{"90931":{"#nid":"90931","#data":{"type":"event","title":"(11-0421) Prof. Tadhg Begley, Texas A\u0026M University","body":[{"value":"\u003Cp\u003EProf. Tadhg Begley, Texas A\u0026amp;M University\n\u003C\/p\u003E\n\u003Cp\u003EThiamin biosynthesis: characterization of two genes of unknown function\n\u003C\/p\u003E\n\u003Cp\u003ESchool Colloquia\n\u003C\/p\u003E\n\u003Cp\u003EThiamin pyrophosphate plays a key role in the stabilization of the acyl carbanion biosynthon in carbohydrate and amino acid metabolism and is an essential cofactor in all living systems. The biosyntheses of the thiamin pyrimidine and thiazole are complex and differ from any of the characterized chemical or biochemical routes to these heterocycles. The complete thiamin biosynthesis has now been reconstituted in a biochemically-defined system and the structures of all of the biosynthetic enzymes have been determined. Our mechanistic understanding of the pathway is also at an advanced stage.\n\u003C\/p\u003E\n\u003Cp\u003EThis presentation will describe recent progress on the functional characterization of the TenA and TenI genes involved in thiamin biosynthesis.\n\u003C\/p\u003E\n\u003Cp\u003EFor more information contact \u003Ca href=\u0022mailto:wendy.kelly@chemistry.gatech.edu\u0022\u003EProf. Wendy Kelly\u003C\/a\u003E (404-385-1154).\u003C\/p\u003E","summary":null,"format":"limited_html"}],"field_subtitle":"","field_summary":[{"value":"Prof. Tadhg Begley, Texas A\u0026amp;M University\n\nThiamin biosynthesis: characterization of two genes of unknown function\n\nSchool Colloquia","format":"limited_html"}],"field_summary_sentence":[{"value":"Prof. Tadhg Begley, Texas A\u0026M University"}],"uid":"27275","created_gmt":"2010-02-09 01:00:00","changed_gmt":"2016-10-08 01:48:23","author":"Shirley Tomes","boilerplate_text":"","field_publication":"","field_article_url":"","field_event_time":{"event_time_start":"2011-04-21T17:00:00-04:00","event_time_end":"2011-04-21T18:00:00-04:00","event_time_end_last":"2011-04-21T18:00:00-04:00","gmt_time_start":"2011-04-21 21:00:00","gmt_time_end":"2011-04-21 22:00:00","gmt_time_end_last":"2011-04-21 22:00:00","rrule":null,"timezone":"America\/New_York"},"extras":[],"related_links":[{"url":"http:\/\/www.chem.tamu.edu\/faculty\/faculty_detail.php?ID=9004\u0026bc=alpha\u0026bc2=dir","title":"Prof. Tadhg Begley, Texas A\u0026M University"}],"groups":[{"id":"85951","name":"School of Chemistry and Biochemistry"}],"categories":[],"keywords":[{"id":"1809","name":"physical chemistry"}],"core_research_areas":[],"news_room_topics":[],"event_categories":[{"id":"1795","name":"Seminar\/Lecture\/Colloquium"}],"invited_audience":[],"affiliations":[],"classification":[],"areas_of_expertise":[],"news_and_recent_appearances":[],"phone":[],"contact":[{"value":"\u003Cstrong\u003EShirley Tomes\u003C\/strong\u003E\u003Cbr \/\u003EChemistry \u0026amp; Biochemistry\u003Cbr \/\u003E\u003Ca href=\u0022http:\/\/www.gatech.edu\/contact\/index.html?id=st81\u0022\u003EContact Shirley Tomes\u003C\/a\u003E\u003Cbr \/\u003E\u003Cstrong\u003E404-894-0591\u003C\/strong\u003E","format":"limited_html"}],"email":[],"slides":[],"orientation":[],"userdata":""}}}