{"660883":{"#nid":"660883","#data":{"type":"event","title":"Special Biochem Seminar: Prof. Berkley Gryder (Case Western Reserve University)","body":[{"value":"\u003Cdiv\u003E\u003Cstrong\u003ETitle: \u003C\/strong\u003E\u003C\/div\u003E\r\n\r\n\u003Cdiv\u003EAndrogen Receptor Inverse Agonists\u0026nbsp;\u003C\/div\u003E\r\n\r\n\u003Cdiv\u003E\r\n\u003Cdiv\u003E\r\n\u003Cdiv\u003E\u0026nbsp;\u003C\/div\u003E\r\n\r\n\u003Cdiv\u003E\u003Cstrong\u003EAbstract:\u003C\/strong\u003E\u003C\/div\u003E\r\n\u003C\/div\u003E\r\n\r\n\u003Cdiv\u003EHuman diseases are often driven by abnormal gene regulation.\u0026nbsp; This involves DNA binding transcription factors (TFs) that begin misinterpreting the genetic information.\u0026nbsp; The Androgen Receptor (AR) is one such TF responsive to testosterone in male-specific organs, and the AR goes rogue in the context of prostate cancer.\u0026nbsp; The\u0026nbsp;Gryder\u0026nbsp;lab has discovered new mechanisms by which the AR rewires the genome and the 3D epigenome in prostate cancer.\u0026nbsp; We have developed a new chemical probe that causes the AR to shutdown 3D loops between enhancers (long-range regulatory DNA elements) and target genes. Furthermore, we are exploring the role of liquid-liquid phase separation as a mechanism for the formation of 3D clusters in the prostate cancer epigenome, providing new clues as to how molecular assembly at key genetic locations is occurring,\u0026nbsp;and how drugs may act upon these clusters for therapeutic\u0026nbsp;benefit.\u0026nbsp;\u003C\/div\u003E\r\n\u003C\/div\u003E\r\n","summary":null,"format":"limited_html"}],"field_subtitle":"","field_summary":[{"value":"\u003Cdiv\u003E\u003Cstrong\u003ETitle: \u003C\/strong\u003E\u003C\/div\u003E\r\n\r\n\u003Cdiv\u003EAndrogen Receptor Inverse Agonists\u0026nbsp;\u003C\/div\u003E\r\n\r\n\u003Cdiv\u003E\r\n\u003Cdiv\u003E\r\n\u003Cdiv\u003E\u0026nbsp;\u003C\/div\u003E\r\n\r\n\u003Cdiv\u003E\u003Cstrong\u003EAbstract:\u003C\/strong\u003E\u003C\/div\u003E\r\n\u003C\/div\u003E\r\n\r\n\u003Cdiv\u003EHuman diseases are often driven by abnormal gene regulation.\u0026nbsp; This involves DNA binding transcription factors (TFs) that begin misinterpreting the genetic information.\u0026nbsp; The Androgen Receptor (AR) is one such TF responsive to testosterone in male-specific organs, and the AR goes rogue in the context of prostate cancer.\u0026nbsp; The\u0026nbsp;Gryder\u0026nbsp;lab has discovered new mechanisms by which the AR rewires the genome and the 3D epigenome in prostate cancer.\u0026nbsp; We have developed a new chemical probe that causes the AR to shutdown 3D loops between enhancers (long-range regulatory DNA elements) and target genes. Furthermore, we are exploring the role of liquid-liquid phase separation as a mechanism for the formation of 3D clusters in the prostate cancer epigenome, providing new clues as to how molecular assembly at key genetic locations is occurring,\u0026nbsp;and how drugs may act upon these clusters for therapeutic\u0026nbsp;benefit.\u0026nbsp;\u003C\/div\u003E\r\n\u003C\/div\u003E\r\n","format":"limited_html"}],"field_summary_sentence":[{"value":"Special Biochem Seminar"}],"uid":"28099","created_gmt":"2022-09-06 11:14:44","changed_gmt":"2022-09-06 16:39:34","author":"Michele Yager","boilerplate_text":"","field_publication":"","field_article_url":"","field_event_time":{"event_time_start":"2022-09-09T12:00:00-04:00","event_time_end":"2022-09-09T13:00:00-04:00","event_time_end_last":"2022-09-09T13:00:00-04:00","gmt_time_start":"2022-09-09 16:00:00","gmt_time_end":"2022-09-09 17:00:00","gmt_time_end_last":"2022-09-09 17:00:00","rrule":null,"timezone":"America\/New_York"},"extras":[],"groups":[{"id":"85951","name":"School of Chemistry and Biochemistry"}],"categories":[],"keywords":[],"core_research_areas":[],"news_room_topics":[],"event_categories":[],"invited_audience":[{"id":"78761","name":"Faculty\/Staff"},{"id":"78771","name":"Public"},{"id":"78751","name":"Undergraduate students"}],"affiliations":[],"classification":[],"areas_of_expertise":[],"news_and_recent_appearances":[],"phone":[],"contact":[{"value":"\u003Cp\u003EHosted by:\u0026nbsp; Adegboyega \u0026quot;Yomi\u0026quot; Oyelere\u003C\/p\u003E\r\n","format":"limited_html"}],"email":[],"slides":[],"orientation":[],"userdata":""}}}