{"90131":{"#nid":"90131","#data":{"type":"event","title":"(11-0419) Dr. Robert Reynolds, Southern Research Institute","body":[{"value":"\u003Cp\u003EDr. Robert Reynolds, Southern Research Institute\n\u003C\/p\u003E\n\u003Cp\u003ETargeting the Mycobacterial ATPome\n\u003C\/p\u003E\n\u003Cp\u003ERiboEvo Seminar Series\n\u003C\/p\u003E\n\u003Cp\u003EIt is commonly known that ATP plays a crucial role in energy metabolism in all living systems, and ATP generation is the established target of the new antitubercular drug candidate TMC-207.  It is also widely accepted that a variety of essential signaling processes rely on ATP-binding and phosphorylation of target proteins through the action of protein kinases.  These processes are crucial for environmental signaling and control of metabolic states in both eukaryotes and prokaryotes.  For example, two kinases, PknA and PknB, are considered essential kinases in Mycobacterium tuberculosis (Mtb), and these proteins are the focus of several ongoing drug design programs.  In addition to these processes\/proteins, there are a variety of other important ATP binding proteins that play critical roles in the mycobacterial life cycle.  This talk will focus on our current knowledge of ATP binding proteins in mycobacteria, particularly relating to our efforts to identify ATP-binding proteins that are critical to the growing versus latent bacillus.  Special emphasis will be placed on alternative ATP binding targets in Mtb.\n\u003C\/p\u003E\n\u003Cp\u003EFor more information contact \u003Ca href=\u0022mailto:loren.williams@chemistry.gatech.edu\u0022\u003EProf. Loren Williams\u003C\/a\u003E (404-894-9752).\u003C\/p\u003E","summary":null,"format":"limited_html"}],"field_subtitle":"","field_summary":[{"value":"Dr. Robert Reynolds, Southern Research Institute\n\nTargeting the Mycobacterial ATPome\n\nRiboEvo Seminar Series","format":"limited_html"}],"field_summary_sentence":[{"value":"Dr. Robert Reynolds, Southern Research Institute"}],"uid":"27275","created_gmt":"2010-09-17 00:00:00","changed_gmt":"2016-10-08 01:47:05","author":"Shirley Tomes","boilerplate_text":"","field_publication":"","field_article_url":"","field_event_time":{"event_time_start":"2011-04-19T17:00:00-04:00","event_time_end":"2011-04-19T18:00:00-04:00","event_time_end_last":"2011-04-19T18:00:00-04:00","gmt_time_start":"2011-04-19 21:00:00","gmt_time_end":"2011-04-19 22:00:00","gmt_time_end_last":"2011-04-19 22:00:00","rrule":null,"timezone":"America\/New_York"},"extras":[],"related_links":[{"url":"http:\/\/www.southernresearch.org\/research\/reynolds.html","title":"Dr. Robert Reynolds, Southern Research Institute"}],"groups":[{"id":"85951","name":"School of Chemistry and Biochemistry"}],"categories":[],"keywords":[{"id":"4910","name":"inorganic chemistry"}],"core_research_areas":[],"news_room_topics":[],"event_categories":[{"id":"1795","name":"Seminar\/Lecture\/Colloquium"}],"invited_audience":[],"affiliations":[],"classification":[],"areas_of_expertise":[],"news_and_recent_appearances":[],"phone":[],"contact":[{"value":"\u003Cstrong\u003EShirley Tomes\u003C\/strong\u003E\u003Cbr \/\u003EChemistry \u0026amp; Biochemistry\u003Cbr \/\u003E\u003Ca href=\u0022http:\/\/www.gatech.edu\/contact\/index.html?id=st81\u0022\u003EContact Shirley Tomes\u003C\/a\u003E\u003Cbr \/\u003E\u003Cstrong\u003E404-894-0591\u003C\/strong\u003E","format":"limited_html"}],"email":[],"slides":[],"orientation":[],"userdata":""}}}