{"662612":{"#nid":"662612","#data":{"type":"news","title":"Andrew Schilling Wins Best Presentation at 2022 Herty Metal Undergrad Research Symposium","body":[{"value":"\u003Cp\u003EBiochemistry undergraduate \u003Ca href=\u0022https:\/\/www.linkedin.com\/in\/andrew-schilling-a71582197\u0022\u003EAndrew Schilling\u003C\/a\u003E has won the Best Presentation Award at the 2022 \u003Ca href=\u0022https:\/\/acsga.org\/herty-medalist-undergraduate-research-symposium-hmurs\/\u0022\u003EHerty Metal Undergrad Research Symposium\u003C\/a\u003E (HMURS).\u003C\/p\u003E\r\n\r\n\u003Cp\u003ESchilling is an undergraduate research assistant in the lab of Regents\u0026#39; Professor \u003Ca href=\u0022https:\/\/chemistry.gatech.edu\/people\/nicholas-hud\u0022\u003ENicholas Hud\u003C\/a\u003E, where he works to synthesize prebiotically plausible biomolecules and use supramolecular assemblies as templates in the generation of proto-nucleic acid oligomer from non-canonical nucleobases and alternative backbones \u0026mdash; while also studying their base-pairing properties to understand the chemical evolution of nucleic acids and possible pathways of informational biopolymers.\u003C\/p\u003E\r\n\r\n\u003Cp\u003ESchilling\u0026#39;s award includes a travel award to the \u003Ca href=\u0022https:\/\/www.acs.org\/content\/acs\/en.html\u0022\u003EAmerican Chemical Society\u003C\/a\u003E (ACS) national meeting, as well as an annual ACS membership.\u003C\/p\u003E\r\n\r\n\u003Cp\u003EHis winning presentation, \u0026quot;Supramolecular Assembly Promotes the Non-enzymatic Generation of Proto-nucleic Acid Oligomers\u0026quot;, is summarized below.\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u003Cstrong\u003EAbstract\u003C\/strong\u003E\u003C\/p\u003E\r\n\r\n\u003Cp\u003EThe means by which biological informational polymers arose are currently unknown. The possibility that RNA was the first genetic polymer of life has motivated researchers to seek a prebiotic synthesis of RNA,\u003Csup\u003E1,2\u003C\/sup\u003E yet demonstration of such a process remains difficult. Alternatively, RNA may be a molecular descendent of proto-RNA. Which in turn may be a descendant of an original polymer or contained nucleobases with an intrinsic capability to base pair at the monomeric level.\u003Csup\u003E3\u003C\/sup\u003E Here we report suitable substituted and prebiotically plausible functionalized non canonical nucleobases as a proto-nucleotides. These proto-nucleotides spontaneously self-assemble and promote long and selectively linear oligomers relative to those in the non-assembled state in the presence of condensing agents. These results highlight a possible pathway by which simple, self-assembling molecules could selectively and favorably elongate to form primitive informational polymers.\u003C\/p\u003E\r\n\r\n\u003Col\u003E\r\n\t\u003Cli\u003E\u0026nbsp;Orgel, L. E. \u003Cem\u003EJ. Mol. Biol.\u003C\/em\u003E \u003Cstrong\u003E1968\u003C\/strong\u003E, \u003Cem\u003E38\u003C\/em\u003E, 381-393.\u003C\/li\u003E\r\n\t\u003Cli\u003ECrick, F. H. C. \u003Cem\u003EJ. Mol. \u003C\/em\u003E\u003Cem\u003EBiol.\u003C\/em\u003E \u003Cstrong\u003E1968\u003C\/strong\u003E, \u003Cem\u003E38\u003C\/em\u003E, 367-379.\u003C\/li\u003E\r\n\t\u003Cli\u003EHud, N. V.; Cafferty, B. J.; Krishnamurthy, R.; Williams, L. D.\u0026nbsp;\u003Cem\u003EChemistry \u0026amp; Biology \u003C\/em\u003E\u003Cstrong\u003E2013\u003C\/strong\u003E,\u0026nbsp;\u003Cem\u003E20\u003C\/em\u003E(4), 466\u0026ndash;474.\u003C\/li\u003E\r\n\u003C\/ol\u003E\r\n","summary":null,"format":"limited_html"}],"field_subtitle":"","field_summary":[{"value":"\u003Cp\u003EBiochemistry undergraduate Andrew Schilling has won the Best Presentation Award at the 2022 Herty Metal Undergrad Research Symposium (HMURS). Schilling is an undergraduate research assistant in the lab of Regents\u0026#39; Professor Nicholas Hud.\u003C\/p\u003E\r\n","format":"limited_html"}],"field_summary_sentence":[{"value":"Biochemistry undergraduate Andrew Schilling has won the Best Presentation Award at the 2022 Herty Metal Undergrad Research Symposium (HMURS)."}],"uid":"34528","created_gmt":"2022-10-26 19:48:17","changed_gmt":"2022-10-26 19:50:52","author":"jhunt7","boilerplate_text":"","field_publication":"","field_article_url":"","dateline":{"date":"2022-10-26T00:00:00-04:00","iso_date":"2022-10-26T00:00:00-04:00","tz":"America\/New_York"},"extras":[],"hg_media":{"662613":{"id":"662613","type":"image","title":"Andrew Schilling","body":null,"created":"1666813748","gmt_created":"2022-10-26 19:49:08","changed":"1666813748","gmt_changed":"2022-10-26 19:49:08","alt":"","file":{"fid":"250910","name":"schilling.jpg","image_path":"\/sites\/default\/files\/images\/schilling.jpg","image_full_path":"http:\/\/www.tlwarc.hg.gatech.edu\/\/sites\/default\/files\/images\/schilling.jpg","mime":"image\/jpeg","size":137629,"path_740":"http:\/\/www.tlwarc.hg.gatech.edu\/sites\/default\/files\/styles\/740xx_scale\/public\/images\/schilling.jpg?itok=nvvaRDkO"}},"662614":{"id":"662614","type":"image","title":"Andrew Schilling at HMURS 2022","body":null,"created":"1666813828","gmt_created":"2022-10-26 19:50:28","changed":"1666813828","gmt_changed":"2022-10-26 19:50:28","alt":"","file":{"fid":"250911","name":"schilling2.jpg","image_path":"\/sites\/default\/files\/images\/schilling2.jpg","image_full_path":"http:\/\/www.tlwarc.hg.gatech.edu\/\/sites\/default\/files\/images\/schilling2.jpg","mime":"image\/jpeg","size":661751,"path_740":"http:\/\/www.tlwarc.hg.gatech.edu\/sites\/default\/files\/styles\/740xx_scale\/public\/images\/schilling2.jpg?itok=prYrpVYW"}}},"media_ids":["662613","662614"],"groups":[{"id":"85951","name":"School of Chemistry and Biochemistry"}],"categories":[],"keywords":[{"id":"166928","name":"School of Chemistry and Biochemistry"}],"core_research_areas":[{"id":"39441","name":"Bioengineering and Bioscience"}],"news_room_topics":[],"event_categories":[],"invited_audience":[],"affiliations":[],"classification":[],"areas_of_expertise":[],"news_and_recent_appearances":[],"phone":[],"contact":[],"email":[],"slides":[],"orientation":[],"userdata":""}}}