{"90181":{"#nid":"90181","#data":{"type":"event","title":"(11-0505) Prof. Lillian Chong, University of Pittsburgh","body":[{"value":"\u003Cp\u003EProf. Lillian Chong, University of Pittsburgh\n\u003C\/p\u003E\n\u003Cp\u003EMolecular simulations of protein binding and switching\n\u003C\/p\u003E\n\u003Cp\u003EPhysical Chemistry Seminar Series\n\u003C\/p\u003E\n\u003Cp\u003EA major challenge in the field of biomolecular simulations is to access the long-timescale dynamics of biologically relevant protein motions such as the relative motions of protein domains and allosteric transitions. My group uses a variety of  approaches for providing detailed views of such motions that might aid the design of molecular sensors or therapeutics. In this talk, I will present recent applications to the simulation of large-scale conformational changes in bi-functional, two-domain protein switches, molecular association kinetics, and how nature might correct for \u00e2\u0080\u009cmistakes\u00e2\u0080\u009d in binding geometry for a model protein-peptide complex.\n\u003C\/p\u003E\n\u003Cp\u003EFor more information contact \u003Ca href=\u0022mailto:hernandez@chemistry.gatech.edu\u0022\u003EProf. Rigoberto Hernandez\u003C\/a\u003E (404-894-0594) or \u003Ca href=\u0022mailto:raquel.lieberman@chemistry.gatech.edu\u0022\u003EProf. Raquel Lieberman\u003C\/a\u003E (404-385-3663).\u003C\/p\u003E","summary":null,"format":"limited_html"}],"field_subtitle":"","field_summary":[{"value":"Prof. Lillian Chong, University of Pittsburgh\n\nMolecular simulations of protein binding and switching\n\nPhysical Chemistry Seminar Series","format":"limited_html"}],"field_summary_sentence":[{"value":"Prof. Lillian Chong, University of Pittsburgh"}],"uid":"27275","created_gmt":"2010-09-15 00:00:00","changed_gmt":"2016-10-08 01:47:05","author":"Shirley Tomes","boilerplate_text":"","field_publication":"","field_article_url":"","field_event_time":{"event_time_start":"2011-05-05T17:00:00-04:00","event_time_end":"2011-05-05T18:00:00-04:00","event_time_end_last":"2011-05-05T18:00:00-04:00","gmt_time_start":"2011-05-05 21:00:00","gmt_time_end":"2011-05-05 22:00:00","gmt_time_end_last":"2011-05-05 22:00:00","rrule":null,"timezone":"America\/New_York"},"extras":[],"related_links":[{"url":"http:\/\/www.chem.pitt.edu\/people\/faculty\/lillian-chong","title":"Lillian Chong profile"}],"groups":[{"id":"85951","name":"School of Chemistry and Biochemistry"}],"categories":[],"keywords":[{"id":"89","name":"chemistry"}],"core_research_areas":[],"news_room_topics":[],"event_categories":[{"id":"1795","name":"Seminar\/Lecture\/Colloquium"}],"invited_audience":[],"affiliations":[],"classification":[],"areas_of_expertise":[],"news_and_recent_appearances":[],"phone":[],"contact":[{"value":"\u003Cstrong\u003EShirley Tomes\u003C\/strong\u003E\u003Cbr \/\u003EChemistry \u0026amp; Biochemistry\u003Cbr \/\u003E\u003Ca href=\u0022http:\/\/www.gatech.edu\/contact\/index.html?id=st81\u0022\u003EContact Shirley Tomes\u003C\/a\u003E\u003Cbr \/\u003E\u003Cstrong\u003E404-894-0591\u003C\/strong\u003E","format":"limited_html"}],"email":[],"slides":[],"orientation":[],"userdata":""}}}