{"92161":{"#nid":"92161","#data":{"type":"event","title":"(09-0326) Prof. Todd Marder, Durham University (UK)","body":[{"value":"\u003Cp\u003EProf. Todd Marder, Durham University (UK)\n\u003C\/p\u003E\n\u003Cp\u003EMetal Catalyzed Synthesis of Retinoids for Stem Cell Differentiation Including Applications of Novel C-H Bond Functionalization Processes\n\u003C\/p\u003E\n\u003Cp\u003ERetinoids are natural and synthetic molecules structurally and\/or functionally analogous to all trans retinoic acid (ATRA). \n\u003C\/p\u003E\n\u003Cp\u003EATRA, the natural metabolite of Vitamin A, regulates a wide range of essential processes such as mammalian embryogenesis, cellular differentiation, proliferation and apoptosis, amongst others. In vitro use of ATRA is complicated by its isomerization under laboratory conditions, as the different isomers activate different biological processes. In order to overcome this, retinoids stable to heat and light have been developed, and we have shown that they are capable of triggering stem cell differentiation reproducibly, but in different ways, depending on their structure. For example, one synthetic system which appears to be more active than ATRA, and which preliminary evidence suggests may function by the same biological pathways, has been developed and used to trigger differentiation to provide neurons (nerve cells).\n\u003C\/p\u003E\n\u003Cp\u003EThe synthetic routes employed to prepare the retinoids will be addressed, which include a variety of cross-coupling procedures. In addition, both aromatic and vinylic C-H bond borylation processes have been combined in a 4-step synthesis of high value retinoid methylesters from simple hydrocarbon precursors. Finally, studies of cell differentiation and preliminary proteomic data will be presented.\n\u003C\/p\u003E\n\u003Cp\u003ED.J. Maltman, V.B. Christie, J.C. Collings, J.H. Barnard, S. Fenyk, T.B. Marder, A. Whiting, and S.A. Przyborski, \u0022Proteomic Profiling of the Stem Cell Response to Retinoic Acid and Synthetic Retinoid Analogues: Identification of Major Retinoid-inducible Proteins,\u0022 Molecular Biosystems, accepted February 2009.\n\u003C\/p\u003E\n\u003Cp\u003EJ.H. Barnard, C.E. Bridgens, A.S. Batsanov, E.B. Cartmell, V.B. Christie, J.C. Collings, T.B. Marder, S.A. Przyborski, and A. Whiting, \u0022Synthesis and Evaluation of Selective Stem Cell Differentiation Agents Based on Synthetic Retinoid Derivatives,\u0022 Org. Biomol. Chem. 6, 3497-3507 (2008).\n\u003C\/p\u003E\n\u003Cp\u003EV.B. Christie, T.B. Marder, A. Whiting, and S.A. Przyborski, \u0022The Role of Retinoids in the Adult Nervous System and their Theraputic Potential,\u0022 Mini Reviews in Medicinal Chemistry, 8, 601-608 (2008).\n\u003C\/p\u003E\n\u003Cp\u003EFor more information contact \u003Ca href=\u0022mailto:seth.marder@chemistry.gatech.edu\u0022\u003EProf. Seth Marder\u003C\/a\u003E (404) 385-6048.\n\u003C\/p\u003E","summary":null,"format":"limited_html"}],"field_subtitle":"","field_summary":[{"value":"Prof. Todd Marder, Durham University (UK)\n\nMetal Catalyzed Synthesis of Retinoids for Stem Cell Differentiation\nIncluding Applications of Novel C-H Bond Functionalization Processes","format":"limited_html"}],"field_summary_sentence":[{"value":"Prof. Todd Marder, Durham University (UK)"}],"uid":"27275","created_gmt":"2009-03-13 00:00:00","changed_gmt":"2016-10-08 01:57:11","author":"Shirley Tomes","boilerplate_text":"","field_publication":"","field_article_url":"","field_event_time":{"event_time_start":"2009-03-26T12:00:00-04:00","event_time_end":"2009-03-26T13:00:00-04:00","event_time_end_last":"2009-03-26T13:00:00-04:00","gmt_time_start":"2009-03-26 16:00:00","gmt_time_end":"2009-03-26 17:00:00","gmt_time_end_last":"2009-03-26 17:00:00","rrule":null,"timezone":"America\/New_York"},"extras":[],"related_links":[{"url":"http:\/\/www.dur.ac.uk\/chemistry\/staff\/profile\/?id=194","title":"Prof. Todd Marder, Durham University, UK"}],"groups":[{"id":"85951","name":"School of Chemistry and Biochemistry"}],"categories":[],"keywords":[{"id":"5191","name":"theoretical chemistry"}],"core_research_areas":[],"news_room_topics":[],"event_categories":[{"id":"1791","name":"Student sponsored"}],"invited_audience":[],"affiliations":[],"classification":[],"areas_of_expertise":[],"news_and_recent_appearances":[],"phone":[],"contact":[{"value":"\u003Cstrong\u003EShirley Tomes\u003C\/strong\u003E\u003Cbr \/\u003EChemistry \u0026amp; Biochemistry\u003Cbr \/\u003E\u003Ca href=\u0022http:\/\/www.gatech.edu\/contact\/index.html?id=st81\u0022\u003EContact Shirley Tomes\u003C\/a\u003E\u003Cbr \/\u003E\u003Cstrong\u003E404-894-0591\u003C\/strong\u003E","format":"limited_html"}],"email":[],"slides":[],"orientation":[],"userdata":""}}}