentence":[{"value":"\u0022Proteolytically Degradable Microparticles for Engineering the Extracellular Microenvironment of Pluripotent Stem Cell Aggregates\u0022"}],"uid":"27917","created_gmt":"2014-11-25 09:59:13","changed_gmt":"2017-04-13 21:21:01","author":"Laura Paige","boilerplate_text":"","field_publication":"","field_article_url":"","field_event_time":{"event_time_start":"2014-12-05T08:00:00-05:00","event_time_end":"2014-12-05T10:00:00-05:00","event_time_end_last":"2014-12-05T10:00:00-05:00","gmt_time_start":"2014-12-05 13:00:00","gmt_time_end":"2014-12-05 15:00:00","gmt_time_end_last":"2014-12-05 15:00:00","rrule":null,"timezone":"America\/New_York"},"extras":[],"related_links":[{"url":"http:\/\/mcdevitt.gatech.edu\/","title":"McDevitt Research Lab"}],"groups":[{"id":"65448","name":"Bioengineering Graduate Program"}],"categories":[],"keywords":[],"core_research_areas":[],"news_room_topics":[],"event_categories":[{"id":"1788","name":"Other\/Miscellaneous"}],"invited_audience":[{"id":"78751","name":"Undergraduate students"},{"id":"78761","name":"Faculty\/Staff"},{"id":"174045","name":"Graduate students"}],"affiliations":[],"classification":[],"areas_of_expertise":[],"news_and_recent_appearances":[],"phone":[],"contact":[{"value":"\u003Cp\u003ELaura Paige\u003C\/p\u003E\u003Cp\u003E404-385-6655\u003C\/p\u003E","format":"limited_html"}],"email":[],"slides":[],"orientation":[],"userdata":""}},"350681":{"#nid":"350681","#data":{"type":"event","title":"MS Thesis Defense- Daniel Burnham","body":[{"value":"\u003Cp\u003EAdvisor: Maysam Ghovanloo, PhD, School of Electrical Engineering\u003Cbr \/\u003E \u003Cbr \/\u003E Committee: Gregory Abowd, PhD\u0026nbsp; School of Interactive Computing\u003Cbr \/\u003E Pamela Bhatti, PhD School of Electrical Engineering.\u003Cbr \/\u003E \u003Cbr \/\u003E Title: Wearable Sensing Modalities for A NeckBased Health Monitoring System\u003Cbr \/\u003E \u003Cbr \/\u003E Advances in modern medicine have led to decline of deaths among youth populations by introducing immunizations and effective treatments for infectious diseases that had previously resulted in high mortality rates. This decline has led to an increasingly aging population which is estimated to be 20% of the population by 2030.\u0026nbsp; This has led more chronic conditions in the population accounting for 75% of healthcare.\u0026nbsp; One method of mitigating this medical burden is the use of personalized eHealth through the use of wearable devices.\u0026nbsp; In this work a novel multimodal neck-worn device is presented for use non-invasive health monitoring.\u0026nbsp; A design of platform for detection of vital signs accessible from the neck including digestive, circulatory respiratory and activity tracking is shown and preliminary results from data collection of wireless tracheal activity using multiple signal modalities is explored.\u003C\/p\u003E","summary":null,"format":"limited_html"}],"field_subtitle":"","field_summary":[{"value":"\u003Cp\u003EMS Thesis Defense- \u0022Wearable Sensing Modalities for A NeckBased Health Monitoring System\u0022- Daniel Burnham\u003C\/p\u003E","format":"limited_html"}],"field_summary_sentence":[{"value":"\u0022Wearable Sensing Modalities for A NeckBased Health Monitoring System\u0022"}],"uid":"27917","created_gmt":"2014-12-01 12:12:20","changed_gmt":"2017-04-13 21:21:00","author":"Laura Paige","boilerplate_text":"","field_publication":"","field_article_url":"","field_event_time":{"event_time_start":"2014-12-09T08:00:00-05:00","event_time_end":"2014-12-09T10:00:00-05:00","event_time_end_last":"2014-12-09T10:00:00-05:00","gmt_time_start":"2014-12-09 13:00:00","gmt_time_end":"2014-12-09 15:00:00","gmt_time_end_last":"2014-12-09 15:00:00","rrule":null,"timezone":"America\/New_York"},"extras":[],"groups":[{"id":"65448","name":"Bioengineering Graduate Program"}],"categories":[],"keywords":[],"core_research_areas":[],"news_room_topics":[],"event_categories":[{"id":"1788","name":"Other\/Miscellaneous"}],"invited_audience":[{"id":"78751","name":"Undergraduate students"},{"id":"78761","name":"Faculty\/Staff"},{"id":"174045","name":"Graduate students"}],"affiliations":[],"classification":[],"areas_of_expertise":[],"news_and_recent_appearances":[],"phone":[],"contact":[{"value":"\u003Cp\u003ELaura Paige 404-385-6655\u003C\/p\u003E","format":"limited_html"}],"email":[],"slides":[],"orientation":[],"userdata":""}},"301631":{"#nid":"301631","#data":{"type":"event","title":"Breakfast Club Seminar","body":[{"value":"\u003Cp\u003E\u003Cstrong\u003E\u0022Arms Race Drives Evolution of Metabolic Diversity\u0022\u003Cbr \/\u003E\u003Cbr \/\u003E\u003C\/strong\u003E\u003Cstrong\u003EJim Spain, PhD\u003Cbr \/\u003E\u003C\/strong\u003E\u003Cstrong\u003EProfessor\u003Cbr \/\u003ESchool of Civil and Environmental Engineering\u003Cbr \/\u003E\u003C\/strong\u003E\u003Cstrong\u003EGeorgia Tech\u003C\/strong\u003E\u003C\/p\u003E\u003Cp\u003E\u003Cbr \/\u003EJim Spain, PhD, joined the School of Civil and Environmental Engineering at the Georgia Institute of Technology at the beginning of 2005. Spain received his PhD in microbiology from The University of Texas at Austin and a BS in Biology from the University of Texas at Arlington. He studied the biodegradation of pesticides in the marine environment for five years as a post doctoral fellow and research scientist at the U.S. Environmental Protection Agency Marine Environmental Research Laboratory. Prior to joining Georgia Tech Spain directed the Environmental Biotechnology research program at the Air Force Research Laboratory in Panama City, Florida where he studied the biodegradation of synthetic organic compounds in the environment. His research interests in environmental biotechnology include: discovery and construction of bacteria for degradation of substituted aromatic compounds; physiological and ecological factors controlling microbial processes; and discovery of biocatalysts for green chemistry synthesis of novel materials. He works at the interface between basic microbiology research and practical applications to solve environmental problems.\u003C\/p\u003E\u003Cp\u003ESpain is a former editor for Applied and Environmental Microbiology and has published over 130 peer reviewed papers, several books, and numerous book chapters on the biodegradation and biosynthesis of organic compounds. He has served on review committees for the EPA, DoE, NIEHS, and DoD and on the editorial boards of a variety of journals.\u003C\/p\u003E\u003Cp\u003E\u003Cbr \/\u003E\u003Cbr \/\u003E\u003C\/p\u003E","summary":null,"format":"limited_html"}],"field_subtitle":"","field_summary":[{"value":"\u003Cp\u003EThe Petit Institute Breakfast Club seminar series was started with the spirit of the Institute\u0027s interdisciplinary mission in mind and started to feature local Petit Institute faculty member\u0027s research in a seminar format. Faculty are often asked to speak at other universities and conferences, but rarely present at their home institution, this seminar series is an attempt to close that gap. The Petit Institute Breakfast Club is open to anyone in the bio-community.\u003C\/p\u003E","format":"limited_html"}],"field_summary_sentence":[{"value":"\u0022Arms Race Drives Evolution of Metabolic Diversity\u0022 - Jim Spain, PhD - Georgia Tech"}],"uid":"27195","created_gmt":"2014-06-05 13:07:04","changed_gmt":"2017-04-13 21:22:28","author":"Colly Mitchell","boilerplate_text":"","field_publication":"","field_article_url":"","field_event_time":{"event_time_start":"2014-12-09T07:30:00-05:00","event_time_end":"2014-12-09T08:30:00-05:00","event_time_end_last":"2014-12-09T08:30:00-05:00","gmt_time_start":"2014-12-09 12:30:00","gmt_time_end":"2014-12-09 13:30:00","gmt_time_end_last":"2014-12-09 13:30:00","rrule":null,"timezone":"America\/New_York"},"extras":[],"hg_media":{"70917":{"id":"70917","type":"image","title":"Breakfast Club Seminar Series","body":null,"created":"1449177328","gmt_created":"2015-12-03 21:15:28","changed":"1475894625","gmt_changed":"2016-10-08 02:43:45","alt":"Breakfast Club Seminar Series","file":{"fid":"193471","name":"logobldg_graphic.png","image_path":"\/sites\/default\/files\/images\/logobldg_graphic_0.png","image_full_path":"http:\/\/www.tlwarc.hg.gatech.edu\/\/sites\/default\/files\/images\/logobldg_graphic_0.png","mime":"image\/png","size":241588,"path_740":"http:\/\/www.tlwarc.hg.gatech.edu\/sites\/default\/files\/styles\/740xx_scale\/public\/images\/logobldg_graphic_0.png?itok=x84xf3Mz"}}},"media_ids":["70917"],"related_links":[{"url":"http:\/\/www.ce.gatech.edu\/people\/faculty\/671\/bio","title":"Spain profile"},{"url":"http:\/\/www.ibb.gatech.edu\/breakfast-club","title":"IBB Breakfast Club"}],"groups":[{"id":"1292","name":"Parker H. Petit Institute for Bioengineering and Bioscience (IBB)"}],"categories":[],"keywords":[{"id":"11879","name":"BK Club"},{"id":"248","name":"IBB"}],"core_research_areas":[],"news_room_topics":[],"event_categories":[{"id":"1795","name":"Seminar\/Lecture\/Colloquium"}],"invited_audience":[{"id":"78751","name":"Undergraduate students"},{"id":"78761","name":"Faculty\/Staff"},{"id":"174045","name":"Graduate students"}],"affiliations":[],"classification":[],"areas_of_expertise":[],"news_and_recent_appearances":[],"phone":[],"contact":[{"value":"\u003Cp\u003E\u003Ca href=\u0022mailto:colly.mitchell@ibb.gatech.edu\u0022\u003EColly Mitchell\u003C\/a\u003E\u003Cbr \/\u003EProgram Coordinator\u003C\/p\u003E","format":"limited_html"}],"email":[],"slides":[],"orientation":[],"userdata":""}},"301381":{"#nid":"301381","#data":{"type":"event","title":"MS Thesis Defense- Jaeho Oh","body":[{"value":"\u003Cp\u003ECOMMITTEE:\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u003C\/p\u003E\u003Cp\u003EDr. Susan N. Thomas, Chair (ME), Advisor\u003C\/p\u003E\u003Cp\u003EDr. J. Brandon Dixon (ME)\u003C\/p\u003E\u003Cp\u003EDr. Todd Sulchek (ME)\u003C\/p\u003E\u003Cp\u003E\u0026nbsp;\u003Cstrong\u003ECell adhesion chromatography system for biophysical to biochemical analysis of human colon cancer metastasis through the vasculature.\u003C\/strong\u003E\u003C\/p\u003E\u003Cp\u003E\u0026nbsp;Cell adhesion under the influence of hemodynamic forces in the vasculature plays a pivota role in physiological and pathophysiological phenomena, including immune cell recruitment, stem cell homing, and cancer metastasis. A key class of adhesion molecules involved in these processes is selectin, which initiate cell-cell interactions by slowing circulating cells down relative to bulk flow to facilitate firm adhesion, suggesting interventions directed at attenuating or increasing selectin adhesion could provide therapeutic means to tune cell homing processes. The selectin binding activity of cells over long time and length scales, which best recapitulates the cell adhesion challenges experienced within the circulatory system to predict the functional capacity of cells to eventually achieve firm adhesion and extravasate, has not been determined. To address this issue, we developed a so-called \u201ccell adhesion chromatography\u201d system based on a microfluidic device to investigate cell adhesion behavior to selectins over long time and length scales. Our system is equipped with a feature that enables uniform cell contact the selectin-coated substrate by exploiting Stoke\u2019s flow. Using the system, we performed residence time distribution experiments with a pulse input of cells at different shear stresses by imaging them within a field of view at prescribed distances from the inlet. Residence time distribution plots were then generated and compared between healthy (human monocyte) and malignant (human colon carcinoma) cells. Differences in the functional capacity of each cell type to sustain interactions with selectins were observed. In summary, we have developed a microfluidic-based system that provides a new way to investigate the efficiency of selectin-mediated cell adhesion for the interrogation of selectin binding biophysics of whole cells in fluid flow and for the screening of adhesion-modulating drugs for eventual translation into therapeutic applications.\u003C\/p\u003E\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E","summary":null,"format":"limited_html"}],"field_subtitle":"","field_summary":[{"value":"\u003Cp\u003EMS Thesis Defense- \u0022Cell adhesion chromatography system for biophysical to biochemical analysis of human colon cancer metastasis through the vasculature\u0022- Jaeho Oh\u003C\/p\u003E","format":"limited_html"}],"field_summary_sentence":[{"value":"\u0022Cell adhesion chromatography system for biophysical to biochemical analysis of human colon cancer metastasis through the vasculature.\u0022"}],"uid":"27917","created_gmt":"2014-06-05 09:02:46","changed_gmt":"2017-04-13 21:22:29","author":"Laura Paige","boilerplate_text":"","field_publication":"","field_article_url":"","field_event_time":{"event_time_start":"2014-06-19T10:00:00-04:00","event_time_end":"2014-06-19T12:00:00-04:00","event_time_end_last":"2014-06-19T12:00:00-04:00","gmt_time_start":"2014-06-19 14:00:00","gmt_time_end":"2014-06-19 16:00:00","gmt_time_end_last":"2014-06-19 16:00:00","rrule":null,"timezone":"America\/New_York"},"extras":[],"related_links":[{"url":"http:\/\/thomas.gatech.edu\/","title":"Thomas lab website"}],"groups":[{"id":"65448","name":"Bioengineering Graduate Program"}],"categories":[],"keywords":[],"core_research_areas":[],"news_room_topics":[],"event_categories":[{"id":"1788","name":"Other\/Miscellaneous"}],"invited_audience":[{"id":"78751","name":"Undergraduate students"},{"id":"78761","name":"Faculty\/Staff"},{"id":"174045","name":"Graduate students"}],"affiliations":[],"classification":[],"areas_of_expertise":[],"news_and_recent_appearances":[],"phone":[],"contact":[{"value":"\u003Cp\u003ELaura Paige\u003C\/p\u003E","format":"limited_html"}],"email":[],"slides":[],"orientation":[],"userdata":""}},"302371":{"#nid":"302371","#data":{"type":"event","title":"PhD Defense - Sharon Norman","body":[{"value":"\u003Cp\u003E\u003Cstrong\u003EQuantifying Dynamics and Variability in Neural Systems\u003C\/strong\u003E\u003C\/p\u003E\u003Cp\u003E\u003Cstrong\u003ECommittee\u003C\/strong\u003E\u003Cbr \/\u003ERobert J. Butera (advisor) - Georgia Institute of Technology and Emory University\u003Cbr \/\u003EGarrett Stanley - Georgia Institute of Technology and Emory University\u003Cbr \/\u003EAstrid Prinz - Emory University\u003Cbr \/\u003ECarmen Canavier - Louisiana State University Health Sciences Center\u003Cbr \/\u003ERobert Clewley - Georgia State University\u003C\/p\u003E\u003Cp\u003ESynchronized neural activity, in which the firing of neurons is coordinated in time, is an observed phenomenon in many neural functions. The conditions that promote synchrony, the dynamics of synchronized activity, and the dynamical effects of spike time variability on synchrony are active areas of investigation because they are incompletely understood.\u003Cbr \/\u003E\u0026nbsp;\u003Cbr \/\u003EPrevious experiments revealed that irregularity in biological neuron spike timing could disrupt synchronization in neural circuits. In this work, we demonstrate that cycle-to-cycle characteristics of the coupled system can be used to infer dynamics of neural circuits, even if they are changing over time. Using this method, we can identify stable phase relationships in the presence of noise and resolve networks with similar phase but different underlying dynamics. The method is a valuable tool for distinguishing dynamics and describing robustness. \u0026nbsp;\u003Cbr \/\u003E\u0026nbsp;\u003Cbr \/\u003EWe also show that interspike interval (ISI) of invertebrate neurons recorded over hours can be represented as a process dependent on past history and a stochastic component with history. Integrate and fire model simulations reveal that stochastic activity in adaptation channels could contribute to the observed features of these neurons. This form of stochastic, history-dependent noise is not typically represented in network simulations; our understanding of network dynamics could be enhanced by incorporating more complex, but relevant, forms of noise in the simulation and interpretation of neural circuits.\u0026nbsp;\u0026nbsp; \u0026nbsp;\u003Cbr \/\u003E\u0026nbsp;\u003Cbr \/\u003EFinally, some larger implications of neuroscience research are discussed. The use of neural interfaces for national security is a current interest. Because these technologies raise a number of unique ethical concerns and guidelines about which technologies should be developed are lacking, we discuss a two-step framework with 1) an initial screen to prioritize technologies that should be reviewed immediately, and 2) a comprehensive ethical review regarding concerns for individuals, operational norms, and multi-use applications in the case of transfer to civilian contexts.\u003C\/p\u003E","summary":null,"format":"limited_html"}],"field_subtitle":"","field_summary":[{"value":"\u003Cp\u003EPhD Defense - Sharon Norman - \u0022Quantifying Dynamics and Variability in Neural Systems\u0022\u003C\/p\u003E","format":"limited_html"}],"field_summary_sentence":[{"value":"Quantifying Dynamics and Variability in Neural Systems"}],"uid":"27349","created_gmt":"2014-06-10 09:10:05","changed_gmt":"2017-04-13 21:22:27","author":"Floyd Wood","boilerplate_text":"","field_publication":"","field_article_url":"","field_event_time":{"event_time_start":"2014-06-23T14:00:00-04:00","event_time_end":"2014-06-23T17:00:00-04:00","event_time_end_last":"2014-06-23T17:00:00-04:00","gmt_time_start":"2014-06-23 18:00:00","gmt_time_end":"2014-06-23 21:00:00","gmt_time_end_last":"2014-06-23 21:00:00","rrule":null,"timezone":"America\/New_York"},"extras":[],"groups":[{"id":"65448","name":"Bioengineering Graduate Program"}],"categories":[],"keywords":[{"id":"5805","name":"Bioegineering"}],"core_research_areas":[],"news_room_topics":[],"event_categories":[{"id":"1788","name":"Other\/Miscellaneous"}],"invited_audience":[{"id":"78751","name":"Undergraduate students"},{"id":"78761","name":"Faculty\/Staff"},{"id":"174045","name":"Graduate students"}],"affiliations":[],"classification":[],"areas_of_expertise":[],"news_and_recent_appearances":[],"phone":[],"contact":[],"email":[],"slides":[],"orientation":[],"userdata":""}},"302851":{"#nid":"302851","#data":{"type":"event","title":"MS Thesis Defense Presentation- Vaclav Beranek","body":[{"value":"\u003Cp\u003ECOMMITTEE:\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u003C\/p\u003E\u003Cp\u003EDr. Cheng Zhu, (BME \u0026amp; ME, Georgia Tech), Advisor\u003C\/p\u003E\u003Cp\u003EDr. Evan Evans (BME, Boston University)\u003C\/p\u003E\u003Cp\u003EDr. Susan N. Thomas (ME, Georgia Tech)\u003C\/p\u003E\u003Cp align=\u0022center\u0022\u003E\u003Cstrong\u003E\u0026nbsp;\u003C\/strong\u003E\u003C\/p\u003E\u003Cp align=\u0022center\u0022\u003E\u003Cstrong\u003EDynamics of composite beads in optical tweezers and their application to study of HIV cell entry.\u003C\/strong\u003E\u003C\/p\u003E\u003Cp align=\u0022center\u0022\u003ESUMMARY\u003C\/p\u003E\u003Cp\u003E\u0026nbsp;In this thesis we report a novel symmetry breaking system in single-beam optical trap. The breaking of symmetry is observed in Brownian dynamics of a linked pair of beads with substantially differing radii (500nm and 100nm). Such composite beads were originally conceived as a manipulation means to study of Brownian interactions between mesoscopic biological agents of the order of 100 \u2013 200 nm (viruses or bacteria) with cell surfaces. During the initial testing of the composite bead system, we discovered that the system displayed thermally activated transitions and energetics of symmetry breaking. This thesis, while making a brief overview of the biological relevance of the composite bead system, focuses primarily on the analysis and experimentation that reveals the complex dynamics observed in the system.\u003C\/p\u003E\u003Cp\u003E\u0026nbsp;We first theoretically analyze the origin of the observed symmetry breaking using electromagnetic theory under both Gaussian beam approximation and full Debye-type integral representation. The theory predicts creation of a bistable rotational potential. Surprisingly, the theory also predicts a second top-down symmetry breaking between the two bistable states as a consequence of radiation pressure.\u003C\/p\u003E\u003Cp\u003E\u0026nbsp;In the second part, we experimentally confirm the theoretical results. First, we quantify the top-down symmetry breaking by measuring the transition rates between the two rotational states. The rotational potential is then explored using an experiment employing a novel algorithm to track rotational state of the composite bead. The results of the theory and experiments are compared with results of a Brownian dynamics simulation based on Smart Monte Carlo algorithm.\u003C\/p\u003E","summary":null,"format":"limited_html"}],"field_subtitle":"","field_summary":[{"value":"\u003Cp\u003EMS Thesis Defense Presentation-\u0026nbsp;\u0022Dynamics of composite beads in optical tweezers and their application to study of HIV cell entry.\u0022- Vaclac Beranek\u003C\/p\u003E","format":"limited_html"}],"field_summary_sentence":[{"value":"\u0022Dynamics of composite beads in optical tweezers and their application to study of HIV cell entry.\u0022"}],"uid":"27917","created_gmt":"2014-06-12 08:13:34","changed_gmt":"2017-04-13 21:22:25","author":"Laura Paige","boilerplate_text":"","field_publication":"","field_article_url":"","field_event_time":{"event_time_start":"2014-06-25T16:00:00-04:00","event_time_end":"2014-06-25T18:00:00-04:00","event_time_end_last":"2014-06-25T18:00:00-04:00","gmt_time_start":"2014-06-25 20:00:00","gmt_time_end":"2014-06-25 22:00:00","gmt_time_end_last":"2014-06-25 22:00:00","rrule":null,"timezone":"America\/New_York"},"extras":[],"related_links":[{"url":"http:\/\/groups.bme.gatech.edu\/groups\/zhu\/","title":"Zhu lab website"}],"groups":[{"id":"65448","name":"Bioengineering Graduate Program"}],"categories":[],"keywords":[],"core_research_areas":[],"news_room_topics":[],"event_categories":[{"id":"1788","name":"Other\/Miscellaneous"}],"invited_audience":[{"id":"78751","name":"Undergraduate students"},{"id":"78761","name":"Faculty\/Staff"},{"id":"174045","name":"Graduate students"}],"affiliations":[],"classification":[],"areas_of_expertise":[],"news_and_recent_appearances":[],"phone":[],"contact":[{"value":"\u003Cp\u003ELaura Paige\u003C\/p\u003E","format":"limited_html"}],"email":[],"slides":[],"orientation":[],"userdata":""}},"293331":{"#nid":"293331","#data":{"type":"event","title":"PhD Defense Presentation- Michelle Kuykendal","body":[{"value":"\u003Cp\u003E\u003Cem\u003EAdvisor: Dr. Stephen P.\u0026nbsp; DeWeerth, School of Biomedical Engineering, Georgia Institute of Technology\u003C\/em\u003E\u003C\/p\u003E\u003Cp\u003E\u003Cem\u003ECommittee:\u003C\/em\u003E\u003C\/p\u003E\u003Cp\u003E\u003Cem\u003EDr. Steve M. Potter, School of Biomedical Engineering, Georgia Institute of Technology\u003C\/em\u003E\u003C\/p\u003E\u003Cp\u003E\u003Cem\u003EDr. Garrett Stanley, School of Biomedical Engineering, Georgia Institute of Technology\u003C\/em\u003E\u003C\/p\u003E\u003Cp\u003E\u003Cem\u003EDr. Martha Grover, School of Chemical and Biomolecular Engineering, Georgia Institute of Technology\u003C\/em\u003E\u003C\/p\u003E\u003Cp\u003E\u003Cem\u003EDr. Cameron McIntyre, Neural Engineering Center, Case Western Reserve University\u003C\/em\u003E\u003C\/p\u003E\u003Cp\u003E\u003Cstrong\u003EClosed-loop optimization of extracellular electrical stimulation for targeted neuronal activation\u003C\/strong\u003E\u003C\/p\u003E\u003Cp\u003EWe have developed a high-throughput system of closed-loop electrical stimulation and optical recording that facilitates the rapid characterization of extracellular stimulus-evoked neural activity. The ability to selectively stimulate a neuron is a defining characteristic of next-generation neural prostheses. Greater stimulus control and differential activation of specific neuronal populations allows for prostheses that better mimic their biological counterparts.\u003C\/p\u003E\u003Cp\u003EIn our system, we deliver square current pulses using a microelectrode array; automated real-time image processing of high-speed digital video identifies the neuronal response; and a feedback controller alters the applied stimulus to achieve a targeted response. The system controller performs directed searches within the strength\u2013duration (SD) stimulus parameter space to build probabilistic neuronal activation curves. An important feature of this closed-loop system is a reduction in the number of stimuli needed to derive the activation curves when compared to the more commonly used open-loop system: this allows the closed-loop system to spend more time probing stimulus regions of interest in the multi-parameter waveform space, facilitating high resolution analysis.\u003C\/p\u003E\u003Cp\u003EThe stimulus-evoked activation data were well-fit to a sigmoid model in both the stimulus strength (current) and duration (pulse width) slices through the waveform space. The 2-D analysis produces a set of probability isoclines corresponding to each neuron-electrode pairing, which were fit to the SD threshold model described by Lapique (1907). We show that stimulus selectivity within a given neuron pair is reversible in the one-parameter search space by using multiple stimulation electrodes. Additionally, by applying simultaneous stimuli to adjacent electrodes, the interaction between stimuli alters the neuronal activation threshold. The interaction between simultaneous multi-electrode multi-parameter stimulus waveforms creates an opportunity for increased stimulus selectivity within a population.\u003C\/p\u003E\u003Cp\u003EWe demonstrate that closed-loop imaging and micro-stimulation technology enable the study of neuronal excitation across a large parameter space, which is requisite for controlling neuronal activation in next generation clinical solutions. \u0026nbsp;\u003C\/p\u003E","summary":null,"format":"limited_html"}],"field_subtitle":"","field_summary":[{"value":"\u003Cp\u003EPhD Defense Presentation-\u0022Closed-loop optimization of extracellular electrical stimulation for targeted neuronal activation\u0022- Michelle Kuykendal\u003C\/p\u003E","format":"limited_html"}],"field_summary_sentence":[{"value":"\u0022Closed-loop optimization of extracellular electrical stimulation for targeted neuronal activation\u0022"}],"uid":"27917","created_gmt":"2014-04-25 14:41:32","changed_gmt":"2017-04-13 21:22:39","author":"Laura Paige","boilerplate_text":"","field_publication":"","field_article_url":"","field_event_time":{"event_time_start":"2014-05-06T18:00:00-04:00","event_time_end":"2014-05-06T20:00:00-04:00","event_time_end_last":"2014-05-06T20:00:00-04:00","gmt_time_start":"2014-05-06 22:00:00","gmt_time_end":"2014-05-07 00:00:00","gmt_time_end_last":"2014-05-07 00:00:00","rrule":null,"timezone":"America\/New_York"},"extras":[],"groups":[{"id":"65448","name":"Bioengineering Graduate Program"}],"categories":[],"keywords":[],"core_research_areas":[],"news_room_topics":[],"event_categories":[{"id":"1788","name":"Other\/Miscellaneous"}],"invited_audience":[{"id":"78751","name":"Undergraduate students"},{"id":"78761","name":"Faculty\/Staff"},{"id":"174045","name":"Graduate students"}],"affiliations":[],"classification":[],"areas_of_expertise":[],"news_and_recent_appearances":[],"phone":[],"contact":[{"value":"\u003Cp\u003E\u003Ca href=\u0022mailto:Laura.Paige@bioengineering.gatech.edu\u0022\u003ELaura.Paige@bioengineering.gatech.edu\u003C\/a\u003E\u003C\/p\u003E","format":"limited_html"}],"email":[],"slides":[],"orientation":[],"userdata":""}},"292701":{"#nid":"292701","#data":{"type":"event","title":"BioE Day","body":[{"value":"\u003Cp\u003EThe first annual BioE Day has been established to celebrate the excellence in science that our students and faculty demonstrate as well as build community between both students and faculty.\u003Cbr \/\u003E\u003Cbr \/\u003ECome and learn about the opportunities and resources available to BioE graduate students at Georgia Tech, such as scholarships, fellowships and joint programs.\u0026nbsp;\u003Cbr \/\u003E \u003Cbr \/\u003EAll students and faculty associated with BioE are invited to attend.\u003C\/p\u003E\u003Cul\u003E\u003Cli\u003EHear from BioE award winners\u003C\/li\u003E\u003Cli\u003EPoster symposium highlighting BioE students\u003C\/li\u003E\u003Cli\u003EInformation on internships and special programs\u003C\/li\u003E\u003Cli\u003ECookout with lawn games and water balloons\u003C\/li\u003E\u003Cli\u003E\u003Ca href=\u0022http:\/\/bioengineering.gatech.edu\/hg_news\/290301\u0022\u003EChris Ruffin Student Leadership Award\u003C\/a\u003E winner announced!\u003C\/li\u003E\u003C\/ul\u003E\u003Cp\u003E\u003Cstrong\u003E\u003Cbr \/\u003EProgram:\u003Cbr \/\u003E\u003C\/strong\u003E\u003Cbr \/\u003E11:00 - Welcome and opening remarks by Andres Garcia, PhD\u003C\/p\u003E\u003Cp\u003E11:10 - Rapid Fire Presentations by BioE Students\u003Cbr \/\u003E11:30 - Poster Presentation and Lunch (**nametags required)\u003Cbr \/\u003E1:00 - Program Presentations\u003Cbr \/\u003E1:00 - Fellowships Office\u003Cbr \/\u003E1:10 - Center for Career Discovery and Development\u003Cbr \/\u003E1:20 - MBA Program\u003Cbr \/\u003E1:30 - Technology Innovation: Generating Economic Results (TI:GER)\u003Cbr \/\u003E1:40 - Graduate Leadership Program (GLP)\u003Cbr \/\u003E1:50 - Center for Enhancement of Teaching and Learning (CETL)\u003Cbr \/\u003E2:00 - Broadening Experiences in Scientific Training (BEST)\u003Cbr \/\u003E2:10 - Program Booths\u003Cbr \/\u003E3:00 - Senior Graduate Student Panel - Opportunity to submit questions in a box the day \u003C\/p\u003E\u003Cp\u003E3:30 -\u0026nbsp;BioE Outstanding Paper Winner, Tom Bongiorno-\u0026nbsp;\u003Cbr \/\u003E3:45 - BioE Outstanding Advisor Winner, Julie Champion, PhD\u003Cbr \/\u003E4:00 - Presentation Awards and Chris Ruffin Award\u003Cbr \/\u003E4:15 - Cookout and Refreshments\u003Cbr \/\u003E4:30 - Faculty water balloon toss competition\u003Cbr \/\u003E5:00 - Games\u003C\/p\u003E\u003Cp\u003E6:00 - Adjourn\u003C\/p\u003E","summary":null,"format":"limited_html"}],"field_subtitle":"","field_summary":[{"value":"\u003Cp\u003EThe first annual BioE Day has been established to celebrate the excellence in science that our students and faculty demonstrate as well as build community between both students and faculty. All students and faculty associated with BioE are invited to attend.\u003C\/p\u003E","format":"limited_html"}],"field_summary_sentence":[{"value":"First annual event is a showcase for science and opportunity to build community between students and faculty"}],"uid":"27299","created_gmt":"2014-04-23 08:48:27","changed_gmt":"2017-04-13 21:22:40","author":"Michael Hagearty","boilerplate_text":"","field_publication":"","field_article_url":"","field_event_time":{"event_time_start":"2014-05-12T16:00:00-04:00","event_time_end":"2014-05-12T23:00:00-04:00","event_time_end_last":"2014-05-12T23:00:00-04:00","gmt_time_start":"2014-05-12 20:00:00","gmt_time_end":"2014-05-13 03:00:00","gmt_time_end_last":"2014-05-13 03:00:00","rrule":null,"timezone":"America\/New_York"},"extras":[],"hg_media":{"176921":{"id":"176921","type":"image","title":"Bioengineering at Georgia Tech","body":null,"created":"1449179031","gmt_created":"2015-12-03 21:43:51","changed":"1475894819","gmt_changed":"2016-10-08 02:46:59","alt":"Bioengineering at Georgia Tech","file":{"fid":"195984","name":"bioe_logo.png","image_path":"\/sites\/default\/files\/images\/bioe_logo.png","image_full_path":"http:\/\/www.tlwarc.hg.gatech.edu\/\/sites\/default\/files\/images\/bioe_logo.png","mime":"image\/png","size":4433,"path_740":"http:\/\/www.tlwarc.hg.gatech.edu\/sites\/default\/files\/styles\/740xx_scale\/public\/images\/bioe_logo.png?itok=yU1ntVWj"}}},"media_ids":["176921"],"related_links":[{"url":"http:\/\/www.bioengineering.gatech.edu\/bgsac\/event\/bioe-day","title":"RSVP to Attend this Event"}],"groups":[{"id":"1292","name":"Parker H. Petit Institute for Bioengineering and Bioscience (IBB)"},{"id":"65448","name":"Bioengineering Graduate Program"}],"categories":[],"keywords":[{"id":"248","name":"IBB"}],"core_research_areas":[],"news_room_topics":[],"event_categories":[{"id":"10377","name":"Career\/Professional development"},{"id":"1788","name":"Other\/Miscellaneous"},{"id":"1791","name":"Student sponsored"}],"invited_audience":[{"id":"78751","name":"Undergraduate students"},{"id":"78761","name":"Faculty\/Staff"},{"id":"78771","name":"Public"},{"id":"174045","name":"Graduate students"}],"affiliations":[],"classification":[],"areas_of_expertise":[],"news_and_recent_appearances":[],"phone":[],"contact":[{"value":"\u003Cp\u003E\u003Ca href=\u0022mailto:jcbb3@gatech.edu\u0022\u003EJessica Butts\u003C\/a\u003E\u003Ca href=\u0022mailto:bongiornot@gatech.edu\u0022\u003E\u003Cbr \/\u003EKaty Hammersmith\u003Cbr \/\u003ETom Bongiorno\u003Cbr \/\u003E\u003C\/a\u003E\u003Ca href=\u0022mailto:jcbb3@gatech.edu\u0022\u003E\u003Cbr \/\u003E\u003C\/a\u003E\u003C\/p\u003E","format":"limited_html"}],"email":[],"slides":[],"orientation":[],"userdata":""}},"295531":{"#nid":"295531","#data":{"type":"event","title":"PhD Defense Presentation - Stephanie Duncanson","body":[{"value":"\u003Cp\u003EAdvisor: Athanassios Sambanis, ChBE\u003Cbr \/\u003E \u003Cbr \/\u003E Committee Members:\u003C\/p\u003E\u003Cp\u003E\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp; Julia Babensee, BME\u003Cbr \/\u003E \u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp; Julie Champion, ChBE\u003C\/p\u003E\u003Cp\u003E\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp; Susan Safley, Emory School of Medicine\u003C\/p\u003E\u003Cp\u003E\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp; Johnna Temenoff, BME\u003C\/p\u003E\u003Cp\u003E\u003Cstrong\u003EAbstract: \u003C\/strong\u003E\u003C\/p\u003E\u003Cp\u003EThe development of a bioartificial pancreas (BAP) has the potential to substantially improve the treatment of insulin-dependent diabetes.\u0026nbsp; Composed of insulin-secreting cells encapsulated in a hydrogel material, a BAP may provide superior glycemic regulation compared with conventional exogenous insulin-delivery therapies. Towards this goal, \u03b2- cells or islets encapsulated in alginate microcapsules remain a promising approach. Due to the limited supply of human islets, alternative cell sources are under investigation for incorporation into a BAP, including porcine islets and \u03b2- cell lines. Several challenges remain to clinical implementation, including loss of islet or \u03b2- cell function and viability following transplantation and host response to the transplanted microcapsules.\u003C\/p\u003E\u003Cp\u003EThe objective of this work was to evaluate strategies to improve a BAP by supporting the function and survival of encapsulated islets and \u03b2 -cells.\u0026nbsp; Towards this goal, two areas were explored: 1) the provision of pro-survival and insulinotropic factors, namely, CXCL12 and GLP-1, to encapsulated islets and \u03b2-cells and 2) modification of the alginate microcapsule to confer long-term resistance to host cell adhesion.\u0026nbsp;\u0026nbsp;\u003C\/p\u003E\u003Cp\u003ETo achieve the first objective, methods to deliver both pro-survival and insulinotropic factors to a BAP were developed and their effects on encapsulated \u03b2-cells and islets were studied, both \u003Cem\u003Ein vitro\u003C\/em\u003E and \u003Cem\u003Ein vivo\u003C\/em\u003E. Results demonstrate that delivery of both pro-survival and insulinotropic factors are a promising strategy to prolong the survival and function of a BAP.\u0026nbsp; To reduce host cell adhesion to the microcapsule, we employed covalent conjugation of PEG to the surface of alginate-PLL capsules to replace the un-crosslinked layer of alginate used in traditional alginate-PLL-alginate (APA) microcapsules.\u0026nbsp; Results demonstrate that while PEGylation of alginate-PLL microcapsules initially reduced host cell adhesion over 2 weeks \u003Cem\u003Ein vivo \u003C\/em\u003Ecompared with APA capsules, the PEG coating did not provide long-term protection over 3 months.\u0026nbsp; Taken together, these studies represent a multipronged approach towards improving the duration of BAP function, with the ultimate goal of advancing this technology to the clinic.\u003C\/p\u003E","summary":null,"format":"limited_html"}],"field_subtitle":"","field_summary":[{"value":"\u003Cp\u003EPhD Defense Presentation-\u0026nbsp;\u0022Improving the bioartificial pancreas: Investigation of the effects of pro-survival and insulinotropic factor delivery and development of PEGylated alginate microcapsules to support the function and survival of encapsulated islets and beta cells\u0022- Stephanie Duncanson\u003C\/p\u003E","format":"limited_html"}],"field_summary_sentence":[{"value":"\u0022Improving the bioartificial pancreas: Investigation of the effects of pro-survival and insulinotropic factor delivery and development of PEGylated alginate microcapsules to support the function and survival of encapsulated islets and beta cells\u0022"}],"uid":"27917","created_gmt":"2014-05-07 09:57:59","changed_gmt":"2017-04-13 21:22:37","author":"Laura Paige","boilerplate_text":"","field_publication":"","field_article_url":"","field_event_time":{"event_time_start":"2014-05-19T19:00:00-04:00","event_time_end":"2014-05-19T21:00:00-04:00","event_time_end_last":"2014-05-19T21:00:00-04:00","gmt_time_start":"2014-05-19 23:00:00","gmt_time_end":"2014-05-20 01:00:00","gmt_time_end_last":"2014-05-20 01:00:00","rrule":null,"timezone":"America\/New_York"},"extras":[],"related_links":[{"url":"http:\/\/sambanis.chbe.gatech.edu\/","title":"http:\/\/sambanis.chbe.gatech.edu\/"}],"groups":[{"id":"65448","name":"Bioengineering Graduate Program"}],"categories":[],"keywords":[],"core_research_areas":[],"news_room_topics":[],"event_categories":[{"id":"1788","name":"Other\/Miscellaneous"}],"invited_audience":[{"id":"78751","name":"Undergraduate students"},{"id":"78761","name":"Faculty\/Staff"},{"id":"174045","name":"Graduate students"}],"affiliations":[],"classification":[],"areas_of_expertise":[],"news_and_recent_appearances":[],"phone":[],"contact":[],"email":[],"slides":[],"orientation":[],"userdata":""}},"294471":{"#nid":"294471","#data":{"type":"event","title":"PhD Proposal - He Zheng","body":[{"value":"\u003Cp\u003E\u003Cstrong\u003EAdaptive Shaping of Cortical Response Selectivity in the Vibrissa Pathway in Awake and Anesthetized States\u003C\/strong\u003E\u003C\/p\u003E\u003Cp\u003E\u003Cstrong\u003EAdvisor:\u003Cbr \/\u003E\u003C\/strong\u003E\u003C\/p\u003E\u003Cp\u003EGarrett Stanley, PhD (Georgia Institute of Technology)\u003C\/p\u003E\u003Cp\u003E\u003Cstrong\u003ECommittee Members:\u003Cbr \/\u003E\u003C\/strong\u003E\u003C\/p\u003E\u003Cp\u003EDieter Jaeger, PhD (Emory University)\u003Cbr \/\u003ERobert Liu, PhD (Emory University)\u003Cbr \/\u003EAnna Roe, PhD (Vanderbilt University)\u003Cbr \/\u003EChris Rozell, PhD (Georgia Institute of Technology)\u003C\/p\u003E\u003Cp\u003EThe brain is inundated with sensory stimuli every waking hour, yet we efficiently extract relevant information to form perceptions and make decisions. The efficient encoding of sensory information necessarily relies on the ability of the pathway to dynamically shift its operating regime, depending on the context under which external stimuli are processed, be it an environmental cue or internal brain state regulation. One embodiment of context-dependent information processing is sensory adaptation, which has been shown to shape the information flow in the sensory pathway and cortical selectivity to stimulus features. Using voltage-sensitive dye imaging in anesthetized rats and the paradigm of detection \/ spatial discrimination task by the ideal observer as a model for context-dependent information processing, I first quantify how adaptation shapes the cortical response to a stimulus in the vibrissa pathway and how the information for detecting and spatially discriminating the stimulus is differentially optimized. I further investigate the effect of adaptation in ethologically relevant contexts. Cortical activation and detection-discrimination tradeoff are quantified in relation to the degree of adaptation, which is modulated continuously by the frequency and velocity of the adapting stimulus. Finally, I will generalize the findings to awake animals and investigate the common effects of adaptation under anesthetized and awake states and potential differences in sensory information processing.\u003Cbr \/\u003E\u003Cbr \/\u003E\u003C\/p\u003E","summary":null,"format":"limited_html"}],"field_subtitle":"","field_summary":[{"value":"\u003Cp\u003EAdaptive Shaping of Cortical Response Selectivity in the Vibrissa \u003Cbr \/\u003EPathway in Awake and Anesthetized States\u003C\/p\u003E","format":"limited_html"}],"field_summary_sentence":[{"value":"Adaptive Shaping of Cortical Response Selectivity in the Vibrissa  Pathway in Awake and Anesthetized States"}],"uid":"27349","created_gmt":"2014-05-01 15:31:34","changed_gmt":"2016-10-08 02:07:42","author":"Floyd Wood","boilerplate_text":"","field_publication":"","field_article_url":"","field_event_time":{"event_time_start":"2014-05-20T15:00:00-04:00","event_time_end":"2014-05-20T18:00:00-04:00","event_time_end_last":"2014-05-20T18:00:00-04:00","gmt_time_start":"2014-05-20 19:00:00","gmt_time_end":"2014-05-20 22:00:00","gmt_time_end_last":"2014-05-20 22:00:00","rrule":null,"timezone":"America\/New_York"},"extras":[],"groups":[{"id":"65448","name":"Bioengineering Graduate Program"}],"categories":[],"keywords":[{"id":"6178","name":"BIOE"},{"id":"569","name":"bioengineering"}],"core_research_areas":[],"news_room_topics":[],"event_categories":[{"id":"1788","name":"Other\/Miscellaneous"}],"invited_audience":[{"id":"78771","name":"Public"}],"affiliations":[],"classification":[],"areas_of_expertise":[],"news_and_recent_appearances":[],"phone":[],"contact":[{"value":"\u003Cp\u003E\u003Cstrong\u003ELaura Paige\u003C\/strong\u003E - \u003Cstrong\u003EAcademic Advisor\u003C\/strong\u003E\u003Cbr \/\u003E 404-385-6655\u003Cbr \/\u003E 404-894-2291 (fax)\u003Cbr \/\u003E \u003Ca href=\u0022mailto:laura.paige@bioengineering.gatech.edu\u0022\u003EEmail \u003C\/a\u003E\u003C\/p\u003E","format":"limited_html"}],"email":[],"slides":[],"orientation":[],"userdata":""}},"233341":{"#nid":"233341","#data":{"type":"event","title":"Integrated Cancer Research Center Seminar Series","body":[{"value":"\u003Cp\u003E\u003Cstrong\u003E\u0022Revealing Tumor Heterogeneity between and within Tumors\u0022\u003Cbr \/\u003E\u003Cbr \/\u003EDana Pe\u0027er, PhD\u003C\/strong\u003E\u003Cbr \/\u003E\u003Cstrong\u003EAssistant Professor\u003C\/strong\u003E\u003Cbr \/\u003E\u003Cstrong\u003EDepartment of Biological Science\u003C\/strong\u003E\u003Cbr \/\u003E\u003Cstrong\u003EColumbia University\u003C\/strong\u003E\u003Cbr \/\u003E\u003Cbr \/\u003EOur lab endeavors to understand the organization, function and evolution of molecular networks. The molecular network needs to sense multiple signals from the environment, robustly process an appropriate cellular response and orchestrate the regulation of hundreds of genes and proteins to execute this response. This remarkable functionality occurs through diverse mechanisms including regulation of transcription, epigenetic changes, translation, degradation, post-translational signaling, and localization The advent of high throughput genomic and proteomic technologies is providing biology with an explosion of new experimental data, quantitatively measuring the molecular workings of the cell at a genome-wide scale.\u003Cbr \/\u003E\u003Cbr \/\u003EHigh throughput datasets are rapidly being produced, probing the diverse facets of the cell\u2019s activity on a genome wide scale.Microarrays provide a global snap shot of gene expression and factor binding under different environmental conditions and stimuli.SNP arrays read up to 500,000 nucleotide polymorphisms in an individual\u2019s genome.Flow cytometry combined with florescent antibodes measure the level and activities of proteins in thousands of individual cells.Small interfering RNA and synthetic biology techniques facilitate the perturbation of the molecular network in a variety of sophisticated ways. Our lab combines high-throughput experimentation along with the development of novel algorithms and computational learning methods to integrate diverse high throughput data and unravel from these the workings of the cell. The computational methodology is used to reconstruct models of the molecular network and these models are then used to elucidate properties of molecular networks, the design principles by which they function, and the forces that drove their evolution.\u003Cbr \/\u003E\u003Cbr \/\u003EThe type of question we ask is \u201cHow does a mutation at one point in the network, propagate through the network and influence signal processing at a more global scale?\u201d A population contains many genetic sequence polymorphisms that lead to variability in the complex web of regulatory interactions between individuals.We study how genetic variation perturbs the regulatory network, leading to changes gene expression and manifesting in phenotypic diversity. We use this approach to ask questions such as: How do changes in the molecular network influence fitness under different environmental conditions? How do changes in the network lead to dysfunctional signal processing, causing human disease such as cancer and autoimmunity?\u003C\/p\u003E","summary":null,"format":"limited_html"}],"field_subtitle":"","field_summary":[{"value":"\u003Cp\u003EIntegrated Cancer Research Seminar Series - Dana Pe\u0027er, PhD, Columbia University\u003C\/p\u003E","format":"limited_html"}],"field_summary_sentence":[{"value":"\u0022Revealing Tumor Heterogeneity between and within Tumors\u0022 - Dana Pe\u0027er, PhD, Columbia University"}],"uid":"27195","created_gmt":"2013-09-03 10:43:40","changed_gmt":"2017-04-13 21:24:01","author":"Colly Mitchell","boilerplate_text":"","field_publication":"","field_article_url":"","field_event_time":{"event_time_start":"2014-02-11T15:00:00-05:00","event_time_end":"2014-02-11T16:00:00-05:00","event_time_end_last":"2014-02-11T16:00:00-05:00","gmt_time_start":"2014-02-11 20:00:00","gmt_time_end":"2014-02-11 21:00:00","gmt_time_end_last":"2014-02-11 21:00:00","rrule":null,"timezone":"America\/New_York"},"extras":[],"related_links":[{"url":"http:\/\/www.columbia.edu\/cu\/biology\/faculty-data\/dana-peer\/faculty.html","title":"Pe\u0027er lab website"},{"url":"http:\/\/www.ibb.gatech.edu\/icrc-seminars","title":"ICRC Seminar Series schedule"},{"url":"http:\/\/www.icrc.gatech.edu\/","title":"Integrated Cancer Research Center website"}],"groups":[{"id":"1292","name":"Parker H. Petit Institute for Bioengineering and Bioscience (IBB)"}],"categories":[],"keywords":[{"id":"248","name":"IBB"},{"id":"52061","name":"ICRC Seminar"}],"core_research_areas":[],"news_room_topics":[],"event_categories":[{"id":"1795","name":"Seminar\/Lecture\/Colloquium"}],"invited_audience":[{"id":"78751","name":"Undergraduate students"},{"id":"78761","name":"Faculty\/Staff"},{"id":"174045","name":"Graduate students"}],"affiliations":[],"classification":[],"areas_of_expertise":[],"news_and_recent_appearances":[],"phone":[],"contact":[{"value":"\u003Cp\u003E\u003Ca href=\u0022mailto:john.mcdonald@biology.gatech.edu\u0022\u003EJohn McDonald, PhD\u003C\/a\u003E\u003C\/p\u003E","format":"limited_html"}],"email":[],"slides":[],"orientation":[],"userdata":""}},"265571":{"#nid":"265571","#data":{"type":"event","title":"Integrated Cancer Research Center Seminar Series","body":[{"value":"\u003Cp\u003E\u003Cstrong\u003E\u0022Dysregulation of Autophagy and Malignant Behavior in Ovarian Cancer\u0022\u003C\/strong\u003E\u003Cbr \/\u003E\u003Cbr \/\u003E\u003Cstrong\u003ECiro Isidoro, MD, PhD\u003C\/strong\u003E\u003Cbr \/\u003E\u003Cstrong\u003EProfessor of Cell and Molecular Pathology\u003C\/strong\u003E\u003Cbr \/\u003E\u003Cstrong\u003ESchool of Sciences and School of Biotechnology\u003C\/strong\u003E\u003Cbr \/\u003E\u003Cstrong\u003EAdjunct Professor of Environmental Medicine\u003C\/strong\u003E\u003Cbr \/\u003E\u003Cstrong\u003ESchool of Medicine\u003C\/strong\u003E\u003Cbr \/\u003E\u003Cstrong\u003EUniversit\u00e0 del Piemonte Orientale \u0022A. Avogadro\u0022\u003C\/strong\u003E\u003Cbr \/\u003E\u003Cbr \/\u003EAutophagy is a cellular process of lysosomal degradation of aged, redundant or abnormal self molecules or organelles. In normal cells, autophagy runs at low basal level to allow macromolecules turnover, and it prevents cell transformation through the constant elimination of pro-oxidant molecules. Autophagy has been implicated in various malignant aspects of cancer, including the resistance of cancer cells to depletion of nutrients, as it occurs in fast growing and insufficiently vascularized tumours, and to chemotherapeutics. Autophagy has also been implicated in cell migration and tumour invasion. Autophagy is regulated by a certain group of oncogenes and tumour suppressor genes and by several microRNAs. Here I present our experimental data supporting the involvement of Autophagy in cell migration and resistance to chemotherapeutic in ovarian cancer, and the role of genetic and epigenetic factors in (dys)-regulation of Autophagy.\u003C\/p\u003E","summary":null,"format":"limited_html"}],"field_subtitle":"","field_summary":[{"value":"\u003Cp\u003EGeorgia Tech has been a leader in the development of collaborative approaches to both cancer diagnostics and therapeutics. The mission of the Integrated Cancer Research Center (ICRC) is to facilitate integration of the diversity of technological, computational, scientific and medical expertise at Georgia Tech and partner institutions in a coordinated effort to develop improved cancer diagnostics and therapeutics.\u003C\/p\u003E","format":"limited_html"}],"field_summary_sentence":[{"value":"\u0022Dysregulation of Autophagy and Malignant Behavior in Ovarian Cancer\u0022 - Ciro Isidoro, MD, PhD - Universit\u00e0 del Piemonte Orientale \u0022A. Avogadro\u0022"}],"uid":"27195","created_gmt":"2014-01-09 15:07:38","changed_gmt":"2017-04-13 21:23:33","author":"Colly Mitchell","boilerplate_text":"","field_publication":"","field_article_url":"","field_event_time":{"event_time_start":"2014-02-13T15:00:00-05:00","event_time_end":"2014-02-13T16:00:00-05:00","event_time_end_last":"2014-02-13T16:00:00-05:00","gmt_time_start":"2014-02-13 20:00:00","gmt_time_end":"2014-02-13 21:00:00","gmt_time_end_last":"2014-02-13 21:00:00","rrule":null,"timezone":"America\/New_York"},"extras":[],"related_links":[{"url":"http:\/\/www.isidorolab.com\/","title":"Isodoro lab website"},{"url":"http:\/\/www.icrc.gatech.edu\/","title":"Integrated Cancer Research Center website"},{"url":"http:\/\/www.ibb.gatech.edu\/icrc-seminars","title":"ICRC Seminar Series schedule"},{"url":"http:\/\/www.ibb.gatech.edu\/","title":"Petit Institute for Bioengineering and Bioscience"}],"groups":[{"id":"1292","name":"Parker H. Petit Institute for Bioengineering and Bioscience (IBB)"},{"id":"65448","name":"Bioengineering Graduate Program"}],"categories":[],"keywords":[{"id":"248","name":"IBB"},{"id":"52061","name":"ICRC Seminar"}],"core_research_areas":[],"news_room_topics":[],"event_categories":[{"id":"1795","name":"Seminar\/Lecture\/Colloquium"}],"invited_audience":[{"id":"78751","name":"Undergraduate students"},{"id":"78761","name":"Faculty\/Staff"},{"id":"174045","name":"Graduate students"}],"affiliations":[],"classification":[],"areas_of_expertise":[],"news_and_recent_appearances":[],"phone":[],"contact":[{"value":"\u003Cp\u003E\u003Ca href=\u0022mailto:john.mcdonald@biology.gatech.edu\u0022\u003EJohn McDonald, PhD\u003C\/a\u003E\u003C\/p\u003E\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E","format":"limited_html"}],"email":[],"slides":[],"orientation":[],"userdata":""}},"236171":{"#nid":"236171","#data":{"type":"event","title":"Stem Cell Engineering Center Seminar Series","body":[{"value":"\u003Cp\u003E\u003Cstrong\u003E\u0022Engineering Biomechanical Cues to Control Stem Cell Fate\u0022\u003Cbr \/\u003E\u003Cbr \/\u003ETaby Ahsan, PhD\u003Cbr \/\u003E\u003C\/strong\u003E\u003Cstrong\u003EAssistant Professor\u003Cbr \/\u003ETulane University\u003C\/strong\u003E\u003C\/p\u003E\u003Cp\u003E\u003Cstrong\u003E\u003Cbr \/\u003E\u003C\/strong\u003ETaby Ahsan, PhD, is an Assistant Professor in the Biomedical Engineering Department at Tulane University and a member of the FDA Cell, Tissues, and Gene Therapies Advisory Council (CTGTAC). She got her B.S.E. degree at the University of Pennsylvania, PhD in Bioengineering with Robert Sah, PhD, at the University of California, San Diego, and completed her postdoctoral training with Robert Nerem, PhD, at Georgia Tech. In addition, Ahsan worked in industry for a few years at the tissue engineering company Advanced Tissue Sciences. The Ahsan research laboratory focuses on using the physical microenvironment to control stem cell fate in the context of tissue engineering and regenerative medicine.\u003C\/p\u003E\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\u003Cp\u003ESuggestions for potential speakers are always welcome, please contact \u003Ca href=\u0022mailto:marissa.cooke@bme.gatech.edu\u0022\u003EMarissa Cooke\u003C\/a\u003E\u003C\/p\u003E","summary":null,"format":"limited_html"}],"field_subtitle":"","field_summary":[{"value":"\u003Cp\u003EThe Stem Cell Engineering Center (SCEC) seminar series showcases enabling technologies and fosters new interdisciplinary and multi-investigator collaborations. The seminars are open to all faculty or trainees interested in stem cell engineering research.\u0026nbsp;\u003C\/p\u003E","format":"limited_html"}],"field_summary_sentence":[{"value":"\u0022Engineering Biomechanical Cues to Control Stem Cell Fate\u0022 - Taby Ahsan, PhD, Tulane University"}],"uid":"27875","created_gmt":"2013-09-11 08:46:34","changed_gmt":"2017-04-13 21:24:00","author":"Marissa Cooke","boilerplate_text":"","field_publication":"","field_article_url":"","field_event_time":{"event_time_start":"2014-02-20T10:00:00-05:00","event_time_end":"2014-02-20T11:00:00-05:00","event_time_end_last":"2014-02-20T11:00:00-05:00","gmt_time_start":"2014-02-20 15:00:00","gmt_time_end":"2014-02-20 16:00:00","gmt_time_end_last":"2014-02-20 16:00:00","rrule":null,"timezone":"America\/New_York"},"extras":[],"hg_media":{"236181":{"id":"236181","type":"image","title":"Taby Ahsan, PhD","body":null,"created":"1449243659","gmt_created":"2015-12-04 15:40:59","changed":"1475894911","gmt_changed":"2016-10-08 02:48:31","alt":"Taby Ahsan, PhD","file":{"fid":"197672","name":"ahsan_photo.jpg","image_path":"\/sites\/default\/files\/images\/ahsan_photo_0.jpg","image_full_path":"http:\/\/www.tlwarc.hg.gatech.edu\/\/sites\/default\/files\/images\/ahsan_photo_0.jpg","mime":"image\/jpeg","size":277746,"path_740":"http:\/\/www.tlwarc.hg.gatech.edu\/sites\/default\/files\/styles\/740xx_scale\/public\/images\/ahsan_photo_0.jpg?itok=xVKR5N3N"}}},"media_ids":["236181"],"related_links":[{"url":"http:\/\/www.tulane.edu\/~tahsan\/","title":"Ahsan Lab website"},{"url":"http:\/\/www.ibb.gatech.edu\/","title":"Petit Institute for Bioengineering and Bioscience"},{"url":"http:\/\/www.scec.gatech.edu\/","title":"SCEC website"},{"url":"http:\/\/www.stemcelligert.gatech.edu\/","title":"Stem Cell Biomanufacturing IGERT"}],"groups":[{"id":"1292","name":"Parker H. Petit Institute for Bioengineering and Bioscience (IBB)"},{"id":"65425","name":"IBB Center - SCEC"},{"id":"65446","name":"IBB Training Grant - Stem Cell Biomanufacturing IGERT"},{"id":"65448","name":"Bioengineering Graduate Program"}],"categories":[],"keywords":[{"id":"248","name":"IBB"},{"id":"167446","name":"SCEC Seminar"}],"core_research_areas":[],"news_room_topics":[],"event_categories":[{"id":"1795","name":"Seminar\/Lecture\/Colloquium"}],"invited_audience":[{"id":"78751","name":"Undergraduate students"},{"id":"78761","name":"Faculty\/Staff"},{"id":"174045","name":"Graduate students"}],"affiliations":[],"classification":[],"areas_of_expertise":[],"news_and_recent_appearances":[],"phone":[],"contact":[{"value":"\u003Cp\u003E\u003Ca href=\u0022mailto:marissa.cooke@bme.gatech.edu\u0022\u003EMarissa Cooke\u003C\/a\u003E\u003C\/p\u003E\u003Cp\u003E\u0026nbsp;(404) 385-6905\u003C\/p\u003E","format":"limited_html"}],"email":[],"slides":[],"orientation":[],"userdata":""}},"269801":{"#nid":"269801","#data":{"type":"event","title":"2014 Suddath Award Winner Presentation","body":[{"value":"\u003Cp\u003E\u003Cstrong\u003E\u0022Understanding the Mechanisms Underlying DSB-induced Mutagenesis at Distant Loci in Yeast\u0022\u003C\/strong\u003E\u003Cbr \/\u003E\u003Cbr \/\u003E\u003Cstrong\u003E 2014 Suddath Award Winner\u003Cbr \/\u003ENatalie Saini\u003Cbr \/\u003EDoctoral Candidate\u003Cbr \/\u003EKirill Lobachev, PhD, Advisor\u003Cbr \/\u003E\u003Cbr \/\u003E\u003C\/strong\u003EAccurate repair of DNA double strand breaks is crucial for the maintenance of genome integrity.\u0026nbsp; At the same time DSB repair can lead to genome rearrangements and mutagenesis, the hallmarks of cancers and hereditary diseases.\u0026nbsp; Break induced replication (BIR) is one of the mechanisms employed to repair DSBs with only one ended homology such as those generated upon the collapse of replication forks and at eroded telomeres.\u0026nbsp; BIR proceeds via invasion of one of the DSB ends into a homologous sequence followed by synthesis of the chromosome arm culminating in a large duplication with a concomitant deletion.\u0026nbsp;\u0026nbsp; Due to the requirement of large scale DNA synthesis and the utilization of almost all DNA replicative proteins, BIR has been considered analogous to the S-phase replication fork.\u0026nbsp; However, the bona fide semiconservative mode of synthesis fails to explain the instabilities inherent to BIR.\u003Cbr \/\u003E\u003Cbr \/\u003EIn this study, we demonstrate that BIR proceeds via an unusual bubble-like replication fork driven by the Pif1 helicase and leading to conservative mode of inheritance for the newly synthesized strands.\u0026nbsp; Additionally, this non-canonical replication fork generates large single-stranded intermediates indicating that during BIR, the leading strand synthesis occurs via a migrating D-loop followed by lagging strand synthesis.\u0026nbsp; The presence of extensive single-strandedness suggests that lagging strand synthesis may not be synchronized with leading strand synthesis.\u0026nbsp; We propose that the structure of the migrating bubble during BIR makes it prone to instabilities including high levels of mutagenesis, increased template switching and generation of half crossovers.\u003C\/p\u003E\u003Cp\u003EThe Parker H. Petit Institute for Bioengineering \u0026amp; Bioscience awards the Suddath Symposium graduate student awards to three students for their grand achievements in biological or biochemical research at the molecular or cellular level.\u0026nbsp; Lauren Austin, advised by Mostafa El-Sayed, PhD, received the 2nd place award in 2014 for her research in nanobiotechnology and Anthony Awojoodu, a doctoral student in the lab of Edward Botchwey, PhD, was recognized for a 3rd place award for his accomplishments in sickle cell disease research.\u003Cbr \/\u003E\u003Cbr \/\u003ELunch to be served immediately following presentation.\u003Cstrong\u003E\u003Cbr \/\u003E\u003C\/strong\u003E\u003C\/p\u003E","summary":null,"format":"limited_html"}],"field_subtitle":"","field_summary":[{"value":"\u003Cp\u003E2014 Suddath Award Winner, Natalie Saini, talks on DNA Repair.\u003C\/p\u003E","format":"limited_html"}],"field_summary_sentence":[{"value":"\u0022Understanding the Mechanisms Underlying DSB-induced Mutagenesis at Distant Loci in Yeast\u0022 - Natalie Saini, Georgia Tech"}],"uid":"27195","created_gmt":"2014-01-21 14:32:57","changed_gmt":"2017-04-13 21:23:24","author":"Colly Mitchell","boilerplate_text":"","field_publication":"","field_article_url":"","field_event_time":{"event_time_start":"2014-02-20T10:30:00-05:00","event_time_end":"2014-02-20T11:30:00-05:00","event_time_end_last":"2014-02-20T11:30:00-05:00","gmt_time_start":"2014-02-20 15:30:00","gmt_time_end":"2014-02-20 16:30:00","gmt_time_end_last":"2014-02-20 16:30:00","rrule":null,"timezone":"America\/New_York"},"extras":[],"related_links":[{"url":"http:\/\/www.biology.gatech.edu\/people\/kirill-lobachev","title":"Kirill Lobachev"},{"url":"http:\/\/ibb.gatech.edu\/suddath-symposium\/suddath-award","title":"Suddath Award info"},{"url":"http:\/\/www.ibb.gatech.edu\/hg_news\/261491","title":"2014 Suddath Award Winner press release"},{"url":"http:\/\/www.ibb.gatech.edu\/suddath-symposium","title":"2013 Suddath Symposium website"}],"groups":[{"id":"1292","name":"Parker H. Petit Institute for Bioengineering and Bioscience (IBB)"},{"id":"65448","name":"Bioengineering Graduate Program"}],"categories":[],"keywords":[{"id":"248","name":"IBB"}],"core_research_areas":[],"news_room_topics":[],"event_categories":[{"id":"1795","name":"Seminar\/Lecture\/Colloquium"}],"invited_audience":[{"id":"78751","name":"Undergraduate students"},{"id":"78761","name":"Faculty\/Staff"},{"id":"174045","name":"Graduate students"}],"affiliations":[],"classification":[],"areas_of_expertise":[],"news_and_recent_appearances":[],"phone":[],"contact":[{"value":"\u003Cp\u003E\u003Ca href=\u0022mailto:colly.mitchell@ibb.gatech.edu\u0022\u003EColly Mitchell\u003C\/a\u003E\u003C\/p\u003E","format":"limited_html"}],"email":[],"slides":[],"orientation":[],"userdata":""}},"216691":{"#nid":"216691","#data":{"type":"event","title":"2014 Suddath Symposium - \u0022DNA Repair \u0026 Human Disease\u0022","body":[{"value":"\u003Cp\u003E\u003Cstrong\u003E22nd Annual Suddath Symposium\u003C\/strong\u003E\u003Cbr \/\u003E\u003Cstrong\u003E\u0022DNA Repair \u0026amp; Human Disease\u003C\/strong\u003E\u0022\u003Cbr \/\u003E\u003Cbr \/\u003EThe Suddath Symposium is held annually to celebrate the life and contribution of F.L. \u0022Bud\u0022 Suddath by discussing the latest developments in the fields of bioengineering and bioscience. The 2014 Suddath Symposium seeks to highlight recent major hurdles and progress in selected key areas of DNA repair.\u003Cbr \/\u003E\u003Cbr \/\u003E\u003Cstrong\u003E2014 Speakers\u003C\/strong\u003E\u003Cbr \/\u003EGang Bao, Georgia Tech \u0026amp; Emory University\u003Cbr \/\u003EGray Crouse, Emory University\u003Cbr \/\u003EPaul Doetsch, Emory University\u003Cbr \/\u003EWilliam Dynan, Emory University \u003Cbr \/\u003EDavid Garfinkel, UGA\u003Cbr \/\u003EWolf-Dietrich Heyer, UC Davis\u003Cbr \/\u003EMaria Jasin, Sloan-Kettering Institute\u003Cbr \/\u003EThomas Kunkel, NIEHS, NIH\u003Cbr \/\u003EKirill Lobachev, Georgia Tech\u003Cbr \/\u003EJohn McDonald, Georgia Tech\u003Cbr \/\u003EThomas Petes, Duke University\u003Cbr \/\u003EMatthew Hirsch, UNC, Chapel Hill\u003Cbr \/\u003EFrancesca Storici, Georgia Tech\u003Cbr \/\u003EKaren Usdin, NIDDKD, NIH\u003Cbr \/\u003EAnne Villeneuve, Stanford University\u003Cbr \/\u003EAlessandro Vindigni, St. Louis University School of Medicine\u003Cbr \/\u003E\u003Cbr \/\u003ESymposium Chairs:\u0026nbsp; \u003Ca href=\u0022mailto:kirill.lobachev@biology.gatech.edu\u0022\u003EKirill Lobachev, PhD\u003C\/a\u003E and \u003Ca href=\u0022mailto:francesca.storici@biology.gatech.edu\u0022\u003EFrancesca Storici, PhD\u003C\/a\u003E\u003Cbr \/\u003E\u003Cbr \/\u003EClick \u003Cstrong\u003E\u003Ca href=\u0022http:\/\/www.ibb.gatech.edu\/suddath-symposium\u0022\u003Ehere\u003C\/a\u003E\u003C\/strong\u003E for complete symposium info\u003Cbr \/\u003E\u003Cbr \/\u003E\u003Cstrong\u003E\u003Ca href=\u0022https:\/\/epay.gatech.edu\/C20793_ustores\/web\/product_detail.jsp?PRODUCTID=1405\u0022\u003ERegistration required\u003C\/a\u003E\u003C\/strong\u003E\u003Cbr \/\u003E\u003Cbr \/\u003E\u003C\/p\u003E","summary":null,"format":"limited_html"}],"field_subtitle":"","field_summary":[{"value":"\u003Cp\u003E22nd Annual Suddath Symposium: \u0022DNA Repair \u0026amp; Human Disease\u0022 - Bringing together leading researchers to discuss recent major hurdles and progress in selected key areas of DNA repair\u003C\/p\u003E","format":"limited_html"}],"field_summary_sentence":[{"value":"Bringing together leading researchers to discuss recent major hurdles and progress in selected key areas of DNA repair"}],"uid":"27195","created_gmt":"2013-06-06 12:19:27","changed_gmt":"2017-04-13 21:24:03","author":"Colly Mitchell","boilerplate_text":"","field_publication":"","field_article_url":"","field_event_time":{"event_time_start":"2014-02-20T11:30:00-05:00","event_time_end":"2014-02-21T15:30:00-05:00","event_time_end_last":"2014-02-21T15:30:00-05:00","gmt_time_start":"2014-02-20 16:30:00","gmt_time_end":"2014-02-21 20:30:00","gmt_time_end_last":"2014-02-21 20:30:00","rrule":null,"timezone":"America\/New_York"},"extras":[],"related_links":[{"url":"http:\/\/www.ibb.gatech.edu\/suddath-symposium","title":"2013 Suddath Symposium website"}],"groups":[{"id":"1292","name":"Parker H. Petit Institute for Bioengineering and Bioscience (IBB)"}],"categories":[],"keywords":[{"id":"248","name":"IBB"},{"id":"167264","name":"Suddath Symposium"}],"core_research_areas":[],"news_room_topics":[],"event_categories":[{"id":"1789","name":"Conference\/Symposium"}],"invited_audience":[{"id":"78751","name":"Undergraduate students"},{"id":"78761","name":"Faculty\/Staff"},{"id":"78771","name":"Public"},{"id":"174045","name":"Graduate students"}],"affiliations":[],"classification":[],"areas_of_expertise":[],"news_and_recent_appearances":[],"phone":[],"contact":[{"value":"\u003Cp\u003E\u003Ca href=\u0022mailto:kirill.lobachev@biology.gatech.edu\u0022\u003EKirill Lobachev, PhD\u003C\/a\u003E - Co-Chair\u003Cbr \/\u003E\u003Ca href=\u0022mailto:francesca.storici@biology.gatech.edu\u0022\u003EFrancesca Storici, PhD\u003C\/a\u003E - Co-Chair\u003Cbr \/\u003E\u003Ca href=\u0022mailto:colly.mitchell@ibb.gatech.edu\u0022\u003EColly Mitchell\u003C\/a\u003E - Symposium administrator\u003C\/p\u003E\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E","format":"limited_html"}],"email":[],"slides":[],"orientation":[],"userdata":""}},"273791":{"#nid":"273791","#data":{"type":"event","title":"PhD Proposal - Jennifer Lei","body":[{"value":"\u003Cp\u003E\u003Cstrong\u003E\u0022Engineering glycosaminoglycan coatings for mesenchymal stem cells-based cartilage tissue repair\u0022\u003C\/strong\u003E\u003Cbr \/\u003E\u003Cbr \/\u003E\u003Cstrong\u003EJennifer Lei\u003Cbr \/\u003EPhD Candidate\u0026nbsp;\u003Cbr \/\u003E\u003Cbr \/\u003E\u003C\/strong\u003E\u003C\/p\u003E\u003Cp\u003EAdvisor: Johnna S. Temenoff, PhD (Georgia Institute of Technology, Emory University)\u003Cbr \/\u003E\u003Cbr \/\u003ECommittee:\u003Cbr \/\u003EEdward A. Botchwey, PhD (Georgia Institute of Technology, Emory University)\u003Cbr \/\u003ERobert Guldberg, PhD (Georgia Institute of Technology)\u003Cbr \/\u003ETodd McDevitt, PhD (Georgia Institute of Technology, Emory University)\u003Cbr \/\u003EWilliam Murphy, PhD (University of Wisconsin-Madison)\u003Cbr \/\u003E\u003Cbr \/\u003EMesenchymal stem cells (MSCs) have been implicated in stem cell therapies for tissue repair and regeneration because of their ability to differentiate into bone, cartilage, muscle, tendon, ligament, fat and other connective tissues, their ability to secrete bioactive molecules with trophic effects and their immunomodulatory properties when aggregated into small spheroids. One limitation of stem cell therapies is that there is minimal control over what soluble factors are being presented to the cells, making in vitro cellular differentiation variable and therefore resulting in a nonhomogeneous population of cell types. A second limitation of stem cell therapies is the loss of MSCs upon injection after 1-2 weeks. Cells are often are delivered with a material vehicle (i.e. scaffold or hydrogel) that facilitates retention at the injury site to prevent cell loss via clearance or dilution into surrounding fluids, however, this introduces extra volume of materials that can limit the number of cells delivered and interfere with defect closure over time.\u003Cbr \/\u003E\u003Cbr \/\u003EThus, the long term goal of this research is to develop an effective MSC-based therapy that maximizes therapeutic potential of cells to regenerate injured cartilage tissue. To achieve this, an injectable platform with sufficient flexibility to address obstacles of degenerated tissue matrix and inflammatory environments in cartilage disease and injury must be established. Therefore, the goal of this project is to implement a multilayer technology that coats MSCs with a molecule that will promote chondrogenic differentiation in vitro or cell retention in an ex vivo cartilage defect site. The rationale for this project is that using these ultrathin surface coatings on MSCs will allow for control over stem cell differentiation down a chondrogenic lineage and retention in a tissue defect site to facilitate integration of delivered cells with surrounding cartilage, ultimately overcoming the previously described limitations. The central hypothesis is that the multilayer coating will facilitate grafting of a negatively charged glycosaminoglycan or a heparin binding peptide sequence onto MSC spheroid surfaces, thus promoting chondrogenic differentiation in vitro and cell retention in cartilage defects.\u003C\/p\u003E\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E","summary":null,"format":"limited_html"}],"field_subtitle":"","field_summary":[{"value":"\u003Cp\u003EPhD Proposal Presentation -\u0026nbsp;\u0022Engineering glycosaminoglycan coatings for mesenchymal stem cells-based cartilage tissue repair\u0022- Jennifer Lei\u003C\/p\u003E\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E","format":"limited_html"}],"field_summary_sentence":[{"value":"\u0022Engineering glycosaminoglycan coatings for mesenchymal stem cells-based cartilage tissue repair\u0022"}],"uid":"27917","created_gmt":"2014-02-04 16:30:53","changed_gmt":"2017-04-13 21:23:15","author":"Laura Paige","boilerplate_text":"","field_publication":"","field_article_url":"","field_event_time":{"event_time_start":"2014-02-26T14:00:00-05:00","event_time_end":"2014-02-26T16:00:00-05:00","event_time_end_last":"2014-02-26T16:00:00-05:00","gmt_time_start":"2014-02-26 19:00:00","gmt_time_end":"2014-02-26 21:00:00","gmt_time_end_last":"2014-02-26 21:00:00","rrule":null,"timezone":"America\/New_York"},"extras":[],"related_links":[{"url":"http:\/\/temenoff.gatech.edu\/","title":"Temenoff Lab website"}],"groups":[{"id":"65448","name":"Bioengineering Graduate Program"}],"categories":[],"keywords":[],"core_research_areas":[],"news_room_topics":[],"event_categories":[{"id":"1788","name":"Other\/Miscellaneous"}],"invited_audience":[{"id":"78751","name":"Undergraduate students"},{"id":"78761","name":"Faculty\/Staff"},{"id":"174045","name":"Graduate students"}],"affiliations":[],"classification":[],"areas_of_expertise":[],"news_and_recent_appearances":[],"phone":[],"contact":[{"value":"\u003Cp\u003E\u003Ca href=\u0022mailto:Laura.Paige@bioengineering.gatech.edu\u0022\u003ELaura Paige\u003C\/a\u003E\u003C\/p\u003E","format":"limited_html"}],"email":[],"slides":[],"orientation":[],"userdata":""}},"269461":{"#nid":"269461","#data":{"type":"event","title":"Georgia ImmunoEngineering Symposium","body":[{"value":"\u003Cp\u003EEmory University and the Georgia Institute for Technology to host the 1st Annual Symposium of the Georgia ImmunoEngineering Consortium (GIEC).\u0026nbsp; \u003Cbr \/\u003E\u003Cbr \/\u003E\u003Cem\u003EFeaturing Key Note Lecture:\u003C\/em\u003E\u003Cbr \/\u003E\u003Cstrong\u003EGeorge Georgiou, PhD\u003C\/strong\u003E\u003Cbr \/\u003E\u003Cstrong\u003EMember NAE IOM\u003C\/strong\u003E\u003Cbr \/\u003E\u003Cstrong\u003ECockrell Family Regents Chair in Engineering\u003C\/strong\u003E\u003Cbr \/\u003E\u003Cstrong\u003EUniversity of Texas at Austin\u003C\/strong\u003E\u003Cbr \/\u003E\u003Cbr \/\u003EWorkshop and sessions to go from 8am-4pm, ending with reception.\u0026nbsp; Detailed agenda to be announced.\u003Cbr \/\u003E\u003Cbr \/\u003E\u003Ca href=\u0022https:\/\/docs.google.com\/forms\/d\/1_KmGuQ50SgyJHXoMUfP3QZp7xWt6MhZz83tiEdQh3LY\/viewform?utm_source=IBB+Update\u0026amp;utm_campaign=6c8ba94ffe-IBB_Update9_30_2011\u0026amp;utm_medium=email\u0026amp;utm_term=0_6079c7ce84-6c8ba94ffe-299230261\u0022\u003ERSVP required\u003C\/a\u003E\u003C\/p\u003E","summary":null,"format":"limited_html"}],"field_subtitle":"","field_summary":[{"value":"\u003Cp\u003EBringing together faculty, students and fellows to discuss the latest research in immunoengineering\u003C\/p\u003E","format":"limited_html"}],"field_summary_sentence":[{"value":"Bringing together faculty, students and fellows to discuss the latest research in immunoengineering"}],"uid":"27195","created_gmt":"2014-01-21 11:39:20","changed_gmt":"2017-04-13 21:23:24","author":"Colly Mitchell","boilerplate_text":"","field_publication":"","field_article_url":"","field_event_time":{"event_time_start":"2014-02-28T07:00:00-05:00","event_time_end":"2014-02-28T15:00:00-05:00","event_time_end_last":"2014-02-28T15:00:00-05:00","gmt_time_start":"2014-02-28 12:00:00","gmt_time_end":"2014-02-28 20:00:00","gmt_time_end_last":"2014-02-28 20:00:00","rrule":null,"timezone":"America\/New_York"},"extras":[],"related_links":[{"url":"https:\/\/docs.google.com\/forms\/d\/1_KmGuQ50SgyJHXoMUfP3QZp7xWt6MhZz83tiEdQh3LY\/viewform?utm_campaign=6c8ba94ffe-IBB_Update9_30_2011\u0026utm_medium=email\u0026utm_source=IBB+Update\u0026utm_term=0_6079c7ce84-6c8ba94ffe-299230261","title":"RSVP and poster submission website"},{"url":"http:\/\/immunoengineering.gatech.edu\/","title":"Immunoengineering website"},{"url":"http:\/\/www.immunoengineering.gatech.edu\/immunoengineering-symposium-2014","title":"Symposium program"}],"groups":[{"id":"1292","name":"Parker H. Petit Institute for Bioengineering and Bioscience (IBB)"}],"categories":[],"keywords":[{"id":"248","name":"IBB"}],"core_research_areas":[],"news_room_topics":[],"event_categories":[{"id":"1789","name":"Conference\/Symposium"}],"invited_audience":[{"id":"78751","name":"Undergraduate students"},{"id":"78761","name":"Faculty\/Staff"},{"id":"174045","name":"Graduate students"}],"affiliations":[],"classification":[],"areas_of_expertise":[],"news_and_recent_appearances":[],"phone":[],"contact":[{"value":"\u003Cp\u003E\u003Ca href=\u0022mailto:krishnendu.roy@bme.gatech.edu\u0022\u003EKrishnendu Roy, PhD\u003C\/a\u003E\u003C\/p\u003E","format":"limited_html"}],"email":[],"slides":[],"orientation":[],"userdata":""}},"260301":{"#nid":"260301","#data":{"type":"event","title":"Bioengineering Seminar Series","body":[{"value":"\u003Cp\u003E\u003Cstrong\u003E\u0022Toward Bioengineering Translation\u0022 \u003Cbr \/\u003E\u003Cbr \/\u003EKyriacos A. Athanasiou, PhD\u003C\/strong\u003E\u003Cbr \/\u003E\u003Cstrong\u003EDistinguished Professor, Chair\u003C\/strong\u003E\u003Cbr \/\u003E\u003Cstrong\u003EDepartment of Biomedical Engineering\u003C\/strong\u003E\u003Cbr \/\u003E\u003Cstrong\u003EUniversity of California, Davis\u003Cbr \/\u003E\u003Cbr \/\u003E\u003C\/strong\u003EThis presentation will cover two different areas: articular cartilage healing and technology translation.\u0026nbsp; Articular cartilage is arguably the tissue most pivotal for motion and overall function.\u0026nbsp; This soft, white tissue that covers the ends of our long bones cannot heal by itself often progressing to osteoarthritis following injury.\u0026nbsp; The demanding biomechanical milieu of a joint, plus cartilage\u2019s relative lack of cells and blood supply, renders this tissue almost unique in its inability to repair adequately.\u0026nbsp; This presentation will describe our group\u0027s efforts toward helping joint cartilages, such as hyaline tissue, knee meniscus, and the TMJ disc, repair themselves via tissue engineering approaches.\u0026nbsp;\u0026nbsp; Central to our efforts is understanding the biomechanical relationships at multiple dimensional levels.\u0026nbsp; Also shown will be some of our latest results using various stem cell sources that indicate that cartilage regeneration is inexorably becoming a tractable problem.\u0026nbsp; The second part of the presentation will be allocated on efforts to commercialize outcomes of our academe-based research. Specific examples and results will be presented to illustrate a specific pathway of commercializing research outcomes.\u003Cbr \/\u003E\u003Cbr \/\u003EKyriacos A. Athanasiou, is a Distinguished Professor of Biomedical Engineering and Orthopaedic Surgery, the Child Family Professor of Engineering, and the Chair of Biomedical Engineering at the University of California Davis.\u0026nbsp; He obtained his PhD in Bioengineering (Mechanical Engineering) from Columbia University in 1989.\u0026nbsp; He has published 280 peer-reviewed papers, five authored books, 12 edited books or journal special issues, and 30 patents.\u0026nbsp; He has also served as president of the Biomedical Engineering Society.\u0026nbsp; Additionally, he is the Editor-in-Chief of the Annals of Biomedical Engineering, the flagship journal of BMES.\u0026nbsp; His list of awards includes the HR Lissner Medal from the American Society of Mechanical Engineers, Nemitsas Prize 2012 (Cyprus\u2019 largest award presented by the President of Cyprus), Distinguished Service Award from BMES, the Wall Street Journal\u2019s 2008 Innovation Award, the Thomas A. Edison Patent Award from ASME, the Hershel Rich Outstanding Invention Award, the Marshal Urist Award for Excellence in Tissue Regeneration Research from the Orthopaedic Research Society, and the Van Mow Medal from ASME.\u0026nbsp; He is a Fellow of BMES, AAAS, AIMBE, and ASME.\u0026nbsp; In addition to his academic interests, he has been involved with effecting the translation of devices and instruments into clinical use and commercialization.\u0026nbsp; \u003Cbr \/\u003E\u003Cbr \/\u003E\u003Ca href=\u0022mailto:robert.nerem@ibb.gatech.edu\u0022\u003EBob Nerem, PhD\u003C\/a\u003E - faculty host\u003C\/p\u003E","summary":null,"format":"limited_html"}],"field_subtitle":"","field_summary":[{"value":"\u003Cp\u003EThe Bioengineering Seminar Series is a joint seminar series between IBB and the BME department. Seminars are held on Tuesdays or Thursdays between 11am-12pm in IBB room 1128 unless otherwise indicated.\u003C\/p\u003E","format":"limited_html"}],"field_summary_sentence":[{"value":"\u0022Toward Bioengineering Translation\u0022 - Kyriacos A. Athanasiou, PhD - University of California, Davis"}],"uid":"27195","created_gmt":"2013-12-11 13:41:44","changed_gmt":"2017-04-13 21:23:43","author":"Colly Mitchell","boilerplate_text":"","field_publication":"","field_article_url":"","field_event_time":{"event_time_start":"2014-03-04T11:00:00-05:00","event_time_end":"2014-03-04T12:00:00-05:00","event_time_end_last":"2014-03-04T12:00:00-05:00","gmt_time_start":"2014-03-04 16:00:00","gmt_time_end":"2014-03-04 17:00:00","gmt_time_end_last":"2014-03-04 17:00:00","rrule":null,"timezone":"America\/New_York"},"extras":[],"hg_media":{"260341":{"id":"260341","type":"image","title":"Kyriacos A. Athanasious, PhD - University of California, Davis","body":null,"created":"1449243987","gmt_created":"2015-12-04 15:46:27","changed":"1475894945","gmt_changed":"2016-10-08 02:49:05","alt":"Kyriacos A. Athanasious, PhD - University of California, Davis","file":{"fid":"198344","name":"athanasiou-small-210x300.jpg","image_path":"\/sites\/default\/files\/images\/athanasiou-small-210x300_0.jpg","image_full_path":"http:\/\/www.tlwarc.hg.gatech.edu\/\/sites\/default\/files\/images\/athanasiou-small-210x300_0.jpg","mime":"image\/jpeg","size":13477,"path_740":"http:\/\/www.tlwarc.hg.gatech.edu\/sites\/default\/files\/styles\/740xx_scale\/public\/images\/athanasiou-small-210x300_0.jpg?itok=QvwaVcbq"}}},"media_ids":["260341"],"related_links":[{"url":"http:\/\/ibb.gatech.edu\/bioe-seminars","title":"BIOE Seminar Series schedule"},{"url":"http:\/\/www.bme.ucdavis.edu\/athanasioulab\/","title":"Athanasiou lab"}],"groups":[{"id":"1292","name":"Parker H. Petit Institute for Bioengineering and Bioscience (IBB)"},{"id":"65448","name":"Bioengineering Graduate Program"}],"categories":[],"keywords":[{"id":"11877","name":"BioE Seminar"},{"id":"248","name":"IBB"}],"core_research_areas":[],"news_room_topics":[],"event_categories":[{"id":"1795","name":"Seminar\/Lecture\/Colloquium"}],"invited_audience":[{"id":"78751","name":"Undergraduate students"},{"id":"78761","name":"Faculty\/Staff"},{"id":"174045","name":"Graduate students"}],"affiliations":[],"classification":[],"areas_of_expertise":[],"news_and_recent_appearances":[],"phone":[],"contact":[{"value":"\u003Cp\u003E\u003Ca href=\u0022mailto:james.godard@ibb.gatech.edu\u0022\u003EJames Godard\u003C\/a\u003E\u003C\/p\u003E","format":"limited_html"}],"email":[],"slides":[],"orientation":[],"userdata":""}},"270751":{"#nid":"270751","#data":{"type":"event","title":"BioEngineering Graduate Committee Meeting","body":[{"value":"\u003Cp\u003EThe BioEngineering Graduate Committee will meet to review\/approve program policies, program faculty applications and submitted student peitions.\u003C\/p\u003E","summary":null,"format":"limited_html"}],"field_subtitle":"","field_summary":[{"value":"\u003Cp\u003EThe BioEngineering graduate committee will meet to review\/approve program policies, program faculty applications and submitted student petitions.\u003C\/p\u003E","format":"limited_html"}],"field_summary_sentence":[{"value":"Programs policies, faculty applications and student petitions to be discussed"}],"uid":"27917","created_gmt":"2014-01-23 14:49:26","changed_gmt":"2017-04-13 21:23:21","author":"Laura Paige","boilerplate_text":"","field_publication":"","field_article_url":"","field_event_time":{"event_time_start":"2014-03-05T12:00:00-05:00","event_time_end":"2014-03-05T13:00:00-05:00","event_time_end_last":"2014-03-05T13:00:00-05:00","gmt_time_start":"2014-03-05 17:00:00","gmt_time_end":"2014-03-05 18:00:00","gmt_time_end_last":"2014-03-05 18:00:00","rrule":null,"timezone":"America\/New_York"},"extras":[],"related_links":[{"url":"http:\/\/bioengineering.gatech.edu\/","title":"BIOE program"}],"groups":[{"id":"65448","name":"Bioengineering Graduate Program"}],"categories":[],"keywords":[],"core_research_areas":[],"news_room_topics":[],"event_categories":[{"id":"1788","name":"Other\/Miscellaneous"}],"invited_audience":[{"id":"78751","name":"Undergraduate students"},{"id":"174045","name":"Graduate students"}],"affiliations":[],"classification":[],"areas_of_expertise":[],"news_and_recent_appearances":[],"phone":[],"contact":[{"value":"\u003Cp\u003E\u003Ca href=\u0022mailto:Laura.Paige@bioengineering.gatech.edu\u0022\u003ELaura Paige\u003C\/a\u003E\u003C\/p\u003E","format":"limited_html"}],"email":[],"slides":[],"orientation":[],"userdata":""}},"261671":{"#nid":"261671","#data":{"type":"event","title":"BioEngineering Program Faculty Meeting","body":[{"value":"\u003Cp\u003EThe BioEngineering Program faculty meet to address program policies, events and future research and academic directions.\u0026nbsp; \u003Cbr \/\u003E\u003Cbr \/\u003ELunch will be served.\u0026nbsp; \u003Cbr \/\u003EPlease RSVP to \u003Ca href=\u0022mailto:laura.paige@bioengineering.gatech.edu\u0022\u003ELaura Paige\u003C\/a\u003E.\u003C\/p\u003E","summary":null,"format":"limited_html"}],"field_subtitle":"","field_summary":[{"value":"\u003Cp\u003EThe BioEngineering Program faculty meet regularly during the semester to address program policies, events and future research and academic directions.\u003C\/p\u003E","format":"limited_html"}],"field_summary_sentence":[{"value":"Program policies, events and directions to be discussed"}],"uid":"27349","created_gmt":"2013-12-17 14:18:49","changed_gmt":"2016-10-08 02:06:02","author":"Floyd Wood","boilerplate_text":"","field_publication":"","field_article_url":"","field_event_time":{"event_time_start":"2014-03-07T10:00:00-05:00","event_time_end":"2014-03-07T11:00:00-05:00","event_time_end_last":"2014-03-07T11:00:00-05:00","gmt_time_start":"2014-03-07 15:00:00","gmt_time_end":"2014-03-07 16:00:00","gmt_time_end_last":"2014-03-07 16:00:00","rrule":null,"timezone":"America\/New_York"},"extras":[],"groups":[{"id":"65448","name":"Bioengineering Graduate Program"}],"categories":[],"keywords":[{"id":"6178","name":"BIOE"},{"id":"5805","name":"Bioegineering"}],"core_research_areas":[],"news_room_topics":[],"event_categories":[{"id":"1788","name":"Other\/Miscellaneous"}],"invited_audience":[{"id":"78761","name":"Faculty\/Staff"}],"affiliations":[],"classification":[],"areas_of_expertise":[],"news_and_recent_appearances":[],"phone":[],"contact":[],"email":[],"slides":[],"orientation":[],"userdata":""}},"226371":{"#nid":"226371","#data":{"type":"event","title":"Bioengineering Seminar Series","body":[{"value":"\u003Cp\u003E\u003Cstrong\u003E\u0022Biomaterials for Cell Transplantation and Drug Delivery for the Treatment of Nerve Injury\u0022\u003Cbr \/\u003E\u003Cbr \/\u003EShelly Sakiyama-Elbert, \u003C\/strong\u003E\u003Cstrong\u003EPhD\u003C\/strong\u003E \u003Cbr \/\u003E\u003Cstrong\u003EProfessor \u0026amp; Associate Chair\u003C\/strong\u003E\u003Cbr \/\u003E\u003Cstrong\u003EWashington University\u003C\/strong\u003E\u003Cbr \/\u003E\u003Cbr \/\u003EThe development of biomaterials to serve as scaffolds for wound healing and tissue repair is crucial for successful tissue engineering. My research focuses on developing biomaterials that promote cell survival and\/or differentiation after transplantation for the treatment of nerve injury.\u0026nbsp; My lab has developed heparin-binding affinity-based drug delivery systems that sequester growth factors within scaffolds and release growth factors in response to cell in-growth during tissue regeneration.\u0026nbsp; More recently we have combined these scaffolds with embryonic stem cell-derived neural progenitor cells and shown that the combination of fibrin scaffolds and growth factor delivery can enhance cell survival and differentiation of neural progenitor cells transplanted after spinal cord injury.\u0026nbsp; Furthermore, we demonstrated this approach enhanced functional recovery after spinal cord injury, as assessed by gridwalk.\u0026nbsp; In conclusion, fibrin scaffold containing our drug delivery system can serve as a platform for cell transplantation for many applications in regenerative medicine by tailoring the choice of growth factors and the cell type used. \u0026nbsp;\u003Cbr \/\u003E\u003Cbr \/\u003ESakiyama-Elbert\u0027s research is highly interdisciplinary, combining an understanding of biology, chemistry, and biomedical engineering to develop new bioactive materials, which can enhance wound healing and tissue regeneration.\u003Cbr \/\u003E\u0026nbsp;\u003Cbr \/\u003EHer research is currently funded by the NIH and focuses on developing biomaterials scaffolds for drug delivery and stem cell transplantation to treat peripheral nerve and spinal cord injuries.\u003Cbr \/\u003E\u003Cbr \/\u003EIn 2000, Sakiyama-Elbert joined the faculty at Washington University in St. Louis. She is a member of the Center for Materials Innovation and the Hope Center for Neurological Disorders.\u003Cbr \/\u003E\u003Cbr \/\u003E\u003Ca href=\u0022mailto:andres.garcia@me.gatech.edu\u0022\u003EAndr\u00e9s Garc\u00eda, PhD\u003C\/a\u003E - faculty host\u003Ca href=\u0022mailto:andres.garcia@me.gatech.edu\u0022\u003E\u003Cbr \/\u003E\u003C\/a\u003E\u003C\/p\u003E","summary":null,"format":"limited_html"}],"field_subtitle":"","field_summary":[{"value":"\u003Cp\u003EThe Bioengineering Seminar Series is a joint seminar series between Petit Institute and the Wallace H. Coulter Department of Biomedical Engineering. Seminars\u0026nbsp;are held on Tuesdays or Thursdays between 11am-12pm in Petit Institute 1128 unless otherwise indicated.\u003C\/p\u003E","format":"limited_html"}],"field_summary_sentence":[{"value":"\u0022Biomaterials for Cell Transplantation and Drug Delivery for the Treatment of Nerve Injury\u0022 - Shelly Sakiyama-Elbert, PhD - Washington University"}],"uid":"27691","created_gmt":"2013-08-02 15:54:49","changed_gmt":"2017-04-13 21:24:01","author":"Karen Cannon","boilerplate_text":"","field_publication":"","field_article_url":"","field_event_time":{"event_time_start":"2014-02-06T10:00:00-05:00","event_time_end":"2014-02-06T11:00:00-05:00","event_time_end_last":"2014-02-06T11:00:00-05:00","gmt_time_start":"2014-02-06 15:00:00","gmt_time_end":"2014-02-06 16:00:00","gmt_time_end_last":"2014-02-06 16:00:00","rrule":null,"timezone":"America\/New_York"},"extras":[],"hg_media":{"226441":{"id":"226441","type":"image","title":"Sakiyama-Elbert","body":null,"created":"1449243566","gmt_created":"2015-12-04 15:39:26","changed":"1475894899","gmt_changed":"2016-10-08 02:48:19","alt":"Sakiyama-Elbert","file":{"fid":"197433","name":"sakiyama.jpg","image_path":"\/sites\/default\/files\/images\/sakiyama_0.jpg","image_full_path":"http:\/\/www.tlwarc.hg.gatech.edu\/\/sites\/default\/files\/images\/sakiyama_0.jpg","mime":"image\/jpeg","size":71838,"path_740":"http:\/\/www.tlwarc.hg.gatech.edu\/sites\/default\/files\/styles\/740xx_scale\/public\/images\/sakiyama_0.jpg?itok=XA_j_-fn"}},"141991":{"id":"141991","type":"image","title":"Bioengineering Seminar Series","body":null,"created":"1449178723","gmt_created":"2015-12-03 21:38:43","changed":"1475894774","gmt_changed":"2016-10-08 02:46:14","alt":"Bioengineering Seminar Series","file":{"fid":"194960","name":"website-graphic.png","image_path":"\/sites\/default\/files\/images\/website-graphic_0.png","image_full_path":"http:\/\/www.tlwarc.hg.gatech.edu\/\/sites\/default\/files\/images\/website-graphic_0.png","mime":"image\/png","size":334882,"path_740":"http:\/\/www.tlwarc.hg.gatech.edu\/sites\/default\/files\/styles\/740xx_scale\/public\/images\/website-graphic_0.png?itok=IXDOvvwR"}}},"media_ids":["226441","141991"],"related_links":[{"url":"http:\/\/engineering.wustl.edu\/facultybio.aspx?faculty=437","title":"Sakiyama-Elbert Profile"},{"url":"http:\/\/www.ibb.gatech.edu\/bioe-seminars","title":"BIOE Seminar Series schedule"}],"groups":[{"id":"1292","name":"Parker H. Petit Institute for Bioengineering and Bioscience (IBB)"},{"id":"65448","name":"Bioengineering Graduate Program"}],"categories":[],"keywords":[{"id":"11877","name":"BioE Seminar"},{"id":"36591","name":"Bioengeneering Seminar Series"},{"id":"248","name":"IBB"},{"id":"167812","name":"Shelly Sakiyama-Elbert"}],"core_research_areas":[],"news_room_topics":[],"event_categories":[{"id":"1795","name":"Seminar\/Lecture\/Colloquium"}],"invited_audience":[{"id":"78751","name":"Undergraduate students"},{"id":"78761","name":"Faculty\/Staff"},{"id":"174045","name":"Graduate students"}],"affiliations":[],"classification":[],"areas_of_expertise":[],"news_and_recent_appearances":[],"phone":[],"contact":[{"value":"\u003Cp\u003E\u003Ca href=\u0022mailto:andres.garcia@me.gatech.edu\u0022\u003EAndr\u00e9s Garc\u00eda, PhD\u003C\/a\u003E\u0026nbsp; - faculty host\u003C\/p\u003E\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E","format":"limited_html"}],"email":[],"slides":[],"orientation":[],"userdata":""}},"274531":{"#nid":"274531","#data":{"type":"event","title":"MS Thesis Defense - Brian Jun","body":[{"value":"\u003Cp\u003E\u003Cstrong\u003E\u0022In vitro Micro Particle Image Velocimetry Measurements in the Hinge Region of a Bileaflet Mechanical Heart Valve\u0022\u003C\/strong\u003E\u003Cbr \/\u003E\u003Cbr \/\u003E\u003Cstrong\u003EBrian Jun\u003C\/strong\u003E\u003Cbr \/\u003E\u003Cstrong\u003EMasters candidate\u003C\/strong\u003E\u003Cbr \/\u003E\u003Cbr \/\u003EAdvisor: Ajit P. Yoganathan, PhD, Georgia Institute of Technology\u003Cbr \/\u003E\u003Cbr \/\u003ECommittee Members:\u003Cbr \/\u003EDon Giddens, PhD, Georgia Institute of Technology\u003Cbr \/\u003EBrandon Dixon, PhD, Georgia Institute of Technology\u003C\/p\u003E\u003Cp\u003E\u003Cbr \/\u003EA number of clinical, in vitro and computational studies have shown the potential for thromboembolic complications in bileaflet mechanical heart valves (BMHV), primarily due to the complex and unsteady flows in the valve hinges. These studies have focused on quantitative and qualitative parameters such as velocity magnitude, turbulent shear stresses, vortex formation and platelet activation to identify potential for blood damage. However, experimental characterization of the whole flow fields within the valve hinges has not yet been conducted. This information can be utilized to investigate instantaneous damage to blood elements and also to validate numerical studies focusing on the hinge\u2019s complex fluid dynamics. The objective of this study was therefore to develop a high-resolution imaging system to characterize the flow fields and global velocity maps in a BMHV hinge. Subsequently, the present study investigated the effect of hinge gap width on flow fields in SJM BMHV. The results from this study suggest that the BMHV hinge design is a delicate balance between reduction of fluid shear stresses and areas of flow stasis during leakage flow, and needs to be optimized to ensure minimal thromboembolic complications. Overall, the current study demonstrates the ability of high-resolution \u00b5PIV to assess the fluid flow fields within the hinges of bileaflet mechanical heart valves, which can be extended to investigate micro-scale flow domains in critical regions of other cardiovascular devices to assess their blood damage potential.\u003C\/p\u003E","summary":null,"format":"limited_html"}],"field_subtitle":"","field_summary":[{"value":"\u003Cp\u003EMS Thesis Defense-\u0026nbsp;\u0022In vitro Micro Particle Image Velocimetry Measurements in the Hinge Region of a Bileaflet Mechanical Heart Valve\u0022- Brian Jun\u003C\/p\u003E","format":"limited_html"}],"field_summary_sentence":[{"value":"\u0022In vitro Micro Particle Image Velocimetry Measurements in the Hinge Region of a Bileaflet Mechanical Heart Valve\u0022- Brian Jun"}],"uid":"27917","created_gmt":"2014-02-06 12:45:32","changed_gmt":"2017-04-13 21:23:12","author":"Laura Paige","boilerplate_text":"","field_publication":"","field_article_url":"","field_event_time":{"event_time_start":"2014-02-13T09:00:00-05:00","event_time_end":"2014-02-13T11:00:00-05:00","event_time_end_last":"2014-02-13T11:00:00-05:00","gmt_time_start":"2014-02-13 14:00:00","gmt_time_end":"2014-02-13 16:00:00","gmt_time_end_last":"2014-02-13 16:00:00","rrule":null,"timezone":"America\/New_York"},"extras":[],"related_links":[{"url":"http:\/\/groups.bme.gatech.edu\/groups\/cfmg\/group\/home.htm","title":"Yoganathan lab"}],"groups":[{"id":"65448","name":"Bioengineering Graduate Program"}],"categories":[],"keywords":[],"core_research_areas":[],"news_room_topics":[],"event_categories":[{"id":"1788","name":"Other\/Miscellaneous"}],"invited_audience":[{"id":"78751","name":"Undergraduate students"},{"id":"78761","name":"Faculty\/Staff"},{"id":"174045","name":"Graduate students"}],"affiliations":[],"classification":[],"areas_of_expertise":[],"news_and_recent_appearances":[],"phone":[],"contact":[{"value":"\u003Cp\u003E\u003Ca href=\u0022mailto:laura.paige@bioengineering.gatech.edu\u0022\u003ELaura Paige\u003C\/a\u003E\u003C\/p\u003E","format":"limited_html"}],"email":[],"slides":[],"orientation":[],"userdata":""}},"252481":{"#nid":"252481","#data":{"type":"event","title":"Breakfast Club Seminar Series","body":[{"value":"\u003Cp\u003E\u003Cstrong\u003E\u0022Making Sense of Muscle Activity in Sensorimotor Deficits: A Neuromechanical Approach\u0022\u003Cbr \/\u003E\u003Cbr \/\u003ELena Ting, PhD\u003C\/strong\u003E\u003Cbr \/\u003E\u003Cstrong\u003EAssociate Professor\u003C\/strong\u003E\u003Cbr \/\u003E\u003Cstrong\u003EWallace H. Coulter Dept. of Biomedical Engineering\u003C\/strong\u003E\u003Cbr \/\u003E\u003Cstrong\u003EEmory University \u0026amp; Georgia Institute of Technology\u003Cbr \/\u003E\u003Cbr \/\u003E\u003C\/strong\u003ENeuromechanics is the study of the interactions between the nervous system and the musculoskeletal system that lead to coordinated movements. We study neuromechanical influences on muscle coordination during balance and locomotion. We are developing experiments and computational models to understand spatial and temporal features of muscle coordination. We use techniques from neuroscience, biomechanics, kinesiology, signal processing, control systems, physiology, and image processing. This work will allow us to better characterize and model normal and impaired performance of fundamental motor tasks. Our findings influence the development of rehabilitation techniques, neural prosthetics, and neural tissue engineering to improve motor function.\u003C\/p\u003E","summary":null,"format":"limited_html"}],"field_subtitle":"","field_summary":[{"value":"\u003Cp\u003EThe Petit Institute Breakfast Club seminar series was started with the spirit of the Institute\u0027s interdisciplinary mission in mind and started to feature local Petit Institute faculty member\u0027s research in a seminar format. Faculty are often asked to speak at other universities and conferences, but rarely present at their home institution, this seminar series is an attempt to close that gap. The Petit Institute Breakfast Club is open to anyone in the bio-community.\u003C\/p\u003E","format":"limited_html"}],"field_summary_sentence":[{"value":"\u0022Making Sense of Muscle Activity in Sensorimotor Deficits: A Neuromechanical Approach\u0022 - Lena Ting, PhD - Emory University \u0026 Georgia Tech"}],"uid":"27195","created_gmt":"2013-11-08 15:06:43","changed_gmt":"2017-04-13 21:23:55","author":"Colly Mitchell","boilerplate_text":"","field_publication":"","field_article_url":"","field_event_time":{"event_time_start":"2014-03-11T09:30:00-04:00","event_time_end":"2014-03-11T10:30:00-04:00","event_time_end_last":"2014-03-11T10:30:00-04:00","gmt_time_start":"2014-03-11 13:30:00","gmt_time_end":"2014-03-11 14:30:00","gmt_time_end_last":"2014-03-11 14:30:00","rrule":null,"timezone":"America\/New_York"},"extras":[],"hg_media":{"70917":{"id":"70917","type":"image","title":"Breakfast Club Seminar Series","body":null,"created":"1449177328","gmt_created":"2015-12-03 21:15:28","changed":"1475894625","gmt_changed":"2016-10-08 02:43:45","alt":"Breakfast Club Seminar Series","file":{"fid":"193471","name":"logobldg_graphic.png","image_path":"\/sites\/default\/files\/images\/logobldg_graphic_0.png","image_full_path":"http:\/\/www.tlwarc.hg.gatech.edu\/\/sites\/default\/files\/images\/logobldg_graphic_0.png","mime":"image\/png","size":241588,"path_740":"http:\/\/www.tlwarc.hg.gatech.edu\/sites\/default\/files\/styles\/740xx_scale\/public\/images\/logobldg_graphic_0.png?itok=x84xf3Mz"}}},"media_ids":["70917"],"related_links":[{"url":"https:\/\/neurolab.gatech.edu\/labs\/ting","title":"Ting lab"},{"url":"http:\/\/www.ibb.gatech.edu\/breakfast-club","title":"IBB Breakfast Club"}],"groups":[{"id":"1292","name":"Parker H. Petit Institute for Bioengineering and Bioscience (IBB)"},{"id":"65448","name":"Bioengineering Graduate Program"}],"categories":[],"keywords":[{"id":"11879","name":"BK Club"},{"id":"248","name":"IBB"}],"core_research_areas":[],"news_room_topics":[],"event_categories":[{"id":"1795","name":"Seminar\/Lecture\/Colloquium"}],"invited_audience":[{"id":"78751","name":"Undergraduate students"},{"id":"78761","name":"Faculty\/Staff"},{"id":"174045","name":"Graduate students"}],"affiliations":[],"classification":[],"areas_of_expertise":[],"news_and_recent_appearances":[],"phone":[],"contact":[{"value":"\u003Cp\u003E\u003Ca href=\u0022mailto:colly.mitchell@ibb.gatech.edu\u0022\u003EColly Mitchell\u003C\/a\u003E\u003C\/p\u003E","format":"limited_html"}],"email":[],"slides":[],"orientation":[],"userdata":""}},"272431":{"#nid":"272431","#data":{"type":"event","title":"PhD Defense - Archana V Boopathy","body":[{"value":"\u003Cp\u003E\u003Cstrong\u003EEngineering Stem Cell Responses using Oxidative Stress and Notch Ligand Containing Hydrogels\u003C\/strong\u003E\u003C\/p\u003E\u003Cp\u003EAdvisor: Dr. Michael E Davis, Associate Professor, Emory University\u003C\/p\u003E\u003Cp\u003ECommittee Members:\u003Cbr \/\u003EDr. Andres Garcia, Department of Mechanical Engineering, Georgia Institute of Technology\u003Cbr \/\u003EDr. Hanjoong Jo, Department of Medicine, Emory University\u003Cbr \/\u003EDr. Manu Platt, Department of Biomedical Engineering, Georgia Institute of Technology\u003Cbr \/\u003EDr. Khalid Salaita, Department of Chemistry, Emory University\u003Cbr \/\u003E\u0026nbsp;\u003Cbr \/\u003EHeart failure is the leading cause of death worldwide.\u0026nbsp;\u0026nbsp; In 2013, the American Heart Association estimated that one American will die of cardiovascular disease every 39 seconds.\u0026nbsp; While heart transplantation is the most viable treatment option, the limited availability of donor hearts has necessitated the search for treatment alternatives such as the use of adult stem cells for cardiac repair and regeneration.\u0026nbsp; Following myocardial infarction (MI), the inflammatory cardiac microenvironment, limited survival of stem\/progenitor cells, myocardial scarring and fibrosis affect cardiac regeneration.\u0026nbsp; This dissertation examines adult stem cell based approaches for cardiac regeneration by studying the effect of i) H2O2- mediated oxidative stress on mesenchymal stem cells, ii) Notch1 activation in cardiac progenitor cells using a self-assembling peptide hydrogel containing the Notch1 ligand mimic RJ in vitro and functional consequences in a rat model of MI. \u003Cbr \/\u003E\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp; Through these approaches, the central hypothesis that modulation of stem cell response using cues such as oxidative stress and activation of Notch1 signaling can improve functional outcome following myocardial infarction has been studied.\u003C\/p\u003E","summary":null,"format":"limited_html"}],"field_subtitle":"","field_summary":[{"value":"\u003Cp\u003EEngineering Stem Cell Responses using Oxidative Stress and Notch Ligand Containing Hydrogels\u003C\/p\u003E","format":"limited_html"}],"field_summary_sentence":[{"value":"Engineering Stem Cell Responses using Oxidative Stress and Notch Ligand Containing Hydrogels"}],"uid":"27349","created_gmt":"2014-01-31 11:08:03","changed_gmt":"2017-04-13 21:23:17","author":"Floyd Wood","boilerplate_text":"","field_publication":"","field_article_url":"","field_event_time":{"event_time_start":"2014-02-07T14:00:00-05:00","event_time_end":"2014-02-07T17:00:00-05:00","event_time_end_last":"2014-02-07T17:00:00-05:00","gmt_time_start":"2014-02-07 19:00:00","gmt_time_end":"2014-02-07 22:00:00","gmt_time_end_last":"2014-02-07 22:00:00","rrule":null,"timezone":"America\/New_York"},"extras":[],"groups":[{"id":"65448","name":"Bioengineering Graduate Program"}],"categories":[],"keywords":[{"id":"6178","name":"BIOE"}],"core_research_areas":[],"news_room_topics":[],"event_categories":[{"id":"1791","name":"Student sponsored"}],"invited_audience":[{"id":"78751","name":"Undergraduate students"},{"id":"174045","name":"Graduate students"}],"affiliations":[],"classification":[],"areas_of_expertise":[],"news_and_recent_appearances":[],"phone":[],"contact":[],"email":[],"slides":[],"orientation":[],"userdata":""}},"278741":{"#nid":"278741","#data":{"type":"event","title":"2014 BioEngineering Graduate Recruiting Day","body":[{"value":"\u003Cp\u003EWe are delighted to host BioEngineering Graduate recruits from across the country, and have planned an exciting day to include faculty interviews, student panels as well as research and training grant presentations. All BioEngineering faculty and students will be available to meet with prospective students for faculty interviews and a planned graduate student panel.\u003Cbr \/\u003E\u003Cbr \/\u003EIf you are a prospective student, please click on the the following link to provide your information: \u003Ca href=\u0022http:\/\/bioengineering.gatech.edu\/bioe-new-student-research-interest-form\u0022\u003EBioE New Student Interest Form\u003C\/a\u003E\u003C\/p\u003E\u003Ch6\u003E\u003Cstrong\u003E\u003Cbr \/\u003EAGENDA\u003Cbr \/\u003E\u003C\/strong\u003E\u003C\/h6\u003E\u003Cp\u003E\u003Cstrong\u003EThursday, March 13, 2014\u003C\/strong\u003E\u003Cbr \/\u003E5pm - 6:30pm - All welcomed! BioE Social at the Georgia Tech Hotel in the lobby restaurant \u003Cbr \/\u003E\u003Cbr \/\u003E\u003Cstrong\u003EFriday, March 14, 2014\u003C\/strong\u003E\u003Cbr \/\u003E9am - BME prospective students meet in hotel lobby to be escorted by current BioEs to GT\u003Cbr \/\u003E\u003Cbr \/\u003E9:20am - ECE \u0026amp; ME prospective students picked up by BioEs\u003Cbr \/\u003E\u003Cbr \/\u003E9:30am - BioE Overview - Petit Institute 1128 - Andr\u00e9s Garc\u00eda, PhD, Director, Bioengineering Program\u003Cbr \/\u003E\u003Cbr \/\u003E10:30am - Q\u0026amp;A with current BioEs - Petit Institute 1128\u003Cbr \/\u003E\u003Cbr \/\u003E11am -1pm - Lunch \u0026amp; Poster Session showcasing labs - Petit Institute Atrium\u003Cbr \/\u003E\u003Cbr \/\u003E1pm- 5pm Faculty Interviews \u003Cbr \/\u003E\u003Cbr \/\u003E5:30pm - BioE social at the \u003Ca href=\u0022http:\/\/pricklypearatlanta.com\/\u0022\u003EPrickly Pear\u003C\/a\u003E\u003C\/p\u003E\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E","summary":null,"format":"limited_html"}],"field_subtitle":"","field_summary":[{"value":"\u003Cp\u003EWe are delighted to host BioEngineering Graduate recruits from across the country, and have planned an exciting day to include faculty interviews, student panels as well as research and training grant presentations. All BioEngineering faculty and students will be available to meet with prospective students for faculty interviews and a planned graduate student panel.\u003Cbr \/\u003E\u003Cbr \/\u003E\u003C\/p\u003E","format":"limited_html"}],"field_summary_sentence":[{"value":"The Interdisciplinary BioEngineering Graduate program welcomes prospective students to campus."}],"uid":"27349","created_gmt":"2014-02-24 17:52:46","changed_gmt":"2017-04-13 21:23:04","author":"Floyd Wood","boilerplate_text":"","field_publication":"","field_article_url":"","field_event_time":{"event_time_start":"2014-03-14T14:30:00-04:00","event_time_end":"2014-03-15T00:00:00-04:00","event_time_end_last":"2014-03-15T00:00:00-04:00","gmt_time_start":"2014-03-14 18:30:00","gmt_time_end":"2014-03-15 04:00:00","gmt_time_end_last":"2014-03-15 04:00:00","rrule":null,"timezone":"America\/New_York"},"extras":[],"related_links":[{"url":"http:\/\/www.bioengineering.gatech.edu\/","title":"BioEngineering website"}],"groups":[{"id":"1292","name":"Parker H. Petit Institute for Bioengineering and Bioscience (IBB)"},{"id":"65448","name":"Bioengineering Graduate Program"}],"categories":[],"keywords":[{"id":"6178","name":"BIOE"},{"id":"569","name":"bioengineering"}],"core_research_areas":[],"news_room_topics":[],"event_categories":[{"id":"1788","name":"Other\/Miscellaneous"}],"invited_audience":[{"id":"78751","name":"Undergraduate students"},{"id":"174045","name":"Graduate students"}],"affiliations":[],"classification":[],"areas_of_expertise":[],"news_and_recent_appearances":[],"phone":[],"contact":[{"value":"\u003Cp\u003E\u003Ca href=\u0022mailto:laura.paige@bioengineering.gatech.edu\u0022\u003ELaura Paige\u003C\/a\u003E\u003C\/p\u003E","format":"limited_html"}],"email":[],"slides":[],"orientation":[],"userdata":""}},"282631":{"#nid":"282631","#data":{"type":"event","title":"PhD Defense - Song Seto","body":[{"value":"\u003Cp\u003E\u003Cstrong\u003EThe Development of Heparin-Based Materials to Treat Rotator Cuff Tendon Injuries\u003C\/strong\u003E\u003C\/p\u003E\u003Cp\u003E\u003Cstrong\u003EAdvisor:\u003C\/strong\u003E Johnna S. Temenoff, Ph.D. (Georgia Tech\/Emory University)\u003C\/p\u003E\u003Cp\u003E\u003Cstrong\u003ECommittee:\u003C\/strong\u003E\u003Cbr \/\u003ERobert E. Guldberg, Ph.D. (Georgia Tech)\u003Cbr \/\u003EAlexandra Peister, Ph.D. (Morehouse College)\u003Cbr \/\u003EManu O. Platt, Ph.D. (Georgia Tech\/Emory University)\u003Cbr \/\u003EAnthanassios Sambanis, Ph.D. (Georgia Tech)\u003Cbr \/\u003E\u0026nbsp;\u003Cbr \/\u003EThe supraspinatus tendon of the rotator cuff is commonly injured due to highly repetitive work and can predispose the tendon to rupture. While surgery can alleviate symptomatic shoulder dysfunction after tendon rupture, the rate of revision surgeries can be very high and do not address the underlying pathophysiology. Commonly cited causes for revision surgeries include poor tendon-bone integration, particularly with degenerative tendon. Tissue engineering strategies, employing the use of multipotent progenitor cells or growth factors, represent potential therapies to improve the outcome of rotator cuff surgery. The use of glycosaminoglycan-based biomaterials in these therapies may enhance the effectiveness of cell and growth factor delivery techniques. Furthermore, understanding the cellular and molecular mediators in tendon overuse can help elucidate the causes for tendon degeneration in order to prevent tendon rupture. Thus the overall goals of this dissertation were to 1) develop heparin-based biomaterials to enhance cell pre-culture and maintain growth factor bioactivity and 2) characterize the histological and enzymatic changes in a supraspinatus tendon overuse model.\u003Cbr \/\u003ETo investigate the use of heparin in enhancing dynamic signaling, mesenchymal stem cells (MSCs) were encapsulated in heparin-containing hydrogels and evaluated for differentiation markers when cocultured with a small population of differentiated cells. Since the sulfation level of heparin may have important effects in growth factor presentation and protection, selectively desulfated heparin species were evaluated for their ability to bind and protect proteins. Finally, to develop a tendon overuse model that can become a test bed for testing future targeted therapeutics, an inbred strain of rat was evaluated for tissue damage and protease activity. Together these studies represent a multi-pronged approach to understand how tendon tissues become degenerative and to develop technologies to improve the biological fixation of tendon to bone in order to prevent shoulder dysfunction and the need for revision surgeries.\u003C\/p\u003E","summary":null,"format":"limited_html"}],"field_subtitle":"","field_summary":[{"value":"\u003Cp\u003EThe Development of Heparin-Based Materials to Treat Rotator Cuff Tendon Injuries - PhD Defense, Song Seto\u003C\/p\u003E","format":"limited_html"}],"field_summary_sentence":[{"value":"The Development of Heparin-Based Materials to Treat Rotator Cuff Tendon Injuries"}],"uid":"27349","created_gmt":"2014-03-11 15:41:18","changed_gmt":"2016-10-08 02:07:10","author":"Floyd Wood","boilerplate_text":"","field_publication":"","field_article_url":"","field_event_time":{"event_time_start":"2014-03-20T20:00:00-04:00","event_time_end":"2014-03-20T23:00:00-04:00","event_time_end_last":"2014-03-20T23:00:00-04:00","gmt_time_start":"2014-03-21 00:00:00","gmt_time_end":"2014-03-21 03:00:00","gmt_time_end_last":"2014-03-21 03:00:00","rrule":null,"timezone":"America\/New_York"},"extras":[],"groups":[{"id":"65448","name":"Bioengineering Graduate Program"}],"categories":[],"keywords":[{"id":"6178","name":"BIOE"},{"id":"569","name":"bioengineering"}],"core_research_areas":[],"news_room_topics":[],"event_categories":[{"id":"1788","name":"Other\/Miscellaneous"}],"invited_audience":[{"id":"78771","name":"Public"}],"affiliations":[],"classification":[],"areas_of_expertise":[],"news_and_recent_appearances":[],"phone":[],"contact":[],"email":[],"slides":[],"orientation":[],"userdata":""}},"280551":{"#nid":"280551","#data":{"type":"event","title":"PhD Defense - Jinsung Hong","body":[{"value":"\u003Cp\u003E\u003Cstrong\u003E2D Kinetics and Force Regulation Study of T cell Recognition and Thymocyte Selection\u003C\/strong\u003E\u003C\/p\u003E\u003Cp\u003E\u003Cstrong\u003EAdvisor:\u003C\/strong\u003E\u003Cbr \/\u003ECheng Zhu, PhD\u003Cbr \/\u003E\u0026nbsp;\u003Cstrong\u003ECommittee:\u003C\/strong\u003E \u003Cbr \/\u003EAndres Garcia, PhD\u003Cbr \/\u003EJulia Babensee, PhD \u0026nbsp;\u003Cbr \/\u003EMelissa Kemp, PhD \u0026nbsp;\u003Cbr \/\u003EBrian Evavold (Emory)\u003Cbr \/\u003E\u0026nbsp;\u003Cbr \/\u003ET cell recognition and thymic selection are thought to be determined by the binding propensity (avidity or affinity) of the T cell receptor (TCR) to its ligands. However, binding propensity quantified by previous 3D TCR\u2013pMHC kinetics such as using tetramer staining or surface plasmon resonance (SPR) under estimate TCR\u2013pMHC interaction due to neglecting physiological conditions. Recent studies considering membrane contribution in TCR\u2013pMHC interaction reported 2D kinetics and force regulated bond dissociation kinetics have better prediction to biological responses in CD8+ T cells.\u003Cbr \/\u003EIn this study, we further tested the findings in CD4+ T cells and CD4+ CD8+ (double-positive, DP) thymocytes. We analyzed TCR\u2013pMHC interaction for a well-characterized panel of altered peptide ligands (APLs) on multiple transgenic mouse TCR systems. Using ultrasensitive 2D mechanical assays, in situ 2D kinetic measurements show better sensitivity than the SPR 3D kinetic measurements in gauging the ligand potency and thymic selection. Furthermore, force-regulated bond lifetime of TCR\u2013pMHC interaction amplifies the discrimination in recognition of APLs and thymic selection. When force was applied to TCR\u2013pMHC\u2013CD4\/8 bonds, two distinct patterns emerged: agonist\/negative selecting ligands formed CD4\/8-dependent catch-slip bonds where lifetime first increased, reached a maximum, then decreased with increasing force, whereas antagonist\/positive selecting ligands formed slip-only bonds where lifetime monotonically decreases with increasing force. Our results highlight an important role of mechanical force in ligand discrimination and suggest a new mechanism for T cell recognition and thymic selection that is distinct from previous models based on 3D measurements.\u003Cbr \/\u003E\u0026nbsp;\u003C\/p\u003E","summary":null,"format":"limited_html"}],"field_subtitle":"","field_summary":[{"value":"\u003Cp\u003E2D Kinetics and Force Regulation Study of T cell Recognition and Thymocyte Selection - PhD Defense - Jinsung Hong\u003C\/p\u003E","format":"limited_html"}],"field_summary_sentence":[{"value":"2D Kinetics and Force Regulation Study of T cell Recognition and Thymocyte Selection"}],"uid":"27349","created_gmt":"2014-03-04 13:40:03","changed_gmt":"2016-10-08 02:07:01","author":"Floyd Wood","boilerplate_text":"","field_publication":"","field_article_url":"","field_event_time":{"event_time_start":"2014-03-24T18:00:00-04:00","event_time_end":"2014-03-24T21:00:00-04:00","event_time_end_last":"2014-03-24T21:00:00-04:00","gmt_time_start":"2014-03-24 22:00:00","gmt_time_end":"2014-03-25 01:00:00","gmt_time_end_last":"2014-03-25 01:00:00","rrule":null,"timezone":"America\/New_York"},"extras":[],"groups":[{"id":"65448","name":"Bioengineering Graduate Program"}],"categories":[],"keywords":[{"id":"6178","name":"BIOE"},{"id":"569","name":"bioengineering"}],"core_research_areas":[],"news_room_topics":[],"event_categories":[{"id":"1788","name":"Other\/Miscellaneous"}],"invited_audience":[{"id":"78771","name":"Public"}],"affiliations":[],"classification":[],"areas_of_expertise":[],"news_and_recent_appearances":[],"phone":[],"contact":[],"email":[],"slides":[],"orientation":[],"userdata":""}},"233371":{"#nid":"233371","#data":{"type":"event","title":"Integrated Cancer Research Center Seminar Series","body":[{"value":"\u003Cp\u003E\u003Cstrong\u003E\u0022Regulating Energy and Lipid Metabolism through Pluripotent Transcriptional Networks\u0022\u003Cbr \/\u003E\u003Cbr \/\u003EMartin J. Walsh, PhD\u003C\/strong\u003E\u003Cbr \/\u003E\u003Cstrong\u003EAssociate Professor, Structural and Chemical Biology\u003C\/strong\u003E\u003Cbr \/\u003E\u003Cstrong\u003EAssociate Professor, Pediatrics, Hepatology\u003C\/strong\u003E\u003Cbr \/\u003E\u003Cstrong\u003EAssociate Professor, Genetics and Genomic Sciences\u003C\/strong\u003E\u003Cbr \/\u003E\u003Cstrong\u003EMt. Sinai School of Medicine\u003C\/strong\u003E\u003Cbr \/\u003E\u003Cbr \/\u003EGlycolysis and lipid biosynthesis are crucial to stem cell behavior, but we know little about the transcriptional regulation of factors driving metabolism in concert with stem cell fate. We demonstrate through use of selective BET-bromodomain inhibitors, and comprehensive RNA-seq and ChIP-seq analysis in mouse embryonic stem cells (ESCs), that Brd4, a master chromatin reader, governs transcription of the core pluripotency network and genes required for lipogenesis. Our studies now show that Brd4 governs glycolysis and lipogenesis at the core of the pluripotency framework of genes and that Brd4 regulates critical nodes of metabolism leading to the production of co-factors needed for modifying the epigenome.\u003C\/p\u003E","summary":null,"format":"limited_html"}],"field_subtitle":"","field_summary":[{"value":"\u003Cp\u003EGeorgia Tech has been a leader in the development of collaborative approaches to both cancer diagnostics and therapeutics. The mission of the Integrated Cancer Research Center (ICRC) is to facilitate integration of the diversity of technological, computational, scientific and medical expertise at Georgia Tech and partner institutions in a coordinated effort to develop improved cancer diagnostics and therapeutics.\u003C\/p\u003E","format":"limited_html"}],"field_summary_sentence":[{"value":"\u0022Regulating Energy and Lipid Metabolism through Pluripotent Transcriptional Networks\u0022 - Martin J. Walsh, PhD, Mt. Sinai School of Medicine"}],"uid":"27195","created_gmt":"2013-09-03 10:50:33","changed_gmt":"2017-04-13 21:24:01","author":"Colly Mitchell","boilerplate_text":"","field_publication":"","field_article_url":"","field_event_time":{"event_time_start":"2014-03-25T17:00:00-04:00","event_time_end":"2014-03-25T18:00:00-04:00","event_time_end_last":"2014-03-25T18:00:00-04:00","gmt_time_start":"2014-03-25 21:00:00","gmt_time_end":"2014-03-25 22:00:00","gmt_time_end_last":"2014-03-25 22:00:00","rrule":null,"timezone":"America\/New_York"},"extras":[],"related_links":[{"url":"http:\/\/www.mountsinai.org\/profiles\/martin-j-walsh","title":"Walsh lab website"},{"url":"http:\/\/www.ibb.gatech.edu\/icrc-seminars","title":"ICRC Seminar Series schedule"},{"url":"http:\/\/www.icrc.gatech.edu\/","title":"Integrated Cancer Research Center website"}],"groups":[{"id":"1292","name":"Parker H. Petit Institute for Bioengineering and Bioscience (IBB)"}],"categories":[],"keywords":[{"id":"248","name":"IBB"},{"id":"52061","name":"ICRC Seminar"}],"core_research_areas":[],"news_room_topics":[],"event_categories":[{"id":"1795","name":"Seminar\/Lecture\/Colloquium"}],"invited_audience":[{"id":"78751","name":"Undergraduate students"},{"id":"78761","name":"Faculty\/Staff"},{"id":"174045","name":"Graduate students"}],"affiliations":[],"classification":[],"areas_of_expertise":[],"news_and_recent_appearances":[],"phone":[],"contact":[{"value":"\u003Cp\u003E\u003Ca href=\u0022mailto:john.mcdonald@biology.gatech.edu\u0022\u003EJohn McDonald, PhD\u003C\/a\u003E\u003C\/p\u003E","format":"limited_html"}],"email":[],"slides":[],"orientation":[],"userdata":""}},"267901":{"#nid":"267901","#data":{"type":"event","title":"Regenerative Medicine Workshop at Hilton Head","body":[{"value":"\u003Cp\u003EThe 18th annual Regenerative Medicine Workshop at Hilton Head will be held March 26-29, 2014 on Hilton Head Island, South Carolina in Harbour Town.\u0026nbsp; The 2014 meeting has a powerhouse line-up of speakers in a breadth of topics in the regenerative medicine field. \u0026nbsp;\u003Cbr \/\u003E\u003Cbr \/\u003EThis year\u2019s workshop will focus on \u201cDiscovery-Driven, Transformative Research\u201d and abstracts are due by December 15, 2013.\u0026nbsp; For the first time, the Georgia Tech and Emory Regenerative Engineering and Medicine Center will partner with both the University of Wisconsin and University of Pittsburgh as organizing institutions. \u0026nbsp;\u003Cbr \/\u003E\u003Cbr \/\u003EIn addition to new partners, the workshop has an entirely new look, to include a new website, and exciting new sponsorship opportunities. \u0026nbsp;\u003Cbr \/\u003E\u003Cbr \/\u003EThis annual workshop sells out each year at around 250 participants.\u0026nbsp; The intimate environment allows for ample discussion time with attending faculty, trainees, industry participants and exhibitors. The program, which spans three days, starts with a focused short course and continues on with presentations ranging in topics. \u0026nbsp;\u003Cbr \/\u003E\u003Cbr \/\u003E\u003Cstrong\u003ENerem Lecturer\u003C\/strong\u003E\u003Cbr \/\u003EDoug Lauffenburger, Massachusetts Institute of Technology\u003Cbr \/\u003E\u003Cbr \/\u003E\u003Cstrong\u003EKeynote Speakers\u003C\/strong\u003E\u003Cbr \/\u003EStephan Duncan, PhD \u2013 Medical College of Wisconsin\u003Cbr \/\u003EJeanne Loring, PhD - The Scripps Research Institute\u003Cbr \/\u003ESean Palecek, PhD \u2013 University of Wisconsin \u2013 Madison\u003Cbr \/\u003ESuzie Pun, PhD \u2013 University of Washington\u003Cbr \/\u003EDave Schaffer, PhD \u2013 University of California, Berkeley\u003Cbr \/\u003ETim Schroeder, PhD - Swiss Federal Institute of Technology, Zurich\u003Cbr \/\u003EMolly Scoichet, PhD \u2013 University of Toronto\u003Cbr \/\u003EMarius Wernig, PhD \u2013 Stanford\u003Cbr \/\u003E\u003Cbr \/\u003EFor more information, please visit: \u003Ca href=\u0022https:\/\/www.regenerativemedicineworkshop.com\/\u0022\u003ERegenerative Medicine Workshop\u003C\/a\u003E\u003C\/p\u003E","summary":null,"format":"limited_html"}],"field_subtitle":"","field_summary":[{"value":"\u003Cp\u003E18th Annual workshop bringing together the world\u0027s leaders in regenerative medicine\u003C\/p\u003E","format":"limited_html"}],"field_summary_sentence":[{"value":"Registration now open!"}],"uid":"27195","created_gmt":"2014-01-15 13:28:07","changed_gmt":"2017-04-13 21:23:27","author":"Colly Mitchell","boilerplate_text":"","field_publication":"","field_article_url":"","field_event_time":{"event_time_start":"2014-03-26T09:00:00-04:00","event_time_end":"2014-03-29T23:00:00-04:00","event_time_end_last":"2014-03-29T23:00:00-04:00","gmt_time_start":"2014-03-26 13:00:00","gmt_time_end":"2014-03-30 03:00:00","gmt_time_end_last":"2014-03-30 03:00:00","rrule":null,"timezone":"America\/New_York"},"extras":[],"hg_media":{"242771":{"id":"242771","type":"image","title":"Regenerative Medicine Workshop at Hilton Head","body":null,"created":"1449243704","gmt_created":"2015-12-04 15:41:44","changed":"1475894919","gmt_changed":"2016-10-08 02:48:39","alt":"Regenerative Medicine Workshop at Hilton Head","file":{"fid":"197831","name":"rmwlogo_0.png","image_path":"\/sites\/default\/files\/images\/rmwlogo_0_0.png","image_full_path":"http:\/\/www.tlwarc.hg.gatech.edu\/\/sites\/default\/files\/images\/rmwlogo_0_0.png","mime":"image\/png","size":17752,"path_740":"http:\/\/www.tlwarc.hg.gatech.edu\/sites\/default\/files\/styles\/740xx_scale\/public\/images\/rmwlogo_0_0.png?itok=MVkLsxgL"}}},"media_ids":["242771"],"related_links":[{"url":"http:\/\/www.regenerativemedicineworkshop.com\/","title":"Regenerative Medicine Workshop website"},{"url":"http:\/\/www.ibb.gatech.edu\/","title":"Petit Institute for Bioengineering and Bioscience"},{"url":"http:\/\/regenerativeengineeringandmedicine.com\/view\/2013-rem-retreat-registrants","title":"Regenerative Medicine \u0026 Engineering Center website"},{"url":"http:\/\/www.mirm.pitt.edu\/","title":"McGowan Institute for Regenerative Medicine"},{"url":"http:\/\/stemcells.wisc.edu\/","title":"Stem Cell \u0026 Regenerative Medicine Center website"}],"groups":[{"id":"1292","name":"Parker H. Petit Institute for Bioengineering and Bioscience (IBB)"}],"categories":[],"keywords":[{"id":"248","name":"IBB"}],"core_research_areas":[],"news_room_topics":[],"event_categories":[{"id":"1789","name":"Conference\/Symposium"}],"invited_audience":[{"id":"78751","name":"Undergraduate students"},{"id":"78761","name":"Faculty\/Staff"},{"id":"78771","name":"Public"},{"id":"174045","name":"Graduate students"}],"affiliations":[],"classification":[],"areas_of_expertise":[],"news_and_recent_appearances":[],"phone":[],"contact":[{"value":"\u003Cp\u003E\u003Ca href=\u0022mailto:mcdevitt@ibb.gatech.edu\u0022\u003EMegan McDevitt\u003C\/a\u003E\u003Cbr \/\u003EDirector of Communications \u0026amp; Marketing\u003Cbr \/\u003EParker H. Petit Institute for Bioengineering \u0026amp; Bioscience\u003C\/p\u003E","format":"limited_html"}],"email":[],"slides":[],"orientation":[],"userdata":""}},"285301":{"#nid":"285301","#data":{"type":"event","title":"PhD Defense Presentation- Teresa Sanders","body":[{"value":"\u003Cp\u003E\u003Cstrong\u003EMultimodal assessment of Parkinson\u0027s disease using electrophysiology and automated motor scoring\u003C\/strong\u003E\u003C\/p\u003E\u003Cp\u003EAdvisor: Mark A. Clements, Sc.D. (Georgia Tech)\u003C\/p\u003E\u003Cp\u003E\u0026nbsp;Committee:\u003C\/p\u003E\u003Cp\u003EThomas Wichmann, M.D. (Emory)\u003Cbr \/\u003EGarrett Stanley, PhD (Georgia Tech\/Emory University)\u003Cbr \/\u003EChris Rozell, PhD (Georgia Tech)\u003Cbr \/\u003EBeth Buffalo, PhD (University of Washington)\u003Cbr \/\u003E\u003Cbr \/\u003E\u003C\/p\u003E\u003Cp\u003EThis research presents signal processing applications for extracting information from brain electrophysiology and movement signals. The approach taken does not assume any particular stimulus, underlying activity, or synchronizing event, nor does it assume any particular encoding scheme. Instead, novel signal processing applications of complex continuous wavelet transforms, cross frequency coupling, feature selection, and canonical correlation were developed to discover the most signifi cant electrophysiologic changes in the basal ganglia and cortex of parkinsononian rhesus monkeys and how these changes are related to the motor signs of parkinsonism. The resulting algorithms e ffectively decode the parkinsonian disease state and, when combined with motor signal decoding algorithms, allow technology-assisted multi-modal grading of the disease. Based on these results, parallel data collection algorithms were implemented in real-time embedded software and o ff-the-shelf hardware to develop a new system to facilitate monitoring of the severity of Parkinson\u0027s disease signs and symptoms.\u003C\/p\u003E\u003Cp\u003EOff-line analysis of data collected with the system was subsequently shown to allow discrimination between normal and parkinsonian conditions in human subjects.\u003C\/p\u003E\u003Cp\u003EA suite of signal processing algorithms designed for decoding neural disease states, along with new insights gained by applying these tools to understanding parkinsonism, are presented. The main contributions of this work are in three areas: 1) Evidence of the importance of optimally selecting multiple, nonredundant features for understanding neural information, 2) Discovery of signifi cant correlations between certain motor signs and brain electrophysiology in di fferent brain regions, and 3) Implementation and human subject testing of multi-modal monitoring technology.\u003C\/p\u003E","summary":null,"format":"limited_html"}],"field_subtitle":"","field_summary":[{"value":"\u003Cp\u003EPhD Defense Presentation- \u0022Multimodal assessment of Parkinson\u0027s disease using electrophysiology and automated motor scoring\u0022- Teresa Sanders\u003C\/p\u003E","format":"limited_html"}],"field_summary_sentence":[{"value":"\u0022Multimodal assessment of Parkinson\u0027s disease using electrophysiology and automated motor scoring\u0022"}],"uid":"27917","created_gmt":"2014-03-25 08:05:46","changed_gmt":"2017-04-13 21:22:52","author":"Laura Paige","boilerplate_text":"","field_publication":"","field_article_url":"","field_event_time":{"event_time_start":"2014-03-31T19:00:00-04:00","event_time_end":"2014-03-31T21:00:00-04:00","event_time_end_last":"2014-03-31T21:00:00-04:00","gmt_time_start":"2014-03-31 23:00:00","gmt_time_end":"2014-04-01 01:00:00","gmt_time_end_last":"2014-04-01 01:00:00","rrule":null,"timezone":"America\/New_York"},"extras":[],"related_links":[{"url":"http:\/\/users.ece.gatech.edu\/~clements\/","title":"Clements Lab Website"}],"groups":[{"id":"65448","name":"Bioengineering Graduate Program"}],"categories":[],"keywords":[],"core_research_areas":[],"news_room_topics":[],"event_categories":[{"id":"1788","name":"Other\/Miscellaneous"}],"invited_audience":[{"id":"78751","name":"Undergraduate students"},{"id":"78761","name":"Faculty\/Staff"},{"id":"174045","name":"Graduate students"}],"affiliations":[],"classification":[],"areas_of_expertise":[],"news_and_recent_appearances":[],"phone":[],"contact":[],"email":[],"slides":[],"orientation":[],"userdata":""}},"252501":{"#nid":"252501","#data":{"type":"event","title":"Breakfast Club Seminar Series","body":[{"value":"\u003Cp\u003E\u003Cstrong\u003E\u0022Ancestry, Admixture and Selection in Colombian Genomes\u0022\u003Cbr \/\u003E\u003Cbr \/\u003EKing Jordan, PhD\u003C\/strong\u003E\u003Cbr \/\u003E\u003Cstrong\u003EAssociate Professor\u003C\/strong\u003E\u003Cbr \/\u003E\u003Cstrong\u003ESchool of Biology\u003C\/strong\u003E\u003Cbr \/\u003E\u003Cstrong\u003EGeorgia Institute of Technology\u003C\/strong\u003E\u003Cbr \/\u003E\u003Cbr \/\u003EKing Jordan\u0027s Computational Biology and Bioinformatics laboratory conducts research in: \u0026nbsp;\u003Cbr \/\u003E\u003Cbr \/\u003ETransposable Elements, Epigenomics \u0026amp; Gene Regulation - the influence of transposable elements (TEs) on the structure, function and evolution of eukaryotic genomes. Understanding the relationship between TEs, chromatin structure and gene expression dynamics.\u003Cbr \/\u003E\u003Cbr \/\u003EComputational Genomics for Public Health - the development and application of computational tools for the analysis of microbial genome sequences. Creation of web-enabled programs for molecular epidemiology and comparative genomics.\u003Cbr \/\u003E\u003Cbr \/\u003EOur bioinformatics research efforts sometimes entail algorithm development for functional genomic applications based on next-generation sequence data, e.g. genome assembly, ChIP-seq, RNA-seq. Jordan also works on the development of local bioinformatics capacity in Latin American countries, Colombia in particular. He is the co-founder of the PanAmerican Bioinformatics Institute (PABI), a network of academics and researchers in Colombia and the United States. PABI\u0027s mission is to facilitate public health and economic development throughout the Americas via education, research and outreach activities in genomics and bioinformatics.\u003C\/p\u003E","summary":null,"format":"limited_html"}],"field_subtitle":"","field_summary":[{"value":"\u003Cp\u003EThe Petit Institute Breakfast Club seminar series was started with the spirit of the Institute\u0027s interdisciplinary mission in mind and started to feature local Petit Institute faculty member\u0027s research in a seminar format. Faculty are often asked to speak at other universities and conferences, but rarely present at their home institution, this seminar series is an attempt to close that gap. The Petit Institute Breakfast Club is open to anyone in the bio-community.\u003C\/p\u003E","format":"limited_html"}],"field_summary_sentence":[{"value":"\u0022Ancestry, Admixture and Selection in Colombian Genomes\u0022 - King Jordan, PhD - Georgia Tech"}],"uid":"27195","created_gmt":"2013-11-08 15:23:41","changed_gmt":"2017-04-13 21:23:55","author":"Colly Mitchell","boilerplate_text":"","field_publication":"","field_article_url":"","field_event_time":{"event_time_start":"2014-04-08T09:30:00-04:00","event_time_end":"2014-04-08T10:30:00-04:00","event_time_end_last":"2014-04-08T10:30:00-04:00","gmt_time_start":"2014-04-08 13:30:00","gmt_time_end":"2014-04-08 14:30:00","gmt_time_end_last":"2014-04-08 14:30:00","rrule":null,"timezone":"America\/New_York"},"extras":[],"hg_media":{"70917":{"id":"70917","type":"image","title":"Breakfast Club Seminar Series","body":null,"created":"1449177328","gmt_created":"2015-12-03 21:15:28","changed":"1475894625","gmt_changed":"2016-10-08 02:43:45","alt":"Breakfast Club Seminar Series","file":{"fid":"193471","name":"logobldg_graphic.png","image_path":"\/sites\/default\/files\/images\/logobldg_graphic_0.png","image_full_path":"http:\/\/www.tlwarc.hg.gatech.edu\/\/sites\/default\/files\/images\/logobldg_graphic_0.png","mime":"image\/png","size":241588,"path_740":"http:\/\/www.tlwarc.hg.gatech.edu\/sites\/default\/files\/styles\/740xx_scale\/public\/images\/logobldg_graphic_0.png?itok=x84xf3Mz"}}},"media_ids":["70917"],"related_links":[{"url":"http:\/\/jordan.biology.gatech.edu\/page\/","title":"Jordan lab"},{"url":"http:\/\/www.ibb.gatech.edu\/breakfast-club","title":"IBB Breakfast Club"}],"groups":[{"id":"1292","name":"Parker H. Petit Institute for Bioengineering and Bioscience (IBB)"},{"id":"65448","name":"Bioengineering Graduate Program"}],"categories":[],"keywords":[{"id":"11879","name":"BK Club"},{"id":"248","name":"IBB"}],"core_research_areas":[],"news_room_topics":[],"event_categories":[{"id":"1795","name":"Seminar\/Lecture\/Colloquium"}],"invited_audience":[{"id":"78751","name":"Undergraduate students"},{"id":"78761","name":"Faculty\/Staff"},{"id":"174045","name":"Graduate students"}],"affiliations":[],"classification":[],"areas_of_expertise":[],"news_and_recent_appearances":[],"phone":[],"contact":[{"value":"\u003Cp\u003E\u003Ca href=\u0022mailto:colly.mitchell@ibb.gatech.edu\u0022\u003EColly Mitchell\u003C\/a\u003E\u003C\/p\u003E","format":"limited_html"}],"email":[],"slides":[],"orientation":[],"userdata":""}},"224291":{"#nid":"224291","#data":{"type":"event","title":"Integrated Cancer Research Center Seminar","body":[{"value":"\u003Cp\u003E\u003Cstrong\u003E\u0022Understanding and Improving Platinum Anticancer Drugs\u0022\u003Cbr \/\u003E\u003Cbr \/\u003EStephen J. Lippard, PhD\u003C\/strong\u003E\u003Cbr \/\u003E\u003Cstrong\u003EArthur Amos Noyes Professor\u003C\/strong\u003E\u003Cbr \/\u003E\u003Cstrong\u003EChemistry Department\u003C\/strong\u003E\u003Cbr \/\u003E\u003Cstrong\u003EMassachusetts Institute of Technology\u003Cbr \/\u003E\u003Cbr \/\u003E\u003C\/strong\u003E\u003C\/p\u003E\u003Cp\u003EPlatinum compounds are a mainstay of cancer therapy, with more than half of all patients receiving an infusion of one of three FDA approved drugs (cisplatin, carboplatin, and oxaliplatin). The biological action of cisplatin was discovered by serendipity in the late 1960s. Our laboratory has subsequently established the chemical nature of events leading up to the binding of platinum anticancer drugs to DNA, their principal target in the nucleus of cancer cells. The major adducts are cross-links between two adjacent nucleotides on one strand of the double helix, which bend and distort the duplex, interrupting cellular processing by RNA and DNA polymerases. We discovered more recently that related platinum compounds, capable of forming only a single link to DNA, are also extremely active against cancer cells, leading to exciting new strategies and candidates for drug development. Details of how these \u0027monofunctional\u0027 compounds work will be described. From the chemical principles learned in the process have emerged a much larger family of anticancer drug candidates, including those based on osmium and rhenium in addition to platinum.\u003C\/p\u003E\u003Cp\u003E\u003Cstrong\u003E\u003Cbr \/\u003E\u003C\/strong\u003EStephen J. Lippard, whose research spans the fields of biological and inorganic chemistry, is the Arthur Amos Noyes Professor of Chemistry at the Massachusetts Institute of Technology.\u003Cbr \/\u003E\u003Cbr \/\u003ELippard studies biological interactions involving metal ions, focusing on reactions and physical and structural properties of metal complexes. Such complexes can be useful as cancer drugs and as models for the active sites of metalloproteins. Metal ions also promote key biological reactions in enzymes and metal complexes can be employed to sense biological signaling agents.\u003Cbr \/\u003E\u003Cbr \/\u003EThis is event is jointly sponsored by the Integrated Cancer Research Center and Georgia Tech\u0027s School of Chemistry and Biochemistry.\u003C\/p\u003E","summary":null,"format":"limited_html"}],"field_subtitle":"","field_summary":[{"value":"\u003Cp\u003EGeorgia Tech has been a leader in the development of collaborative approaches to both cancer diagnostics and therapeutics. The mission of the Integrated Cancer Research Center (ICRC) is to facilitate integration of the diversity of technological, computational, scientific and medical expertise at Georgia Tech and partner institutions in a coordinated effort to develop improved cancer diagnostics and therapeutics. \u0026nbsp;\u003Cbr \/\u003E\u003Cbr \/\u003EThis event is jointly sponsored with Georgia Tech\u0027s School of Chemistry and Biochemistry.\u003C\/p\u003E","format":"limited_html"}],"field_summary_sentence":[{"value":"\u0022Understanding and Improving Platinum Anticancer Drugs\u0022 - Stephen J. Lippard, PhD - Massachusetts Institute of Technology"}],"uid":"27195","created_gmt":"2013-07-23 09:26:24","changed_gmt":"2017-04-13 21:24:01","author":"Colly Mitchell","boilerplate_text":"","field_publication":"","field_article_url":"","field_event_time":{"event_time_start":"2014-04-22T17:00:00-04:00","event_time_end":"2014-04-22T18:00:00-04:00","event_time_end_last":"2014-04-22T18:00:00-04:00","gmt_time_start":"2014-04-22 21:00:00","gmt_time_end":"2014-04-22 22:00:00","gmt_time_end_last":"2014-04-22 22:00:00","rrule":null,"timezone":"America\/New_York"},"extras":[],"related_links":[{"url":"http:\/\/www.ibb.gatech.edu\/icrc-seminars","title":"ICRC Seminar Series schedule"},{"url":"http:\/\/web.mit.edu\/lippardlab\/","title":"Lippard lab website"}],"groups":[{"id":"1292","name":"Parker H. Petit Institute for Bioengineering and Bioscience (IBB)"}],"categories":[],"keywords":[{"id":"248","name":"IBB"},{"id":"52061","name":"ICRC Seminar"}],"core_research_areas":[],"news_room_topics":[],"event_categories":[{"id":"1795","name":"Seminar\/Lecture\/Colloquium"}],"invited_audience":[{"id":"78751","name":"Undergraduate students"},{"id":"78761","name":"Faculty\/Staff"},{"id":"174045","name":"Graduate students"}],"affiliations":[],"classification":[],"areas_of_expertise":[],"news_and_recent_appearances":[],"phone":[],"contact":[{"value":"\u003Cp\u003E\u003Ca href=\u0022mailto:john.mcdonald@biology.gatech.edu\u0022\u003EJohn McDonald, PhD\u003C\/a\u003E\u003C\/p\u003E","format":"limited_html"}],"email":[],"slides":[],"orientation":[],"userdata":""}},"285391":{"#nid":"285391","#data":{"type":"event","title":"BioEngineering Graduate Committee Meeting","body":[{"value":"\u003Cp\u003EThe BioEngineering graduate committee will meet to review\/approve program policies, program faculty applications and submitted student petitions.\u003Cbr \/\u003E\u003Cbr \/\u003EStudent Petitions due to\u003Ca href=\u0022mailto:laura.paige@bioengineering.gatech.edu\u0022\u003E\u0026nbsp;Laura Paige\u003C\/a\u003E\u0026nbsp;no later than:\u0026nbsp; Thursday, April 17, 2014\u003C\/p\u003E","summary":null,"format":"limited_html"}],"field_subtitle":"","field_summary":[{"value":"\u003Cp\u003EProgram policies, faculty applications and student petitions to be discussed\u003C\/p\u003E","format":"limited_html"}],"field_summary_sentence":[{"value":"BioEngineering Graduate Committee Meeting"}],"uid":"27917","created_gmt":"2014-03-25 10:30:54","changed_gmt":"2017-04-13 21:22:52","author":"Laura Paige","boilerplate_text":"","field_publication":"","field_article_url":"","field_event_time":{"event_time_start":"2014-04-24T16:00:00-04:00","event_time_end":"2014-04-24T17:00:00-04:00","event_time_end_last":"2014-04-24T17:00:00-04:00","gmt_time_start":"2014-04-24 20:00:00","gmt_time_end":"2014-04-24 21:00:00","gmt_time_end_last":"2014-04-24 21:00:00","rrule":null,"timezone":"America\/New_York"},"extras":[],"groups":[{"id":"65448","name":"Bioengineering Graduate Program"}],"categories":[],"keywords":[],"core_research_areas":[],"news_room_topics":[],"event_categories":[{"id":"1788","name":"Other\/Miscellaneous"}],"invited_audience":[{"id":"78751","name":"Undergraduate students"},{"id":"174045","name":"Graduate students"}],"affiliations":[],"classification":[],"areas_of_expertise":[],"news_and_recent_appearances":[],"phone":[],"contact":[{"value":"\u003Cp\u003E\u003Ca href=\u0022mailto:laura.paige@bioengineering.gatech.edu\u0022\u003ELaura Paige\u0026nbsp;\u003C\/a\u003E\u003C\/p\u003E","format":"limited_html"}],"email":[],"slides":[],"orientation":[],"userdata":""}},"292311":{"#nid":"292311","#data":{"type":"event","title":"PhD Defense - Lucas Lane","body":[{"value":"\u003Cp\u003E\u003Cstrong\u003EAdvancement of Blinking Suppressed Quantum Dots for Enhanced Single Molecule Imaging\u003C\/strong\u003E\u003C\/p\u003E\u003Cp\u003E\u003Cstrong\u003ECommittee:\u003C\/strong\u003E\u003C\/p\u003E\u003Cp\u003EDr. Shuming Nie, Advisor - School of Biomedical Engineering, Georgia Institute of Technology\u003C\/p\u003E\u003Cp\u003EDr. Younan Xia - School of Biomedical Engineering, Georgia Institute of Technology\u003C\/p\u003E\u003Cp\u003EDr. Mostafa El-Sayed - School of Chemistry, Georgia Institute of Technology\u003C\/p\u003E\u003Cp\u003EDr. Gang Bao - School of Biomedical Engineering, Georgia Institute of Technology\u003C\/p\u003E\u003Cp\u003EDr. Adam Marcus - School of Oncology, Emory University\u003C\/p\u003E\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\u003Cp\u003E\u003Cstrong\u003ESummary:\u003C\/strong\u003E\u003C\/p\u003E\u003Cp\u003ESemiconductor nanocrystalline quantum dots (QDs) have been intensely studied in bioimaging applications due to their exceptional optical properties such as size-tunable narrow emission spectra, broad absorption envelopes, and high resistance to chemical and photodegradation in comparison to conventional fluorophores or fluorescent proteins. An inherent problem that quantum dots have shared with other single emitters is fluorescent intermittency or blinking. The blinking of a single molecule or single QD refers to random transitions amid absorption and emission cycles followed by sustained intervals of time without fluorescence regardless of continuous laser excitation. Frequent and prolonged off times raise difficulties in correspondence between frames when tracking the position of single molecules in cellular experiments due to cells not being homogeneous vessels with a single diffusion coefficient. In the last six years there has been success suppressing the blinking of quantum dots in practice, but were limited to thick shell particles with large diameters, gradient dots with overlapping multi-peak emission, or immersing the probes in specific solutions of reducing reagents. All of these methods present major difficulties when considering application to live molecular tracking experiments. Within the past year, however, efforts have demonstrated success in overcoming a few of these hurdles, but still lack a general methodology in creating blinking suppressed probes. Among these reports, only one to date has demonstrated single molecule tracking potential.\u003C\/p\u003E\u003Cp\u003EThis study composes a generalizable framework by means of physical-chemical theory undertaking the mechanisms of fluorescent intermittency and synthesis measures designed in light of this information, to develop blinking suppressed particles which are better suited for single molecular imaging than currently available QDs and validates their use in a biological setting. Such probes were found to provide superior frame correspondence in trajectory reconstruction of tracking studies due to having short infrequent off times. Controlling blinking towards brief and infrequent off-times offer negligible signal loss, leading to continuous dynamical information at higher acquisition rates. In addition to the enhanced on times, the emission spectra were observed to be single peaked with thin full width at half maximums (FWHMs) due to synthesis techniques preserving monodispersity, thus permitting multiplexed single molecule tracking of different species.\u0026nbsp;\u003C\/p\u003E\u003Cp\u003EThe innovation of the study is synthesizing QDs within a general framework that have greatly diminished fluorescent off-times while preserving small sizes, solution independency, and no multi-peak emission. The work presented yields the following outcomes: First, it establishes a general structure based on theoretical forethought in which to synthesize blinking suppressed imaging probes. Next, synthesis techniques are developed to produce QDs with the structure outlined within the general framework. Finally, a comparative test of blinking suppressed to conventional core\/shell particles elucidating the benefits is shown in a single molecule tracking experiment.\u0026nbsp; These studies present that when adhering to the prescribed framework outlined, one can produce blinking suppressed QDs with sensible sizes for single molecule tracking experiments with minimal signal loss.\u0026nbsp;\u0026nbsp;\u0026nbsp;\u003C\/p\u003E","summary":null,"format":"limited_html"}],"field_subtitle":"","field_summary":[{"value":"\u003Cp\u003EPhD Defense - Lucas Lane - \u0022Advancement of Blinking Suppressed Quantum Dots for Enhanced Single Molecule Imaging\u0022\u003C\/p\u003E","format":"limited_html"}],"field_summary_sentence":[{"value":"\u0022Advancement of Blinking Suppressed Quantum Dots for Enhanced Single Molecule Imaging\u0022"}],"uid":"27349","created_gmt":"2014-04-22 09:42:55","changed_gmt":"2017-04-13 21:22:40","author":"Floyd Wood","boilerplate_text":"","field_publication":"","field_article_url":"","field_event_time":{"event_time_start":"2014-05-02T17:00:00-04:00","event_time_end":"2014-05-02T20:00:00-04:00","event_time_end_last":"2014-05-02T20:00:00-04:00","gmt_time_start":"2014-05-02 21:00:00","gmt_time_end":"2014-05-03 00:00:00","gmt_time_end_last":"2014-05-03 00:00:00","rrule":null,"timezone":"America\/New_York"},"extras":[],"groups":[{"id":"65448","name":"Bioengineering Graduate Program"}],"categories":[],"keywords":[{"id":"6178","name":"BIOE"},{"id":"569","name":"bioengineering"}],"core_research_areas":[],"news_room_topics":[],"event_categories":[{"id":"1788","name":"Other\/Miscellaneous"}],"invited_audience":[{"id":"78751","name":"Undergraduate students"},{"id":"78761","name":"Faculty\/Staff"},{"id":"174045","name":"Graduate students"}],"affiliations":[],"classification":[],"areas_of_expertise":[],"news_and_recent_appearances":[],"phone":[],"contact":[{"value":"\u003Cp\u003E\u003Cstrong\u003ELaura Paige\u003C\/strong\u003E - \u003Cstrong\u003EAcademic Advisor\u003C\/strong\u003E\u003Cbr \/\u003E 404-385-6655\u003Cbr \/\u003E 404-894-2291 (fax)\u003Cbr \/\u003E \u003Ca href=\u0022mailto:laura.paige@bioengineering.gatech.edu\u0022\u003EEmail \u003C\/a\u003E\u003C\/p\u003E","format":"limited_html"}],"email":[],"slides":[],"orientation":[],"userdata":""}},"286721":{"#nid":"286721","#data":{"type":"event","title":"Petit Institute Seminar","body":[{"value":"\u003Cp\u003E\u003Cstrong\u003E\u201cRegenerative Medicine for Treating Intervertebral Disc Disorders\u201d\u003C\/strong\u003E\u003Cbr \/\u003E\u003Cbr \/\u003E\u003Cstrong\u003ELori A. Setton, PhD\u003C\/strong\u003E\u003Cbr \/\u003E\u003Cstrong\u003EWilliam Bevan Professor of Biomedical Engineering and Orthopaedic Surgery\u003C\/strong\u003E\u003Cbr \/\u003E\u003Cstrong\u003EDuke University\u003C\/strong\u003E\u003Cbr \/\u003E\u003Cbr \/\u003E\u003C\/p\u003E\u003Cp\u003ELow back pain now ranks as #1 for disease impact in the USA, due in part to intervertebral disc disorders that contribute to pain and disability in millions of affected individuals. Pathological processes for resident cells of the intervertebral disc, the nucleus pulposus cells, contribute to a dysfunctional production of inflammatory cytokines and premature cell death that can drive loss of intervertebral disc height, tissue destruction and herniation. Inflammatory cytokines produced by resident cells and recruited monocytes are known to mediate the painful symptoms of intervertebral disc herniation, although systemic treatment with inflammatory antagonists (e.g., tumor necrosis factor \u201cblockers\u201d) has failed to date. Her laboratory has developed in situ forming drug depots for local delivery of \u201cTNF blockers\u201d and other inflammatory antagonists to increase drug residence time and bioactivity in the treatment of intervertebral disc herniation. Her laboratory has also advanced knowledge of environmental cues that are necessary to maintain healthy, biosynthetically active nucleus pulposus cells, factors that can be manipulated to attenuate inflammatory cytokine expression, promote matrix biosynthesis, and control progenitor cell differentiation. In this talk, she will describe their work with engineering substrates and protein-conjugated biomaterials to deliver cells to the disc, and drugs to the perineural space, for regeneration purposes.\u003C\/p\u003E\u003Cp\u003ELori Setton received her B.S.E. from Princeton University in Mechanical and Aerospace Engineering, with M.S. and Ph.D. degrees in Mechanical Engineering from Columbia University. She joined the Department of Biomedical Engineering at Duke University in 1994, where she has serves as the Bevan Distinguished Professor of Biomedical Engineering and Orthopaedic Surgery. Her research focuses on understanding the mechanisms for degeneration and regeneration of soft tissues of the musculoskeletal system. Recent work focuses on development of in situ forming hydrogels for drug delivery and tissue regeneration in the knee joints and spine. She has funded her lab through grants from the NIH, NSF, Whitaker Foundation, Coulter Foundation, OREF, AO Foundation, and North Carolina Biotechnology Center and research agreements with several corporations. She has over 140 peer-reviewed publications and has licensed several patents for commercial development. She has served on the Editorial Advisory Boards of the Annual Reviews of Biomedical Engineering, Journal of Biomechanical Engineering, Osteoarthritis and Cartilage, and Journal of Biomechanics. She has also served as a permanent member of NIH and NSF study sections, as a consultant to NIH and AAOS, and on the Boards of the Biomedical Engineering Society, Orthopaedic Research Society and World Council on Biomechanics. She is a Fellow of the BMES, the AIMBE and has received a PECASE Award, Dean\u0027s Award for Outstanding Research, Graduate Dean\u0027s Award for Excellence in Mentoring, and ASME\u2019s Mow Medal.\u003C\/p\u003E","summary":null,"format":"limited_html"}],"field_subtitle":"","field_summary":[{"value":"\u003Cp\u003EThe Petit Institute hosts special guests and visitors throughout the year.\u0026nbsp; These seminars are open to all faculty and students.\u003C\/p\u003E","format":"limited_html"}],"field_summary_sentence":[{"value":"\u201cRegenerative Medicine for Treating Intervertebral Disc Disorders\u201d - Lori A. Setton, PhD - Duke University"}],"uid":"27959","created_gmt":"2014-03-28 14:44:12","changed_gmt":"2017-04-13 21:22:49","author":"Karen Ethier","boilerplate_text":"","field_publication":"","field_article_url":"","field_event_time":{"event_time_start":"2014-05-06T17:00:00-04:00","event_time_end":"2014-05-06T18:00:00-04:00","event_time_end_last":"2014-05-06T18:00:00-04:00","gmt_time_start":"2014-05-06 21:00:00","gmt_time_end":"2014-05-06 22:00:00","gmt_time_end_last":"2014-05-06 22:00:00","rrule":null,"timezone":"America\/New_York"},"extras":[],"hg_media":{"69773":{"id":"69773","type":"image","title":"Parker H. Petit Institute for Bioengineering and Bioscience","body":null,"created":"1449177264","gmt_created":"2015-12-03 21:14:24","changed":"1475894611","gmt_changed":"2016-10-08 02:43:31","alt":"Parker H. Petit Institute for Bioengineering and Bioscience","file":{"fid":"192836","name":"10c3041-p1-266.jpg","image_path":"\/sites\/default\/files\/images\/10c3041-p1-266_0.jpg","image_full_path":"http:\/\/www.tlwarc.hg.gatech.edu\/\/sites\/default\/files\/images\/10c3041-p1-266_0.jpg","mime":"image\/jpeg","size":2271177,"path_740":"http:\/\/www.tlwarc.hg.gatech.edu\/sites\/default\/files\/styles\/740xx_scale\/public\/images\/10c3041-p1-266_0.jpg?itok=aplnv5pz"}}},"media_ids":["69773"],"related_links":[{"url":"http:\/\/www.ibb.gatech.edu\/petit-institute-seminars","title":"Petit Institute Seminar Schedule"}],"groups":[{"id":"1292","name":"Parker H. Petit Institute for Bioengineering and Bioscience (IBB)"},{"id":"65448","name":"Bioengineering Graduate Program"}],"categories":[],"keywords":[{"id":"248","name":"IBB"},{"id":"5168","name":"IBB Seminar"}],"core_research_areas":[],"news_room_topics":[],"event_categories":[{"id":"1795","name":"Seminar\/Lecture\/Colloquium"}],"invited_audience":[{"id":"78751","name":"Undergraduate students"},{"id":"78761","name":"Faculty\/Staff"},{"id":"174045","name":"Graduate students"}],"affiliations":[],"classification":[],"areas_of_expertise":[],"news_and_recent_appearances":[],"phone":[],"contact":[{"value":"\u003Cp\u003EFaculty host - \u003Ca href=\u0022%20robert.guldberg@me.gatech.edu\u0022\u003ERobert E. Guldberg, PhD\u003C\/a\u003E\u003C\/p\u003E","format":"limited_html"}],"email":[],"slides":[],"orientation":[],"userdata":""}},"292731":{"#nid":"292731","#data":{"type":"event","title":"PhD Proposal Presentation- Ahmed Faisal","body":[{"value":"\u003Cp\u003E\u003Cstrong\u003EAdvisor: Gilda A. Barabino, Ph.D. (City College of NY, Georgia Institute of Technology (adjunct)) \u003C\/strong\u003E\u003C\/p\u003E\u003Cp\u003E\u003Cstrong\u003E\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;Cyrus K. Aidun, Ph.D. (Georgia Institute of Technology)\u003C\/strong\u003E\u003C\/p\u003E\u003Cp\u003E\u003Cstrong\u003E\u0026nbsp;\u003C\/strong\u003E\u003C\/p\u003E\u003Cp\u003E\u003Cstrong\u003ECommittee: \u003C\/strong\u003E\u003C\/p\u003E\u003Cp\u003E\u003Cstrong\u003EEdward A. Botchwey, Ph.D. (Georgia Institute of Technology)\u003C\/strong\u003E\u003C\/p\u003E\u003Cp\u003E\u003Cstrong\u003EWilbur A. Lam, Ph.D. (Georgia Institute of Technology)\u003C\/strong\u003E\u003C\/p\u003E\u003Cp\u003E\u003Cstrong\u003EJ. Brandon Dixon, Ph.D. (Georgia Institute of Technology)\u003C\/strong\u003E\u003C\/p\u003E\u003Cp\u003E\u003Cstrong\u003E\u0026nbsp;\u003C\/strong\u003E\u003C\/p\u003E\u003Cp\u003E\u003Cstrong\u003E\u0026nbsp;\u003C\/strong\u003E\u003C\/p\u003E\u003Cp align=\u0022center\u0022\u003E\u003Cstrong\u003ENovel Prognostic Microfluidic Systems for Blood Cell Separation\u003C\/strong\u003E\u003C\/p\u003E\u003Cp align=\u0022center\u0022\u003E\u003Cstrong\u003E\u0026nbsp;\u003C\/strong\u003E\u003C\/p\u003E\u003Cp\u003EBlood, one of the most important fluid in human body, contains myriad of information about body functioning because of its spread throughout the whole body. This why, blood analysis has been a primary diagnostic test in our health care system. Cells being one of the major constituents of blood, are often the target of different diseases \u2013 expression of different bio-markers and bio-mechanical properties (stiffness, shape, size) change. Separation and analysis of these cellular components are likely to lead to prognostically validated biomarkers and strategies of treatment.\u003C\/p\u003E\u003Cp\u003EObjective of this research is to develop a microfluidic platform based blood cell separation device, which will separate sub-populations of Red Blood Cells from whole blood sample of Sickle Cell Disease patients based on cell stiffness and morphology. The device will require minimal amount of patient blood sample, will pose no additional non-physiological force on the cells that can trigger expression of additional biomarkers overpowering the original ones activated by the disease, will exploit a new aspect of fluid physics that is much observed but not well understood and, will be high-throughput but inexpensive. Such a device will eventually lead to the development of a Point-of-care testing blood analysis kit.\u003C\/p\u003E","summary":null,"format":"limited_html"}],"field_subtitle":"","field_summary":[{"value":"\u003Cp\u003EPhD Proposal Presentation- \u0022\u003Cstrong\u003ENovel Prognostic Microfluidic Systems for Blood Cell Separation\u0022- Faisal Ahmed\u003C\/strong\u003E\u003C\/p\u003E","format":"limited_html"}],"field_summary_sentence":[{"value":"Novel Prognostic Microfluidic Systems for Blood Cell Separation"}],"uid":"27917","created_gmt":"2014-04-23 10:06:37","changed_gmt":"2017-04-13 21:22:40","author":"Laura Paige","boilerplate_text":"","field_publication":"","field_article_url":"","field_event_time":{"event_time_start":"2014-05-07T19:00:00-04:00","event_time_end":"2014-05-07T21:00:00-04:00","event_time_end_last":"2014-05-07T21:00:00-04:00","gmt_time_start":"2014-05-07 23:00:00","gmt_time_end":"2014-05-08 01:00:00","gmt_time_end_last":"2014-05-08 01:00:00","rrule":null,"timezone":"America\/New_York"},"extras":[],"groups":[{"id":"65448","name":"Bioengineering Graduate Program"}],"categories":[],"keywords":[],"core_research_areas":[],"news_room_topics":[],"event_categories":[{"id":"1788","name":"Other\/Miscellaneous"}],"invited_audience":[{"id":"78751","name":"Undergraduate students"},{"id":"78761","name":"Faculty\/Staff"},{"id":"174045","name":"Graduate students"}],"affiliations":[],"classification":[],"areas_of_expertise":[],"news_and_recent_appearances":[],"phone":[],"contact":[{"value":"\u003Cp\u003E\u003Ca href=\u0022%20Laura.Paige@bioengineering.gatech.edu\u0022\u003ELaura.Paige@bioengineering.gatech.edu\u003C\/a\u003E\u003C\/p\u003E","format":"limited_html"}],"email":[],"slides":[],"orientation":[],"userdata":""}},"261681":{"#nid":"261681","#data":{"type":"event","title":"BioEngineering Program Faculty Meeting","body":[{"value":"\u003Cp\u003EThe BioEngineering Program faculty meet to address program policies, events and future research and academic directions.\u0026nbsp; Lunch will be served.\u0026nbsp; \u003Cbr \/\u003EPlease RSVP to\u003Ca href=\u0022mailto:laura.paige@bioengineering.gatech.edu\u0022\u003E Laura Paige.\u003C\/a\u003E\u003Cbr \/\u003E\u003Cbr \/\u003E\u003Cbr \/\u003E\u003C\/p\u003E","summary":null,"format":"limited_html"}],"field_subtitle":"","field_summary":[{"value":"\u003Cp\u003EThe BioEngineering Program faculty meet regularly during the semester to address program policies, events and future research and academic directions.\u003Cbr \/\u003E\u003Cbr \/\u003E\u003C\/p\u003E","format":"limited_html"}],"field_summary_sentence":[{"value":"Program policies, events and directions to be discussed"}],"uid":"27349","created_gmt":"2013-12-17 14:21:03","changed_gmt":"2016-10-08 02:06:02","author":"Floyd Wood","boilerplate_text":"","field_publication":"","field_article_url":"","field_event_time":{"event_time_start":"2014-05-13T12:00:00-04:00","event_time_end":"2014-05-13T13:00:00-04:00","event_time_end_last":"2014-05-13T13:00:00-04:00","gmt_time_start":"2014-05-13 16:00:00","gmt_time_end":"2014-05-13 17:00:00","gmt_time_end_last":"2014-05-13 17:00:00","rrule":null,"timezone":"America\/New_York"},"extras":[],"groups":[{"id":"65448","name":"Bioengineering Graduate Program"}],"categories":[],"keywords":[{"id":"6178","name":"BIOE"},{"id":"569","name":"bioengineering"}],"core_research_areas":[],"news_room_topics":[],"event_categories":[{"id":"1788","name":"Other\/Miscellaneous"}],"invited_audience":[{"id":"78761","name":"Faculty\/Staff"}],"affiliations":[],"classification":[],"areas_of_expertise":[],"news_and_recent_appearances":[],"phone":[],"contact":[],"email":[],"slides":[],"orientation":[],"userdata":""}},"252471":{"#nid":"252471","#data":{"type":"event","title":"Breakfast Club Seminar Series","body":[{"value":"\u003Cp\u003E\u003Cstrong\u003E\u0022The Effects of Lipid Composition in Protein Insertion and Function at the Inner and Outer Membranes\u0022\u003Cbr \/\u003E\u003Cbr \/\u003EJames (JC) Gumbart, PhD\u003C\/strong\u003E\u003Cbr \/\u003E\u003Cstrong\u003EAssistant Professor\u003C\/strong\u003E\u003Cbr \/\u003E\u003Cstrong\u003ESchool of Physics\u003C\/strong\u003E\u003Cbr \/\u003E\u003Cstrong\u003EGeorgia Tech\u003Cbr \/\u003E\u003Cbr \/\u003E\u003C\/strong\u003EJC Gumbart\u0027s lab is focused on understanding how proteins and other biological systems function at a molecular level.\u0026nbsp; To probe these systems, they carry out molecular dynamics simulations, modeling biological behavior one atom at a time.\u0026nbsp; The simulations serve as a \u0022computational microscope\u0022 that permits glimpses into a cell\u0027s inner workings through the application of advanced software and high-powered supercomputers.\u0026nbsp; He is particularly interested in how bacteria utilize unique pathways to synthesize proteins and insert them into both the inner and outer membranes, how they import nutrients across two membranes, and how their cell walls provide shape and mechanical strength.\u0026nbsp;\u003Cstrong\u003E \u003Cbr \/\u003E\u003C\/strong\u003E\u003C\/p\u003E","summary":null,"format":"limited_html"}],"field_subtitle":"","field_summary":[{"value":"\u003Cp\u003EThe Petit Institute Breakfast Club seminar series was started with the spirit of the Institute\u0027s interdisciplinary mission in mind and started to feature local Petit Institute faculty member\u0027s research in a seminar format. Faculty are often asked to speak at other universities and conferences, but rarely present at their home institution, this seminar series is an attempt to close that gap. The Petit Institute Breakfast Club is open to anyone in the bio-community.\u003C\/p\u003E","format":"limited_html"}],"field_summary_sentence":[{"value":"\u0022The Effects of Lipid Composition in Protein Insertion and Function at the Inner and Outer Membranes\u0022 - James (JC) Gumbart, PhD - Georgia Tech"}],"uid":"27195","created_gmt":"2013-11-08 14:59:27","changed_gmt":"2017-04-13 21:23:55","author":"Colly Mitchell","boilerplate_text":"","field_publication":"","field_article_url":"","field_event_time":{"event_time_start":"2014-05-13T09:30:00-04:00","event_time_end":"2014-05-13T10:30:00-04:00","event_time_end_last":"2014-05-13T10:30:00-04:00","gmt_time_start":"2014-05-13 13:30:00","gmt_time_end":"2014-05-13 14:30:00","gmt_time_end_last":"2014-05-13 14:30:00","rrule":null,"timezone":"America\/New_York"},"extras":[],"hg_media":{"70917":{"id":"70917","type":"image","title":"Breakfast Club Seminar Series","body":null,"created":"1449177328","gmt_created":"2015-12-03 21:15:28","changed":"1475894625","gmt_changed":"2016-10-08 02:43:45","alt":"Breakfast Club Seminar Series","file":{"fid":"193471","name":"logobldg_graphic.png","image_path":"\/sites\/default\/files\/images\/logobldg_graphic_0.png","image_full_path":"http:\/\/www.tlwarc.hg.gatech.edu\/\/sites\/default\/files\/images\/logobldg_graphic_0.png","mime":"image\/png","size":241588,"path_740":"http:\/\/www.tlwarc.hg.gatech.edu\/sites\/default\/files\/styles\/740xx_scale\/public\/images\/logobldg_graphic_0.png?itok=x84xf3Mz"}}},"media_ids":["70917"],"related_links":[{"url":"http:\/\/simbac.gatech.edu\/","title":"Gumbart lab"},{"url":"http:\/\/www.ibb.gatech.edu\/breakfast-club","title":"IBB Breakfast Club"}],"groups":[{"id":"1292","name":"Parker H. Petit Institute for Bioengineering and Bioscience (IBB)"},{"id":"65448","name":"Bioengineering Graduate Program"}],"categories":[],"keywords":[{"id":"11879","name":"BK Club"},{"id":"248","name":"IBB"}],"core_research_areas":[],"news_room_topics":[],"event_categories":[{"id":"1795","name":"Seminar\/Lecture\/Colloquium"}],"invited_audience":[{"id":"78751","name":"Undergraduate students"},{"id":"78761","name":"Faculty\/Staff"},{"id":"174045","name":"Graduate students"}],"affiliations":[],"classification":[],"areas_of_expertise":[],"news_and_recent_appearances":[],"phone":[],"contact":[{"value":"\u003Cp\u003E\u003Ca href=\u0022mailto:colly.mitchell@ibb.gatech.edu\u0022\u003EColly Mitchell\u003C\/a\u003E\u003C\/p\u003E","format":"limited_html"}],"email":[],"slides":[],"orientation":[],"userdata":""}},"295161":{"#nid":"295161","#data":{"type":"event","title":"PhD Proposal Presentation - Shaun Eshraghi","body":[{"value":"\u003Cp\u003E\u003Cstrong\u003EAdvisor: Suman Das, Ph.D. (Georgia Institute of Technology)\u003C\/strong\u003E\u003C\/p\u003E\u003Cp\u003E\u003Cstrong\u003E\u0026nbsp;\u003C\/strong\u003E\u003C\/p\u003E\u003Cp\u003E\u003Cstrong\u003ECommittee:\u003C\/strong\u003E\u003C\/p\u003E\u003Cp\u003E\u003Cstrong\u003EKyriaki Kalaitzidou, Ph.D. (Georgia Institute of Technology)\u003C\/strong\u003E\u003C\/p\u003E\u003Cp\u003E\u003Cstrong\u003EWilbur A. Lam, Ph.D. (Georgia Institute of Technology)\u003C\/strong\u003E\u003C\/p\u003E\u003Cp\u003E\u003Cstrong\u003EDavid Ku, Ph.D. (Georgia Institute of Technology)\u003C\/strong\u003E\u003C\/p\u003E\u003Cp\u003E\u003Cstrong\u003EJeannette Yen, Ph.D. (Georgia Institute of Technology)\u003C\/strong\u003E\u003C\/p\u003E\u003Cp\u003E\u003Cstrong\u003E\u0026nbsp;\u003C\/strong\u003E\u003C\/p\u003E\u003Cp align=\u0022center\u0022\u003E\u003Cstrong\u003EAdditive Manufacturing of Tissue Engineering Scaffolds for Bone and Cartilage\u003C\/strong\u003E\u003C\/p\u003E\u003Cp align=\u0022center\u0022\u003E\u003Cstrong\u003E\u0026nbsp;\u003C\/strong\u003E\u003C\/p\u003E\u003Cp\u003EBone and cartilage constructs are often plagued with mechanical failure, poor nutrient transport, poor tissue ingrowth, and necrosis of embedded cells. However, advances in computer aided design (CAD) and computational modeling enable the design of scaffolds with complex internal michroarchitectures and the a priori prediction of their transport and mechanical properties, such that the design of constructs satisfying the needs of the tissue environment can be optimized. The goal of this research is to investigate the capability of additive manufacturing technologies to create designed microarchitectured tissue engineering scaffolds for bone and cartilage regeneration. This goal will be achieved by pursuing the following two objectives: (1) the manufacture of bioresorbable thermoplastic scaffolds by selective laser sintering (SLS) (2) and the manufacture of hydrogel scaffolds by large area maskless photopolymerization (LAMP). SLS is a laser based additive manufacturing method in which an object is built layer-by-layer by fusing powdered material using a computer-controlled scanning laser. \u0026nbsp;LAMP is a massively parallel ultraviolet curing-based process that can be used to create hydrogels from a photomonomer on a large-scale (558x558mm) while maintaining extremely high feature resolution (20\u00b5m). In this research, SLS is used to process polycaprolactone (PCL) and composites of PCL with hydroxyapatite (HA) for bone tissue engineering applications while LAMP is used to process polyethylene glycol diacrylate (PEGDA) which can be used for hard and soft tissue applications.\u003C\/p\u003E","summary":null,"format":"limited_html"}],"field_subtitle":"","field_summary":[{"value":"\u003Cp\u003EPhD Proposal Presentation-\u0026nbsp;\u0022Additive Manufacturing of Tissue Engineering Scaffolds for Bone and Cartilage\u0022- Shaun Eshraghi\u003C\/p\u003E","format":"limited_html"}],"field_summary_sentence":[{"value":"\u0022Additive Manufacturing of Tissue Engineering Scaffolds for Bone and Cartilage\u0022"}],"uid":"27917","created_gmt":"2014-05-05 14:43:15","changed_gmt":"2017-04-13 21:22:37","author":"Laura Paige","boilerplate_text":"","field_publication":"","field_article_url":"","field_event_time":{"event_time_start":"2014-05-15T18:00:00-04:00","event_time_end":"2014-05-15T20:00:00-04:00","event_time_end_last":"2014-05-15T20:00:00-04:00","gmt_time_start":"2014-05-15 22:00:00","gmt_time_end":"2014-05-16 00:00:00","gmt_time_end_last":"2014-05-16 00:00:00","rrule":null,"timezone":"America\/New_York"},"extras":[],"groups":[{"id":"65448","name":"Bioengineering Graduate Program"}],"categories":[],"keywords":[],"core_research_areas":[],"news_room_topics":[],"event_categories":[{"id":"1788","name":"Other\/Miscellaneous"}],"invited_audience":[{"id":"78751","name":"Undergraduate students"},{"id":"78761","name":"Faculty\/Staff"},{"id":"174045","name":"Graduate students"}],"affiliations":[],"classification":[],"areas_of_expertise":[],"news_and_recent_appearances":[],"phone":[],"contact":[{"value":"\u003Cp\u003E\u003Ca href=\u0022mailto:Laura.Paige@bioengineering.gatech.edu\u0022\u003ELaura.Paige@bioengineering.gatech.edu\u003C\/a\u003E\u003C\/p\u003E\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E","format":"limited_html"}],"email":[],"slides":[],"orientation":[],"userdata":""}},"286821":{"#nid":"286821","#data":{"type":"event","title":"Petit Institute Seminar","body":[{"value":"\u003Cp\u003E\u003Cstrong\u003E\u00223D Printed Modular Scaffolds: From Concept to Clinic\u0022\u003Cbr \/\u003E\u003Cbr \/\u003EScott Hollister, PhD\u003Cbr \/\u003E\u003C\/strong\u003E\u003Cstrong\u003EProfessor, Biomedical Engineering\u003Cbr \/\u003E\u003C\/strong\u003E\u003Cstrong\u003EAssociate Professor, Surgery\u003Cbr \/\u003E\u003C\/strong\u003E\u003Cstrong\u003EProfessor, Mechanical Engineering\u003Cbr \/\u003E\u003C\/strong\u003E\u003Cstrong\u003EUniversity of Michigan\u003C\/strong\u003E\u003C\/p\u003E\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\u003Cp\u003EDespite its positioning as a translational field and 25 years of existence, tissue engineering has not had significant clinical impact. This is in large part due to the tension of complex therapies (new, resorbable materials plus biologics) juxtaposed with significant regulatory hurdles, requiring validation and quality systems for each therapy component (i.e. scaffold, coatings, biologics). They have adopted a philosophy of modularity, in which the therapy itself, the manufacturing processes used to produce the therapy and the design process are incorporated in separate modules that may be assembled to produce flexibility in therapy combinations. Specifically, they view 3D printing\/additive manufacturing as the cornerstone of making patient specific scaffolds that can then be modified with add on processes like fluid based functionalization to create more complex therapies. In this talk, he will discuss the background of regulatory challenges in tissue engineering, followed by our implementation of modular tissue engineering therapies. He will then present their experiences translating these modular 3D printed scaffold centric therapies into pre-clinical animals models and human clinical use.\u003C\/p\u003E\u003Cp\u003EScott Hollister is a Professor of Biomedical Engineering and Mechanical Engineering at the University of Michigan where he directs the Scaffold Tissue Engineering Group. His research focuses on the design, fabrication and evaluation of biomaterial platform systems for tissue reconstruction. He is a fellow of the American Institute of Medical and Biological Engineering. His work on a bioresorbable tracheal splint along with Glenn Green was awarded a Popular Mechanics 2013 Breakthrough Innovation award and featured on the Today Show, USA Today, NPR, Time magazine, Popular Mechanics among other media.\u003C\/p\u003E","summary":null,"format":"limited_html"}],"field_subtitle":"","field_summary":[{"value":"\u003Cp\u003EThe Petit Institute hosts special guests and visitors throughout the year.\u0026nbsp; These seminars are open to all faculty and students.\u003C\/p\u003E","format":"limited_html"}],"field_summary_sentence":[{"value":"\u00223D Printed Modular Scaffolds: From Concept to Clinic\u0022 - Scott Hollister, PhD - University of Michigan"}],"uid":"27959","created_gmt":"2014-03-28 16:08:09","changed_gmt":"2017-04-13 21:22:49","author":"Karen Ethier","boilerplate_text":"","field_publication":"","field_article_url":"","field_event_time":{"event_time_start":"2014-05-15T17:00:00-04:00","event_time_end":"2014-05-15T18:00:00-04:00","event_time_end_last":"2014-05-15T18:00:00-04:00","gmt_time_start":"2014-05-15 21:00:00","gmt_time_end":"2014-05-15 22:00:00","gmt_time_end_last":"2014-05-15 22:00:00","rrule":null,"timezone":"America\/New_York"},"extras":[],"related_links":[{"url":"http:\/\/www.ibb.gatech.edu\/petit-institute-seminars","title":"Petit Institute Seminar Schedule"}],"groups":[{"id":"1292","name":"Parker H. Petit Institute for Bioengineering and Bioscience (IBB)"},{"id":"65448","name":"Bioengineering Graduate Program"}],"categories":[],"keywords":[{"id":"248","name":"IBB"},{"id":"5168","name":"IBB Seminar"}],"core_research_areas":[],"news_room_topics":[],"event_categories":[{"id":"1795","name":"Seminar\/Lecture\/Colloquium"}],"invited_audience":[{"id":"78751","name":"Undergraduate students"},{"id":"78761","name":"Faculty\/Staff"},{"id":"174045","name":"Graduate students"}],"affiliations":[],"classification":[],"areas_of_expertise":[],"news_and_recent_appearances":[],"phone":[],"contact":[{"value":"\u003Cp\u003EFaculty host - \u003Ca href=\u0022%20robert.guldberg@me.gatech.edu\u0022\u003ERobert E. Guldberg, PhD\u003C\/a\u003E\u003C\/p\u003E","format":"limited_html"}],"email":[],"slides":[],"orientation":[],"userdata":""}},"296531":{"#nid":"296531","#data":{"type":"event","title":"BioE Free Photo Session","body":[{"value":"\u003Cp\u003EMy 27th and May 29th\u003C\/p\u003E\u003Cp\u003E3pm - 5pm\u003C\/p\u003E\u003Cp\u003ECome have your photo professionally taken for your LinkedIn profile or lab websites! \u003Ca href=\u0022http:\/\/www.signupgenius.com\/go\/10C0A49AAA929A3FF2-professional?uToken=25EFC3FCFA03FD075EC3DECA02E8\u0022 target=\u0022_blank\u0022\u003EClick here\u003C\/a\u003E\u0026nbsp; to sign up for a time slot before they are all filled! Refreshments will be provided.\u003Cbr \/\u003ESponsored by BGSAC \u0026amp;\u0026amp; BBUGS\u003C\/p\u003E","summary":null,"format":"limited_html"}],"field_subtitle":"","field_summary":"","field_summary_sentence":[{"value":"Come have your photo professionally taken for your LinkedIn profile or lab websites!"}],"uid":"27349","created_gmt":"2014-05-12 11:50:57","changed_gmt":"2017-04-13 21:22:36","author":"Floyd Wood","boilerplate_text":"","field_publication":"","field_article_url":"","field_event_time":{"event_time_start":"2014-05-27T20:00:00-04:00","event_time_end":"2014-05-29T22:00:00-04:00","event_time_end_last":"2014-05-29T22:00:00-04:00","gmt_time_start":"2014-05-28 00:00:00","gmt_time_end":"2014-05-30 02:00:00","gmt_time_end_last":"2014-05-30 02:00:00","rrule":null,"timezone":"America\/New_York"},"extras":[],"groups":[{"id":"65448","name":"Bioengineering Graduate Program"}],"categories":[],"keywords":[{"id":"6178","name":"BIOE"},{"id":"569","name":"bioengineering"}],"core_research_areas":[],"news_room_topics":[],"event_categories":[{"id":"1788","name":"Other\/Miscellaneous"}],"invited_audience":[{"id":"78751","name":"Undergraduate students"},{"id":"174045","name":"Graduate students"}],"affiliations":[],"classification":[],"areas_of_expertise":[],"news_and_recent_appearances":[],"phone":[],"contact":[],"email":[],"slides":[],"orientation":[],"userdata":""}},"265801":{"#nid":"265801","#data":{"type":"event","title":"Petit Institute Seminar","body":[{"value":"\u003Cp\u003E\u003Cstrong\u003E\u0022Systems Tissue Engineering\u0022\u003Cbr \/\u003E\u003Cbr \/\u003ELonnie D. Shea, PhD\u003C\/strong\u003E\u003Cbr \/\u003E\u003Cstrong\u003EProfessor\u003C\/strong\u003E\u003Cbr \/\u003E\u003Cstrong\u003EChemical \u0026amp; Biological Engineering\u003C\/strong\u003E\u003Cbr \/\u003E\u003Cstrong\u003ENorthwestern University\u003C\/strong\u003E\u003Cbr \/\u003E\u003Cbr \/\u003ESystems and strategies for promoting tissue growth provide enabling technologies for either enhancing regeneration for diseased or injured tissues, or to investigate abnormal tissue formation such as cancer. Given the complexity inherent in tissues, my laboratory is working towards the concept of \u0022Systems Tissue Engineering\u0022, which indicates the dual need i) to develop systems capable of presenting combinations of factors that drive tissue growth, as well as ii) to incorporate systems biology approaches that can identify the appropriate combination of factors. Biomaterial scaffolds represent a central component of many approaches and provide the enabling tools for creating an environment and\/or deliver factors that can direct cellular processes toward tissue formation. We have developed scaffolds with the objective of providing factors to stimulate growth and also blocking factors that inhibit regeneration, and will illustrate this approach through our work with islet transplantation in Type 1 Diabetes therapy and scaffolds for the early detection of cancer. The immune response has become a central focus, and will present results for local immunomodulation around the scaffold, as well as the development of nanoparticles for modulating the immune response, in order to induce tolerance in autoimmune disease and allogeneic cell transplantation.\u0026nbsp; The ability to present multiple factors raises the challenge of identifying the combination that will maximally promote tissue formation. Toward this goal, we have developed a cellular array for the large scale profiling of transcription factor activity throughout tissue formation, which we propose can identify the factors necessary to drive cells towards the desired phenotype. This array represents a novel systems biology tool for molecularly dissecting tissue formation. This approach of relating tissue development to molecular design of the scaffold may ultimately lead to the formation of engineered tissues that could provide alternatives to whole organ or tissue transplantation.\u003C\/p\u003E\u003Cp\u003E\u003Cbr \/\u003E\u003Ca href=\u0022mailto:robert.guldberg@ibb.gatech.edu\u0022\u003EBob Guldberg, PhD\u003C\/a\u003E - faculty host\u003C\/p\u003E\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E","summary":null,"format":"limited_html"}],"field_subtitle":"","field_summary":[{"value":"\u003Cp\u003EThe Petit Institute hosts special guests and visitors throughout the year.\u0026nbsp; These seminars are open to all faculty and students.\u003C\/p\u003E","format":"limited_html"}],"field_summary_sentence":[{"value":"\u0022Systems Tissue Engineering\u0022 - Lonnie D. Shea, MD - Northwestern University"}],"uid":"27195","created_gmt":"2014-01-10 11:15:54","changed_gmt":"2017-04-13 21:23:33","author":"Colly Mitchell","boilerplate_text":"","field_publication":"","field_article_url":"","field_event_time":{"event_time_start":"2014-01-23T11:00:00-05:00","event_time_end":"2014-01-23T12:00:00-05:00","event_time_end_last":"2014-01-23T12:00:00-05:00","gmt_time_start":"2014-01-23 16:00:00","gmt_time_end":"2014-01-23 17:00:00","gmt_time_end_last":"2014-01-23 17:00:00","rrule":null,"timezone":"America\/New_York"},"extras":[],"related_links":[{"url":"http:\/\/www.shearesearch.northwestern.edu\/","title":"Shea lab website"}],"groups":[{"id":"1292","name":"Parker H. Petit Institute for Bioengineering and Bioscience (IBB)"},{"id":"65448","name":"Bioengineering Graduate Program"}],"categories":[],"keywords":[{"id":"248","name":"IBB"},{"id":"5168","name":"IBB Seminar"}],"core_research_areas":[],"news_room_topics":[],"event_categories":[{"id":"1795","name":"Seminar\/Lecture\/Colloquium"}],"invited_audience":[{"id":"78751","name":"Undergraduate students"},{"id":"78761","name":"Faculty\/Staff"},{"id":"174045","name":"Graduate students"}],"affiliations":[],"classification":[],"areas_of_expertise":[],"news_and_recent_appearances":[],"phone":[],"contact":[{"value":"\u003Cp\u003E\u003Ca href=\u0022mailto:robert.guldberg@ibb.gatech.edu\u0022\u003EBob Guldberg, PhD\u003C\/a\u003E\u003C\/p\u003E","format":"limited_html"}],"email":[],"slides":[],"orientation":[],"userdata":""}},"266191":{"#nid":"266191","#data":{"type":"event","title":"BioEngineering Graduate Committee Meeting","body":[{"value":"\u003Cp\u003EThe BioEngineering graduate committee will meet to review\/approve program policies, program faculty applications and submitted student petitions.\u003Cbr \/\u003E\u003Cbr \/\u003EStudent Petitions due to\u003Ca href=\u0022mailto:laura.paige@bioengineering.gatech.edu\u0022\u003E Laura Paige\u003C\/a\u003E no later than:\u0026nbsp; Wednesday, January 15, 2014\u003Cbr \/\u003E\u003Cbr \/\u003E\u003Cbr \/\u003E\u003C\/p\u003E","summary":null,"format":"limited_html"}],"field_subtitle":"","field_summary":[{"value":"\u003Cp\u003EProgram policies, faculty applications and student petitions to be discussed\u003C\/p\u003E","format":"limited_html"}],"field_summary_sentence":[{"value":"Program policies, faculty applications and student petitions to be discussed"}],"uid":"27195","created_gmt":"2014-01-13 09:20:09","changed_gmt":"2016-10-08 02:06:16","author":"Colly Mitchell","boilerplate_text":"","field_publication":"","field_article_url":"","field_event_time":{"event_time_start":"2014-01-22T11:00:00-05:00","event_time_end":"2014-01-22T12:00:00-05:00","event_time_end_last":"2014-01-22T12:00:00-05:00","gmt_time_start":"2014-01-22 16:00:00","gmt_time_end":"2014-01-22 17:00:00","gmt_time_end_last":"2014-01-22 17:00:00","rrule":null,"timezone":"America\/New_York"},"extras":[],"related_links":[{"url":"http:\/\/www.bioengineering.gatech.edu\/","title":"BioEngineering website"}],"groups":[{"id":"65448","name":"Bioengineering Graduate Program"}],"categories":[],"keywords":[],"core_research_areas":[],"news_room_topics":[],"event_categories":[{"id":"1788","name":"Other\/Miscellaneous"}],"invited_audience":[{"id":"78761","name":"Faculty\/Staff"}],"affiliations":[],"classification":[],"areas_of_expertise":[],"news_and_recent_appearances":[],"phone":[],"contact":[{"value":"\u003Cp\u003E\u003Ca href=\u0022mailto:laura.paige@bioengineering.gatech.edu\u0022\u003ELaura Paige\u003C\/a\u003E\u003C\/p\u003E","format":"limited_html"}],"email":[],"slides":[],"orientation":[],"userdata":""}},"236931":{"#nid":"236931","#data":{"type":"event","title":"Stem Cell Engineering Center Seminar Series","body":[{"value":"\u003Cp\u003E\u003Cstrong\u003E\u0022Turning Fat Into Bone and Muscle\u0022\u003Cbr \/\u003E\u003Cbr \/\u003EWarren Grayson, PhD\u003Cbr \/\u003EAssistant Professor\u003Cbr \/\u003EJohns Hopkins University\u003Cbr \/\u003E\u003C\/strong\u003E\u003Cbr \/\u003EWarren Grayson, PhD is an Assistant Professor in the Johns Hopkins\u2019 Biomedical Engineering and Translational Tissue Engineering Center. He obtained his B.Sc. in Chemical \u0026amp; Process Engineering at The University of the West Indies, his PhD in Biomedical Engineering from Florida State University, and completed his postdoctoral training at Columbia University in New York. His research interests focus on engineering musculoskeletal grafts for craniofacial and orthopaedic tissue regeneration. Dr. Grayson\u2019s previous work on bioreactor design and engineering anatomically shaped bone grafts has received national and international coverage in the New York Times, BBC, and Science Translational Medicine, among others. \u0026nbsp;He has been recognized by the Maryland Science Center as an Outstanding Young Engineer and has received awards from the Orthopaedic Research Society and the American Society for Bone and Mineral Research. Currently, his lab focuses on spatial and temporal regulation of stem cell differentiation in 3D constructs to generate clinically useful engineered grafts.\u003C\/p\u003E\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\u003Cp\u003ESuggestions for potential speakers are always welcome, please contact \u003Ca href=\u0022mailto:marissa.cooke@bme.gatech.edu\u0022\u003EMarissa Cooke\u003C\/a\u003E\u003C\/p\u003E","summary":null,"format":"limited_html"}],"field_subtitle":"","field_summary":[{"value":"\u003Cp\u003EThe Stem Cell Engineering Center (SCEC) seminar series showcases enabling technologies and fosters new interdisciplinary and multi-investigator collaborations. The seminars are open to all faculty or trainees interested in stem cell engineering research.\u003C\/p\u003E","format":"limited_html"}],"field_summary_sentence":[{"value":"\u0022Turning Fat Into Bone and Muscle\u0022 - Warren Grayson, PhD, Johns Hopkins University"}],"uid":"27875","created_gmt":"2013-09-12 11:42:54","changed_gmt":"2017-04-13 21:24:00","author":"Marissa Cooke","boilerplate_text":"","field_publication":"","field_article_url":"","field_event_time":{"event_time_start":"2014-03-11T12:00:00-04:00","event_time_end":"2014-03-11T13:00:00-04:00","event_time_end_last":"2014-03-11T13:00:00-04:00","gmt_time_start":"2014-03-11 16:00:00","gmt_time_end":"2014-03-11 17:00:00","gmt_time_end_last":"2014-03-11 17:00:00","rrule":null,"timezone":"America\/New_York"},"extras":[],"hg_media":{"236941":{"id":"236941","type":"image","title":"Warren Grayson, PhD","body":null,"created":"1449243659","gmt_created":"2015-12-04 15:40:59","changed":"1475894911","gmt_changed":"2016-10-08 02:48:31","alt":"Warren Grayson, PhD","file":{"fid":"197694","name":"grayson_photo.jpg","image_path":"\/sites\/default\/files\/images\/grayson_photo_0.jpg","image_full_path":"http:\/\/www.tlwarc.hg.gatech.edu\/\/sites\/default\/files\/images\/grayson_photo_0.jpg","mime":"image\/jpeg","size":36549,"path_740":"http:\/\/www.tlwarc.hg.gatech.edu\/sites\/default\/files\/styles\/740xx_scale\/public\/images\/grayson_photo_0.jpg?itok=krhippj0"}}},"media_ids":["236941"],"related_links":[{"url":"http:\/\/www.scec.gatech.edu\/","title":"SCEC website"},{"url":"http:\/\/www.jhu.edu\/graysonlab\/","title":"Grayson Lab website"},{"url":"http:\/\/www.stemcelligert.gatech.edu\/","title":"Stem Cell Biomanufacturing IGERT"},{"url":"http:\/\/www.ibb.gatech.edu\/","title":"Petit Institute for Bioengineering and Bioscience"}],"groups":[{"id":"65425","name":"IBB Center - SCEC"},{"id":"65446","name":"IBB Training Grant - Stem Cell Biomanufacturing IGERT"}],"categories":[],"keywords":[{"id":"248","name":"IBB"},{"id":"167446","name":"SCEC Seminar"}],"core_research_areas":[],"news_room_topics":[],"event_categories":[{"id":"1795","name":"Seminar\/Lecture\/Colloquium"}],"invited_audience":[{"id":"78751","name":"Undergraduate students"},{"id":"78761","name":"Faculty\/Staff"},{"id":"174045","name":"Graduate students"}],"affiliations":[],"classification":[],"areas_of_expertise":[],"news_and_recent_appearances":[],"phone":[],"contact":[{"value":"\u003Cp\u003E\u003Ca href=\u0022mailto:marissa.cooke@bme.gatech.edu\u0022\u003EMarissa Cooke\u003C\/a\u003E\u003C\/p\u003E\u003Cp\u003E(404) 385-6905\u003C\/p\u003E","format":"limited_html"}],"email":[],"slides":[],"orientation":[],"userdata":""}},"261661":{"#nid":"261661","#data":{"type":"event","title":"BioEngineering Program Faculty Meeting","body":[{"value":"\u003Cp\u003EThe BioEngineering Program faculty meet to address program policies, events and future research and academic directions.\u0026nbsp; \u003Cbr \/\u003E\u003Cbr \/\u003ELunch will be served.\u0026nbsp; \u003Cbr \/\u003EPlease RSVP to \u003Ca href=\u0022mailto:laura.paige@bioengineering.gatech.edu\u0022\u003ELaura Paige\u003C\/a\u003E.\u003C\/p\u003E","summary":null,"format":"limited_html"}],"field_subtitle":"","field_summary":[{"value":"\u003Cp\u003EThe BioEngineering Program faculty meet regularly during the semester to address program policies, events and future research and academic directions.\u003Cbr \/\u003E\u003Cbr \/\u003E\u003C\/p\u003E","format":"limited_html"}],"field_summary_sentence":[{"value":"Program policies, events and directions to be discussed"}],"uid":"27349","created_gmt":"2013-12-17 14:14:45","changed_gmt":"2016-10-08 02:06:02","author":"Floyd Wood","boilerplate_text":"","field_publication":"","field_article_url":"","field_event_time":{"event_time_start":"2014-01-23T10:00:00-05:00","event_time_end":"2014-01-23T11:00:00-05:00","event_time_end_last":"2014-01-23T11:00:00-05:00","gmt_time_start":"2014-01-23 15:00:00","gmt_time_end":"2014-01-23 16:00:00","gmt_time_end_last":"2014-01-23 16:00:00","rrule":null,"timezone":"America\/New_York"},"extras":[],"groups":[{"id":"65448","name":"Bioengineering Graduate Program"}],"categories":[],"keywords":[{"id":"569","name":"bioengineering"},{"id":"5035","name":"Bioengineering and Bioscience Unified Graduate Students"}],"core_research_areas":[],"news_room_topics":[],"event_categories":[{"id":"1788","name":"Other\/Miscellaneous"}],"invited_audience":[{"id":"78761","name":"Faculty\/Staff"}],"affiliations":[],"classification":[],"areas_of_expertise":[],"news_and_recent_appearances":[],"phone":[],"contact":[],"email":[],"slides":[],"orientation":[],"userdata":""}},"229761":{"#nid":"229761","#data":{"type":"event","title":"Stem Cell Engineering Center Seminar Series","body":[{"value":"\u003Cp\u003E\u003Cstrong\u003E\u0022Materials-Directed Myogenesis of Adipose-Derived Stem Cells and their Therapeutic Use\u0022\u003Cbr \/\u003E\u003C\/strong\u003E\u003Cstrong\u003E\u003Cbr \/\u003EAdam Engler, PhD\u003Cbr \/\u003EAssistant Professor\u003Cbr \/\u003EUniversity of California, San Diego\u003C\/strong\u003E\u003C\/p\u003E\u003Cp\u003E\u003Cstrong\u003E\u003Cbr \/\u003E\u003C\/strong\u003EAdam J. Engler, PhD, is an assistant professor of Bioengineering at UC San Diego and is affiliated with the Material Science and Biomedical Sciences Programs. He also is a resident scientist at the Sanford Consortium for Regenerative Medicine. His research focuses on how physical properties of the niche influence stem cell function and misregulate muscle function and heart performance during disease and aging. Engler earned his B.S.E. degree in bioengineering and a PhD in mechanical engineering and applied mechanics at the University of Pennsylvania in the lab of Dennis Discher, PhD. Engler then moved to Princeton University\u0027s Department of Molecular Biology as a Postdoctoral Research Fellow in the lab of Jean Schwarzbauer, PhD, where his work was funded by the National Cancer Institute. Engler is the 2008 recipient of the Rupert Timpl and Rita Schaffer Young Investigator Awards from the International Society for Matrix Biology and the Biomedical Engineering Society, respectively. He is also a 2009 NIH Innovator Award recipient, a 2010 Young Investigator Awardee from the Human Frontier Science Program, and 2013 DoD IDEA awardee for his work on the extracellular matrix and cancer stem cells.\u003C\/p\u003E\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\u003Cp\u003ESuggestions for potential speakers are always welcome, please contact \u003Ca href=\u0022mailto:marissa.cooke@bme.gatech.edu\u0022\u003EMarissa Cooke\u003C\/a\u003E\u003C\/p\u003E","summary":null,"format":"limited_html"}],"field_subtitle":"","field_summary":[{"value":"\u003Cp\u003EThe Stem Cell Engineering Center (SCEC) seminar series showcases enabling technologies and fosters new interdisciplinary and multi-investigator collaborations. \u0026nbsp;The seminars are open to all faculty or trainees interested in stem cell engineering research.\u003C\/p\u003E","format":"limited_html"}],"field_summary_sentence":[{"value":"\u0022Materials-Directed Myogenesis of Adipose-Derived Stem Cells and their Therapeutic Use\u0022 - Adam Engler, PhD, University of California, San Diego"}],"uid":"27875","created_gmt":"2013-08-19 14:36:20","changed_gmt":"2017-04-13 21:24:01","author":"Marissa Cooke","boilerplate_text":"","field_publication":"","field_article_url":"","field_event_time":{"event_time_start":"2014-01-14T10:00:00-05:00","event_time_end":"2014-01-14T11:00:00-05:00","event_time_end_last":"2014-01-14T11:00:00-05:00","gmt_time_start":"2014-01-14 15:00:00","gmt_time_end":"2014-01-14 16:00:00","gmt_time_end_last":"2014-01-14 16:00:00","rrule":null,"timezone":"America\/New_York"},"extras":[],"hg_media":{"230851":{"id":"230851","type":"image","title":"Adam Engler, PhD","body":null,"created":"1449243602","gmt_created":"2015-12-04 15:40:02","changed":"1475894903","gmt_changed":"2016-10-08 02:48:23","alt":"Adam Engler, PhD","file":{"fid":"197535","name":"engler.jpg","image_path":"\/sites\/default\/files\/images\/engler_0.jpg","image_full_path":"http:\/\/www.tlwarc.hg.gatech.edu\/\/sites\/default\/files\/images\/engler_0.jpg","mime":"image\/jpeg","size":28205,"path_740":"http:\/\/www.tlwarc.hg.gatech.edu\/sites\/default\/files\/styles\/740xx_scale\/public\/images\/engler_0.jpg?itok=bcAIlyMm"}}},"media_ids":["230851"],"related_links":[{"url":"http:\/\/ecm.ucsd.edu\/","title":"Engler Lab website"},{"url":"http:\/\/www.ibb.gatech.edu\/","title":"Petit Institute for Bioengineering and Bioscience"},{"url":"http:\/\/www.scec.gatech.edu\/","title":"SCEC website"},{"url":"http:\/\/www.stemcelligert.gatech.edu\/","title":"Stem Cell Biomanufacturing IGERT"}],"groups":[{"id":"1292","name":"Parker H. Petit Institute for Bioengineering and Bioscience (IBB)"},{"id":"65425","name":"IBB Center - SCEC"},{"id":"65446","name":"IBB Training Grant - Stem Cell Biomanufacturing IGERT"},{"id":"65448","name":"Bioengineering Graduate Program"}],"categories":[],"keywords":[{"id":"248","name":"IBB"},{"id":"167446","name":"SCEC Seminar"}],"core_research_areas":[],"news_room_topics":[],"event_categories":[{"id":"1795","name":"Seminar\/Lecture\/Colloquium"}],"invited_audience":[{"id":"78751","name":"Undergraduate students"},{"id":"78761","name":"Faculty\/Staff"},{"id":"174045","name":"Graduate students"}],"affiliations":[],"classification":[],"areas_of_expertise":[],"news_and_recent_appearances":[],"phone":[],"contact":[{"value":"\u003Cp\u003E\u003Ca href=\u0022mailto:marissa.cooke@bme.gatech.edu\u0022\u003EMarissa Cooke\u003C\/a\u003E\u003C\/p\u003E\u003Cp\u003E(404) 385-6905\u003C\/p\u003E","format":"limited_html"}],"email":[],"slides":[],"orientation":[],"userdata":""}},"333041":{"#nid":"333041","#data":{"type":"event","title":"PhD Defense Presentation- Christopher Phaneuf","body":[{"value":"\u003Cp\u003EDr. Craig R. Forest, Chair (ME)\u003C\/p\u003E\u003Cp\u003EDr. Suman Das (ME)\u003C\/p\u003E\u003Cp\u003EDr. Peter J. Hesketh (ME)\u003C\/p\u003E\u003Cp\u003EDr. James P. Landers (Chemistry (Univ. of Virginia))\u003C\/p\u003E\u003Cp\u003EDr. Hang Lu (ChBE)\u003C\/p\u003E\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\u003Cp\u003ESUMMARY\u003C\/p\u003E\u003Cp\u003EThe ability to rapidly, sensitively, and accurately detect the presence of a pathogen is a vital capability for first responders in the assessment and treatment of scenarios such as disease outbreak and bioterrorism. Nucleic acid tests such as the polymerase chain reaction (PCR) are supplanting traditional techniques due to the improved speed, specificity, sensitivity, and simplicity. Still, amplification by PCR is often the bottleneck when processing genetic samples. Conventional PCR machines are bulky, slow, and consume large reagent volumes and an affordable, compact, efficient, easy-to-use alternative has yet to emerge.\u003C\/p\u003E\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\u003Cp\u003EIn this work, a microfluidic PCR platform was developed consisting of a low-cost, multi-chamber polymer microchip and a laser-mediated thermocycler capable of independent thermal control of each reaction chamber. Innovations in polymer microchip modeling, fabrication, and characterization yielded a low-cost solution for sample handling. A simple optical system featuring an infrared laser diode and solenoid-driven optical shutter was combined with a microfluidic temperature measurement system utilizing embedded thermocouples to achieve rapid thermocycling capable of multiplexed temperature control. We validated the instrument with sensitive amplifications of multiple viral targets simultaneously. This technology is a breakthrough in practical microfluidic PCR instrumentation, providing the foundation for a paradigm shift in low-cost, high-throughput genetic diagnostics.\u003C\/p\u003E\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E","summary":null,"format":"limited_html"}],"field_subtitle":"","field_summary":[{"value":"\u003Cp\u003EPhD Defense Presentation-\u0026nbsp;\u0022Infrared Laser-mediated Polymerase Chain Reaction in a Polymer Microfluidic Device\u0022- Christopher Phaneuf\u003C\/p\u003E","format":"limited_html"}],"field_summary_sentence":[{"value":"\u0022Infrared Laser-mediated Polymerase Chain Reaction in a Polymer Microfluidic Device\u0022"}],"uid":"27917","created_gmt":"2014-10-10 13:07:33","changed_gmt":"2017-04-13 21:21:27","author":"Laura Paige","boilerplate_text":"","field_publication":"","field_article_url":"","field_event_time":{"event_time_start":"2014-10-15T13:00:00-04:00","event_time_end":"2014-10-15T15:00:00-04:00","event_time_end_last":"2014-10-15T15:00:00-04:00","gmt_time_start":"2014-10-15 17:00:00","gmt_time_end":"2014-10-15 19:00:00","gmt_time_end_last":"2014-10-15 19:00:00","rrule":null,"timezone":"America\/New_York"},"extras":[],"groups":[{"id":"65448","name":"Bioengineering Graduate Program"}],"categories":[],"keywords":[],"core_research_areas":[],"news_room_topics":[],"event_categories":[{"id":"1788","name":"Other\/Miscellaneous"}],"invited_audience":[{"id":"78751","name":"Undergraduate students"},{"id":"78761","name":"Faculty\/Staff"},{"id":"174045","name":"Graduate students"}],"affiliations":[],"classification":[],"areas_of_expertise":[],"news_and_recent_appearances":[],"phone":[],"contact":[{"value":"\u003Cp\u003ELaura Paige\u0026nbsp;\u003C\/p\u003E","format":"limited_html"}],"email":[],"slides":[],"orientation":[],"userdata":""}}}