{"666539":{"#nid":"666539","#data":{"type":"event","title":"ISyE Seminar- Ralph Smith","body":[{"value":"\u003Cp\u003E\u003Cstrong\u003EAbstract: \u003C\/strong\u003EEngineering and biological models generally have a number of parameters which are nonidentifiable in the sense that they are not uniquely determined by measured responses.\u0026nbsp; Furthermore, the computational cost of high-fidelity simulation codes often precludes their direct use for Bayesian model calibration and uncertainty propagation.\u0026nbsp; In this presentation, we will discuss techniques to isolate influential parameters for subsequent surrogate model construction, Bayesian inference and uncertainty propagation.\u0026nbsp; For parameter selection, we will discuss advantages and shortcomings of global sensitivity analysis to isolate influential inputs and detail the use of parameter subset selection and active subspace techniques as an alternative.\u0026nbsp; We will also discuss the manner in which Bayesian calibration on active subspaces can be used to quantify uncertainties in physical parameters.\u0026nbsp; These techniques will be illustrated for models arising in nuclear power plant design and quantitative systems pharmacology (QSP), as well as models for transductive materials.\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u003Cstrong\u003EBiography:\u003C\/strong\u003E Ralph C. Smith joined the North Carolina State University faculty in 1998 where he is presently a Distinguished University Professor of Mathematics.\u0026nbsp; He is co-author of the research monograph \u003Cem\u003ESmart Material Structures: Modeling, Estimation and Control\u003C\/em\u003E and author of the books \u003Cem\u003ESmart Material Systems: Model Development\u003C\/em\u003E and \u003Cem\u003EUncertainty Quantification: Theory, Implementation, and Applications\u003C\/em\u003E.\u0026nbsp; He is on the editorial boards of the \u003Cem\u003EJournal of Intelligent Material Systems and Structures\u003C\/em\u003E and the \u003Cem\u003ESIAM\/ASA Journal on Uncertainty Quantification\u003C\/em\u003E. He is the recipient of the 2016 ASME \u003Cem\u003EAdaptive Structures and Material Systems Prize \u003C\/em\u003Eand the SPIE 2017 \u003Cem\u003ESmart Structures and Materials Lifetime Achievement, \u003C\/em\u003Eand he was named a \u003Cem\u003ESIAM Fellow\u003C\/em\u003E in 2018 and an \u003Cem\u003EASME Fellow\u003C\/em\u003E in 2022\u003Cem\u003E. \u003C\/em\u003EHis research areas include mathematical modeling of smart material systems, numerical analysis and methods for physical systems, Bayesian model calibration, sensitivity analysis, control, and uncertainty quantification for physical and biological systems.\u003C\/p\u003E\r\n","summary":null,"format":"limited_html"}],"field_subtitle":"","field_summary":"","field_summary_sentence":[{"value":"Parameter Subset Selection and Active Subspace Techniques for Engineering and Biological Models"}],"uid":"36358","created_gmt":"2023-03-08 19:10:15","changed_gmt":"2023-03-09 14:23:10","author":"chumphrey30","boilerplate_text":"","field_publication":"","field_article_url":"","field_event_time":{"event_time_start":"2023-03-27T12:00:00-04:00","event_time_end":"2023-03-27T13:15:00-04:00","event_time_end_last":"2023-03-27T13:15:00-04:00","gmt_time_start":"2023-03-27 16:00:00","gmt_time_end":"2023-03-27 17:15:00","gmt_time_end_last":"2023-03-27 17:15:00","rrule":null,"timezone":"America\/New_York"},"extras":["free_food"],"groups":[{"id":"1242","name":"School of Industrial and Systems Engineering (ISYE)"}],"categories":[],"keywords":[],"core_research_areas":[],"news_room_topics":[],"event_categories":[{"id":"1795","name":"Seminar\/Lecture\/Colloquium"}],"invited_audience":[{"id":"78761","name":"Faculty\/Staff"},{"id":"78771","name":"Public"},{"id":"78751","name":"Undergraduate students"}],"affiliations":[],"classification":[],"areas_of_expertise":[],"news_and_recent_appearances":[],"phone":[],"contact":[],"email":[],"slides":[],"orientation":[],"userdata":""}}}