{"671937":{"#nid":"671937","#data":{"type":"event","title":"PhD Proposal by Gloriani S\u00e1nchez Marrero","body":[{"value":"\u003Cp\u003E\u003Cspan\u003E\u003Cspan\u003E\u003Cstrong\u003E\u003Cspan\u003EGloriani S\u003C\/span\u003E\u003Cspan\u003E\u00e1\u003C\/span\u003E\u003Cspan\u003Enchez Marrero\u003C\/span\u003E\u003C\/strong\u003E\u003C\/span\u003E\u003C\/span\u003E\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u003Cspan\u003E\u003Cspan\u003E\u003Cspan\u003EBioE Ph.D. Proposal\u003C\/span\u003E\u003C\/span\u003E\u003C\/span\u003E\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u003Cspan\u003E\u003Cspan\u003E\u003Cspan\u003EJanuary 17, 2024\u003C\/span\u003E\u003C\/span\u003E\u003C\/span\u003E\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u003Cspan\u003E\u003Cspan\u003E\u003Cspan\u003E11:00 AM\u003C\/span\u003E\u003C\/span\u003E\u003C\/span\u003E\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u003Cspan\u003E\u003Cspan\u003E\u003Cspan\u003ELocation: E-160 HSRB I, Emory University\u003C\/span\u003E\u003C\/span\u003E\u003C\/span\u003E\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u003Cspan\u003E\u003Cspan\u003E\u003Cspan\u003EZoom Link: \u003C\/span\u003E\u003Ca href=\u0022https:\/\/gatech.zoom.us\/j\/94000206297\u0022\u003Ehttps:\/\/gatech.zoom.us\/j\/94000206297\u003C\/a\u003E\u003C\/span\u003E\u003C\/span\u003E\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u003Cspan\u003E\u003Cspan\u003E\u0026nbsp;\u003C\/span\u003E\u003C\/span\u003E\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u003Cspan\u003E\u003Cspan\u003E\u003Cstrong\u003E\u003Cspan\u003ECommittee:\u003C\/span\u003E\u003C\/strong\u003E\u003C\/span\u003E\u003C\/span\u003E\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u003Cspan\u003E\u003Cspan\u003E\u003Cstrong\u003ELuke Brewster, M.D., Ph.D. \u003C\/strong\u003E(Ph.D. Advisor) \u003Cstrong\u003E\u0026nbsp;\u003C\/strong\u003E(Vascular Surgery, Emory University)\u003C\/span\u003E\u003C\/span\u003E\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u003Cspan\u003E\u003Cspan\u003E\u003Cstrong\u003EHanjoong Jo, Ph.D. \u003C\/strong\u003E(Biomedical Engineering, Emory and GT)\u003C\/span\u003E\u003C\/span\u003E\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u003Cspan\u003E\u003Cspan\u003E\u003Cstrong\u003ERudolph Gleason, Ph.D. \u0026nbsp;\u003C\/strong\u003E(Biomedical Engineering and Mechanical Engineering, GT)\u003C\/span\u003E\u003C\/span\u003E\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u003Cspan\u003E\u003Cspan\u003E\u003Cstrong\u003EMichael Walsh, Ph.D. \u003C\/strong\u003E(Biomedical Engineering, University of Limerick)\u003C\/span\u003E\u003C\/span\u003E\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u003Cspan\u003E\u003Cspan\u003E\u003Cstrong\u003EBrian Aguado, Ph.D. \u003C\/strong\u003E(Bioengineering, University of California San Diego)\u003C\/span\u003E\u003C\/span\u003E\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u003Cspan\u003E\u003Cspan\u003E\u0026nbsp;\u0026nbsp;\u003C\/span\u003E\u003C\/span\u003E\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u003Cspan\u003E\u003Cspan\u003E\u0026nbsp;\u003C\/span\u003E\u003C\/span\u003E\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u003Cspan\u003E\u003Cspan\u003E\u003Cstrong\u003EEffect of Artery Type and Function on Atherosclerotic Plaque Progression and Phenotype\u003C\/strong\u003E\u003C\/span\u003E\u003C\/span\u003E\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u003Cspan\u003E\u003Cspan\u003EArteries are classified as elastic or muscular. Elastic arteries, like the carotid artery (CA), store elastic energy during systole while muscular arteries, like the femoral artery (FA), regulate blood flow to peripheral organs. Interestingly, atherosclerotic plaque composition varies with artery type; elastic arteries develop lipid-rich plaque and muscular arteries develop fibrotic plaque. Arterial remodeling is a complex process involving arterial stiffening and atherosclerotic plaque formation. Atherosclerosis is characterized by the deposition of plaque at locations of disturbed blood flow (d-flow). Endothelial cells (ECs) sense d-flow and stiffness leading to EC dysfunction, fibroinflammatory pathway activation, and inwards remodeling of the artery. The goal of this proposal is to better understand how the mechanical stiffness and fluid dynamic profiles of the elastic CAs and muscular FAs lead to distinct atherosclerotic plaque formation. Differences across biological sex will also be evaluated. Murine models of partial ligation in the CAs and FAs will be used to induce d-flow conditions and fibulin-5 knockout mice will be used to induce arterial stiffening. Innovative tools in transcriptomics and established tests in biomechanics will be used to characterize atherosclerosis progression. Finally, a 1D fluid-solid-growth-remodeling computational model will be developed to predict changes in the hemodynamic profiles, geometries, and biomechanical properties of the arteries as atherosclerosis progresses taking into consideration the differences found due to artery type and arterial stiffness.\u003C\/span\u003E\u003C\/span\u003E\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\r\n","summary":"","format":"limited_html"}],"field_subtitle":"","field_summary":[{"value":"\u003Cp\u003E\u003Cspan\u003E\u003Cspan\u003E\u003Cstrong\u003EEffect of Artery Type and Function on Atherosclerotic Plaque Progression and Phenotype\u003C\/strong\u003E\u003C\/span\u003E\u003C\/span\u003E\u003C\/p\u003E\r\n","format":"limited_html"}],"field_summary_sentence":[{"value":"Effect of Artery Type and Function on Atherosclerotic Plaque Progression and Phenotype"}],"uid":"27707","created_gmt":"2024-01-08 18:59:27","changed_gmt":"2024-01-08 18:59:27","author":"Tatianna Richardson","boilerplate_text":"","field_publication":"","field_article_url":"","field_event_time":{"event_time_start":"2024-01-17T11:00:00-05:00","event_time_end":"2024-01-17T13:00:00-05:00","event_time_end_last":"2024-01-17T13:00:00-05:00","gmt_time_start":"2024-01-17 16:00:00","gmt_time_end":"2024-01-17 18:00:00","gmt_time_end_last":"2024-01-17 18:00:00","rrule":null,"timezone":"America\/New_York"},"location":"E-160 HSRB I, Emory University","extras":[],"groups":[{"id":"221981","name":"Graduate Studies"}],"categories":[],"keywords":[{"id":"102851","name":"Phd proposal"}],"core_research_areas":[],"news_room_topics":[],"event_categories":[{"id":"1788","name":"Other\/Miscellaneous"}],"invited_audience":[{"id":"78771","name":"Public"}],"affiliations":[],"classification":[],"areas_of_expertise":[],"news_and_recent_appearances":[],"phone":[],"contact":[],"email":[],"slides":[],"orientation":[],"userdata":""}}}